Eps8l3 (EPS8-like 3) - Rat Genome Database

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Gene: Eps8l3 (EPS8-like 3) Mus musculus
Analyze
Symbol: Eps8l3
Name: EPS8-like 3
RGD ID: 1318008
MGI Page MGI
Description: Predicted to enable actin binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI504489; epidermal growth factor receptor kinase substrate 8-like protein 3; epidermal growth factor receptor pathway substrate 8 related protein 3; epidermal growth factor receptor pathway substrate 8-related protein 3; EPS8-like protein 3; EPS8-related protein 3; Eps8r3; ESP8-like 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,781,177 - 107,800,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,784,545 - 107,800,216 (+)EnsemblGRCm39 Ensembl
GRCm383107,873,860 - 107,892,900 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,877,229 - 107,892,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,680,148 - 107,695,818 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,005,286 - 108,020,956 (+)NCBIMGSCv36mm8
Celera3110,209,978 - 110,225,648 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12620401   PMID:14565974   PMID:14681479   PMID:15489334   PMID:15558031   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23266329  


Genomics

Comparative Map Data
Eps8l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,781,177 - 107,800,216 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,784,545 - 107,800,216 (+)EnsemblGRCm39 Ensembl
GRCm383107,873,860 - 107,892,900 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,877,229 - 107,892,900 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,680,148 - 107,695,818 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,005,286 - 108,020,956 (+)NCBIMGSCv36mm8
Celera3110,209,978 - 110,225,648 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
EPS8L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,750,080 - 109,763,923 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,750,080 - 109,764,027 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,292,702 - 110,306,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,094,225 - 110,108,087 (-)NCBINCBI36Build 36hg18NCBI36
Celera1108,539,315 - 108,553,178 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,162,462 - 108,176,399 (-)NCBIHuRef
CHM1_11110,407,520 - 110,421,459 (-)NCBICHM1_1
T2T-CHM13v2.01109,760,224 - 109,774,060 (-)NCBIT2T-CHM13v2.0
Eps8l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,202,862 - 198,216,255 (+)NCBIGRCr8
mRatBN7.22195,514,692 - 195,528,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,514,692 - 195,528,085 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02210,668,249 - 210,681,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,668,403 - 210,681,796 (+)EnsemblRnor6.0rn6Rnor6.0
Celera2188,160,992 - 188,174,676 (+)NCBICelera
Cytogenetic Map2q34NCBI
Eps8l3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,261,429 - 13,274,613 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,261,730 - 13,277,117 (-)NCBIChiLan1.0ChiLan1.0
EPS8L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,281,866 - 117,295,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,429,928 - 116,443,772 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,394,042 - 112,407,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,935,678 - 127,947,406 (+)NCBIpanpan1.1PanPan1.1panPan2
EPS8L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,163,609 - 42,176,671 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,167,049 - 42,176,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,937,506 - 44,952,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,493,370 - 42,508,178 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,495,093 - 42,507,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,226,388 - 42,241,169 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,184,135 - 42,198,913 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,618,936 - 42,633,727 (+)NCBIUU_Cfam_GSD_1.0
Eps8l3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,860,313 - 18,873,124 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367041,241,341 - 1,251,702 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,311,519 - 110,326,994 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,311,533 - 110,326,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,833,586 - 120,849,043 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPS8L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,780,116 - 23,795,946 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,781,999 - 23,795,989 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,663,415 - 34,677,409 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps8l3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247725,502,020 - 5,515,704 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eps8l3
353 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:102
Interacting mature miRNAs:109
Transcripts:ENSMUST00000037375
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1357599msrvh1_mmodifier of susceptibility to renal vascular hypertrophy/hyperplasia 1 (mouse)Not determined3107376936115624197Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse

Markers in Region
AI504489  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383107,892,650 - 107,892,869UniSTSGRCm38
MGSCv373107,695,568 - 107,695,787UniSTSGRCm37
Celera3110,225,398 - 110,225,617UniSTS
Cytogenetic Map3F2.3UniSTS
Whitehead/MRC_RH31175.56UniSTS
Eps8l3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F2.3UniSTS
cM Map346.83UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037375   ⟹   ENSMUSP00000042004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,784,545 - 107,800,216 (+)Ensembl
GRCm38.p6 Ensembl3107,877,229 - 107,892,900 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199990   ⟹   ENSMUSP00000143754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,784,578 - 107,788,945 (+)Ensembl
GRCm38.p6 Ensembl3107,877,262 - 107,881,629 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200198
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3107,784,560 - 107,788,569 (+)Ensembl
GRCm38.p6 Ensembl3107,877,244 - 107,881,253 (+)Ensembl
RefSeq Acc Id: NM_133867   ⟹   NP_598628
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,784,546 - 107,800,216 (+)NCBI
GRCm383107,877,230 - 107,892,900 (+)NCBI
MGSCv373107,680,148 - 107,695,818 (+)RGD
Celera3110,209,978 - 110,225,648 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502463   ⟹   XP_006502526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,781,177 - 107,800,209 (+)NCBI
GRCm383107,873,861 - 107,892,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502464   ⟹   XP_006502527
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,781,179 - 107,800,213 (+)NCBI
GRCm383107,873,863 - 107,892,897 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006502465   ⟹   XP_006502528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393107,781,177 - 107,800,209 (+)NCBI
GRCm383107,873,860 - 107,892,897 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598628   ⟸   NM_133867
- UniProtKB: Q3TJ14 (UniProtKB/Swiss-Prot),   Q91WL0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502526   ⟸   XM_006502463
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006502527   ⟸   XM_006502464
- Peptide Label: isoform X2
- UniProtKB: Q3TJ14 (UniProtKB/Swiss-Prot),   Q91WL0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006502528   ⟸   XM_006502465
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000143754   ⟸   ENSMUST00000199990
RefSeq Acc Id: ENSMUSP00000042004   ⟸   ENSMUST00000037375
Protein Domains
PTB   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91WL0-F1-model_v2 AlphaFold Q91WL0 1-600 view protein structure

Promoters
RGD ID:6882028
Promoter ID:EPDNEW_M4465
Type:initiation region
Name:Eps8l3_1
Description:Mus musculus EPS8-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383107,877,244 - 107,877,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2139743 AgrOrtholog
Ensembl Genes ENSMUSG00000040600 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000052960
Ensembl Transcript ENSMUST00000037375 ENTREZGENE
  ENSMUST00000037375.10 UniProtKB/Swiss-Prot
  ENSMUST00000199990.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot
InterPro EPS8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/Swiss-Prot
  Eps8_SH3 UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot
  SAM_3 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:99662 UniProtKB/Swiss-Prot
MGD MGI:2139743 ENTREZGENE
NCBI Gene 99662 ENTREZGENE
PANTHER EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12287 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_3 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Eps8l3 PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot
SMART SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2JGZ0_MOUSE UniProtKB/TrEMBL
  ES8L3_MOUSE UniProtKB/Swiss-Prot
  Q3TJ14 ENTREZGENE
  Q91WL0 ENTREZGENE
UniProt Secondary Q3TJ14 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Eps8l3  EPS8-like 3  Eps8l3  ESP8-like 3  Symbol and/or name change 5135510 APPROVED