Pla2g12b (phospholipase A2, group XIIB) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pla2g12b (phospholipase A2, group XIIB) Mus musculus
Analyze
Symbol: Pla2g12b
Name: phospholipase A2, group XIIB
RGD ID: 1558545
MGI Page MGI
Description: Predicted to enable calcium ion binding activity and phospholipase A2 activity. Acts upstream of or within cholesterol homeostasis; low-density lipoprotein particle remodeling; and triglyceride homeostasis. Predicted to be located in extracellular region. Is expressed in alimentary system; liver; liver lobe; and yolk sac endoderm. Orthologous to human PLA2G12B (phospholipase A2 group XIIB).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010002E04Rik; Fksg71; group XIIB phospholipase A2; group XIIB secretory phospholipase A2-like protein; group XIII secretory phospholipase A2-like protein; GXIIB; GXIII sPLA2-like; hlb21; hlb218; phospholipase A2, group XIII; Pla2; Pla2g13; sPLA2-GXIIB
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,239,242 - 59,257,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)EnsemblGRCm39 Ensembl
GRCm381059,403,420 - 59,421,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,866,433 - 58,884,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,799,042 - 58,817,333 (+)NCBIMGSCv36mm8
Celera1060,503,964 - 60,522,245 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14516201   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17683524   PMID:21267068   PMID:21274867  
PMID:21677750   PMID:21873635   PMID:22912808   PMID:27471003   PMID:27534441   PMID:30922124   PMID:37757774   PMID:38453914  


Genomics

Comparative Map Data
Pla2g12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,239,242 - 59,257,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)EnsemblGRCm39 Ensembl
GRCm381059,403,420 - 59,421,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,866,433 - 58,884,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,799,042 - 58,817,333 (+)NCBIMGSCv36mm8
Celera1060,503,964 - 60,522,245 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
PLA2G12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,934,762 - 72,954,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,694,520 - 74,714,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,364,944 - 74,384,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,364,943 - 74,384,516NCBI
Celera1067,980,077 - 67,999,649 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,688,779 - 68,708,351 (-)NCBIHuRef
CHM1_11074,976,668 - 74,996,240 (-)NCBICHM1_1
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBIT2T-CHM13v2.0
Pla2g12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,910,620 - 27,931,734 (+)NCBIGRCr8
mRatBN7.22027,369,196 - 27,389,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,370,266 - 27,388,743 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02028,989,440 - 29,007,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,989,491 - 29,007,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,793,778 - 30,812,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,813,714 - 28,832,140 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pla2g12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,694,496 - 18,719,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,694,496 - 18,723,311 (+)NCBIChiLan1.0ChiLan1.0
PLA2G12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,111,134 - 85,130,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,116,402 - 85,135,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,482,065 - 69,502,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,946,072 - 71,965,616 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,946,506 - 71,965,482 (-)Ensemblpanpan1.1panPan2
PLA2G12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,539,909 - 23,561,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBIUU_Cfam_GSD_1.0
Pla2g12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,579,733 - 57,604,031 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,072,486 - 6,096,791 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,072,487 - 6,096,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,819,851 - 81,844,252 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,311,609 - 58,335,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,312,500 - 58,336,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,907,588 - 18,935,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,653,698 - 6,680,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,653,307 - 6,680,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pla2g12b
621 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:156
Interacting mature miRNAs:176
Transcripts:ENSMUST00000009790, ENSMUST00000162643
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
12904011Cfq11_mconditioned fear QTL 11 (mouse)105648015660940841Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
AI255352  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381059,421,584 - 59,421,670UniSTSGRCm38
MGSCv371058,884,332 - 58,884,418UniSTSGRCm37
Celera1060,521,853 - 60,521,939UniSTS
Cytogenetic Map10B3UniSTS
Whitehead/MRC_RH10695.15UniSTS
Pla2g12b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381059,421,467 - 59,421,946UniSTSGRCm38
MGSCv371058,884,215 - 58,884,694UniSTSGRCm37
Celera1060,521,736 - 60,522,215UniSTS
Cytogenetic Map10B3UniSTS
cM Map10 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000009790   ⟹   ENSMUSP00000009790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)Ensembl
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)Ensembl
Ensembl Acc Id: ENSMUST00000162643   ⟹   ENSMUSP00000123842
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1059,246,849 - 59,257,792 (+)Ensembl
GRCm38.p6 Ensembl1059,411,027 - 59,421,970 (+)Ensembl
RefSeq Acc Id: NM_023530   ⟹   NP_076019
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391059,239,507 - 59,257,798 (+)NCBI
GRCm381059,403,685 - 59,421,976 (+)NCBI
MGSCv371058,866,433 - 58,884,724 (+)RGD
Celera1060,503,964 - 60,522,245 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514061   ⟹   XP_006514124
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391059,239,243 - 59,257,798 (+)NCBI
GRCm381059,403,425 - 59,421,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514062   ⟹   XP_006514125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391059,239,242 - 59,257,798 (+)NCBI
GRCm381059,403,420 - 59,421,976 (+)NCBI
Sequence:
RefSeq Acc Id: NP_076019   ⟸   NM_023530
- Peptide Label: precursor
- UniProtKB: Q99P27 (UniProtKB/Swiss-Prot),   Q8VC81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514125   ⟸   XM_006514062
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006514124   ⟸   XM_006514061
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000009790   ⟸   ENSMUST00000009790
Ensembl Acc Id: ENSMUSP00000123842   ⟸   ENSMUST00000162643

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P27-F1-model_v2 AlphaFold Q99P27 1-195 view protein structure

Promoters
RGD ID:6819736
Promoter ID:MM_KWN:4207
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver
Transcripts:ENSMUST00000009790
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361058,866,209 - 58,866,709 (+)MPROMDB
RGD ID:8672034
Promoter ID:EPDNEW_M14048
Type:multiple initiation site
Name:Pla2g12b_1
Description:Mus musculus phospholipase A2, group XIIB , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381059,403,660 - 59,403,720EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917086 AgrOrtholog
Ensembl Genes ENSMUSG00000009646 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000009790 ENTREZGENE
  ENSMUST00000009790.14 UniProtKB/TrEMBL
  ENSMUST00000162643.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PLA2G12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69836 UniProtKB/TrEMBL
MGD MGI:1917086 ENTREZGENE
NCBI Gene 69836 ENTREZGENE
PANTHER GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PLA2G12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pla2g12b PhenoGen
PROSITE ER_TARGET UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6UTM6_MOUSE UniProtKB/TrEMBL
  PG12B_MOUSE UniProtKB/Swiss-Prot
  Q8VC81 ENTREZGENE, UniProtKB/TrEMBL
  Q99P27 ENTREZGENE