Csf1r (colony stimulating factor 1 receptor) - Rat Genome Database

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Gene: Csf1r (colony stimulating factor 1 receptor) Mus musculus
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Symbol: Csf1r
Name: colony stimulating factor 1 receptor
RGD ID: 10412
MGI Page MGI
Description: Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of intracellular signal transduction; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; diabetes mellitus; gastrointestinal system cancer (multiple); lung cancer (multiple); and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI323359; c-fms; CD115; Csf; CSF-; CSF-1 receptor; CSF-1-R; CSF-1R; Csfmr; Fim; Fim-; Fim-2; Fim2; Fm; Fms; M-CS; M-CSF-R; M-CSFR; macrophage colony-stimulating factor 1 receptor; proto-oncogene c-Fms; proto-oncogene fms
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Csf1r-rs  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,238,644 - 61,264,211 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,233,670 - 61,265,221 (+)EnsemblGRCm39 Ensembl
GRCm381861,105,572 - 61,131,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,100,598 - 61,132,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,265,226 - 61,290,793 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,230,941 - 61,256,506 (+)NCBIMGSCv36mm8
Celera1862,392,678 - 62,417,929 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IMP)
acute myeloid leukemia  (ISO)
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia  (ISO)
Alzheimer's disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
bone development disease  (ISO)
BRAIN ABNORMALITIES, NEURODEGENERATION, AND DYSOSTEOSCLEROSIS  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (IMP,ISO)
Breast Neoplasms  (ISO)
Carcinoma, Lewis Lung  (IMP)
Carotid Artery Injuries  (ISO)
cervical squamous cell carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
colon adenocarcinoma  (IMP,ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
crescentic glomerulonephritis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP,ISO)
disease of cellular proliferation  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis  (ISO)
familial adenomatous polyposis 1  (ISO)
Foreign-Body Reaction  (ISO)
frontotemporal dementia  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Hematologic Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
infertility  (ISO)
Kidney Reperfusion Injury  (IMP)
Leukoencephalopathies  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphopenia  (ISO)
malignant pleural mesothelioma  (ISO)
myeloid neoplasm  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neurodevelopmental Disorders  (ISO)
Optic Nerve Injuries  (ISO)
Parkinsonism  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (IMP,ISO)
stomach cancer  (ISO)
Transplant Rejection  (ISO)
ureteral obstruction  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-tert-butylhydroquinone  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
buspirone  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-gluconic acid  (ISO)
deguelin  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dimethyl fumarate  (EXP)
dimethyl sulfoxide  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenofibrate  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folpet  (EXP)
fulvestrant  (ISO)
gamma-tocopherol  (EXP)
genistein  (ISO)
gentamycin  (ISO)
GW 4064  (EXP)
Heliotrine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
indoles  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
KN-93  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
maneb  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodimethylamine  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
Octicizer  (EXP)
oleuropein  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pexidartinib  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
ponatinib  (ISO)
pravastatin  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
starch  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tocopherol  (EXP)
tributyl phosphate  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (EXP)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IMP)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cardiac muscle cell proliferation  (ISO)
cell population proliferation  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IDA,IMP)
cell-cell junction maintenance  (IEA,ISO)
cellular response to cytokine stimulus  (IMP)
cellular response to macrophage colony-stimulating factor stimulus  (IMP,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
cytokine-mediated signaling pathway  (ISO)
dentate gyrus development  (ISO)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
forebrain neuron differentiation  (IMP)
hemopoiesis  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IDA)
microglia development  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (IGI,ISO)
monocyte homeostasis  (ISO)
mononuclear cell differentiation  (ISO)
myoblast proliferation  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cellular process  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of platelet formation  (ISO)
neuron projection extension  (ISO)
neutrophil homeostasis  (ISO)
olfactory bulb development  (IMP)
osteoclast differentiation  (IBA,IMP,ISO)
peptidyl-tyrosine phosphorylation  (IDA,ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation by host of viral process  (IGI)
positive regulation of astrocyte activation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell migration  (IBA)
positive regulation of cell motility  (ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of leukocyte proliferation  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage migration  (ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IMP)
protein autophosphorylation  (IDA,ISO)
regulation of actin cytoskeleton organization  (IMP)
regulation of bone resorption  (ISO,ISS)
regulation of cell shape  (IMP,ISO)
regulation of macrophage migration  (IMP)
regulation of MAPK cascade  (IBA)
regulation of mononuclear cell proliferation  (ISO)
response to axon injury  (ISO)
response to hypoxia  (ISO)
response to ischemia  (IDA)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
ruffle organization  (IMP)
skeletal muscle cell proliferation  (ISO)
skeletal muscle tissue development  (ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal brain white matter morphology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal compact bone lamellar structure  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteocyte dendritic process morphology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal sexual interaction  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent Langerhans cell  (IAGP)
absent teeth  (IAGP)
ataxia  (IAGP)
axonal spheroids  (IAGP)
deafness  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone strength  (IAGP)
decreased compact bone thickness  (IAGP)
decreased coping response  (IAGP)
decreased Langerhans cell number  (IAGP)
decreased length of long bones  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased testes secretion  (IAGP)
delayed endochondral bone ossification  (IAGP)
demyelination  (IAGP)
domed cranium  (IAGP)
enlarged lateral ventricles  (IAGP)
failure of bone resorption  (IAGP)
failure of tooth eruption  (IAGP)
fragile skeleton  (IAGP)
hypermyelination  (IAGP)
impaired coordination  (IAGP)
impaired olfaction  (IAGP)
increased anxiety-related response  (IAGP)
increased bone mineral density  (IAGP)
increased granulocyte number  (IAGP)
increased oligodendrocyte progenitor number  (IAGP)
increased spleen weight  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
kinked tail  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
osteopetrosis  (IAGP)
osteoporosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prolonged diestrus  (IAGP)
prolonged estrous cycle  (IAGP)
reduced male fertility  (IAGP)
round snout  (IAGP)
short limbs  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers. Baghdadi M, etal., Sci Rep. 2018 Jan 11;8(1):418. doi: 10.1038/s41598-017-18796-8.
2. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. Conway JG, etal., J Pharmacol Exp Ther. 2008 Jul;326(1):41-50. doi: 10.1124/jpet.107.129429. Epub 2008 Apr 23.
3. CSF1R methylation is a key regulatory mechanism of tumor-associated macrophages in hepatocellular carcinoma. Cui B, etal., Oncol Lett. 2020 Aug;20(2):1835-1845. doi: 10.3892/ol.2020.11726. Epub 2020 Jun 11.
4. [Methylation status of c-fms oncogene in hepatocellular carcinoma and its relation with clinical pathology]. Cui J and Yang D, Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):137-8.
5. The potential mechanism of INHBC and CSF1R in diabetic nephropathy. Du XY, etal., Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):1970-1978. doi: 10.26355/eurrev_202002_20374.
6. qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL. Fassunke J, etal., BMC Mol Biol. 2010 Dec 20;11:100. doi: 10.1186/1471-2199-11-100.
7. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Hammes LS, etal., Gynecol Oncol. 2008 Jun 18.
8. Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis. Han Y, etal., Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1043-53. doi: 10.1152/ajprenal.00389.2012. Epub 2013 Feb 13.
9. c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. Han Y, etal., Lab Invest. 2011 Jul;91(7):978-91. doi: 10.1038/labinvest.2011.61. Epub 2011 Apr 25.
10. Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity. Hoves S, etal., J Exp Med. 2018 Mar 5;215(3):859-876. doi: 10.1084/jem.20171440. Epub 2018 Feb 7.
11. Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE. Hu X, etal., J Neuroinflammation. 2020 Jun 10;17(1):182. doi: 10.1186/s12974-020-01862-w.
12. Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE. Hu X, etal., Oxid Med Cell Longev. 2020 Oct 7;2020:6801587. doi: 10.1155/2020/6801587. eCollection 2020.
13. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. Huynh D, etal., PLoS One. 2013;8(2):e56951. doi: 10.1371/journal.pone.0056951. Epub 2013 Feb 22.
14. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Ide H, etal., Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14404-9. Epub 2002 Oct 15.
15. A novel glycobiomarker, Wisteria floribunda agglutinin macrophage colony-stimulating factor receptor, for predicting carcinogenesis of liver cirrhosis. Iio E, etal., Int J Cancer. 2016 Mar 15;138(6):1462-71. doi: 10.1002/ijc.29880. Epub 2015 Oct 20.
16. Preventive and therapeutic effects of imatinib in Wistar-Kyoto rats with anti-glomerular basement membrane glomerulonephritis. Iyoda M, etal., Kidney Int. 2009 May;75(10):1060-70. doi: 10.1038/ki.2009.43. Epub 2009 Feb 25.
17. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. Jang MH, etal., J Immunol. 2006 Sep 15;177(6):4055-63.
18. Ultrasound Molecular Imaging as a Potential Non-invasive Diagnosis to Detect the Margin of Hepatocarcinoma via CSF-1R Targeting. Jiang Q, etal., Front Bioeng Biotechnol. 2020 Jul 14;8:783. doi: 10.3389/fbioe.2020.00783. eCollection 2020.
19. Expression of proto-oncogene cFMS protein in lung, breast, and ovarian cancers. Kakiuchi-Kiyota S, etal., Appl Immunohistochem Mol Morphol. 2014 Mar;22(3):188-99. doi: 10.1097/PAI.0b013e31828e7104.
20. A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. Kang HG, etal., J Thorac Oncol. 2014 Nov;9(11):1647-55. doi: 10.1097/JTO.0000000000000310.
21. Macrophage colony-stimulating factor-1 receptor expression is associated with poor outcome in breast cancer by large cohort tissue microarray analysis. Kluger HM, etal., Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):173-7.
22. Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice. Lim AK, etal., Diabetologia. 2009 May 23.
23. Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
24. Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic rats. Liu W, etal., Curr Eye Res. 2009 Feb;34(2):123-33. doi: 10.1080/02713680802650369.
25. Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Lohela M, etal., Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5086-95. doi: 10.1073/pnas.1419899111. Epub 2014 Nov 10.
26. Macrophages contribute to cellular but not humoral mechanisms of acute rejection in rat renal allografts. Ma FY, etal., Transplantation. 2013 Dec 15;96(11):949-57. doi: 10.1097/TP.0b013e3182a4befa.
27. Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth. Menke J, etal., Cancer Res. 2012 Jan 1;72(1):187-200. doi: 10.1158/0008-5472.CAN-11-1232. Epub 2011 Nov 3.
28. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
29. MGDs mouse GO annotations MGD data from the GO Consortium
30. Role of macrophage colony-stimulating factor in the development of neointimal thickening following arterial injury. Mishra V, etal., Cardiovasc Pathol. 2016 Jul-Aug;25(4):284-292. doi: 10.1016/j.carpath.2016.04.003. Epub 2016 Apr 11.
31. Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer. Okugawa Y, etal., Int J Oncol. 2018 Aug;53(2):737-749. doi: 10.3892/ijo.2018.4406. Epub 2018 May 16.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin. Pass HI, etal., Oncotarget. 2016 Aug 30;7(35):56408-56421. doi: 10.18632/oncotarget.10895.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Priceman SJ, etal., Blood. 2010 Feb 18;115(7):1461-71. doi: 10.1182/blood-2009-08-237412. Epub 2009 Dec 11.
36. Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus. Pridans C, etal., J Immunol. 2018 Nov 1;201(9):2683-2699. doi: 10.4049/jimmunol.1701783. Epub 2018 Sep 24.
37. Mouse MP Annotation Import Pipeline RGD automated import pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma. Richardsen E, etal., Histopathology. 2008 May 28;.
41. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Ries CH, etal., Cancer Cell. 2014 Jun 16;25(6):846-59. doi: 10.1016/j.ccr.2014.05.016. Epub 2014 Jun 2.
42. Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer. Shi X, etal., Cell Mol Gastroenterol Hepatol. 2020;10(2):391-418. doi: 10.1016/j.jcmgh.2020.04.002. Epub 2020 Apr 15.
43. The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. Slattery ML, etal., Genes Chromosomes Cancer. 2017 Nov;56(11):769-787. doi: 10.1002/gcc.22481. Epub 2017 Jul 30.
44. c-fms is present in primary tumours as well as in their metastases in bone marrow. Storga D, etal., Int J Exp Pathol. 1992 Aug;73(4):527-33.
45. The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor. Swierczak A, etal., Cancer Immunol Res. 2014 Aug;2(8):765-76. doi: 10.1158/2326-6066.CIR-13-0190. Epub 2014 Apr 29.
46. Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. Szymanowska-Narloch A, etal., Adv Med Sci. 2013;58(2):196-206. doi: 10.2478/ams-2013-0025.
47. Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array. Toma MI, etal., Neoplasia. 2008 Jul;10(7):634-42.
48. The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma. Yang DH, etal., Hepatobiliary Pancreat Dis Int. 2004 Feb;3(1):86-9.
49. Identification of prognostic biomarkers for response to radiotherapy by DNA microarray in nasopharyngeal carcinoma patients. Yang S, etal., Int J Oncol. 2012 May;40(5):1590-600. doi: 10.3892/ijo.2012.1341. Epub 2012 Jan 20.
50. Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer. Yoo SS, etal., Cancer Genet. 2017 Apr;212-213:8-12. doi: 10.1016/j.cancergen.2017.03.003. Epub 2017 Mar 20.
51. Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Zhang L, etal., Cell. 2020 Apr 16;181(2):442-459.e29. doi: 10.1016/j.cell.2020.03.048.
52. CSF-1 signaling mediates recovery from acute kidney injury. Zhang MZ, etal., J Clin Invest. 2012 Dec 3;122(12):4519-32. doi: 10.1172/JCI60363. Epub 2012 Nov 12.
53. Four hub genes regulate tumor infiltration by immune cells, antitumor immunity in the tumor microenvironment, and survival outcomes in lung squamous cell carcinoma patients. Zhang T, etal., Aging (Albany NY). 2021 Jan 10;13(3):3819-3842. doi: 10.18632/aging.202351. Epub 2021 Jan 10.
Additional References at PubMed
PMID:1302014   PMID:1314163   PMID:1354640   PMID:1354644   PMID:1372092   PMID:1374350   PMID:1427864   PMID:1643308   PMID:1660841   PMID:1673105   PMID:1679325   PMID:1710023  
PMID:1840281   PMID:2160591   PMID:2172781   PMID:2408759   PMID:2456920   PMID:2554332   PMID:2567264   PMID:2902233   PMID:2905686   PMID:2963140   PMID:2966922   PMID:3066742  
PMID:3110291   PMID:3464762   PMID:6289129   PMID:6364482   PMID:6641714   PMID:7542761   PMID:7626889   PMID:7669676   PMID:7745707   PMID:7894173   PMID:7962166   PMID:8007983  
PMID:8094303   PMID:8094988   PMID:8095010   PMID:8099512   PMID:8207122   PMID:8262059   PMID:8390965   PMID:8415751   PMID:8441691   PMID:8497248   PMID:8499630   PMID:8632916  
PMID:8661696   PMID:8706013   PMID:8777716   PMID:8786318   PMID:8896402   PMID:8922060   PMID:8947469   PMID:8981357   PMID:8981363   PMID:9176397   PMID:9180904   PMID:9312046  
PMID:9324354   PMID:9372970   PMID:9421432   PMID:9590173   PMID:9593684   PMID:9611252   PMID:9811459   PMID:9823776   PMID:9852586   PMID:9893162   PMID:10330148   PMID:10330270  
PMID:10349636   PMID:10381505   PMID:10438963   PMID:10529424   PMID:10556427   PMID:10585470   PMID:10597251   PMID:10679268   PMID:10981960   PMID:11027604   PMID:11027835   PMID:11042159  
PMID:11076861   PMID:11114734   PMID:11217851   PMID:11698278   PMID:11698502   PMID:11756160   PMID:11796577   PMID:11964285   PMID:12101129   PMID:12223521   PMID:12466851   PMID:12477932  
PMID:12517946   PMID:12540842   PMID:12614284   PMID:12618529   PMID:14749363   PMID:14767486   PMID:15073037   PMID:15178709   PMID:15215307   PMID:15297464   PMID:15312244   PMID:15483629  
PMID:15489334   PMID:15580571   PMID:15616565   PMID:15860730   PMID:15914564   PMID:16081819   PMID:16141072   PMID:16141073   PMID:16172397   PMID:16444257   PMID:16600665   PMID:16602821  
PMID:16705167   PMID:16823860   PMID:16877523   PMID:16925795   PMID:16944957   PMID:17116688   PMID:17121910   PMID:17353186   PMID:17420256   PMID:17438263   PMID:17512498   PMID:17932563  
PMID:17967422   PMID:18287559   PMID:18328744   PMID:18375440   PMID:18519746   PMID:18523268   PMID:18691974   PMID:18814279   PMID:19017797   PMID:19059913   PMID:19100238   PMID:19109221  
PMID:19273628   PMID:19339695   PMID:19733489   PMID:19772887   PMID:19966810   PMID:20008528   PMID:20035012   PMID:20123678   PMID:20181277   PMID:20388654   PMID:20418886   PMID:20489731  
PMID:20504948   PMID:20571037   PMID:20581147   PMID:20647008   PMID:20682855   PMID:20803546   PMID:20889566   PMID:20966214   PMID:21041311   PMID:21141543   PMID:21267068   PMID:21308776  
PMID:21549805   PMID:21610095   PMID:21677750   PMID:21727904   PMID:21873635   PMID:21930791   PMID:22046273   PMID:22084313   PMID:22129827   PMID:22153499   PMID:22294205   PMID:22375015  
PMID:22451653   PMID:22516201   PMID:22542597   PMID:22565823   PMID:22573666   PMID:22575736   PMID:22579672   PMID:22749353   PMID:22826234   PMID:23144792   PMID:23177320   PMID:23296467  
PMID:23314290   PMID:23383005   PMID:23392676   PMID:23418320   PMID:23575636   PMID:23648053   PMID:23956422   PMID:24052571   PMID:24056773   PMID:24145216   PMID:24367707   PMID:24378336  
PMID:24652541   PMID:24742461   PMID:24912173   PMID:24952961   PMID:25308957   PMID:25335894   PMID:25425146   PMID:25497733   PMID:25529853   PMID:25757564   PMID:25810298   PMID:25826454  
PMID:26056232   PMID:26169940   PMID:26235516   PMID:26407006   PMID:26514084   PMID:26642357   PMID:26876171   PMID:26884166   PMID:27174644   PMID:27207794   PMID:27224507   PMID:27353657  
PMID:27464987   PMID:27581360   PMID:27601030   PMID:27748374   PMID:27776109   PMID:28159742   PMID:28254742   PMID:28399411   PMID:28521131   PMID:28626216   PMID:28655719   PMID:28759044  
PMID:28780306   PMID:28914985   PMID:29136508   PMID:29440354   PMID:29523656   PMID:29572360   PMID:29593242   PMID:29861285   PMID:29973370   PMID:30018535   PMID:30026565   PMID:30054204  
PMID:30142160   PMID:30258231   PMID:30538245   PMID:30635412   PMID:30635555   PMID:30647151   PMID:30767584   PMID:30799229   PMID:30971820   PMID:30982609   PMID:31029597   PMID:31042769  
PMID:31064775   PMID:31065073   PMID:31091440   PMID:31324781   PMID:31421080   PMID:31616414   PMID:31626642   PMID:31693894   PMID:31695671   PMID:31914683   PMID:32027825   PMID:32071385  
PMID:32082318   PMID:32130903   PMID:32234210   PMID:32325033   PMID:32372032   PMID:32493987   PMID:32541832   PMID:32554809   PMID:32621847   PMID:32756440   PMID:32895539   PMID:32908485  
PMID:33029008   PMID:33037771   PMID:33054973   PMID:33079443   PMID:33097690   PMID:33139489   PMID:33159168   PMID:33232786   PMID:33323375   PMID:33402196   PMID:33511454   PMID:33536334  
PMID:33544755   PMID:33607650   PMID:33841415   PMID:34007995   PMID:34160349   PMID:34210853   PMID:34321999   PMID:34395414   PMID:34433559   PMID:35187175   PMID:35315360   PMID:35333324  
PMID:35353625   PMID:35705056   PMID:35793624   PMID:35917184   PMID:35970974   PMID:36104343   PMID:36147476   PMID:36227799   PMID:36333098   PMID:36352225   PMID:36584406   PMID:36635255  
PMID:36922518   PMID:37231583   PMID:37542262   PMID:37552802   PMID:37562753   PMID:37582369   PMID:37704707   PMID:37889001   PMID:37909242   PMID:37957324   PMID:38048572   PMID:38167979  
PMID:38170572   PMID:38281257   PMID:38309258   PMID:38355793   PMID:38377133   PMID:38492223   PMID:38589666   PMID:38636374   PMID:38775708   PMID:38897209   PMID:38961498   PMID:39142282  
PMID:39424804   PMID:39425203  


Genomics

Comparative Map Data
Csf1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,238,644 - 61,264,211 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,233,670 - 61,265,221 (+)EnsemblGRCm39 Ensembl
GRCm381861,105,572 - 61,131,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,100,598 - 61,132,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv371861,265,226 - 61,290,793 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361861,230,941 - 61,256,506 (+)NCBIMGSCv36mm8
Celera1862,392,678 - 62,417,929 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
CSF1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,053,295 - 150,113,365 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,053,291 - 150,113,372 (-)EnsemblGRCh38hg38GRCh38
GRCh375149,432,858 - 149,492,928 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,413,051 - 149,473,128 (-)NCBINCBI36Build 36hg18NCBI36
Build 345149,413,050 - 149,473,128NCBI
Celera5145,514,237 - 145,574,309 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,580,804 - 144,640,914 (-)NCBIHuRef
CHM1_15148,865,545 - 148,925,516 (-)NCBICHM1_1
T2T-CHM13v2.05150,589,842 - 150,649,957 (-)NCBIT2T-CHM13v2.0
Csf1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81856,834,152 - 56,860,804 (+)NCBIGRCr8
mRatBN7.21854,546,673 - 54,590,418 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,546,659 - 54,590,415 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1856,651,929 - 56,678,637 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,366,526 - 57,393,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,187,862 - 55,214,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,414,493 - 56,458,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,414,488 - 56,458,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01855,662,670 - 55,689,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41857,080,324 - 57,107,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1852,716,221 - 52,742,736 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Csf1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,434,453 - 4,461,751 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554154,434,486 - 4,462,505 (+)NCBIChiLan1.0ChiLan1.0
CSF1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24145,283,044 - 145,316,620 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,422,593 - 143,481,722 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,478,725 - 145,537,858 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,483,948 - 151,543,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,483,572 - 151,517,415 (-)Ensemblpanpan1.1panPan2
CSF1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,980,699 - 59,010,683 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,980,788 - 59,010,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha458,746,695 - 58,776,657 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0459,461,238 - 59,491,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,444,535 - 59,544,925 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,249,977 - 59,279,943 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,364,574 - 59,394,530 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,895,615 - 59,925,571 (+)NCBIUU_Cfam_GSD_1.0
Csf1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,324,957 - 143,353,222 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365044,898,945 - 4,928,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365044,898,947 - 4,927,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSF1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2151,102,147 - 151,147,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12151,102,138 - 151,130,311 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,855,536 - 157,882,913 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSF1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,663,290 - 52,723,652 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,664,076 - 52,697,304 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603424,993,437 - 25,053,747 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csf1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,363,908 - 9,391,986 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247749,363,156 - 9,391,939 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Csf1r
928 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:950
Count of miRNA genes:429
Interacting mature miRNAs:510
Transcripts:ENSMUST00000025523, ENSMUST00000115268
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
4141431Msmr2_mMSM lymphoma resistance 2 (mouse)Not determined5497587361238870Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
27226720Tibw5_mtibia width 5, proximal, 10 week (mouse)185043306762633071Mouse

Markers in Region
X06368  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,130,558 - 61,130,688UniSTSGRCm38
MGSCv371861,290,212 - 61,290,342UniSTSGRCm37
Celera1862,417,348 - 62,417,478UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
Whitehead/MRC_RH18789.33UniSTS
AI323359  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,130,943 - 61,131,036UniSTSGRCm38
MGSCv371861,290,597 - 61,290,690UniSTSGRCm37
Celera1862,417,733 - 62,417,826UniSTS
Cytogenetic Map18DUniSTS
Cytogenetic Map18E1UniSTS
cM Map1830.0UniSTS
Whitehead/MRC_RH18793.18UniSTS
D18Mit140  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,105,665 - 61,105,798UniSTSGRCm38
MGSCv371861,265,319 - 61,265,452UniSTSGRCm37
Celera1862,392,771 - 62,392,904UniSTS
Cytogenetic Map18DUniSTS
cM Map1837.0UniSTS
Whitehead Genetic1825.1UniSTS
Whitehead_YAC18 UniSTS
AI413166  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,131,535 - 61,131,674UniSTSGRCm38
MGSCv371861,291,189 - 61,291,328UniSTSGRCm37
Celera1862,418,325 - 62,418,464UniSTS
Cytogenetic Map18E1UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
Whitehead/MRC_RH18793.18UniSTS
UniSTS:224344  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,130,900 - 61,131,079UniSTSGRCm38
MGSCv371861,290,554 - 61,290,733UniSTSGRCm37
Celera1862,417,690 - 62,417,869UniSTS
Cytogenetic Map18DUniSTS
Cytogenetic Map18E1UniSTS
cM Map1830.0UniSTS
Csf1r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,109,686 - 61,110,373UniSTSGRCm38
MGSCv371861,269,340 - 61,270,027UniSTSGRCm37
Celera1862,396,772 - 62,397,459UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
MARC_12115-12116:1004707389:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,129,749 - 61,130,166UniSTSGRCm38
MGSCv371861,289,403 - 61,289,820UniSTSGRCm37
Celera1862,416,539 - 62,416,956UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
PMC186377P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,108,553 - 61,108,914UniSTSGRCm38
MGSCv371861,268,207 - 61,268,568UniSTSGRCm37
Celera1862,395,639 - 62,396,000UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
PMC219482P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,107,913 - 61,107,993UniSTSGRCm38
MGSCv371861,267,567 - 61,267,647UniSTSGRCm37
Celera1862,395,001 - 62,395,081UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
PMC219482P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,108,716 - 61,108,797UniSTSGRCm38
MGSCv371861,268,370 - 61,268,451UniSTSGRCm37
Celera1862,395,802 - 62,395,883UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
CSF1R_1770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381861,130,460 - 61,131,127UniSTSGRCm38
MGSCv371861,290,114 - 61,290,781UniSTSGRCm37
Celera1862,417,250 - 62,417,917UniSTS
Cytogenetic Map18DUniSTS
cM Map1830.0UniSTS
Csf1r  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18DUniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB738990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000025523   ⟹   ENSMUSP00000025523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,238,644 - 61,264,206 (+)Ensembl
GRCm38.p6 Ensembl1861,105,572 - 61,131,134 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115268   ⟹   ENSMUSP00000110923
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,238,924 - 61,265,221 (+)Ensembl
GRCm38.p6 Ensembl1861,105,852 - 61,132,149 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235447   ⟹   ENSMUSP00000158568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,238,663 - 61,243,402 (+)Ensembl
GRCm38.p6 Ensembl1861,105,591 - 61,110,330 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237485
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,238,951 - 61,253,963 (+)Ensembl
GRCm38.p6 Ensembl1861,105,879 - 61,120,891 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237706   ⟹   ENSMUSP00000157861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,238,722 - 61,242,947 (+)Ensembl
GRCm38.p6 Ensembl1861,105,650 - 61,109,875 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237873
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1861,233,670 - 61,238,870 (+)Ensembl
GRCm38.p6 Ensembl1861,100,598 - 61,105,798 (+)Ensembl
RefSeq Acc Id: NM_001037859   ⟹   NP_001032948
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391861,238,644 - 61,264,211 (+)NCBI
GRCm381861,105,572 - 61,131,139 (+)NCBI
MGSCv371861,265,226 - 61,290,793 (+)RGD
Celera1862,392,678 - 62,417,929 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001032948   ⟸   NM_001037859
- Peptide Label: precursor
- UniProtKB: Q3U3P1 (UniProtKB/Swiss-Prot),   Q9DBH9 (UniProtKB/Swiss-Prot),   P09581 (UniProtKB/Swiss-Prot),   Q0P635 (UniProtKB/TrEMBL),   Q3UKC6 (UniProtKB/TrEMBL),   Q3U1Y3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000157861   ⟸   ENSMUST00000237706
Ensembl Acc Id: ENSMUSP00000110923   ⟸   ENSMUST00000115268
Ensembl Acc Id: ENSMUSP00000025523   ⟸   ENSMUST00000025523
Ensembl Acc Id: ENSMUSP00000158568   ⟸   ENSMUST00000235447
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09581-F1-model_v2 AlphaFold P09581 1-977 view protein structure

Promoters
RGD ID:13677932
Promoter ID:EPDNEW_M23115
Type:initiation region
Name:Csf1r_1
Description:Mus musculus colony stimulating factor 1 receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381861,105,874 - 61,105,934EPDNEW
RGD ID:6847493
Promoter ID:MM_ACW:25105
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:CSF1R.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,260,166 - 61,260,666 (+)MPROMDB
RGD ID:6829156
Promoter ID:MM_KWN:25417
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000091885,   ENSMUST00000115268,   NM_001037859,   UC008FBO.1,   UC008FBP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,264,736 - 61,265,667 (+)MPROMDB
RGD ID:6847489
Promoter ID:MM_ACW:25106
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:CSF1R.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,269,159 - 61,269,659 (+)MPROMDB
RGD ID:6848707
Promoter ID:MM_TRO:4811
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:MTR014687.18.949.6
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,276,681 - 61,277,181 (+)MPROMDB
RGD ID:6847490
Promoter ID:MM_ACW:25107
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:CSF1R.FSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,278,334 - 61,278,834 (+)MPROMDB
RGD ID:6847492
Promoter ID:MM_ACW:25108
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6,   Spleen
Transcripts:CSF1R.GSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361861,287,171 - 61,287,671 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339758 AgrOrtholog
Ensembl Genes ENSMUSG00000024621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025523 ENTREZGENE
  ENSMUST00000025523.13 UniProtKB/Swiss-Prot
  ENSMUST00000115268.4 UniProtKB/Swiss-Prot
  ENSMUST00000235447.2 UniProtKB/TrEMBL
  ENSMUST00000237706.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cell_Adh-Cytoskel_Orgn UniProtKB/TrEMBL
  CSF-1_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGFRL UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1339758 ENTREZGENE
NCBI Gene 12978 ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WRAPPER_REGA-1_KLINGON HOMOLOG UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CSF1R RGD
PhenoGen Csf1r PhenoGen
PIRSF CSF-1_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BA23_MOUSE UniProtKB/TrEMBL
  A0A494BBK8_MOUSE UniProtKB/TrEMBL
  CSF1R_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0P635 ENTREZGENE, UniProtKB/TrEMBL
  Q3TAZ7_MOUSE UniProtKB/TrEMBL
  Q3TBH6_MOUSE UniProtKB/TrEMBL
  Q3U1X4_MOUSE UniProtKB/TrEMBL
  Q3U1Y3 ENTREZGENE, UniProtKB/TrEMBL
  Q3U210_MOUSE UniProtKB/TrEMBL
  Q3U3P1 ENTREZGENE
  Q3U3W0_MOUSE UniProtKB/TrEMBL
  Q3U4N8_MOUSE UniProtKB/TrEMBL
  Q3UKC6 ENTREZGENE, UniProtKB/TrEMBL
  Q6NXV8_MOUSE UniProtKB/TrEMBL
  Q9DBH9 ENTREZGENE
UniProt Secondary Q3U3P1 UniProtKB/Swiss-Prot
  Q9DBH9 UniProtKB/Swiss-Prot