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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:736276 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:736276 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | A-kinase anchoring proteins: from protein complexes to physiology and disease. | Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406. |
2. | Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis. | Garnis C, etal., Int J Cancer. 2005 Sep 20;116(5):813-9. doi: 10.1002/ijc.21065. |
3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. | Lester LB, etal., J Biol Chem 1996 Apr 19;271(16):9460-5. |
6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
7. | AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. | Okutsu R, etal., Kidney Int. 2008 Dec;74(11):1429-33. Epub 2008 Aug 13. |
8. | PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. | Radeva MY, etal., PLoS One. 2014 Sep 4;9(9):e106733. doi: 10.1371/journal.pone.0106733. eCollection 2014. |
9. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
11. | Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. | Schillace RV and Scott JD, Curr Biol. 1999 Mar 25;9(6):321-4. |
12. | A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. | Tanji C, etal., J Biol Chem. 2002 Oct 4;277(40):36955-61. Epub 2002 Jul 29. |
13. | Localized effects of cAMP mediated by distinct routes of protein kinase A. | Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67. |
14. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
15. | GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. | Yang L, etal., J Pharmacol Sci. 2008 Apr;106(4):578-84. Epub 2008 Apr 3. |
Akap11 (Rattus norvegicus - Norway rat) |
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AKAP11 (Homo sapiens - human) |
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Akap11 (Mus musculus - house mouse) |
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Akap11 (Chinchilla lanigera - long-tailed chinchilla) |
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AKAP11 (Pan paniscus - bonobo/pygmy chimpanzee) |
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AKAP11 (Canis lupus familiaris - dog) |
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Akap11 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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AKAP11 (Sus scrofa - pig) |
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AKAP11 (Chlorocebus sabaeus - green monkey) |
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Akap11 (Heterocephalus glaber - naked mole-rat) |
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Variants in Akap11
187 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
D2Wox33 |
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RH134720 |
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RH138383 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 40 | 30 | 14 | 18 | 14 | 8 | 8 | 74 | 35 | 38 | 11 | 8 | |
Low | 3 | 3 | 27 | 27 | 1 | 27 | 3 | 3 | |||||
Below cutoff |
RefSeq Transcripts | NM_001394793 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006252344 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017599779 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017599780 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039093595 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039093596 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XR_001841263 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | CH473951 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
JACYVU010000272 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000013333 ⟹ ENSRNOP00000013333 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000058148 ⟹ ENSRNOP00000054952 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000079978 ⟹ ENSRNOP00000071064 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000099037 ⟹ ENSRNOP00000096795 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001394793 ⟹ NP_001381722 | ||||||||
RefSeq Status: | VALIDATED | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_017599779 ⟹ XP_017455268 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017599780 ⟹ XP_017455269 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039093595 ⟹ XP_038949523 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_039093596 ⟹ XP_038949524 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001381722 | (Get FASTA) | NCBI Sequence Viewer |
XP_017455268 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017455269 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038949523 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038949524 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDM02339 | (Get FASTA) | NCBI Sequence Viewer |
Q62924 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | XP_017455268 ⟸ XM_017599779 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A0G2JZI9 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_017455269 ⟸ XM_017599780 |
- Peptide Label: | isoform X5 |
- UniProtKB: | A0A8I6GLR8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000071064 ⟸ ENSRNOT00000079978 |
RefSeq Acc Id: | ENSRNOP00000054952 ⟸ ENSRNOT00000058148 |
RefSeq Acc Id: | ENSRNOP00000013333 ⟸ ENSRNOT00000013333 |
RefSeq Acc Id: | XP_038949523 ⟸ XM_039093595 |
- Peptide Label: | isoform X3 |
- UniProtKB: | A6HTX6 (UniProtKB/TrEMBL), D3ZS99 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038949524 ⟸ XM_039093596 |
- Peptide Label: | isoform X4 |
- UniProtKB: | A0A8I6GLR8 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000096795 ⟸ ENSRNOT00000099037 |
RefSeq Acc Id: | NP_001381722 ⟸ NM_001394793 |
- UniProtKB: | A6HTX6 (UniProtKB/TrEMBL), D3ZS99 (UniProtKB/TrEMBL) |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q62924-F1-model_v2 | AlphaFold | Q62924 | 1-1129 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:2079 | AgrOrtholog |
BioCyc Gene | G2FUF-13014 | BioCyc |
Ensembl Genes | ENSRNOG00000009987 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000013333.6 | UniProtKB/TrEMBL |
ENSRNOP00000054952 | ENTREZGENE | |
ENSRNOP00000054952.3 | UniProtKB/TrEMBL | |
ENSRNOP00000071064.2 | UniProtKB/TrEMBL | |
ENSRNOP00000096795 | ENTREZGENE | |
ENSRNOP00000096795.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000013333.6 | UniProtKB/TrEMBL |
ENSRNOT00000058148 | ENTREZGENE | |
ENSRNOT00000058148.6 | UniProtKB/TrEMBL | |
ENSRNOT00000079978.2 | UniProtKB/TrEMBL | |
ENSRNOT00000099037 | ENTREZGENE | |
ENSRNOT00000099037.1 | UniProtKB/TrEMBL | |
InterPro | SPHK1-interactor_AKAP_110 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
KEGG Report | rno:498549 | UniProtKB/TrEMBL |
NCBI Gene | 498549 | ENTREZGENE |
PANTHER | A-KINASE ANCHOR PROTEIN 11 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR10226 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Akap11 | PhenoGen |
TIGR | TC231481 | |
UniProt | A0A0G2JZI9 | ENTREZGENE, UniProtKB/TrEMBL |
A0A8I6GLR8 | ENTREZGENE, UniProtKB/TrEMBL | |
A6HTX6 | ENTREZGENE, UniProtKB/TrEMBL | |
AKA11_RAT | UniProtKB/Swiss-Prot | |
D3ZS99 | ENTREZGENE, UniProtKB/TrEMBL | |
F1LR81_RAT | UniProtKB/TrEMBL | |
Q62924 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2015-11-25 | Akap11 | A-kinase anchoring protein 11 | Akap11 | A kinase (PRKA) anchor protein 11 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2003-04-09 | Akap11 | A kinase (PRKA) anchor protein 11 | Akap | A-kinase anchoring protein | Symbol and Name updated | 629477 | APPROVED |
2002-06-10 | Akap | A-kinase anchoring protein | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
---|---|---|
gene_cellular_localization | localized to peroxisome microbodies | 632175 |
gene_domains | contains a protein kinase A binding doimain | 632175 |
gene_domains | contains a peroxisome targeting motif | 632175 |
gene_expression | expressed in brain and testis | 632175 |
gene_function | binds type II cyclic AMP-dependent kinase (PKA) | 632175 |
gene_process | may play a role in directing PKA involvement in metabolism in peroxisomes | 632175 |
gene_protein | 220 kDa protein | 632175 |
gene_transcript | mRNA transcripts of 9.7 and 7.3 kb are detected | 632175 |