Dspp (dentin sialophosphoprotein) - Rat Genome Database
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Gene: Dspp (dentin sialophosphoprotein) Rattus norvegicus
Analyze
Symbol: Dspp
Name: dentin sialophosphoprotein
RGD ID: 2525
Description: Exhibits collagen binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and odontoblast differentiation. Localizes to several cellular components, including collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein); INTERACTS WITH ammonium chloride; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dentin sailophosphoprotein; Dentin sialoprotein; Dentine sialoprotein; Dsp; RDSP2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2145,565,562 - 5,571,669 (-)NCBI
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0146,926,972 - 6,933,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0146,914,385 - 6,920,492 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,674,662 - 6,680,769 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1146,674,663 - 6,680,769 (-)NCBI
Celera145,704,631 - 5,710,738 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
collagen binding  (IBA,IDA)
protein binding  (IPI,ISO)

References

References - curated
1. Alvares K, etal., J Biol Chem. 2013 May 3;288(18):13036-45. doi: 10.1074/jbc.M112.389627. Epub 2013 Mar 22.
2. Baba O, etal., Matrix Biol. 2004 Oct;23(6):371-9.
3. Dong J, etal., Am J Med Genet A. 2005 Jan 30;132A(3):305-9.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Ito K, etal., Int Endod J. 2015 Feb;48(2):115-23. doi: 10.1111/iej.12288. Epub 2014 May 12.
7. Jittapiromsak N, etal., Tissue Eng Part A. 2010 Jun;16(6):1997-2006. doi: 10.1089/ten.TEA.2009.0593.
8. Liu J, etal., J Pineal Res. 2013 Mar;54(2):170-8. doi: 10.1111/jpi.12002. Epub 2012 Sep 4.
9. Magne D, etal., Connect Tissue Res. 2004;45(2):101-8.
10. MGD data from the GO Consortium
11. Mitomi T, etal., Arch Oral Biol. 2014 Jan;59(1):47-59.
12. Moses KD, etal., Eur J Oral Sci. 2006 Jun;114(3):216-22.
13. Narayanan K, etal., J Biol Chem. 2004 Oct 29;279(44):45423-32. Epub 2004 Aug 12.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Oliva-Rodríguez R, etal., In Vitro Cell Dev Biol Anim. 2011 Dec;47(10):681-8. doi: 10.1007/s11626-011-9459-7. Epub 2011 Oct 20.
16. OMIM Disease Annotation Pipeline
17. Qin C, etal., J Biol Chem 2001 Jan 12;276(2):904-9.
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. RGD comprehensive gene curation
21. Ritchie HH and Li X, Eur J Oral Sci 2001 Oct;109(5):342-7.
22. Ritchie HH and Wang LH, J Biol Chem 1996 Sep 6;271(36):21695-8.
23. Ritchie HH, etal., Connect Tissue Res 2002;43(2-3):331-7.
24. Ritchie HH, etal., J Biol Chem 1994 Feb 4;269(5):3698-702.
25. Sun H, etal., Aust Endod J. 2010 Aug;36(2):54-8.
26. Sun Y, etal., Int J Oral Maxillofac Surg. 2010 Mar;39(3):272-81. doi: 10.1016/j.ijom.2009.12.017. Epub 2010 Jan 25.
27. Sun Y, etal., J Histochem Cytochem. 2010 Nov;58(11):1033-43. doi: 10.1369/jhc.2010.956771. Epub 2010 Aug 2.
28. Tang XN, etal., J Dermatol Sci. 2011 Nov;64(2):92-8. doi: 10.1016/j.jdermsci.2011.08.009. Epub 2011 Aug 27.
29. Thyagarajan T, etal., J Biol Chem 2001 Apr 6;276(14):11016-20. Epub 2000 Dec 14.
30. Wan Hassan WN, etal., J Dent. 2012 May;40(5):406-15. doi: 10.1016/j.jdent.2012.02.002. Epub 2012 Feb 8.
31. Xiao S, etal., Nat Genet. 2001 Feb;27(2):201-4.
32. Xie X, etal., Dent Traumatol. 2014 Aug;30(4):285-95. doi: 10.1111/edt.12093. Epub 2014 Feb 6.
33. Xu T, etal., J Mol Histol. 2014 Feb;45(1):11-9. doi: 10.1007/s10735-013-9533-4. Epub 2013 Aug 22.
34. Yokose S and Naka T, J Bone Miner Metab. 2010 Apr 28.
35. Zhu YQ, etal., Arch Oral Biol. 2017 May 31;82:33-37. doi: 10.1016/j.archoralbio.2017.04.031.
36. Zurick KM, etal., J Biomed Mater Res A. 2012 Sep;100(9):2492-8. doi: 10.1002/jbm.a.34159. Epub 2012 May 21.
Additional References at PubMed
PMID:9395101   PMID:10403786   PMID:10978503   PMID:11566357   PMID:11856645   PMID:15193538   PMID:16014627   PMID:16046405   PMID:16937369   PMID:17286598   PMID:17698853   PMID:19001636  
PMID:20387077   PMID:22798071   PMID:23161527   PMID:23611378   PMID:23900597   PMID:25027178   PMID:25138274   PMID:25583546   PMID:26972716  


Genomics

Comparative Map Data
Dspp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2145,565,562 - 5,571,669 (-)NCBI
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0146,926,972 - 6,933,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0146,914,385 - 6,920,492 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,674,662 - 6,680,769 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1146,674,663 - 6,680,769 (-)NCBI
Celera145,704,631 - 5,710,738 (-)NCBICelera
Cytogenetic Map14p22NCBI
DSPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl487,608,529 - 87,616,873 (+)EnsemblGRCh38hg38GRCh38
GRCh38487,608,529 - 87,616,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37488,529,681 - 88,538,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,748,705 - 88,757,049 (+)NCBINCBI36hg18NCBI36
Build 34488,886,859 - 88,895,204NCBI
Celera485,818,035 - 85,826,406 (+)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,275,661 - 84,283,858 (+)NCBIHuRef
CHM1_1488,506,445 - 88,514,787 (+)NCBICHM1_1
Dspp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,318,569 - 104,327,993 (+)NCBIGRCm39mm39
GRCm385104,170,703 - 104,180,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,170,712 - 104,180,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,599,731 - 104,609,146 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,411,005 - 104,420,429 (+)NCBImm8
Celera5101,476,457 - 101,494,758 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.59NCBI
Dspp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554742,254,842 - 2,259,303 (-)NCBIChiLan1.0ChiLan1.0
DSPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1490,630,300 - 90,635,681 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0479,903,923 - 79,909,836 (+)NCBIMhudiblu_PPA_v0panPan3
DSPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,017,440 - 11,022,780 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dspp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936905458,062 - 463,359 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,319,983 - 131,472,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,318,187 - 131,444,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,512,001 - 140,540,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235939
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,993,669 - 35,999,443 (+)NCBI
Dspp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248724,096,001 - 4,102,392 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14222782512680613Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14222782519230541Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14483323310729268Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14483323319909932Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14483323319909932Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14483323323004027Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14483323326466248Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14483323333040042Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000002943, ENSRNOT00000002946, ENSRNOT00000002947
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low
Below cutoff 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002943   ⟹   ENSRNOP00000002943
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000002946   ⟹   ENSRNOP00000002946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,928,502 - 6,933,070 (-)Ensembl
RefSeq Acc Id: NM_012790   ⟹   NP_036922
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2145,565,562 - 5,571,669 (-)NCBI
Rnor_6.0146,926,972 - 6,933,079 (-)NCBI
Rnor_5.0146,914,385 - 6,920,492 (-)NCBI
RGSC_v3.4146,674,662 - 6,680,769 (-)RGD
Celera145,704,631 - 5,710,738 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091624   ⟹   XP_038947552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2145,565,778 - 5,571,660 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036922   ⟸   NM_012790
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000002946   ⟸   ENSRNOT00000002946
RefSeq Acc Id: ENSRNOP00000002943   ⟸   ENSRNOT00000002943
RefSeq Acc Id: XP_038947552   ⟸   XM_039091624
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2525 AgrOrtholog
Ensembl Genes ENSRNOG00000002168 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002943 UniProtKB/TrEMBL
  ENSRNOP00000002946 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002943 UniProtKB/TrEMBL
  ENSRNOT00000002946 ENTREZGENE, UniProtKB/TrEMBL
KEGG Report rno:25254 UniProtKB/TrEMBL
NCBI Gene 25254 ENTREZGENE
PhenoGen Dspp PhenoGen
UniProt DSPP_RAT UniProtKB/Swiss-Prot
  E9PTW3_RAT UniProtKB/TrEMBL
  F1MAQ2_RAT UniProtKB/TrEMBL
  Q62598 ENTREZGENE
  Q8VBY1_RAT UniProtKB/TrEMBL
UniProt Secondary P70578 UniProtKB/Swiss-Prot
  Q9R057 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dspp  dentin sialophosphoprotein    dentin sailophosphoprotein  Name updated 1299863 APPROVED
2002-06-10 Dspp  dentin sailophosphoprotein      Symbol and Name status set to approved 70586 APPROVED
2002-01-14 Dspp  dentin sailophosphoprotein      Correction to spelling of name 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog are associated with Dentinogenesis imperfecta I and II 728746
gene_process may play a role in formation of dentin and bone 62422
gene_transcript may be encoded, at least in part, by transcripts encoding both Dsp and phosphophoryn (PP) 728746