(-)-demecolcine decreases expression ISO ORC1 (Homo sapiens) 6480464 Demecolcine results in decreased expression of ORC1 mRNA CTD PMID:23649840 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of ORC1 mRNA CTD PMID:22206623 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of ORC1 mRNA CTD PMID:21404309 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of ORC1 mRNA CTD PMID:15598610 17beta-estradiol increases expression ISO Orc1 (Rattus norvegicus) 6480464 Estradiol results in increased expression of ORC1 mRNA CTD PMID:32145629 17beta-estradiol increases expression ISO ORC1 (Homo sapiens) 6480464 Estradiol results in increased expression of ORC1 mRNA CTD PMID:19167446 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ORC1 mRNA CTD PMID:16962184 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ORC1 mRNA CTD PMID:26159488 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO ORC1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of ORC1 mRNA CTD PMID:22574217 2-butoxyethanol increases expression EXP 6480464 n-butoxyethanol results in increased expression of ORC1 mRNA CTD PMID:19812364 2-palmitoylglycerol increases expression ISO ORC1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of ORC1 mRNA CTD PMID:37199045 3,3',4,4',5-pentachlorobiphenyl increases expression ISO Orc1 (Rattus norvegicus) 6480464 3 more ... CTD PMID:23196670 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP 6480464 Oxazolone results in increased expression of ORC1 mRNA CTD PMID:21404309 4-nitrophenol decreases expression EXP 6480464 4-nitrophenol results in decreased expression of ORC1 mRNA CTD PMID:34673133 6-propyl-2-thiouracil increases expression ISO Orc1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of ORC1 mRNA CTD PMID:24780913 and PMID:30047161 acetamide increases expression ISO Orc1 (Rattus norvegicus) 6480464 acetamide results in increased expression of ORC1 mRNA CTD PMID:31881176 acrylamide increases expression ISO Orc1 (Rattus norvegicus) 6480464 Acrylamide results in increased expression of ORC1 mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO ORC1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of ORC1 mRNA CTD PMID:22100608 aflatoxin B1 increases methylation ISO ORC1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of ORC1 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO ORC1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of ORC1 mRNA CTD PMID:21934132 and PMID:33167477 all-trans-retinoic acid increases expression ISO Orc1 (Rattus norvegicus) 6480464 Tretinoin results in increased expression of ORC1 mRNA CTD PMID:20488242 amitrole increases expression ISO Orc1 (Rattus norvegicus) 6480464 Amitrole results in increased expression of ORC1 mRNA CTD PMID:30047161 ammonium chloride affects expression ISO Orc1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of ORC1 mRNA CTD PMID:16483693 aristolochic acid A decreases expression ISO ORC1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of ORC1 protein CTD PMID:33212167 azathioprine decreases expression ISO ORC1 (Homo sapiens) 6480464 Azathioprine results in decreased expression of ORC1 mRNA CTD PMID:22623647 benzene affects expression ISO ORC1 (Homo sapiens) 6480464 Benzene affects the expression of ORC1 mRNA CTD PMID:16188086 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to ORC1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO ORC1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of ORC1 mRNA CTD PMID:32234424 benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of ORC1 exon and Benzo(a)pyrene results in increased methylation of ORC1 intron CTD PMID:27901495 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of ORC1 mRNA CTD PMID:20713471 benzo[a]pyrene diol epoxide I decreases expression ISO ORC1 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 benzo[e]pyrene increases methylation ISO ORC1 (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of ORC1 intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ORC1 mRNA CTD PMID:26063408 and PMID:32156529 bisphenol A increases expression ISO Orc1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of ORC1 mRNA CTD PMID:32145629 bisphenol A decreases expression ISO ORC1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of ORC1 mRNA CTD PMID:29275510 bisphenol A affects expression ISO ORC1 (Homo sapiens) 6480464 bisphenol A affects the expression of ORC1 mRNA CTD PMID:30903817 bisphenol A decreases expression ISO Orc1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of ORC1 mRNA CTD PMID:25181051 bromobenzene increases expression ISO Orc1 (Rattus norvegicus) 6480464 bromobenzene results in increased expression of ORC1 mRNA CTD PMID:32479839 caffeine affects phosphorylation ISO ORC1 (Homo sapiens) 6480464 Caffeine affects the phosphorylation of ORC1 protein CTD PMID:35688186 calcitriol decreases expression ISO ORC1 (Homo sapiens) 6480464 Calcitriol results in decreased expression of ORC1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ORC1 mRNA CTD PMID:21592394 cannabidiol decreases expression ISO ORC1 (Homo sapiens) 6480464 Cannabidiol results in decreased expression of ORC1 mRNA CTD PMID:33244087 and PMID:36519830 chlorpromazine decreases expression ISO ORC1 (Homo sapiens) 6480464 Chlorpromazine analog results in decreased expression of ORC1 mRNA CTD PMID:15924885 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of ORC1 mRNA CTD PMID:37019170 cisplatin increases expression ISO ORC1 (Homo sapiens) 6480464 Cisplatin results in increased expression of ORC1 mRNA CTD PMID:27594783 clotrimazole increases expression ISO Orc1 (Rattus norvegicus) 6480464 Clotrimazole results in increased expression of ORC1 mRNA CTD PMID:30047161 copper atom multiple interactions ISO ORC1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of ORC1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO ORC1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of ORC1 mRNA CTD PMID:20971185 coumarin decreases phosphorylation ISO ORC1 (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of ORC1 protein CTD PMID:35688186 coumestrol multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO ORC1 (Homo sapiens) 6480464 Coumestrol results in increased expression of ORC1 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO ORC1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of ORC1 mRNA CTD PMID:19159671 more ... dicrotophos increases expression ISO ORC1 (Homo sapiens) 6480464 dicrotophos results in increased expression of ORC1 mRNA CTD PMID:28302478 diethyl maleate increases expression ISO Orc1 (Rattus norvegicus) 6480464 diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 dioxygen decreases expression ISO ORC1 (Homo sapiens) 6480464 Oxygen deficiency results in decreased expression of ORC1 mRNA CTD PMID:26516004 endosulfan multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ORC1 mRNA CTD PMID:26159488 Enterolactone multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of ORC1 mRNA CTD PMID:19167446 FR900359 decreases phosphorylation ISO ORC1 (Homo sapiens) 6480464 FR900359 results in decreased phosphorylation of ORC1 protein CTD PMID:37730182 furan increases expression ISO Orc1 (Rattus norvegicus) 6480464 furan results in increased expression of ORC1 mRNA CTD PMID:25539665 gentamycin decreases expression ISO Orc1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of ORC1 mRNA CTD PMID:33387578 glyphosate decreases expression ISO ORC1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of ORC1 mRNA CTD PMID:31295307 GW 3965 decreases expression ISO ORC1 (Homo sapiens) 6480464 GW 3965 results in decreased expression of ORC1 mRNA CTD PMID:31437187 GW 4064 increases expression ISO ORC1 (Homo sapiens) 6480464 GW 4064 results in increased expression of ORC1 mRNA CTD PMID:31437187 irinotecan increases response to substance ISO ORC1 (Homo sapiens) 6480464 ORC1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 Lasiocarpine increases expression ISO ORC1 (Homo sapiens) 6480464 lasiocarpine results in increased expression of ORC1 mRNA CTD PMID:32234424 lidocaine increases expression ISO Orc1 (Rattus norvegicus) 6480464 Lidocaine results in increased expression of ORC1 mRNA CTD PMID:35283115 MeIQx increases expression ISO ORC1 (Homo sapiens) 6480464 2-amino-3 more ... CTD PMID:20816883 methamphetamine decreases expression ISO ORC1 (Homo sapiens) 6480464 Methamphetamine results in decreased expression of ORC1 mRNA CTD PMID:25290377 methapyrilene increases methylation ISO ORC1 (Homo sapiens) 6480464 Methapyrilene results in increased methylation of ORC1 intron CTD PMID:30157460 methimazole increases expression ISO Orc1 (Rattus norvegicus) 6480464 Methimazole results in increased expression of ORC1 mRNA CTD PMID:30047161 methyl methanesulfonate increases expression ISO ORC1 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of ORC1 mRNA CTD PMID:23649840 N-methyl-4-phenylpyridinium decreases expression ISO ORC1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of ORC1 mRNA CTD PMID:24810058 niclosamide decreases expression ISO ORC1 (Homo sapiens) 6480464 Niclosamide results in decreased expression of ORC1 mRNA CTD PMID:28284560 and PMID:36318118 nitrofen decreases expression ISO Orc1 (Rattus norvegicus) 6480464 nitrofen results in decreased expression of ORC1 mRNA CTD PMID:33484710 oxaliplatin multiple interactions ISO Orc1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ORC1 mRNA CTD PMID:25729387 oxaliplatin decreases expression ISO Orc1 (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of ORC1 mRNA CTD PMID:25729387 ozone increases expression EXP 6480464 Ozone results in increased expression of ORC1 mRNA CTD PMID:31626304 ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of ORC1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of ORC1 mRNA CTD PMID:34911549 paracetamol increases expression ISO Orc1 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of ORC1 mRNA CTD PMID:33387578 perfluorooctanoic acid multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of ORC1 mRNA CTD PMID:33325755 perfluorooctanoic acid decreases expression ISO ORC1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of ORC1 mRNA CTD PMID:36326898 phenacetin increases expression ISO Orc1 (Rattus norvegicus) 6480464 Phenacetin results in increased expression of ORC1 mRNA CTD PMID:17698508 phenylhydrazine increases expression ISO Orc1 (Rattus norvegicus) 6480464 phenylhydrazine results in increased expression of ORC1 mRNA CTD PMID:17698508 phytoestrogen multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of ORC1 mRNA CTD PMID:33325755 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of ORC1 mRNA CTD PMID:23608068 pravastatin decreases expression ISO Orc1 (Rattus norvegicus) 6480464 Pravastatin results in decreased expression of ORC1 mRNA CTD PMID:27225895 pravastatin affects expression EXP 6480464 Pravastatin affects the expression of ORC1 mRNA CTD PMID:27225895 propanal decreases expression ISO ORC1 (Homo sapiens) 6480464 propionaldehyde results in decreased expression of ORC1 mRNA CTD PMID:26079696 quercetin increases expression ISO ORC1 (Homo sapiens) 6480464 Quercetin results in increased expression of ORC1 mRNA CTD PMID:21632981 resveratrol multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of ORC1 mRNA CTD PMID:19167446 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of ORC1 protein CTD PMID:25505154 silicon dioxide decreases expression ISO ORC1 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of ORC1 mRNA CTD PMID:23806026 silver atom decreases expression EXP 6480464 Silver results in decreased expression of ORC1 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of ORC1 mRNA CTD PMID:27131904 sodium arsenite increases expression ISO ORC1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of ORC1 mRNA CTD PMID:28595984 sodium arsenite affects expression ISO ORC1 (Homo sapiens) 6480464 sodium arsenite affects the expression of ORC1 mRNA CTD PMID:34032870 sodium dichromate affects expression ISO Orc1 (Rattus norvegicus) 6480464 sodium bichromate affects the expression of ORC1 mRNA CTD PMID:22110744 sunitinib decreases expression ISO ORC1 (Homo sapiens) 6480464 Sunitinib results in decreased expression of ORC1 mRNA CTD PMID:31533062 testosterone multiple interactions ISO ORC1 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of ORC1 mRNA CTD PMID:21592394 testosterone decreases expression ISO ORC1 (Homo sapiens) 6480464 Testosterone results in decreased expression of ORC1 mRNA CTD PMID:21592394 thioacetamide increases expression ISO Orc1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of ORC1 mRNA CTD PMID:23411599 and PMID:34492290 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of ORC1 mRNA CTD PMID:29264374 toluene 2,4-diisocyanate increases expression EXP 6480464 Toluene 2 and 4-Diisocyanate results in increased expression of ORC1 mRNA CTD PMID:21404309 topotecan multiple interactions ISO Orc1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ORC1 mRNA CTD PMID:25729387 topotecan decreases expression ISO Orc1 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of ORC1 mRNA CTD PMID:25729387 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of ORC1 mRNA CTD PMID:19042947 Triptolide increases expression ISO Orc1 (Rattus norvegicus) 6480464 triptolide results in increased expression of ORC1 mRNA CTD PMID:23639586 troglitazone decreases expression ISO ORC1 (Homo sapiens) 6480464 troglitazone results in decreased expression of ORC1 mRNA CTD PMID:19140230 urethane decreases expression ISO ORC1 (Homo sapiens) 6480464 Urethane results in decreased expression of ORC1 mRNA CTD PMID:28818685 zaragozic acid A decreases expression ISO Orc1 (Rattus norvegicus) 6480464 squalestatin 1 results in decreased expression of ORC1 mRNA CTD PMID:27225895 zaragozic acid A decreases expression EXP 6480464 squalestatin 1 results in decreased expression of ORC1 mRNA CTD PMID:27225895