Prom2 (prominin 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Prom2 (prominin 2) Mus musculus
Analyze
Symbol: Prom2
Name: prominin 2
RGD ID: 734240
MGI Page MGI
Description: Predicted to have cholesterol binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; positive regulation of protein phosphorylation; and regulation of GTPase activity. Localizes to cell surface; plasma membrane; and prominosome. Predicted to colocalize with membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and naris epithelium. Orthologous to human PROM2 (prominin 2); INTERACTS WITH 1,1-dichloroethene; 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI507243; MGC31164; mPROML2; PROM-2; Prom-rp; prominin-2; prominin-like protein 2; prominin-related protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,368,873 - 127,383,337 (-)NCBIGRCm39mm39
GRCm39 Ensembl2127,368,393 - 127,383,387 (-)Ensembl
GRCm382127,526,953 - 127,541,417 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,526,473 - 127,541,467 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,352,689 - 127,367,153 (-)NCBIGRCm37mm9NCBIm37
MGSCv362127,217,914 - 127,232,908 (-)NCBImm8
Celera2128,771,840 - 128,786,259 (-)NCBICelera
Cytogenetic Map2F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
cholesterol binding  (IBA,ISO,ISS)
protein binding  (ISO)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17109118   PMID:17874118   PMID:18536929   PMID:20333396   PMID:20562862  
PMID:21267068   PMID:21565611   PMID:21873635   PMID:21947380   PMID:23643363   PMID:24194600   PMID:25758223   PMID:27626380   PMID:28700664  


Genomics

Comparative Map Data
Prom2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,368,873 - 127,383,337 (-)NCBIGRCm39mm39
GRCm39 Ensembl2127,368,393 - 127,383,387 (-)Ensembl
GRCm382127,526,953 - 127,541,417 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,526,473 - 127,541,467 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,352,689 - 127,367,153 (-)NCBIGRCm37mm9NCBIm37
MGSCv362127,217,914 - 127,232,908 (-)NCBImm8
Celera2128,771,840 - 128,786,259 (-)NCBICelera
Cytogenetic Map2F1NCBI
PROM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl295,274,449 - 95,291,308 (+)EnsemblGRCh38hg38GRCh38
GRCh38295,274,449 - 95,291,320 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37295,940,197 - 95,957,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36295,303,928 - 95,320,781 (+)NCBINCBI36hg18NCBI36
Build 34295,362,074 - 95,378,928NCBI
Celera290,293,346 - 90,310,195 (+)NCBI
Cytogenetic Map2q11.1NCBI
HuRef289,967,276 - 89,984,207 (+)NCBIHuRef
CHM1_1295,944,549 - 95,961,410 (+)NCBICHM1_1
Prom2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23114,747,654 - 114,761,787 (-)NCBI
Rnor_6.0 Ensembl3120,092,582 - 120,106,697 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03120,087,633 - 120,107,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03127,225,616 - 127,239,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,030,864 - 115,044,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13114,936,437 - 114,950,560 (-)NCBI
Celera3113,584,551 - 113,598,660 (-)NCBICelera
Cytogenetic Map3q36NCBI
Prom2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,524,805 - 3,538,935 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,524,900 - 3,538,882 (+)NCBIChiLan1.0ChiLan1.0
PROM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A96,177,524 - 96,194,382 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A104,117,086 - 104,138,298 (-)NCBIMhudiblu_PPA_v0panPan3
PROM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,814,260 - 34,827,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,815,735 - 34,827,740 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,583,025 - 34,596,585 (-)NCBI
ROS_Cfam_1.01735,585,103 - 35,598,677 (-)NCBI
UMICH_Zoey_3.11734,713,897 - 34,727,445 (-)NCBI
UNSW_CanFamBas_1.01734,782,431 - 34,795,991 (-)NCBI
UU_Cfam_GSD_1.01734,991,754 - 35,005,323 (-)NCBI
Prom2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,819,249 - 82,832,968 (+)NCBI
SpeTri2.0NW_00493674473,004 - 85,911 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl346,003,238 - 46,023,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1346,001,949 - 46,025,425 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2348,368,831 - 48,381,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114305,442 - 323,187 (+)NCBI
ChlSab1.1 Ensembl14306,515 - 323,909 (+)Ensembl
Vero_WHO_p1.0NW_023666041167,709,896 - 167,727,720 (+)NCBI
Prom2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247492,036,335 - 2,049,434 (+)NCBI

Position Markers
AI507243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382127,527,120 - 127,527,254UniSTSGRCm38
MGSCv372127,352,856 - 127,352,990UniSTSGRCm37
Celera2128,772,006 - 128,772,140UniSTS
Cytogenetic Map2F1UniSTS
Whitehead/MRC_RH21586.64UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274693773129371085Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11041906Lmr28a_mleishmaniasis resistance 28a (mouse)2103265371129371085Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
1300798Actre3_mactivity response to ethanol 3 (mouse)Not determined2112194642128331901Mouse
1301415Actre4_mactivity response to ethanol 4 (mouse)Not determined2112194642128331901Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2332
Count of miRNA genes:676
Interacting mature miRNAs:866
Transcripts:ENSMUST00000028855, ENSMUST00000103214, ENSMUST00000140156, ENSMUST00000155581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000028855   ⟹   ENSMUSP00000028855
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2127,526,473 - 127,541,467 (-)Ensembl
RefSeq Acc Id: ENSMUST00000103214   ⟹   ENSMUSP00000099503
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2127,526,955 - 127,541,385 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140156
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2127,534,766 - 127,535,197 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155581
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2127,540,239 - 127,541,414 (-)Ensembl
RefSeq Acc Id: NM_138750   ⟹   NP_620089
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,368,873 - 127,383,337 (-)NCBI
GRCm382127,526,953 - 127,541,417 (-)ENTREZGENE
MGSCv372127,352,689 - 127,367,153 (-)RGD
Celera2128,771,840 - 128,786,259 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_178047   ⟹   NP_835148
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392127,368,873 - 127,383,337 (-)NCBI
GRCm382127,526,953 - 127,541,417 (-)ENTREZGENE
MGSCv372127,352,689 - 127,367,153 (-)RGD
Celera2128,771,840 - 128,786,259 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_835148   ⟸   NM_178047
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3UUY6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_620089   ⟸   NM_138750
- Peptide Label: isoform 1 precursor
- UniProtKB: Q3UUY6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028855   ⟸   ENSMUST00000028855
RefSeq Acc Id: ENSMUSP00000099503   ⟸   ENSMUST00000103214

Promoters
RGD ID:6878654
Promoter ID:EPDNEW_M2778
Type:initiation region
Name:Prom2_1
Description:Mus musculus prominin 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382127,541,397 - 127,541,457EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2138997 AgrOrtholog
Ensembl Genes ENSMUSG00000027376 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000028855 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000099503 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028855 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000103214 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Prominin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:192212 UniProtKB/Swiss-Prot
MGD MGI:2138997 ENTREZGENE
NCBI Gene 192212 ENTREZGENE
PANTHER PTHR22730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prominin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prom2 PhenoGen
UniProt PROM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R1Y1_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AHT1 UniProtKB/Swiss-Prot
  Q8CDM5 UniProtKB/Swiss-Prot
  Q8CHT5 UniProtKB/Swiss-Prot
  Q8R4Y7 UniProtKB/Swiss-Prot
  Q9WUC7 UniProtKB/Swiss-Prot