En1 (engrailed homeobox 1) - Rat Genome Database

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Gene: En1 (engrailed homeobox 1) Rattus norvegicus
Analyze
Symbol: En1
Name: engrailed homeobox 1
RGD ID: 1595088
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cocaine. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH bisphenol A; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: engrailed 1; homeobox protein engrailed-1; LOC685360; similar to Homeobox protein engrailed-1 (Mo-En-1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease. Haubenberger D, etal., Neurobiol Aging. 2011 Feb;32(2):302-7. Epub 2009 Apr 3.
3. Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties. Joliot A, etal., Development. 1997 May;124(10):1865-75.
4. Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. Leo D, etal., Exp Neurol. 2007 Feb;203(2):472-80. Epub 2006 Oct 27.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice. Sgado P, etal., Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15242-7. Epub 2006 Oct 2.
Additional References at PubMed
PMID:7624797   PMID:8684466   PMID:8848044   PMID:9102311   PMID:9362463   PMID:11312297   PMID:15175251   PMID:15242796   PMID:15340832   PMID:15607945   PMID:17267560   PMID:20042388  
PMID:21672318   PMID:23863478   PMID:24399192  


Genomics

Comparative Map Data
En1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81334,303,684 - 34,309,269 (+)NCBIGRCr8
mRatBN7.21331,750,892 - 31,756,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1334,309,142 - 34,314,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01335,596,963 - 35,602,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01332,871,391 - 32,876,977 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
EN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,842,171 - 118,847,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,842,171 - 118,847,648 (-)EnsemblGRCh38hg38GRCh38
GRCh372119,599,747 - 119,605,224 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362119,316,217 - 119,322,229 (-)NCBINCBI36Build 36hg18NCBI36
Build 342119,315,995 - 119,321,989NCBI
Celera2112,924,401 - 112,930,414 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2111,924,919 - 111,930,585 (-)NCBIHuRef
CHM1_12119,603,429 - 119,609,441 (-)NCBICHM1_1
T2T-CHM13v2.02119,275,530 - 119,281,008 (-)NCBIT2T-CHM13v2.0
En1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,530,246 - 120,535,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,530,147 - 120,535,721 (+)EnsemblGRCm39 Ensembl
GRCm381120,602,487 - 120,607,991 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,602,418 - 120,607,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,499,064 - 122,504,568 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,430,227 - 122,435,517 (+)NCBIMGSCv36mm8
Celera1123,260,515 - 123,266,033 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.74NCBI
En1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545910,839,581 - 10,844,198 (+)NCBIChiLan1.0ChiLan1.0
EN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,867,576 - 20,875,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,882,547 - 20,888,391 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,798,557 - 5,804,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,124,325 - 31,129,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1931,388,610 - 31,392,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01932,511,803 - 32,516,772 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1932,511,803 - 32,516,949 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,195,351 - 31,200,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01931,362,291 - 31,366,665 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01932,548,697 - 32,553,632 (+)NCBIUU_Cfam_GSD_1.0
En1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530390,166,409 - 90,170,431 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646951,439,944 - 51,451,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1524,402,370 - 24,407,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11524,402,605 - 24,408,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21528,041,846 - 28,047,020 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216935
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11011,470,295 - 11,558,688 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1011,475,221 - 11,479,475 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606111,121,703 - 11,124,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
En1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473226,333,653 - 26,337,904 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473226,333,642 - 26,338,450 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in En1
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:82
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000074125
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat

Markers in Region
RH104030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,756,240 - 31,756,393 (+)MAPPERmRatBN7.2
Rnor_6.01336,537,655 - 36,537,807NCBIRnor6.0
Rnor_5.01341,638,663 - 41,638,815UniSTSRnor5.0
Celera1331,628,830 - 31,628,982UniSTS
PMC314463P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,755,369 - 31,756,174 (+)MAPPERmRatBN7.2
Rnor_6.01336,536,784 - 36,537,588NCBIRnor6.0
Rnor_5.01341,637,792 - 41,638,596UniSTSRnor5.0
Celera1331,627,959 - 31,628,763UniSTS
AU047989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,750,275 - 31,750,426 (+)MAPPERmRatBN7.2
Rnor_6.01336,531,487 - 36,531,639NCBIRnor6.0
Rnor_5.01341,632,776 - 41,632,928UniSTSRnor5.0
Celera1331,622,875 - 31,623,027UniSTS
En1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21331,755,823 - 31,756,407 (+)MAPPERmRatBN7.2
Rnor_6.01336,537,238 - 36,537,821NCBIRnor6.0
Rnor_5.01341,638,246 - 41,638,829UniSTSRnor5.0
Celera1331,628,413 - 31,628,996UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 5
Low 7 10 35 21 7
Below cutoff 1 19 8 8 8 1 1 16 4 10 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000083007   ⟹   ENSRNOP00000068605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1331,751,545 - 31,755,943 (+)Ensembl
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)Ensembl
RefSeq Acc Id: NM_001398705   ⟹   NP_001385634
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81334,303,684 - 34,309,269 (+)NCBI
mRatBN7.21331,750,892 - 31,756,477 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385634 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068605.2
RefSeq Acc Id: ENSRNOP00000068605   ⟸   ENSRNOT00000083007
RefSeq Acc Id: NP_001385634   ⟸   NM_001398705
- UniProtKB: A0A0G2JT82 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JT82-F1-model_v2 AlphaFold A0A0G2JT82 1-399 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595088 AgrOrtholog
BioCyc Gene G2FUF-18503 BioCyc
Ensembl Genes ENSRNOG00000056580 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083007.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-engrailed_C-terminal UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_engrailed UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homoebox-engrailed_CS UniProtKB/TrEMBL
NCBI Gene 685360 ENTREZGENE
PANTHER HOMEOBOX PROTEIN ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN ENGRAILED-1 UniProtKB/TrEMBL
Pfam Engrail_1_C_sig UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
PhenoGen En1 PhenoGen
PRINTS ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX UniProtKB/TrEMBL
PROSITE ENGRAILED UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056580 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  SSF46689 UniProtKB/TrEMBL
UniProt A0A0G2JT82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 En1  engrailed homeobox 1  LOC679094  similar to Homeobox protein engrailed-1 (Mo-En-1)  Data merged from RGD:1593033 1643240 APPROVED
2008-10-28 En1  engrailed homeobox 1  En1  engrailed 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 En1  engrailed 1  LOC685360  similar to Homeobox protein engrailed-1 (Mo-En-1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685360  similar to Homeobox protein engrailed-1 (Mo-En-1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC679094  similar to Homeobox protein engrailed-1 (Mo-En-1)      Symbol and Name status set to provisional 70820 PROVISIONAL