RGD Reference Report - Significance of P16INK4A Expression and PTEN Loss of Heterozygosity in Human Papilloma Virus-related Oral Squamous Cell Carcinoma. - Rat Genome Database

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Significance of P16INK4A Expression and PTEN Loss of Heterozygosity in Human Papilloma Virus-related Oral Squamous Cell Carcinoma.

Authors: DE Jesus Oliveira Kato, Valdenira  DE Abreu, Michelle Carvalho  DE Brito Kato, Alberto Mitsuyuki  DE Souza, Lucas Lacerda  Pontes, Flavia Sirotheau Correa  DE Castro Sant'anna, Carla  GonÇalves, Arnaldo  Pontes, HÉlder AntÔnio Rebelo  Khayat, Andre Salim  Burbano, Rommel Mario Rodriguez 
Citation: DE Jesus Oliveira Kato V, etal., Anticancer Res. 2020 Nov;40(11):6355-6366. doi: 10.21873/anticanres.14656.
RGD ID: 127285606
Pubmed: PMID:33109573   (View Abstract at PubMed)
DOI: DOI:10.21873/anticanres.14656   (Journal Full-text)


BACKGROUND/AIM: p16 and PTEN are tumor suppressor genes. Loss of these molecules in oral squamous cell carcinoma (OSCC) has been studied worldwide. In this study, we explored whether p16 cooperates with inactive PTEN during the pathogenesis of OSCC, especially in regard to tumor aggressiveness and proliferation.
MATERIALS AND METHODS: Immunocytochemistry and western blot analysis were used to examine the levels of p16 and PTEN. Sequencing analysis was performed to identify mutations in the PTEN gene and HPV infection. Fluorescence in situ hybridization was used to examine the presence of the PTEN locus.
RESULTS: PTEN analysis showed high positivity in T4 samples. HPV-positive tumors correlated with tabagism, tumor size 3 and 4, disease stages 3 and 4, presence of lymph node metastasis (N1) and poor differentiation. Immunoexpression of p16 was strongly correlated with the presence of HPV.
CONCLUSION: PTEN demonstrated a higher reactivity in advanced disease stages and p16 was strongly associated with HPV. Viral presence decreases tumor aggressiveness. Patients with advanced stage lesions demonstrated lower survival rate.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
oral squamous cell carcinoma disease_progressionIEP 127285606protein:increased expression:oral epithelium (human)RGD 
oral squamous cell carcinoma disease_progressionISOPTEN (Homo sapiens)127285606; 127285606protein:increased expression:oral epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pten  (phosphatase and tensin homolog)

Genes (Mus musculus)
Pten  (phosphatase and tensin homolog)

Genes (Homo sapiens)
PTEN  (phosphatase and tensin homolog)


Additional Information