Dock2 (dedicator of cyto-kinesis 2) - Rat Genome Database

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Gene: Dock2 (dedicator of cyto-kinesis 2) Mus musculus
Analyze
Symbol: Dock2
Name: dedicator of cyto-kinesis 2
RGD ID: 1323175
MGI Page MGI
Description: Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI662014; AW122239; CED-5; dedicator of cytokinesis protein 2; Hch; MBC
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,176,815 - 34,674,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,176,815 - 34,674,719 (-)EnsemblGRCm39 Ensembl
GRCm381134,226,815 - 34,783,905 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,226,815 - 34,783,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv371134,495,792 - 34,597,325 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv371134,126,864 - 34,414,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,127,668 - 34,414,536 (-)NCBIMGSCv36mm8
Celera1138,463,751 - 38,560,177 (-)NCBICelera
Celera1136,638,309 - 36,926,598 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IEA)
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal CD8-positive, alpha-beta T cell number  (IEA)
abnormal cell migration  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IEA)
abnormal immunoglobulin level  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal lymphocyte morphology  (IEA)
abnormal organ of Corti morphology  (IAGP)
abnormal otolithic membrane morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal sensorimotor gating  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal startle reflex  (IAGP)
abnormal T cell morphology  (IEA)
abnormal T cell physiology  (IAGP)
absent marginal zone B cells  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
decreased B cell number  (IAGP)
decreased B-1a cell number  (IAGP)
decreased B-1b cell number  (IEA)
decreased bone mineral density  (IEA)
decreased CD4-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased double-positive T cell number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgE level  (IEA)
decreased IgG level  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased NK cell number  (IEA)
decreased plasmacytoid dendritic cell number  (IAGP)
decreased response to antigen  (IEA)
decreased single-positive T cell number  (IEA)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
glomerulonephritis  (IAGP)
impaired coordination  (IAGP)
impaired hearing  (IAGP)
impaired hematopoiesis  (IEA)
impaired neutrophil chemotaxis  (IAGP)
impaired wound healing  (IAGP)
increased alpha-beta T cell number  (IEA)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-histone antibody level  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased B cell number  (IAGP)
increased B cell proliferation  (IAGP)
increased B-1 B cell number  (IEA)
increased B-1b cell number  (IAGP)
increased CD4-positive, alpha-beta memory T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgG3 level  (IAGP)
increased IgM level  (IAGP)
increased immature B cell number  (IAGP)
increased macrophage cell number  (IEA)
increased neutrophil cell number  (IEA)
increased NK cell number  (IEA)
increased plasmacytoid dendritic cell number  (IAGP)
increased single-positive T cell number  (IEA)
increased spleen weight  (IEA)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased vertical activity  (IAGP)
lymph node hypoplasia  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
spleen hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11518968   PMID:12191913   PMID:12477932   PMID:12518436   PMID:12871644   PMID:14610273   PMID:15357953  
PMID:15368895   PMID:16141072   PMID:16141073   PMID:16230477   PMID:16585555   PMID:16602821   PMID:16772603   PMID:16943182   PMID:17325199   PMID:17420276   PMID:17767160   PMID:18157938  
PMID:18198348   PMID:18662984   PMID:18818380   PMID:19103880   PMID:19325080   PMID:19451552   PMID:19728314   PMID:19729484   PMID:20185585   PMID:20231379   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:21892172   PMID:22431588   PMID:22724066   PMID:22761313   PMID:23050005   PMID:23291967   PMID:23300459   PMID:23318649   PMID:23719299   PMID:24038871   PMID:24365888  
PMID:24659802   PMID:24821968   PMID:24913231   PMID:25044556   PMID:25339677   PMID:25477463   PMID:25788409   PMID:26283380   PMID:27210752   PMID:27291827   PMID:27748370   PMID:28378742  
PMID:28607113   PMID:28716822   PMID:28892060   PMID:29503648   PMID:29777221   PMID:30012848   PMID:30065028   PMID:30196744   PMID:31405607   PMID:31740487   PMID:31775048   PMID:32325033  
PMID:33382969   PMID:33662140   PMID:34710342   PMID:34767813   PMID:35079145   PMID:35395356   PMID:35584329   PMID:35844563   PMID:36341455   PMID:36804596   PMID:37021575   PMID:37383235  


Genomics

Comparative Map Data
Dock2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,176,815 - 34,674,732 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,176,815 - 34,674,719 (-)EnsemblGRCm39 Ensembl
GRCm381134,226,815 - 34,783,905 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,226,815 - 34,783,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv371134,495,792 - 34,597,325 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv371134,126,864 - 34,414,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,127,668 - 34,414,536 (-)NCBIMGSCv36mm8
Celera1138,463,751 - 38,560,177 (-)NCBICelera
Celera1136,638,309 - 36,926,598 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.68NCBI
DOCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385169,637,275 - 170,083,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5169,637,268 - 170,083,382 (+)EnsemblGRCh38hg38GRCh38
GRCh375169,064,279 - 169,510,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365168,996,871 - 169,442,959 (+)NCBINCBI36Build 36hg18NCBI36
Build 345168,996,870 - 169,442,959NCBI
Celera5165,095,818 - 165,542,012 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5164,162,763 - 164,608,396 (+)NCBIHuRef
CHM1_15168,496,748 - 168,942,815 (+)NCBICHM1_1
T2T-CHM13v2.05170,172,648 - 170,621,822 (+)NCBIT2T-CHM13v2.0
Dock2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,331,412 - 19,748,987 (-)NCBIGRCr8
mRatBN7.21018,827,237 - 19,244,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1018,827,239 - 19,244,808 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01019,181,512 - 19,603,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1019,465,771 - 19,574,094 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01019,060,032 - 19,481,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,207,499 - 19,660,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1018,459,930 - 18,875,791 (-)NCBICelera
Cytogenetic Map10q12NCBI
Dock2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540822,630,364 - 23,059,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540822,630,375 - 23,059,832 (+)NCBIChiLan1.0ChiLan1.0
DOCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24164,798,085 - 165,244,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15162,937,632 - 163,384,090 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05165,000,368 - 165,447,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15171,761,545 - 172,206,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5171,778,952 - 172,206,238 (+)Ensemblpanpan1.1panPan2
DOCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,779,950 - 42,177,957 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,780,436 - 42,235,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,732,263 - 42,129,986 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0442,156,230 - 42,590,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl442,156,232 - 42,589,985 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1441,973,746 - 42,371,199 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0442,160,212 - 42,557,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0442,671,083 - 43,068,964 (-)NCBIUU_Cfam_GSD_1.0
Dock2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721395,972,507 - 96,376,425 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366094,695,628 - 5,099,038 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366094,695,202 - 5,099,038 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,843,252 - 54,248,638 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,843,248 - 54,248,708 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21658,215,082 - 58,276,353 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12371,866,196 - 72,299,066 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2371,866,251 - 72,299,056 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660346,363,159 - 6,797,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473319,883,027 - 20,315,128 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473319,882,234 - 20,315,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dock2
12754 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1228
Count of miRNA genes:675
Interacting mature miRNAs:815
Transcripts:ENSMUST00000093193, ENSMUST00000101364, ENSMUST00000101365, ENSMUST00000127846, ENSMUST00000143540, ENSMUST00000154178, ENSMUST00000157036
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300607Tnbs2_mtri-nitrobenzene sulfonic acid susceptible 2 (mouse)Not determined112489805235126680Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse

Markers in Region
AW122239  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381134,227,394 - 34,227,519UniSTSGRCm38
MGSCv371134,127,394 - 34,127,519UniSTSGRCm37
Celera1136,638,839 - 36,638,964UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11489.04UniSTS
AI662014  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381134,307,718 - 34,307,867UniSTSGRCm38
MGSCv371134,207,718 - 34,207,867UniSTSGRCm37
Celera1136,719,107 - 36,719,255UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11489.18UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_033374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK031033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY027438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR392356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR762384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT005230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LO016975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LO016981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02000379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02010743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000093193   ⟹   ENSMUSP00000090884
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,176,815 - 34,674,719 (-)Ensembl
GRCm38.p6 Ensembl1134,226,815 - 34,783,892 (-)Ensembl
RefSeq Acc Id: ENSMUST00000101364   ⟹   ENSMUSP00000098915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,311,959 - 34,579,306 (-)Ensembl
GRCm38.p6 Ensembl1134,361,959 - 34,688,479 (-)Ensembl
RefSeq Acc Id: ENSMUST00000101365   ⟹   ENSMUSP00000098916
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,223,045 - 34,674,719 (-)Ensembl
GRCm38.p6 Ensembl1134,273,045 - 34,783,892 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,180,559 - 34,181,670 (-)Ensembl
GRCm38.p6 Ensembl1134,230,559 - 34,231,670 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143540   ⟹   ENSMUSP00000116893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,387,312 - 34,674,719 (-)Ensembl
GRCm38.p6 Ensembl1134,437,312 - 34,783,892 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,387,312 - 34,674,710 (-)Ensembl
GRCm38.p6 Ensembl1134,437,312 - 34,783,883 (-)Ensembl
RefSeq Acc Id: ENSMUST00000157036
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1134,257,651 - 34,262,637 (-)Ensembl
GRCm38.p6 Ensembl1134,307,651 - 34,312,637 (-)Ensembl
RefSeq Acc Id: NM_033374   ⟹   NP_203538
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391134,176,815 - 34,674,732 (-)NCBI
GRCm381134,226,815 - 34,783,905 (-)NCBI
MGSCv371134,126,864 - 34,414,545 (-)RGD
Celera1138,463,760 - 38,560,259 (-)NCBI
Celera1136,638,260 - 36,926,598 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017314862   ⟹   XP_017170351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391134,177,194 - 34,600,323 (-)NCBI
GRCm381134,227,194 - 34,709,507 (-)NCBI
Sequence:
RefSeq Acc Id: NP_203538   ⟸   NM_033374
- UniProtKB: Q5SRI4 (UniProtKB/Swiss-Prot),   Q99M79 (UniProtKB/Swiss-Prot),   Q8C3J5 (UniProtKB/Swiss-Prot),   Q6A0A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017170351   ⟸   XM_017314862
- Peptide Label: isoform X1
- UniProtKB: Q6A0A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000116893   ⟸   ENSMUST00000143540
RefSeq Acc Id: ENSMUSP00000090884   ⟸   ENSMUST00000093193
RefSeq Acc Id: ENSMUSP00000098915   ⟸   ENSMUST00000101364
RefSeq Acc Id: ENSMUSP00000098916   ⟸   ENSMUST00000101365
Protein Domains
C2 DOCK-type   DOCKER   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C3J5-F1-model_v2 AlphaFold Q8C3J5 1-1828 view protein structure

Promoters
RGD ID:6820734
Promoter ID:MM_KWN:6937
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:ENSMUST00000101364,   ENSMUST00000101365,   OTTMUST00000012054,   OTTMUST00000012058,   OTTMUST00000018342
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361134,596,989 - 34,597,489 (-)MPROMDB
RGD ID:8674290
Promoter ID:EPDNEW_M15175
Type:initiation region
Name:Dock2_1
Description:Mus musculus dedicator of cyto-kinesis 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381134,783,892 - 34,783,952EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2149010 AgrOrtholog
Ensembl Genes ENSMUSG00000020143 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093193 ENTREZGENE
  ENSMUST00000093193.12 UniProtKB/Swiss-Prot
  ENSMUST00000101364.3 UniProtKB/TrEMBL
  ENSMUST00000101365.9 UniProtKB/TrEMBL
  ENSMUST00000143540.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHR-1_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHR-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:94176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2149010 ENTREZGENE
NCBI Gene 94176 ENTREZGENE
PANTHER PTHR45653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45653:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOCK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dock2 PhenoGen
PROSITE DHR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RGU3_MOUSE UniProtKB/TrEMBL
  DOCK2_MOUSE UniProtKB/Swiss-Prot
  Q3TMS1_MOUSE UniProtKB/TrEMBL
  Q5SRI3_MOUSE UniProtKB/TrEMBL
  Q5SRI4 ENTREZGENE
  Q6A0A3 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3J5 ENTREZGENE
  Q99M79 ENTREZGENE
UniProt Secondary Q5SRI4 UniProtKB/Swiss-Prot
  Q99M79 UniProtKB/Swiss-Prot