Mcph1 (microcephalin 1) - Rat Genome Database

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Gene: Mcph1 (microcephalin 1) Rattus norvegicus
Analyze
Symbol: Mcph1
Name: microcephalin 1
RGD ID: 1560642
Description: Predicted to enable identical protein binding activity. Predicted to be involved in mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including establishment of mitotic spindle orientation; neuronal stem cell population maintenance; and protein localization to centrosome. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Orthologous to human MCPH1 (microcephalin 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306594; microcephalin; microcephaly, primary autosomal recessive 1; RGD1560642; similar to microcephalin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,724,251 - 77,926,773 (-)NCBIGRCr8
mRatBN7.21671,021,855 - 71,224,067 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,024,588 - 71,224,122 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01675,904,087 - 76,110,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,904,006 - 76,110,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,508,903 - 75,716,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,839,877 - 76,026,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,871,372 - 69,069,330 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoskeleton  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression. Alsiary R, etal., PLoS One. 2014 May 15;9(5):e97059. doi: 10.1371/journal.pone.0097059. eCollection 2014.
2. Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer. Bilbao C, etal., Eur J Cancer. 2010 Oct;46(15):2821-7. doi: 10.1016/j.ejca.2010.06.116. Epub 2010 Jul 16.
3. A clinical and molecular genetic study of 112 Iranian families with primary microcephaly. Darvish H, etal., J Med Genet. 2010 Dec;47(12):823-8. doi: 10.1136/jmg.2009.076398. Epub 2010 Oct 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Identification of microcephalin, a protein implicated in determining the size of the human brain. Jackson AP, etal., Am J Hum Genet. 2002 Jul;71(1):136-42. Epub 2002 Jun 3.
6. MCPH1 protein expression and polymorphisms are associated with risk of breast cancer. Jo YH, etal., Gene. 2013 Apr 1;517(2):184-90. doi: 10.1016/j.gene.2012.12.088. Epub 2013 Jan 4.
7. The c.940G variant of the Microcephalin (MCPH1) gene is not associated with microcephaly or mental retardation. Maghirang-Rodriguez R, etal., Am J Med Genet A. 2009 Feb 15;149A(4):622-5. doi: 10.1002/ajmg.a.32721.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
10. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Rai R, etal., Cancer Cell. 2006 Aug;10(2):145-57. Epub 2006 Jul 27.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation. Richardson J, etal., Breast Cancer Res Treat. 2011 Jun;127(3):639-48. doi: 10.1007/s10549-010-1019-4. Epub 2010 Jul 15.
16. Genetic heterogeneity in Pakistani microcephaly families. Sajid Hussain M, etal., Clin Genet. 2013 May;83(5):446-51. doi: 10.1111/j.1399-0004.2012.01932.x. Epub 2012 Aug 7.
17. Mutations in microcephalin cause aberrant regulation of chromosome condensation. Trimborn M, etal., Am J Hum Genet. 2004 Aug;75(2):261-6. Epub 2004 Jun 15.
18. Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma. Venkatesh T, etal., PLoS One. 2013;8(3):e54643. doi: 10.1371/journal.pone.0054643. Epub 2013 Mar 5.
19. Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a. Wang N, etal., Int J Clin Exp Pathol. 2014 Jul 15;7(8):4895-903. eCollection 2014.
20. DNA damage response in microcephaly development of MCPH1 mouse model. Zhou ZW, etal., DNA Repair (Amst). 2013 Aug;12(8):645-55. doi: 10.1016/j.dnarep.2013.04.017. Epub 2013 May 15.
Additional References at PubMed
PMID:12837246   PMID:18660752   PMID:20169082   PMID:21737879   PMID:21947081   PMID:23516444   PMID:24633962  


Genomics

Comparative Map Data
Mcph1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,724,251 - 77,926,773 (-)NCBIGRCr8
mRatBN7.21671,021,855 - 71,224,067 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1671,024,588 - 71,224,122 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01675,904,087 - 76,110,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,904,006 - 76,110,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,508,903 - 75,716,058 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,839,877 - 76,026,968 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,871,372 - 69,069,330 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
MCPH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3886,406,627 - 6,648,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl86,406,592 - 6,648,508 (+)EnsemblGRCh38hg38GRCh38
GRCh3786,264,148 - 6,506,029 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3686,251,529 - 6,493,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 3486,276,479 - 6,489,214NCBI
Celera86,241,660 - 6,478,643 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef86,046,225 - 6,282,052 (+)NCBIHuRef
CHM1_186,352,911 - 6,590,285 (+)NCBICHM1_1
T2T-CHM13v2.086,161,207 - 6,402,976 (+)NCBIT2T-CHM13v2.0
Mcph1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39818,645,132 - 18,858,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl818,645,147 - 18,853,205 (+)EnsemblGRCm39 Ensembl
GRCm38818,595,116 - 18,808,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl818,595,131 - 18,803,189 (+)EnsemblGRCm38mm10GRCm38
MGSCv37818,595,173 - 18,803,189 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36818,595,150 - 18,803,166 (+)NCBIMGSCv36mm8
Celera818,728,614 - 18,936,696 (+)NCBICelera
Cytogenetic Map8A1.3NCBI
cM Map810.24NCBI
Mcph1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540354,143,454 - 54,273,201 (-)NCBIChiLan1.0ChiLan1.0
MCPH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2721,203,748 - 21,473,839 (+)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v08624,877 - 877,839 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.186,409,072 - 6,651,846 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl86,409,072 - 6,646,394 (+)Ensemblpanpan1.1panPan2
MCPH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11658,306,761 - 58,529,090 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1658,295,280 - 58,529,433 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1653,827,270 - 54,059,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01657,520,814 - 57,753,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1657,520,814 - 57,753,412 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11658,441,000 - 58,688,068 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01655,530,366 - 55,762,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01655,905,580 - 56,138,767 (-)NCBIUU_Cfam_GSD_1.0
Mcph1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049434,386,615 - 4,580,738 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366154,386,635 - 4,580,747 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366154,386,667 - 4,580,720 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCPH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1537,455,551 - 37,673,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11537,455,186 - 37,674,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21542,711,671 - 42,747,818 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCPH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.186,190,272 - 6,425,683 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl86,190,047 - 6,425,131 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605448,304,204 - 48,541,439 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcph1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248614,373,743 - 4,556,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcph1
1386 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:74
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000043384
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
D16Rat16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,225,672 - 71,225,844 (+)MAPPERmRatBN7.2
Rnor_6.01676,111,887 - 76,112,058NCBIRnor6.0
Rnor_5.01675,717,429 - 75,717,600UniSTSRnor5.0
RGSC_v3.41676,030,795 - 76,030,967RGDRGSC3.4
RGSC_v3.41676,030,796 - 76,030,967UniSTSRGSC3.4
RGSC_v3.11676,031,061 - 76,031,232RGD
Celera1669,070,598 - 69,070,753UniSTS
RH 3.4 Map16697.1RGD
RH 3.4 Map16697.1UniSTS
RH 2.0 Map16805.2RGD
FHH x ACI Map1640.2499RGD
Cytogenetic Map16q12.5UniSTS
BF399189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,141,121 - 71,141,252 (+)MAPPERmRatBN7.2
Rnor_6.01676,018,464 - 76,018,594NCBIRnor6.0
Rnor_5.01675,624,285 - 75,624,415UniSTSRnor5.0
RGSC_v3.41675,944,572 - 75,944,702UniSTSRGSC3.4
Celera1668,986,631 - 68,986,761UniSTS
RH 3.4 Map16695.7UniSTS
Cytogenetic Map16q12.5UniSTS
AU048376  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01676,106,388 - 76,106,635NCBIRnor6.0
Rnor_5.01675,711,930 - 75,712,177UniSTSRnor5.0
RGSC_v3.41676,023,455 - 76,023,702UniSTSRGSC3.4
Cytogenetic Map16q12.5UniSTS
RH129137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,138,572 - 71,138,771 (+)MAPPERmRatBN7.2
Rnor_6.01676,015,918 - 76,016,113NCBIRnor6.0
Rnor_5.01675,621,739 - 75,621,934UniSTSRnor5.0
RGSC_v3.41675,942,023 - 75,942,221UniSTSRGSC3.4
Celera1668,984,082 - 68,984,280UniSTS
RH 3.4 Map16694.1UniSTS
Cytogenetic Map16q12.5UniSTS
RH129360  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,138,553 - 71,138,738 (+)MAPPERmRatBN7.2
Rnor_6.01676,015,899 - 76,016,080NCBIRnor6.0
Rnor_5.01675,621,720 - 75,621,901UniSTSRnor5.0
RGSC_v3.41675,942,004 - 75,942,188UniSTSRGSC3.4
Celera1668,984,063 - 68,984,247UniSTS
RH 3.4 Map16697.0UniSTS
Cytogenetic Map16q12.5UniSTS
RH142622  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,223,997 - 71,224,188 (+)MAPPERmRatBN7.2
Rnor_6.01676,110,212 - 76,110,402NCBIRnor6.0
Rnor_5.01675,715,754 - 75,715,944UniSTSRnor5.0
RGSC_v3.41676,027,279 - 76,027,469UniSTSRGSC3.4
Celera1669,068,919 - 69,069,109UniSTS
RH 3.4 Map16693.0UniSTS
Cytogenetic Map16q12.5UniSTS
BF405139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21671,078,310 - 71,078,560 (+)MAPPERmRatBN7.2
Rnor_6.01675,956,427 - 75,956,676NCBIRnor6.0
Rnor_5.01675,562,248 - 75,562,497UniSTSRnor5.0
RGSC_v3.41675,881,704 - 75,881,953UniSTSRGSC3.4
Celera1668,923,800 - 68,924,049UniSTS
RH 3.4 Map16702.6UniSTS
Cytogenetic Map16q12.5UniSTS
RH141778  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81677,792,105 - 77,792,290 (+)Marker Load Pipeline
mRatBN7.21671,089,708 - 71,089,894 (+)MAPPERmRatBN7.2
Rnor_6.01675,967,825 - 75,968,010NCBIRnor6.0
Rnor_5.01675,573,646 - 75,573,831UniSTSRnor5.0
RGSC_v3.41675,893,102 - 75,893,287UniSTSRGSC3.4
Celera1668,935,192 - 68,935,377UniSTS
RH 3.4 Map16704.71UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000043384   ⟹   ENSRNOP00000046380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1671,024,588 - 71,224,122 (-)Ensembl
Rnor_6.0 Ensembl1675,904,006 - 76,110,553 (-)Ensembl
RefSeq Acc Id: NM_001427088   ⟹   NP_001414017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,724,251 - 77,926,462 (-)NCBI
RefSeq Acc Id: XM_006253383   ⟹   XP_006253445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,724,251 - 77,926,773 (-)NCBI
mRatBN7.21671,021,855 - 71,224,067 (-)NCBI
Rnor_6.01675,904,087 - 76,110,624 (-)NCBI
Rnor_5.01675,508,903 - 75,716,058 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253385   ⟹   XP_006253447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,724,251 - 77,926,003 (-)NCBI
mRatBN7.21671,021,855 - 71,223,581 (-)NCBI
Rnor_6.01675,904,087 - 76,109,604 (-)NCBI
Rnor_5.01675,508,903 - 75,716,058 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063275460   ⟹   XP_063131530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,724,251 - 77,926,004 (-)NCBI
RefSeq Acc Id: XP_006253445   ⟸   XM_006253383
- Peptide Label: isoform X1
- UniProtKB: D3ZJM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253447   ⟸   XM_006253385
- Peptide Label: isoform X2
- UniProtKB: D3ZJM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046380   ⟸   ENSRNOT00000043384
RefSeq Acc Id: NP_001414017   ⟸   NM_001427088
- UniProtKB: D3ZJM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131530   ⟸   XM_063275460
- Peptide Label: isoform X3
- UniProtKB: D3ZJM7 (UniProtKB/TrEMBL)
Protein Domains
BRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJM7-F1-model_v2 AlphaFold D3ZJM7 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560642 AgrOrtholog
BioCyc Gene G2FUF-10805 BioCyc
Ensembl Genes ENSRNOG00000028586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043384 ENTREZGENE
  ENSRNOT00000043384.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCT UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  Microcephalin UniProtKB/TrEMBL
  Microcephalin_mammal UniProtKB/TrEMBL
NCBI Gene 306594 ENTREZGENE
PANTHER MICROCEPHALIN UniProtKB/TrEMBL
  PTHR14625 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  BRCT_2 UniProtKB/TrEMBL
  Microcephalin UniProtKB/TrEMBL
  PTCB-BRCT UniProtKB/TrEMBL
PhenoGen Mcph1 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028586 RatGTEx
SMART BRCT UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
UniProt D3ZJM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Mcph1  microcephalin 1  Mcph1  microcephaly, primary autosomal recessive 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Mcph1  microcephaly, primary autosomal recessive 1  RGD1560642_predicted  similar to microcephalin (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560642_predicted  similar to microcephalin (predicted)  LOC306594  similar to microcephalin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306594  similar to microcephalin      Symbol and Name status set to provisional 70820 PROVISIONAL