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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Mouth Neoplasms
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Accession:DOID:9007364 term browser browse the term
Definition:Tumors or cancer of the MOUTH.
Synonyms:exact_synonym: Cancer of Mouth;   Cancer of the Mouth;   Mouth Cancer;   Mouth Cancers;   Mouth Neoplasm;   Oral Cancer;   Oral Cancers;   Oral Neoplasm;   Oral Neoplasms
 narrow_synonym: MALIGNANT TUMOR OF FLOOR OF MOUTH
 primary_id: MESH:D009062
 xref: EFO:0003868


show annotations for term's descendants           Sort by:
Mouth Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138216 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18500343 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Akap11 A-kinase anchoring protein 11 ISO mRNA:increased expression:oral mucosa: RGD PMID:15849745 RGD:14348954 NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605 		JBrowse link
G Anxa1 annexin A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa5 annexin A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Atp7b ATPase copper transporting beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:12509969 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Cbr3 carbonyl reductase 3 ISO mRNA:decreased expression:oral squamous cell carcinoma (human) RGD PMID:19088887 RGD:2316291 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 no_association ISO DNA:polymorphism::2518G>A(human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:25199511 PMID:21570337 RGD:8661698 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism:cds:pV64I(human) RGD PMID:21570337 RGD:8661698 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24991542 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cldn1 claudin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33665778 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Clptm1l CLPTM1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:27749845 NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G Cryab crystallin, alpha B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22114726 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dspp dentin sialophosphoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21103065 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672 		JBrowse link
G Eno1 enolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEP protein:increased expression:oral epithelium RGD PMID:17704947 RGD:2289941 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP protein:increased expression:oral epithelium RGD PMID:17704947 RGD:2289941 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit susceptibility ISO DNA:polymorphisms:cds:p.D312N,K751Q(human) RGD PMID:17290401 RGD:8552678 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor disease_progression IEP associated with Diabetes Mellitus, Experimental;protein:increased expression: RGD PMID:17708355 RGD:2303822 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Fga fibrinogen alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:16239339 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fubp1 far upstream element binding protein 1 ISO mRNA:increased expression:oral cavity (human) RGD PMID:32481602 RGD:151361197 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpn1 GPN-loop GTPase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27749845 NCBI chr 6:24,947,350...24,965,025
Ensembl chr 6:24,947,325...24,965,031 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27816970 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hoxa5 homeo box A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22227861 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Hoxd10 homeo box D10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22227861 NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725 		JBrowse link
G Hoxd11 homeobox D11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22227861 NCBI chr 3:59,584,840...59,587,257
Ensembl chr 3:59,585,039...59,586,783 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEP
ISO		 associated with Diabetes Mellitus;protein:increased expression:oral region
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:24224046 PMID:19283661 RGD:2314840 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24069166 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24349532 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19435901 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lamc3 laminin subunit gamma 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27749845 NCBI chr 3:15,165,220...15,226,697
Ensembl chr 3:15,165,220...15,226,697 		JBrowse link
G Lgals7 galectin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24991542 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 7:86,951,541...86,973,147
Ensembl chr 7:86,951,541...86,973,577 		JBrowse link
G Mt1 metallothionein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17418620 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28501332 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nat2 N-acetyltransferase 2 susceptibility ISO DNA:polymorphisms,haplotype:exon: RGD PMID:17290401 RGD:8552678 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22972152 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nras NRAS proto-oncogene, GTPase disease_progression IEP associated with Diabetes Mellitus, Experimental RGD PMID:17708355 RGD:2303822 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malignant tumor of floor of mouth		 CTD
ClinVar		 PMID:17376864 PMID:21824802 PMID:22729224 PMID:24033266 PMID:24224046 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Plau plasminogen activator, urokinase ISO DNA:snp:3' utr:g.4065C>T (human) RGD PMID:15356878 RGD:7241146 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ppia peptidylprolyl isomerase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17599052 NCBI chr17:83,549,608...83,654,517
Ensembl chr17:83,548,803...83,655,179 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Malignant tumor of floor of mouth ClinVar PMID:1945792 PMID:9915974 PMID:10866302 PMID:11051241 PMID:11504908 More... NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12969226 PMID:20051374 RGD:5135063 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:25199511 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Serpinb3 serpin family B member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Sfn stratifin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sirt3 sirtuin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21472714 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sod2 superoxide dismutase 2 susceptibility ISO DNA:polymorphism: :rs4342445(human)
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12543247 PMID:15274141 PMID:21940907 RGD:8158078 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27862620 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
G Tp53 tumor protein p53 IEP
ISO		 associated with Diabetes Mellitus, Experimental; protein:increased expression:oral epithelium
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19435901 PMID:24224046 PMID:17595763 PMID:16778087 RGD:2290572, RGD:8547873 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Tsc1 TSC complex subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18538015 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18538015 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Umps uridine monophosphate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16757204 NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15274141 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:haplotye:: RGD PMID:17290401 RGD:8552678 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
congenital heart defects, hamartomas of tongue, and polysyndactyly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wdpcp WD repeat containing planar cell polarity effector ISO ClinVar Annotator: match by term: Heart defect - tongue hamartoma - polysyndactyly syndrome | ClinVar Annotator: match by term: WDPCP-related condition
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:9536098 PMID:16199547 PMID:17576681 PMID:20671153 PMID:25326635 More... NCBI chr14:95,645,955...95,977,120
Ensembl chr14:95,646,038...95,977,113 		JBrowse link
lip cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:26723902 RGD:14975265 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
Lip Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO RGD PMID:17238970 RGD:8662391 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:17238970 RGD:8662391 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
oral cavity cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:decreased activity:saliva: RGD PMID:16120121 RGD:152995281 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit susceptibility ISO DNA:SNP: :rs578776(human) RGD PMID:24505444 RGD:151347542 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO RGD PMID:17461521 RGD:14700965 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO RGD PMID:16721740 RGD:14700978 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO RGD PMID:23057317 PMID:17418613 PMID:17461521 RGD:14700938, RGD:14700968, RGD:14700965 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO RGD PMID:22594240 PMID:14735473 RGD:14700997, RGD:14701001 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Sod3 superoxide dismutase 3 ISO RGD PMID:23057317 RGD:14700938 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
oral cavity carcinoma in situ term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nuf2 NUF2 component of NDC80 kinetochore complex disease_progression ISO RGD PMID:27499128 RGD:28867233 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766 		JBrowse link
oral mucosa leukoplakia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase severity ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 PMID:18288488 RGD:150340604, RGD:150340709 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Axin2 axin 2 disease_progression ISO RGD PMID:28939076 RGD:151356661 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP protein:increased expression:tongue: RGD PMID:12167434 RGD:8547871 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A susceptibility ISO DNA:polymorphism:exon:149A>G(human) RGD PMID:10873097 PMID:10873097 RGD:8662371, RGD:8662371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit susceptibility ISO DNA:polymorphism:cds:p.K751Q(human) RGD PMID:17290401 RGD:8552678 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO RGD PMID:18507060 RGD:14700975 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO RGD PMID:18507060 RGD:14700975 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H2ax H2A.X variant histone disease_progression ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 RGD:150340604 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Nat2 N-acetyltransferase 2 susceptibility ISO DNA:polymorphisms,haplotype:exon: RGD PMID:17290401 RGD:8552678 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18202791 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Snai1 snail family transcriptional repressor 1 disease_progression ISO RGD PMID:28939076 RGD:151356661 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Tp53 tumor protein p53 ISO
IEP
IMP		 protein:increased expression:oral mucosa:
protein:increased expression:tongue:
DNA:mutations:cds:		 RGD PMID:23776093 PMID:12167434 PMID:12167434 RGD:8547855, RGD:8547871, RGD:8547871 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:polymorphism,haplotye:cds:p.R399Q(human) RGD PMID:17290401 RGD:8552678 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
oral squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase severity ISO DNA:mutations RGD PMID:16676365 RGD:126925209 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Ada adenosine deaminase disease_progression ISO RGD PMID:27221867 RGD:152995268 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr 7:62,897,282...62,914,295
Ensembl chr 7:62,897,282...62,914,295 		JBrowse link
G Angpt1 angiopoietin 1 ISO protein:decreased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Arid2 AT-rich interaction domain 2 disease_progression ISO RGD PMID:31918270 RGD:150340710 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B severity ISO protein:increased expression:oral mucosa (human) RGD PMID:26138391 RGD:11046268 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Atm ATM serine/threonine kinase disease_progression ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 PMID:18288488 RGD:150340604, RGD:150340709 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 ISO RGD PMID:26984774 RGD:14700648 NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278 		JBrowse link
G Axin1 axin 1 disease_progression ISO protein:decreased expression:oral epithelium (human)
mRNA:increased expression:oral epithelium (human)		 RGD PMID:17143481 PMID:21393552 RGD:150530474, RGD:150530486 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 susceptibility
ameliorates
disease_progression		 ISO DNA:SNP:intron: C>T (rs3923087)(human) RGD PMID:21393552 PMID:33046030 PMID:33046030 RGD:150530486, RGD:151356656, RGD:151356656 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding ISO protein:increased expression:saliva
protein:decreased expression:saliva		 RGD PMID:29199150 PMID:33564003 RGD:153350131, RGD:153350144 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Barhl2 BarH-like homeobox 2 ISO protein:decreased expression:mouth mucosa RGD PMID:27542258 RGD:14390167 NCBI chr14:3,340,465...3,345,362
Ensembl chr14:3,340,465...3,345,353 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 treatment ISO Human cells in mouse model RGD PMID:27602964 RGD:151665310 NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 disease_progression
ameliorates		 ISO protein:increased expression:oral cavity (human)
mRNA:increased expression:oral cavity (human)
protein:decreased expression:oral cavity (human)		 RGD PMID:23852810 PMID:20967871 PMID:29286141 PMID:21952624 RGD:152998980, RGD:152999012, RGD:152999009, RGD:152998987 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brinp2 BMP/retinoic acid inducible neural specific 2 ISO DNA:amplication:oral epithelium RGD PMID:21334929 RGD:14398483 NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 disease_progression ISO RGD PMID:24706327 RGD:14398491 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Btk Bruton tyrosine kinase treatment ISO mRNA:increased expression:oral epithelium (human) RGD PMID:33640903 RGD:151347851 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Calr calreticulin exacerbates ISO protein:increased expression:oral epithelium (human)
protein:increased expression:mouth (human)		 RGD PMID:23375593 PMID:28599487 RGD:150521688, RGD:150520158 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 ISO RGD PMID:30205384 RGD:18337270 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Car12 carbonic anhydrase 12 disease_progression ISO RGD PMID:22172588 RGD:153352330 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Cbx2 chromobox 2 disease_progression ISO RGD PMID:24885002 RGD:9586732 NCBI chr10:104,278,517...104,287,384
Ensembl chr10:104,278,549...104,287,383 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility
disease_progression		 ISO
IEP		 DNA:polymorphism,haplotype::2518A>G(human)
associated with social isolation;protein:increased expression:tongue (rat)		 RGD PMID:21883707 PMID:33411841 RGD:8661694, RGD:152998999 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism,haplotype:cds:p.V64I(human) RGD PMID:21883707 RGD:8661694 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cdc73 cell division cycle 73 ISO mRNA:altered expression: tongue, oral cavity (human) RGD PMID:24257751 RGD:150537040 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Cdh1 cadherin 1 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A susceptibility
no_association
disease_progression		 ISO DNA:polymorphism:exon:149A>G(human)
DNA:polymorphism: :98C>A(human)		 RGD PMID:10873097 PMID:18251939 PMID:15817070 PMID:10873097 RGD:8662371, RGD:8662395, RGD:8662374, RGD:8662371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cers1 ceramide synthase 1 exacerbates ISO RGD PMID:33753723 RGD:156431057 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,104,466...19,112,519 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B disease_progression ISO protein:increased expression:mouth mucosa: RGD PMID:22882088 RGD:9587477 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Clptm1l CLPTM1-like susceptibility ISO DNA:SNP: :rs402710(human) RGD PMID:28025427 RGD:150530487 NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530 		JBrowse link
G Ctnnd1 catenin delta 1 disease_progression ISO RGD PMID:26464646 RGD:11526681 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO RGD PMID:22660220 RGD:14700952 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 susceptibility ISO DNA:SNP:exon: (rs2296241) (human) RGD PMID:22612324 RGD:151665337 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO RGD PMID:22954124 RGD:14700880 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Daxx death-domain associated protein ameliorates ISO human cell line in a mouse model RGD PMID:26205068 RGD:152025200 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO mRNA, protein:increased expression:mouth (human) RGD PMID:31253192 RGD:151347620 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 severity ISO RGD PMID:29945346 RGD:150429700 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO RGD PMID:24625449 PMID:24625449 RGD:9589120, RGD:9589120 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dock6 dedicator of cytokinesis 6 disease_progression ISO RGD PMID:34742001 RGD:155791563 NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552 		JBrowse link
G Efnb2 ephrin B2 ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:11673832 RGD:126781761 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:11673832 RGD:126781761 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:14595263 RGD:126781770 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit susceptibility ISO associated with oral mucosa leukoplakia
DNA:SNPs, haplotypes: :multiple		 RGD PMID:24122997 PMID:21697275 PMID:26807327 RGD:126779588, RGD:126781699, RGD:126779606 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fat1 FAT atypical cadherin 1 onset ISO protein:increased expression:tongue (mouse)
DNA:mutations:multiple		 RGD PMID:30624777 PMID:28435450 RGD:151347668, RGD:151347687 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO associated with human papillomavirus;DNA:missense mutation:cds: p.S249C (human) RGD PMID:30563911 RGD:38500239 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 severity ISO DNA:SNP:exon 9: p.G388R (human) RGD PMID:20127014 RGD:150520164 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 ISO mRNA:decreased expression:oral epithelium (human) RGD PMID:32048621 RGD:149735374 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IEP RGD PMID:27375172 RGD:13792673 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gpx1 glutathione peroxidase 1 exacerbates ISO protein:increased expression:oral cavity (human) RGD PMID:28653098 RGD:152995473 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 disease_progression ISO protein:increased expression:oral cavity (human) RGD PMID:28653098 RGD:152995473 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta susceptibility ISO DNA:SNP:intron: (rs9879992) (human) RGD PMID:21393552 RGD:150530486 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 severity ISO DNA:deletion: : (human) RGD PMID:22213390 PMID:14662415 RGD:12792245, RGD:14700962 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO mRNA,protein:decreased expression:mucosa: RGD PMID:16982972 RGD:10755432 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone disease_progression ISO protein:increased expression:mucosa of oral region (human) RGD PMID:29928356 RGD:150340604 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO protein:increased expression:tongue (mouse) RGD PMID:30624777 RGD:151347668 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hp haptoglobin ISO protein:increased expression:saliva RGD PMID:29199150 RGD:153350131 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Il10 interleukin 10 susceptibility ISO DNA:SNP:promoter:-592A>C (human) RGD PMID:28157558 RGD:14975130 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:19065664 RGD:8549498 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Il1b interleukin 1 beta disease_progression IEP associated with social isolation;protein:increased expression:tongue (rat) RGD PMID:33411841 RGD:152998999 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:10389944 RGD:8662949 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 disease_progression ISO RGD PMID:24625449 RGD:9589120 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO associated with papillomavirus infectious disease;protein:increased expression:oral cavity (human) RGD PMID:28155253 RGD:151347666 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kmt2d lysine methyltransferase 2D severity ISO RGD PMID:31660637 RGD:150521713 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Mcph1 microcephalin 1 ISO mRNA:protein:decreased expression:oral cavity, tissue (human) RGD PMID:23472065 RGD:9589036 NCBI chr16:71,021,855...71,224,067
Ensembl chr16:71,024,588...71,224,122 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression, altered expression:mouth mucosa: RGD PMID:20662906 RGD:8548617 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:30194167 PMID:28413645 PMID:29909906 RGD:21079420, RGD:24922225, RGD:21079468 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir187 microRNA 187 ISO RNA:increased expression:plasma RGD PMID:27542258 RGD:14390167 NCBI chr18:15,731,194...15,731,297
Ensembl chr18:15,731,194...15,731,297 		JBrowse link
G Mir20a microRNA 20a ISO RGD PMID:26781875 RGD:26884343 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir221 microRNA 221 exacerbates ISO RGD PMID:21226887 RGD:151708999 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 disease_progression
exacerbates		 ISO RGD PMID:31841247 PMID:21226887 RGD:151708741, RGD:151708999 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mir31 microRNA 31 treatment ISO RGD PMID:20233326 RGD:153297767 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:missense mutation:cds:677C>T (human) RGD PMID:16365753 RGD:10449416 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 ISO protein:increased expression:oral cavity (human) RGD PMID:20967871 RGD:152999012 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Notch1 notch receptor 1 ISO protein:increased expression:tongue (mouse) RGD PMID:30624777 RGD:151347668 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO protein:increased expression:oral mucosa (rat) RGD PMID:15878520 RGD:8547730 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plcg1 phospholipase C, gamma 1 disease_progression
ameliorates		 ISO protein:decreased expression:oral cavity (human) RGD PMID:26464646 PMID:25085076 RGD:11526681, RGD:151356936 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Prdx2 peroxiredoxin 2 ISO protein:increased expression:saliva RGD PMID:29199150 RGD:153350131 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Pten phosphatase and tensin homolog disease_progression ISO protein:increased expression:oral epithelium (human) RGD PMID:33109573 RGD:127285606 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO mRNA,protein:decreased expression:mouth mucosa (human) RGD PMID:30532780 RGD:151347832 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 treatment ISO RGD PMID:21176871 RGD:152600900 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Rad21 RAD21 cohesin complex component exacerbates ISO mRNA:decreased expression:oral cavity (human) RGD PMID:16416296 RGD:150520028 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mouth (human) RGD PMID:34111459 RGD:153344573 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 severity
disease_progression		 ISO protein:increased expression:oral mucosa (rat) RGD PMID:15878520 PMID:24999729 RGD:8547730, RGD:13208508 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO protein:increased expression:mucosa of oral region (human) RGD PMID:24743017 RGD:151665336 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 severity ISO RGD PMID:23801167 RGD:151361213 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Tert telomerase reverse transcriptase susceptibility ISO DNA:SNPs: :rs2736100,rs2736098(human) RGD PMID:28025427 RGD:150530487 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 ISO protein:decreased expression:oral epithelium (human) RGD PMID:24122999 RGD:150429611 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tnf tumor necrosis factor disease_progression IEP associated with social isolation;protein:increased expression:tongue (rat) RGD PMID:33411841 RGD:152998999 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:missense mutations: :multiple
protein:increased expression:mouth (human)		 RGD PMID:27283772 PMID:34111459 RGD:14995497, RGD:153344573 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttr transthyretin ISO protein:increased expression:saliva (human) RGD PMID:23784731 RGD:151664609 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:oral mucosa (human) RGD PMID:26044849 RGD:153323290 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wnt11 Wnt family member 11 susceptibility ISO DNA:SNP:exon: A>G (rs1533767) (human) RGD PMID:21393552 RGD:150530486 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
pleomorphic adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plag1 PLAG1 zinc finger ISO CTD Direct Evidence: marker/mechanism CTD
OMIM
RGD		 PMID:10029085 RGD:1599086 NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647 		JBrowse link
salivary gland adenoid cystic carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir155 microRNA 155 disease_progression ISO RGD PMID:28668836 RGD:24922215 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 disease_progression ISO RGD PMID:25885343 RGD:25330345 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 susceptibility ISO DNA:SNP:intron: (rs13180356) (human) RGD PMID:26035306 RGD:151361290 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
salivary gland cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gon4l gon-4 like ISS MouseDO NCBI chr 2:174,233,461...174,306,636
Ensembl chr 2:174,233,461...174,306,634 		JBrowse link
salivary gland carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor disease_progression ISO RGD PMID:26498950 RGD:126907998 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 disease_progression ISO RGD PMID:26498950 RGD:126907998 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Rad52 RAD52 homolog, DNA repair protein sexual_dimorphism ISO DNA:SNP:intron: (rs3748522) (human) RGD PMID:26035306 RGD:151361290 NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 sexual_dimorphism ISO DNA:SNP:intron: (rs13180356) (human) RGD PMID:26035306 RGD:151361290 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
Salivary Gland Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa7 annexin A7 ISO protein:decreased expression:salivary gland RGD PMID:17708571 RGD:2292654 NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385 		JBrowse link
G Aqp1 aquaporin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aspm assembly factor for spindle microtubules ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755 		JBrowse link
G Bcl11a BCL11 transcription factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180 		JBrowse link
G Ccnd1 cyclin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17520682 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A onset ISO RGD PMID:11103935 RGD:8662404 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B disease_progression ISO protein:increased expression:salivary gland: RGD PMID:21109952 RGD:9587467 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890 		JBrowse link
G Efhd1 EF-hand domain family, member D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917 		JBrowse link
G En1 engrailed homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943 		JBrowse link
G Espl1 extra spindle pole bodies like 1, separase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984 		JBrowse link
G Fanca FA complementation group A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527 		JBrowse link
G Fat1 FAT atypical cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fgf8 fibroblast growth factor 8 ISO associated with Mammary Neoplasms, Experimental RGD PMID:9840935 RGD:2301098 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Gas2 growth arrest-specific 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619 		JBrowse link
G Gas6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gins2 GINS complex subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Homer3 homer scaffold protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Salivary gland neoplasm ClinVar PMID:17384584 PMID:19255327 PMID:19773371 PMID:23406027 PMID:24006476 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Irx4 iroquois homeobox 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979 		JBrowse link
G Itgb4 integrin subunit beta 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Krt15 keratin 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt5 keratin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Salivary gland neoplasm ClinVar PMID:17384584 PMID:19255327 PMID:19773371 PMID:23406027 PMID:24006476 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652 		JBrowse link
G Mier2 MIER family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 7:10,153,501...10,169,381
Ensembl chr 7:10,153,649...10,169,378 		JBrowse link
G Mlc1 modulator of VRAC current 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 7:120,046,705...120,067,049
Ensembl chr 7:120,046,705...120,067,049 		JBrowse link
G Neto2 neuropilin and tolloid like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566 		JBrowse link
G Pdzk1 PDZ domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Prkd1 protein kinase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25240283 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Pygb glycogen phosphorylase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691 		JBrowse link
G Serpinf1 serpin family F member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Slc24a3 solute carrier family 24 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 3:132,552,119...133,051,192
Ensembl chr 3:132,551,595...133,051,192 		JBrowse link
G Son SON DNA and RNA binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167 		JBrowse link
G Sox11 SRY-box transcription factor 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 6:44,008,333...44,010,354
Ensembl chr 6:44,008,340...44,010,354 		JBrowse link
G Sox4 SRY-box transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G Top2a DNA topoisomerase II alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Vcan versican ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Wnt5b Wnt family member 5B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762588 NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 severity ISO protein:decreased expression:saliva-secreting gland (human) RGD PMID:33202356 RGD:150530645 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
tongue cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked ameliorates ISO RGD PMID:25918862 RGD:151356506 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 severity ISO associated with human papillomavirus;protein:decreased expression:tumor cells RGD PMID:30061236 RGD:36947883 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:decreased expression:tongue RGD PMID:30617160 RGD:21081517 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 disease_progression ISO protein:increased expression:tongue (human) RGD PMID:25749387 RGD:152995520 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426 		JBrowse link
tongue carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B ISO associated with oral squamous cell carcinoma; protein:increased expression: oral mucosa squamous cell, cervical lymph node (human) RGD PMID:20204288 RGD:27372889 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
Tongue Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment IDA RGD PMID:17374970 RGD:1625338 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21401805 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP protein:increased expression:tongue: RGD PMID:12167434 RGD:8547871 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO RGD PMID:11488071 RGD:8662423 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A severity IAGP
IEP		 DNA:point mutations, missense mutation:exon
protein:decreased expression:tongue
DNA:loss of heterozygosity		 RGD PMID:17091472 PMID:18804414 PMID:16527513 RGD:1600814, RGD:11252155, RGD:1578522 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IAGP DNA:loss of heterozygosity RGD PMID:16527513 RGD:1578522 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cryab crystallin, alpha B ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hras HRas proto-oncogene, GTPase susceptibility ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20043093 PMID:20043093 RGD:12738401 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840781 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:blood: RGD PMID:8493451 RGD:8548876 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue epithelium RGD PMID:14674993 RGD:2293780 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Krt14 keratin 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Mir222 microRNA 222 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19487542 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mt1 metallothionein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO protein:decreased expression:saliva RGD PMID:19789535 RGD:8657148 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16543248 PMID:22561872 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sod2 superoxide dismutase 2 ISO mRNA,protein:increased expression:tongue:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20618948 PMID:20618948 RGD:8547519 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 disease_progression ISO RGD PMID:17169602 PMID:22302289 RGD:8694287, RGD:8694311 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Terc telomerase RNA component ISO CTD Direct Evidence: therapeutic CTD PMID:16051514 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tlr5 toll-like receptor 5 ISO protein:increased expression:tongue: RGD PMID:23287987 RGD:7814374 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tnf tumor necrosis factor ISO mRNA,protein:increased expression:tongue:
protein:increased expression:saliva		 RGD PMID:14747060 PMID:21397550 RGD:7401243, RGD:7401244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ISO
IEP
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:tongue:
DNA:mutations:cds:		 CTD
RGD		 PMID:16543248 PMID:21903770 PMID:9485768 PMID:12167434 RGD:8547850, RGD:8547872, RGD:8547871 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tyms thymidylate synthetase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16280240 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C disease_progression ISO RGD PMID:15289890 RGD:7488946 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing disease_progression ISO protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 exacerbates ISO protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Brinp3 BMP/retinoic acid inducible neural specific 3 ISO mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770 		JBrowse link
G Cav2 caveolin 2 ISO protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244 		JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO RGD PMID:12162767 RGD:8662376 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:19691460 RGD:126781771 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 severity ISO RGD PMID:19691460 RGD:126781771 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fancb FA complementation group B ISO RGD PMID:17409780 RGD:11049143 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192 		JBrowse link
G Fancc FA complementation group C ISO RGD PMID:17409780 RGD:11049143 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376 		JBrowse link
G Fancf FA complementation group F ISO mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923 		JBrowse link
G Fancg FA complementation group G ISO RGD PMID:17409780 RGD:11049143 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fanci FA complementation group I ISO RGD PMID:17409780 RGD:11049143 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640 		JBrowse link
G Fancl FA complementation group L ISO RGD PMID:17409780 RGD:11049143 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255 		JBrowse link
G Fancm FA complementation group M ISO RGD PMID:17409780 RGD:11049143 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit ISO protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Fubp1 far upstream element binding protein 1 exacerbates ISO mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Hgf hepatocyte growth factor ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Ifng interferon gamma disease_progression IEP protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 disease_progression IEP protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il2 interleukin 2 IEP protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il33 interleukin 33 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Jak3 Janus kinase 3 disease_progression IEP RGD PMID:26860129 RGD:11531126 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kdr kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtus1 microtubule associated scaffold protein 1 disease_progression ISO RGD PMID:22153618 RGD:25330347 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 severity ISO RGD PMID:24762957 RGD:151361157 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Sox2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:21689966 RGD:8661665 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Tp53 tumor protein p53 IEP protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    Stomatognathic Diseases 1348
      mouth disease 1019
        Mouth Neoplasms 269
          Gingival Neoplasms 0
          Lip Neoplasms + 3
          Palatal Neoplasms + 0
          Salivary Gland Neoplasms + 58
          Tongue Neoplasms + 86
          oral cavity cancer + 145
          oral mucosa leukoplakia + 13
Path 2
Term Annotations click to browse term
  disease 18969
    Pathological Conditions, Signs and Symptoms 13343
      Signs and Symptoms 10819
        Neurologic Manifestations 10053
          sensory system disease 6962
            mouth disease 1019
              Mouth Neoplasms 269
                Gingival Neoplasms 0
                Lip Neoplasms + 3
                Palatal Neoplasms + 0
                Salivary Gland Neoplasms + 58
                Tongue Neoplasms + 86
                oral cavity cancer + 145
                oral mucosa leukoplakia + 13
paths to the root