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Gene: Dock2 (dedicator of cyto-kinesis 2) Mus musculus
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Symbol: Dock2
Name: dedicator of cyto-kinesis 2
Description: Exhibits GTPase activator activity. Involved in several processes, including T cell activation; membrane raft polarization; and myeloid dendritic cell activation involved in immune response. Predicted to localize to the cytoplasm; cytoskeleton; and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in central nervous system and retina. Orthologous to human DOCK2 (dedicator of cytokinesis 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI662014; AW122239; CED-5; dedicator of cytokinesis protein 2; Hch; MBC
Orthologs:
Homo sapiens (human) : DOCK2 (dedicator of cytokinesis 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dock2 (dedicator of cytokinesis 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock2 (dedicator of cytokinesis 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK2 (dedicator of cytokinesis 2)
Canis lupus familiaris (dog) : DOCK2 (dedicator of cytokinesis 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock2 (dedicator of cytokinesis 2)
Sus scrofa (pig) : DOCK2 (dedicator of cytokinesis 2)
Chlorocebus sabaeus (green monkey) : DOCK2 (dedicator of cytokinesis 2)
Heterocephalus glaber (naked mole-rat) : Dock2 (dedicator of cytokinesis 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1134,226,815 - 34,783,892 (-)Ensembl
GRCm381134,226,815 - 34,783,905 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371134,126,864 - 34,414,545 (-)NCBIGRCm37mm9NCBIm37
MGSCv371134,495,792 - 34,597,325 (-)NCBIGRCm37mm9NCBIm37
MGSCv361134,127,668 - 34,414,536 (-)NCBImm8
Celera1136,638,260 - 36,926,598 (-)NCBICelera
Celera1138,463,760 - 38,560,259 (-)NCBICelera
Cytogenetic Map11 A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dock2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323175
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.