 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway Annotations
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References - curated| 1. | Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406. |
| 2. | Garnis C, etal., Int J Cancer. 2005 Sep 20;116(5):813-9. doi: 10.1002/ijc.21065. |
| 3. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 4. | GOA data from the GO Consortium |
| 5. | Lester LB, etal., J Biol Chem 1996 Apr 19;271(16):9460-5. |
| 6. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. | Okutsu R, etal., Kidney Int. 2008 Dec;74(11):1429-33. Epub 2008 Aug 13. |
| 8. | Radeva MY, etal., PLoS One. 2014 Sep 4;9(9):e106733. doi: 10.1371/journal.pone.0106733. eCollection 2014. |
| 9. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 10. | RGD automated import pipeline for gene-chemical interactions |
| 11. | Schillace RV and Scott JD, Curr Biol. 1999 Mar 25;9(6):321-4. |
| 12. | Tanji C, etal., J Biol Chem. 2002 Oct 4;277(40):36955-61. Epub 2002 Jul 29. |
| 13. | Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67. |
| 14. | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 15. | Yang L, etal., J Pharmacol Sci. 2008 Apr;106(4):578-84. Epub 2008 Apr 3. |
Genomics
Comparative Map Data| Akap11 (Rattus norvegicus - Norway rat) |
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| AKAP11 (Homo sapiens - human) |
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| Akap11 (Mus musculus - house mouse) |
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| Akap11 (Chinchilla lanigera - long-tailed chinchilla) |
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| AKAP11 (Pan paniscus - bonobo/pygmy chimpanzee) |
No map positions available. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AKAP11 (Canis lupus familiaris - dog) |
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| Akap11 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| AKAP11 (Sus scrofa - pig) |
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| AKAP11 (Chlorocebus sabaeus - African green monkey) |
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| Akap11 (Heterocephalus glaber - naked mole-rat) |
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Position Markers| D2Wox33 |
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| RH134720 |
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| RH138383 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 40 | 30 | 14 | 18 | 14 | 8 | 8 | 74 | 35 | 38 | 11 | 8 | |
| Low | 3 | 3 | 27 | 27 | 1 | 27 | 3 | 3 | |||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_012773 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006252344 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017599778 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017599779 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017599780 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XR_001841263 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR07018478 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07018479 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01084072 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01084073 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473951 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000013333 ⟹ ENSRNOP00000013333 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000058148 ⟹ ENSRNOP00000054952 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000079978 ⟹ ENSRNOP00000071064 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_012773 ⟹ NP_036905 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
ACAGTTATGGCGGCTTTCCAGCCTTTCAGAAATAGTCACACGAAGACTAAAGCATCTGTCCGAAhide sequence |
| RefSeq Acc Id: | XM_006252344 ⟹ XP_006252406 | ||||||||||||
| RefSeq Status: | |||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| Sequence: |
ACGGGGTTGTTCTCGCGAGAGGTGTGTTGTGGATTGACTCCGACAGTATCGCACACTGCAGTAAhide sequence |
| RefSeq Acc Id: | XM_017599778 ⟹ XP_017455267 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GTGTGTTGTGGATTGACTCCGACAGTATCGCACACTGCAGTAACACAGTTATGGCGGCTTTCCAhide sequence |
| RefSeq Acc Id: | XM_017599779 ⟹ XP_017455268 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GTGTGTTGTGGATTGACTCCGACAGTATCGCACACTGCAGTAACACAGTTATGGCGGCTTTCCAhide sequence |
| RefSeq Acc Id: | XM_017599780 ⟹ XP_017455269 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| Sequence: |
GTGTGTTGTGGATTGACTCCGACAGTATCGCACACTGCAGTAACACAGTTATGGCGGCTTTCCAhide sequence |
| RefSeq Acc Id: | XR_001841263 | ||||||||
| RefSeq Status: | |||||||||
| Type: | NON-CODING | ||||||||
| Position: |
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| Sequence: |
GTGTGTTGTGGATTGACTCCGACAGTATCGCACACTGCAGTAACACAGTTATGGCGGCTTTCCAhide sequence |
Protein Sequences| Protein RefSeqs | NP_036905 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006252406 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017455267 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017455268 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017455269 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | EDM02339 | (Get FASTA) | NCBI Sequence Viewer |
| Q62924 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_036905 ⟸ NM_012773 |
| - UniProtKB: | D3ZS99 (UniProtKB/TrEMBL) |
| - Sequence: |
MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVSGGECLNQDEHAQLTEITFLGhide sequence |
| RefSeq Acc Id: | XP_006252406 ⟸ XM_006252344 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | A0A0G2JZI9 (UniProtKB/TrEMBL) |
| - Sequence: |
MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVSGGECLNQDEHAQLTEITFLGhide sequence |
| RefSeq Acc Id: | XP_017455268 ⟸ XM_017599779 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVSGGECLNQDEHAQLTEITFLGhide sequence |
| RefSeq Acc Id: | XP_017455267 ⟸ XM_017599778 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVSGGECLNQDEHAQLTEITFLGhide sequence |
| RefSeq Acc Id: | XP_017455269 ⟸ XM_017599780 |
| - Peptide Label: | isoform X4 |
| - Sequence: |
MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVSGGECLNQDEHAQLTEITFLGhide sequence |
| RefSeq Acc Id: | ENSRNOP00000071064 ⟸ ENSRNOT00000079978 |
| RefSeq Acc Id: | ENSRNOP00000054952 ⟸ ENSRNOT00000058148 |
| RefSeq Acc Id: | ENSRNOP00000013333 ⟸ ENSRNOT00000013333 |
TranscriptomePromoters| RGD ID: | 13699844 | ||||||||
| Promoter ID: | EPDNEW_R10366 | ||||||||
| Type: | initiation region | ||||||||
| Name: | Akap11_1 | ||||||||
| Description: | A-kinase anchoring protein 11 | ||||||||
| SO ACC ID: | SO:0000170 | ||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
| Experiment Methods: | Single-end sequencing. | ||||||||
| Position: |
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Strain Variation
Strain Sequence Variants (Rnor 6.0)
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Damaging VariantsAssembly: Rnor_5.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 15 | 64410148 | 64410149 | T | A | snv | HTX/Kyo (KyushuU), F344/NSlc (KyushuU) |
| 15 | 64410149 | 64410150 | T | A | snv | HTX/Kyo (KyushuU), F344/NSlc (KyushuU) |
Assembly: Rnor_6.0
| Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
| 15 | 60740185 | 60740186 | T | A | snv | BBDP/Wor (RGD) |
| 15 | 60743897 | 60743898 | C | A | snv | SR/JrHsd (RGD) |
Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:2079 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000009987 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013333 | UniProtKB/TrEMBL |
| ENSRNOP00000054952 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOP00000071064 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000013333 | UniProtKB/TrEMBL |
| ENSRNOT00000058148 | ENTREZGENE, UniProtKB/TrEMBL | |
| ENSRNOT00000079978 | ENTREZGENE, UniProtKB/TrEMBL | |
| InterPro | SPHK1-interactor_AKAP_110 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:498549 | UniProtKB/TrEMBL |
| NCBI Gene | 498549 | ENTREZGENE |
| PANTHER | PTHR10226 | UniProtKB/Swiss-Prot |
| PhenoGen | Akap11 | PhenoGen |
| TIGR | TC231481 | |
| UniGene | Rn.219324 | ENTREZGENE |
| UniProt | A0A0G2JZI9 | ENTREZGENE, UniProtKB/TrEMBL |
| AKA11_RAT | UniProtKB/Swiss-Prot | |
| D3ZS99 | ENTREZGENE, UniProtKB/TrEMBL | |
| F1LR81_RAT | UniProtKB/TrEMBL | |
| Q62924 | ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2015-11-25 | Akap11 | A-kinase anchoring protein 11 | Akap11 | A kinase (PRKA) anchor protein 11 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2003-04-09 | Akap11 | A kinase (PRKA) anchor protein 11 | Akap | A-kinase anchoring protein | Symbol and Name updated | 629477 | APPROVED |
| 2002-06-10 | Akap | A-kinase anchoring protein | Symbol and Name status set to approved | 70586 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localized to peroxisome microbodies | 632175 |
| gene_domains | contains a protein kinase A binding doimain | 632175 |
| gene_domains | contains a peroxisome targeting motif | 632175 |
| gene_expression | expressed in brain and testis | 632175 |
| gene_function | binds type II cyclic AMP-dependent kinase (PKA) | 632175 |
| gene_process | may play a role in directing PKA involvement in metabolism in peroxisomes | 632175 |
| gene_protein | 220 kDa protein | 632175 |
| gene_transcript | mRNA transcripts of 9.7 and 7.3 kb are detected | 632175 |
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| More on Akap11 | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 2079 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2020-03-04 |
| Status: | ACTIVE |
