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Gene: Dock2 (dedicator of cyto-kinesis 2) Mus musculus
Symbol: Dock2
Name: dedicator of cyto-kinesis 2
Description: Exhibits GTPase activator activity. Involved in several processes, including T cell activation; membrane raft polarization; and myeloid dendritic cell activation involved in immune response. Predicted to localize to the cytoplasm; cytoskeleton; and membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in central nervous system and retina. Orthologous to human DOCK2 (dedicator of cytokinesis 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI662014; AW122239; CED-5; dedicator of cytokinesis protein 2; Hch; MBC
Homo sapiens (human) : DOCK2 (dedicator of cytokinesis 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dock2 (dedicator of cytokinesis 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock2 (dedicator of cytokinesis 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK2 (dedicator of cytokinesis 2)
Canis lupus familiaris (dog) : DOCK2 (dedicator of cytokinesis 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock2 (dedicator of cytokinesis 2)
Sus scrofa (pig) : DOCK2 (dedicator of cytokinesis 2)
Chlorocebus sabaeus (green monkey) : DOCK2 (dedicator of cytokinesis 2)
Heterocephalus glaber (naked mole-rat) : Dock2 (dedicator of cytokinesis 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Annotation category: suggests misassembly
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1134,226,815 - 34,783,892 (-)Ensembl
GRCm381134,226,815 - 34,783,905 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371134,126,864 - 34,414,545 (-)NCBIGRCm37mm9NCBIm37
MGSCv371134,495,792 - 34,597,325 (-)NCBIGRCm37mm9NCBIm37
MGSCv361134,127,668 - 34,414,536 (-)NCBImm8
Celera1136,638,260 - 36,926,598 (-)NCBICelera
Celera1138,463,760 - 38,560,259 (-)NCBICelera
Cytogenetic Map11 A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dock2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323175
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.