RGD Reference Report - Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma. - Rat Genome Database

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Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma.

Authors: Guo, XH  Wang, JY  Gao, Y  Gao, M  Yu, GY  Xiang, RL  Li, L  Yang, NY  Cong, X  Xu, XY  Li, SL  Peng, X  Wu, LL 
Citation: Guo XH, etal., Cancer Sci. 2013 Feb;104(2):206-13. doi: 10.1111/cas.12077. Epub 2013 Jan 20.
RGD ID: 8694469
Pubmed: PMID:23181352   (View Abstract at PubMed)
PMCID: PMC7657126   (View Article at PubMed Central)
DOI: DOI:10.1111/cas.12077   (Journal Full-text)

Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (n = 37) and western blot (n = 30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 +/- 2.4 vs 8.4 +/- 3.5 mug/mL, P < 0.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor-node-metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the TSCC patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of SCC15 cells in vitro. These results indicate that a decreased adiponectin level is associated with risk of TSCC. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of TSCC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOQHumantongue squamous cell carcinoma disease_progressionIEP protein:decreased expression:serumRGD 
AdipoqRattongue squamous cell carcinoma disease_progressionISOADIPOQ (Homo sapiens)protein:decreased expression:serumRGD 
AdipoqMousetongue squamous cell carcinoma disease_progressionISOADIPOQ (Homo sapiens)protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information