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Gene: En1 (engrailed homeobox 1) Rattus norvegicus
Symbol: En1
Name: engrailed homeobox 1
RGD ID: 1595088
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cocaine. Localizes to membrane and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH bisphenol A; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: engrailed 1; homeobox protein engrailed-1; LOC685360; LOW QUALITY PROTEIN: homeobox protein engrailed-1; similar to Homeobox protein engrailed-1 (Mo-En-1)
Homo sapiens (human) : EN1 (engrailed homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : En1 (engrailed 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En1 (engrailed homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EN1 (engrailed homeobox 1)
Canis lupus familiaris (dog) : EN1 (engrailed homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En1 (engrailed homeobox 1)
Sus scrofa (pig) : EN1 (engrailed homeobox 1)
Chlorocebus sabaeus (African green monkey) : EN1 (engrailed homeobox 1)
Heterocephalus glaber (naked mole-rat) : En1 (engrailed homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1336,532,758 - 36,537,093 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on En1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1595088
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.