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Gene: Fdft1 (farnesyl diphosphate farnesyl transferase 1) Mus musculus
Symbol: Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Description: Predicted to have farnesyl-diphosphate farnesyltransferase activity and squalene synthase activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: farnesyl-diphosphate farnesyltransferase; FPP:FPP farnesyltransferase; S; SQS; squalene synthase; squalene synthetase; SS
Homo sapiens (human) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fdft1 (farnesyl diphosphate farnesyl transferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Canis lupus familiaris (dog) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
Sus scrofa (pig) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Chlorocebus sabaeus (African green monkey) : FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Fdft1 (farnesyl-diphosphate farnesyltransferase 1)
more info ...
Related Pseudogenes: Gm6781  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1463,145,150 - 63,179,578 (-)EnsemblGRCm38mm10GRCm38
GRCm381463,145,150 - 63,181,687 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371463,763,987 - 63,796,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv361462,099,260 - 62,131,903 (-)NCBImm8
Celera1460,907,922 - 60,941,524 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fdft1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62125
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.