Akap11 (A-kinase anchoring protein 11) - Rat Genome Database

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Gene: Akap11 (A-kinase anchoring protein 11) Rattus norvegicus
Analyze
Symbol: Akap11
Name: A-kinase anchoring protein 11
RGD ID: 2079
Description: Enables kinase regulator activity; protein kinase A binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of establishment of endothelial barrier and positive regulation of protein phosphorylation. Located in peroxisome. Part of protein-containing complex. Orthologous to human AKAP11 (A-kinase anchoring protein 11); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein 11; A-kinase anchor protein 11; A-kinase anchor protein 220 kDa; A-kinase anchoring protein; A-kinase anchoring protein 220 AKAP 220; A-kinase anchoring protein 220, AKAP 220; Akap; AKAP 220; AKAP-11; PRKA11; protein kinase A-anchoring protein 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81560,320,839 - 60,365,480 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1560,320,839 - 60,365,335 (-)EnsemblGRCr8
mRatBN7.21553,911,635 - 53,956,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1553,911,657 - 53,941,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1558,044,930 - 58,089,415 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01559,163,315 - 59,207,800 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01555,988,186 - 56,032,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01560,722,138 - 60,766,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1560,722,160 - 60,766,579 (-)Ensemblrn6Rnor6.0
Rnor_5.01564,390,111 - 64,434,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41559,649,461 - 59,679,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1553,502,729 - 53,532,469 (-)NCBICelera
RGSC_v3.11559,667,851 - 59,686,848 (-)NCBI
Cytogenetic Map15q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
nucleolus  (IEA,ISO)
peroxisome  (IDA,IEA)
plasma membrane  (IEA,ISO)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Alteration of AKAP220, an upstream component of the Rb pathway, in oral carcinogenesis. Garnis C, etal., Int J Cancer. 2005 Sep 20;116(5):813-9. doi: 10.1002/ijc.21065.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. Lester LB, etal., J Biol Chem 1996 Apr 19;271(16):9460-5.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Okutsu R, etal., Kidney Int. 2008 Dec;74(11):1429-33. Epub 2008 Aug 13.
8. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. Radeva MY, etal., PLoS One. 2014 Sep 4;9(9):e106733. doi: 10.1371/journal.pone.0106733. eCollection 2014.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Schillace RV and Scott JD, Curr Biol. 1999 Mar 25;9(6):321-4.
12. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta. Tanji C, etal., J Biol Chem. 2002 Oct 4;277(40):36955-61. Epub 2002 Jul 29.
13. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. GABAC-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. Yang L, etal., J Pharmacol Sci. 2008 Apr;106(4):578-84. Epub 2008 Apr 3.
Additional References at PubMed
PMID:21502359   PMID:27402760  


Genomics

Comparative Map Data
Akap11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81560,320,839 - 60,365,480 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1560,320,839 - 60,365,335 (-)EnsemblGRCr8
mRatBN7.21553,911,635 - 53,956,138 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1553,911,657 - 53,941,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1558,044,930 - 58,089,415 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01559,163,315 - 59,207,800 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01555,988,186 - 56,032,676 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01560,722,138 - 60,766,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1560,722,160 - 60,766,579 (-)Ensemblrn6Rnor6.0
Rnor_5.01564,390,111 - 64,434,755 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41559,649,461 - 59,679,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1553,502,729 - 53,532,469 (-)NCBICelera
RGSC_v3.11559,667,851 - 59,686,848 (-)NCBI
Cytogenetic Map15q11NCBI
AKAP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381342,271,477 - 42,323,261 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1342,272,152 - 42,323,261 (+)Ensemblhg38GRCh38
GRCh371342,846,288 - 42,897,397 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361341,744,289 - 41,795,402 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341341,744,288 - 41,782,992NCBI
Celera1323,903,720 - 23,954,839 (+)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1323,649,570 - 23,700,689 (+)NCBIHuRef
CHM1_11342,813,753 - 42,864,863 (+)NCBICHM1_1
T2T-CHM13v2.01341,491,099 - 41,543,005 (+)NCBIT2T-CHM13v2.0
Akap11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391478,729,686 - 78,774,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1478,729,686 - 78,774,248 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381478,492,246 - 78,536,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1478,492,246 - 78,536,808 (-)Ensemblmm10GRCm38
MGSCv371478,892,053 - 78,936,667 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361477,226,401 - 77,253,274 (-)NCBIMGSCv36mm8
Celera1476,008,096 - 76,052,775 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1441.46NCBI
Akap11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555184,032,448 - 4,083,697 (-)Ensembl
ChiLan1.0NW_0049555184,032,738 - 4,083,720 (-)NCBIChiLan1.0ChiLan1.0
AKAP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21441,765,525 - 41,820,436 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11332,869,144 - 32,924,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01323,453,478 - 23,505,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AKAP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1228,462,058 - 8,509,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl228,465,797 - 8,509,955 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha228,454,180 - 8,502,984 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0228,684,334 - 8,733,152 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,687,219 - 8,732,517 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,378,640 - 8,427,434 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,429,251 - 8,478,037 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0228,440,950 - 8,489,748 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akap11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945152,547,325 - 152,594,570 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367471,482,114 - 1,526,485 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367471,479,241 - 1,526,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1124,702,154 - 24,752,084 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11124,702,157 - 24,752,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21125,404,617 - 25,429,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1320,447,394 - 20,498,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl320,462,176 - 20,494,670 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605723,710,925 - 23,762,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474812,770,056 - 12,812,976 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474812,769,698 - 12,820,815 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap11
189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:658
Count of miRNA genes:288
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000013333, ENSRNOT00000058148
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)155284790873690657Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
D2Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8233,227,745 - 33,227,986 (+)Marker Load Pipeline
Cytogenetic Map15q11UniSTS
RH134720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21553,911,786 - 53,912,006 (+)MAPPERmRatBN7.2
Rnor_6.01560,722,290 - 60,722,509NCBIRnor6.0
Rnor_5.01564,390,263 - 64,390,482UniSTSRnor5.0
RGSC_v3.41559,649,591 - 59,649,810UniSTSRGSC3.4
Celera1553,502,859 - 53,503,078UniSTS
RH 3.4 Map15466.2UniSTS
Cytogenetic Map15q11UniSTS
RH138383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21553,914,346 - 53,914,527 (+)MAPPERmRatBN7.2
Rnor_6.01560,724,850 - 60,725,030NCBIRnor6.0
Rnor_5.01564,392,823 - 64,393,003UniSTSRnor5.0
RGSC_v3.41559,652,151 - 59,652,331UniSTSRGSC3.4
Celera1553,505,419 - 53,505,599UniSTS
RH 3.4 Map15468.7UniSTS
Cytogenetic Map15q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013333   ⟹   ENSRNOP00000013333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,326,522 - 60,341,972 (-)Ensembl
mRatBN7.2 Ensembl1553,917,318 - 53,932,768 (-)Ensembl
Rnor_6.0 Ensembl1560,725,707 - 60,743,064 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000058148   ⟹   ENSRNOP00000054952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,322,325 - 60,365,335 (-)Ensembl
mRatBN7.2 Ensembl1553,911,657 - 53,941,605 (-)Ensembl
Rnor_6.0 Ensembl1560,722,160 - 60,752,106 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079978   ⟹   ENSRNOP00000071064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,327,233 - 60,365,335 (-)Ensembl
mRatBN7.2 Ensembl1553,914,273 - 53,941,605 (-)Ensembl
Rnor_6.0 Ensembl1560,725,422 - 60,766,579 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099037   ⟹   ENSRNOP00000096795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,328,397 - 60,365,335 (-)Ensembl
mRatBN7.2 Ensembl1553,914,347 - 53,941,605 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138587   ⟹   ENSRNOP00000103320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,326,522 - 60,342,336 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144010   ⟹   ENSRNOP00000108234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,320,839 - 60,365,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150759   ⟹   ENSRNOP00000101853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,320,839 - 60,365,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169244   ⟹   ENSRNOP00000101392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,320,839 - 60,365,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171831   ⟹   ENSRNOP00000103392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1560,332,052 - 60,365,335 (-)Ensembl
RefSeq Acc Id: NM_001394793   ⟹   NP_001381722
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,365,335 (-)NCBI
mRatBN7.21553,911,635 - 53,956,129 (-)NCBI
RefSeq Acc Id: XM_017599779   ⟹   XP_017455268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,352,124 (-)NCBI
mRatBN7.21553,911,635 - 53,941,649 (-)NCBI
Rnor_6.01560,722,138 - 60,752,150 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599780   ⟹   XP_017455269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,336,759 - 60,352,124 (-)NCBI
mRatBN7.21553,927,557 - 53,941,649 (-)NCBI
Rnor_6.01560,738,108 - 60,752,150 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093595   ⟹   XP_038949523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,365,330 (-)NCBI
mRatBN7.21553,911,635 - 53,956,138 (-)NCBI
RefSeq Acc Id: XM_039093596   ⟹   XP_038949524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,332,004 - 60,352,124 (-)NCBI
mRatBN7.21553,922,802 - 53,941,649 (-)NCBI
RefSeq Acc Id: XM_063274562   ⟹   XP_063130632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,352,124 (-)NCBI
RefSeq Acc Id: XM_063274563   ⟹   XP_063130633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,352,124 (-)NCBI
RefSeq Acc Id: XM_063274564   ⟹   XP_063130634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,365,480 (-)NCBI
RefSeq Acc Id: XM_063274565   ⟹   XP_063130635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,320,839 - 60,365,365 (-)NCBI
RefSeq Acc Id: XM_063274566   ⟹   XP_063130636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81560,338,628 - 60,352,124 (-)NCBI
RefSeq Acc Id: XP_017455268   ⟸   XM_017599779
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JZI9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455269   ⟸   XM_017599780
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GLR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071064   ⟸   ENSRNOT00000079978
Ensembl Acc Id: ENSRNOP00000054952   ⟸   ENSRNOT00000058148
Ensembl Acc Id: ENSRNOP00000013333   ⟸   ENSRNOT00000013333
RefSeq Acc Id: XP_038949523   ⟸   XM_039093595
- Peptide Label: isoform X1
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949524   ⟸   XM_039093596
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GLR8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096795   ⟸   ENSRNOT00000099037
RefSeq Acc Id: NP_001381722   ⟸   NM_001394793
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130634   ⟸   XM_063274564
- Peptide Label: isoform X1
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130635   ⟸   XM_063274565
- Peptide Label: isoform X1
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130633   ⟸   XM_063274563
- Peptide Label: isoform X2
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130632   ⟸   XM_063274562
- Peptide Label: isoform X1
- UniProtKB: A6HTX6 (UniProtKB/TrEMBL),   D3ZS99 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130636   ⟸   XM_063274566
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GLR8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108234   ⟸   ENSRNOT00000144010
Ensembl Acc Id: ENSRNOP00000103392   ⟸   ENSRNOT00000171831
Ensembl Acc Id: ENSRNOP00000103320   ⟸   ENSRNOT00000138587
Ensembl Acc Id: ENSRNOP00000101392   ⟸   ENSRNOT00000169244
Ensembl Acc Id: ENSRNOP00000101853   ⟸   ENSRNOT00000150759

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62924-F1-model_v2 AlphaFold Q62924 1-1129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699844
Promoter ID:EPDNEW_R10366
Type:initiation region
Name:Akap11_1
Description:A-kinase anchoring protein 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01560,766,578 - 60,766,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2079 AgrOrtholog
BioCyc Gene G2FUF-13014 BioCyc
Ensembl Genes ENSRNOG00000009987 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000150759 ENTREZGENE
  ENSRNOT00000169244 ENTREZGENE
  ENSRNOT00000171831 ENTREZGENE
InterPro SPHK1-interactor_AKAP_110 UniProtKB/Swiss-Prot
NCBI Gene Akap11 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 11 UniProtKB/Swiss-Prot
  PTHR10226 UniProtKB/Swiss-Prot
PhenoGen Akap11 PhenoGen
RatGTEx ENSRNOG00000009987 RatGTEx
TIGR TC231481
UniProt A0A0G2JZI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLR8 ENTREZGENE, UniProtKB/TrEMBL
  A6HTX6 ENTREZGENE, UniProtKB/TrEMBL
  AKA11_RAT UniProtKB/Swiss-Prot
  D3ZS99 ENTREZGENE, UniProtKB/TrEMBL
  F1LR81_RAT UniProtKB/TrEMBL
  Q62924 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap11  A-kinase anchoring protein 11  Akap11  A kinase (PRKA) anchor protein 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Akap11  A kinase (PRKA) anchor protein 11  Akap  A-kinase anchoring protein  Symbol and Name updated 629477 APPROVED
2002-06-10 Akap  A-kinase anchoring protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to peroxisome microbodies 632175
gene_domains contains a protein kinase A binding doimain 632175
gene_domains contains a peroxisome targeting motif 632175
gene_expression expressed in brain and testis 632175
gene_function binds type II cyclic AMP-dependent kinase (PKA) 632175
gene_process may play a role in directing PKA involvement in metabolism in peroxisomes 632175
gene_protein 220 kDa protein 632175
gene_transcript mRNA transcripts of 9.7 and 7.3 kb are detected 632175