Cyp2j5 (cytochrome P450, family 2, subfamily j, polypeptide 5) - Rat Genome Database

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Gene: Cyp2j5 (cytochrome P450, family 2, subfamily j, polypeptide 5) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2j5
Name: cytochrome P450, family 2, subfamily j, polypeptide 5
RGD ID: 1623318
MGI Page MGI
Description: Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of estrogen secretion; and renal tubular secretion. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arachidonic acid epoxygenase; CYPIIJ5; cytochrome P450 2J5; cytochrome P450, 2j5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39496,517,010 - 96,552,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl496,517,010 - 96,552,391 (-)EnsemblGRCm39 Ensembl
GRCm38496,627,432 - 96,664,171 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl496,628,773 - 96,664,154 (-)EnsemblGRCm38mm10GRCm38
MGSCv37496,294,123 - 96,330,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36496,120,793 - 96,156,095 (-)NCBIMGSCv36mm8
Celera494,996,683 - 95,033,287 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map444.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9570962   PMID:10349636   PMID:10364221   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12745259   PMID:15489334   PMID:15530921   PMID:16141072  
PMID:16141073   PMID:18716027   PMID:21873635   PMID:22323595   PMID:23041291   PMID:23696562   PMID:29030652   PMID:32116704   PMID:32325033   PMID:34162680  


Genomics

Variants

.
Variants in Cyp2j5
1156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:127
Interacting mature miRNAs:129
Transcripts:ENSMUST00000030299
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824979Epid1_mepididymis and vas deferens weight 1 (mouse)48988823799857197Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
13506251Cytrq1_mcytokine response QTL 1 (mouse)46571808699718086Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined471982069105982216Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)490888237108457197Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
27095938Ulnl6_mulna length 6, 10 week (mouse)46671823798588237Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
26884406Huml3_mhumerus length 3, 10 week (mouse)475618237100157197Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487518237103257197Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1357870Pfat1_mpredicted fat percentage 1 (mouse)Not determined46361952697619685Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470067227104067464Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485118237104957197Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
12879903Berr8_mberghei resistance locus 8 (mouse)46422246098222460Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)471982069105982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
1357561Mbsyd_mmetabolic syndrome (mouse)Not determined466888445100888588Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
1301757Tlsr4_mthymic lymphoma suppressor region 4 (mouse)Not determined466757130100757258Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined471982069105982216Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse

Markers in Region
Results_ER_9_5_95_8.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38496,643,159 - 96,643,355UniSTSGRCm38
MGSCv37496,309,850 - 96,310,046UniSTSGRCm37
Celera495,012,440 - 95,012,636UniSTS
Cytogenetic Map4C5UniSTS
cM Map446.5UniSTS
Whitehead_YAC4 UniSTS
Cyp2j5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37496,295,874 - 96,296,333UniSTSGRCm37
Celera494,998,434 - 94,998,893UniSTS
Cytogenetic Map4C5UniSTS
cM Map446.5UniSTS
cM Map446.5UniSTS
PMC291882P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38496,663,220 - 96,663,976UniSTSGRCm38
MGSCv37496,329,911 - 96,330,667UniSTSGRCm37
Celera495,032,388 - 95,033,144UniSTS
Cytogenetic Map4C5UniSTS
cM Map446.5UniSTS
Cyp2j5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38496,629,183 - 96,629,642UniSTSGRCm38
MGSCv37496,295,874 - 96,296,333UniSTSGRCm37
Celera494,998,434 - 94,998,893UniSTS
Cytogenetic Map4C5UniSTS
cM Map446.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030299   ⟹   ENSMUSP00000030299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl496,517,010 - 96,552,391 (-)Ensembl
GRCm38.p6 Ensembl496,628,773 - 96,664,154 (-)Ensembl
RefSeq Acc Id: NM_001418421   ⟹   NP_001405350
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39496,517,010 - 96,552,391 (-)NCBI
RefSeq Acc Id: NM_001418422   ⟹   NP_001405351
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39496,517,010 - 96,552,391 (-)NCBI
RefSeq Acc Id: NM_010007   ⟹   NP_034137
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39496,517,010 - 96,552,391 (-)NCBI
GRCm38496,627,432 - 96,664,119 (-)NCBI
MGSCv37496,294,123 - 96,330,810 (-)RGD
Celera494,996,683 - 95,033,287 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034137   ⟸   NM_010007
- Peptide Label: isoform 1
- UniProtKB: O54749 (UniProtKB/Swiss-Prot),   Q3TNC5 (UniProtKB/TrEMBL),   Q3UEF7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030299   ⟸   ENSMUST00000030299
RefSeq Acc Id: NP_001405350   ⟸   NM_001418421
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001405351   ⟸   NM_001418422
- Peptide Label: isoform 3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54749-F1-model_v2 AlphaFold O54749 1-501 view protein structure

Promoters
RGD ID:6835104
Promoter ID:MM_KWN:38540
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000018013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36496,330,761 - 96,331,762 (-)MPROMDB
RGD ID:6883900
Promoter ID:EPDNEW_M5401
Type:initiation region
Name:Cyp2j5_1
Description:Mus musculus cytochrome P450, family 2, subfamily j, polypeptide5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38496,664,128 - 96,664,188EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270149 AgrOrtholog
Ensembl Genes ENSMUSG00000052520 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030299 ENTREZGENE
  ENSMUST00000030299.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2J-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1270149 ENTREZGENE
NCBI Gene 13109 ENTREZGENE
PANTHER CYTOCHROME P450 2J2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2j5 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2J UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP2J5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TNC5 ENTREZGENE, UniProtKB/TrEMBL
  Q3UEF7 ENTREZGENE, UniProtKB/TrEMBL