Dspp (dentin sialophosphoprotein) - Rat Genome Database

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Gene: Dspp (dentin sialophosphoprotein) Rattus norvegicus
Symbol: Dspp
Name: dentin sialophosphoprotein
RGD ID: 2525
Description: Enables collagen binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; mandibular condyle articular cartilage development; and odontoblast differentiation. Acts upstream of or within positive regulation of calcium ion import. Located in several cellular components, including collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein); INTERACTS WITH ammonium chloride; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dentin sailophosphoprotein; Dentin sialoprotein; Dentine sialoprotein; Dsp; RDSP2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2145,565,562 - 5,571,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,565,629 - 5,571,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,534,670 - 5,540,793 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0146,834,894 - 6,841,017 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0145,533,249 - 5,539,381 (-)NCBIRnor_WKY
Rnor_6.0146,926,972 - 6,933,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,914,385 - 6,920,492 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,674,662 - 6,680,769 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,674,663 - 6,680,769 (-)NCBI
Celera145,704,631 - 5,710,738 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
collagen binding  (IBA,IDA)
protein binding  (IPI,ISO)


References - curated
# Reference Title Reference Citation
1. Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. Alvares K, etal., J Biol Chem. 2013 May 3;288(18):13036-45. doi: 10.1074/jbc.M112.389627. Epub 2013 Mar 22.
2. Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development. Baba O, etal., Matrix Biol. 2004 Oct;23(6):371-9.
3. Dentin phosphoprotein compound mutation in dentin sialophosphoprotein causes dentinogenesis imperfecta type III. Dong J, etal., Am J Med Genet A. 2005 Jan 30;132A(3):305-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Hypoxic condition promotes differentiation and mineralization of dental pulp cells in vivo. Ito K, etal., Int Endod J. 2015 Feb;48(2):115-23. doi: 10.1111/iej.12288. Epub 2014 May 12.
7. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Jittapiromsak N, etal., Tissue Eng Part A. 2010 Jun;16(6):1997-2006. doi: 10.1089/ten.TEA.2009.0593.
8. Melatonin influences proliferation and differentiation of rat dental papilla cells in vitro and dentine formation in vivo by altering mitochondrial activity. Liu J, etal., J Pineal Res. 2013 Mar;54(2):170-8. doi: 10.1111/jpi.12002. Epub 2012 Sep 4.
9. Development of an odontoblast in vitro model to study dentin mineralization. Magne D, etal., Connect Tissue Res. 2004;45(2):101-8.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Effect of the antineoplastic agent busulfan on rat molar root development. Mitomi T, etal., Arch Oral Biol. 2014 Jan;59(1):47-59.
12. Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages. Moses KD, etal., Eur J Oral Sci. 2006 Jun;114(3):216-22.
13. The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. Narayanan K, etal., J Biol Chem. 2004 Oct 29;279(44):45423-32. Epub 2004 Aug 12.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Design of a controlled release system of OP-1 and TGF-ß1 based in microparticles of sodium alginate and release characterization by HPLC-UV. Oliva-Rodríguez R, etal., In Vitro Cell Dev Biol Anim. 2011 Dec;47(10):681-8. doi: 10.1007/s11626-011-9459-7. Epub 2011 Oct 20.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Identification and characterization of the carboxyl-terminal region of rat dentin sialoprotein. Qin C, etal., J Biol Chem 2001 Jan 12;276(2):904-9.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. A novel rat dentin mRNA coding only for dentin sialoprotein. Ritchie HH and Li X, Eur J Oral Sci 2001 Oct;109(5):342-7.
22. Sequence determination of an extremely acidic rat dentin phosphoprotein. Ritchie HH and Wang LH, J Biol Chem 1996 Sep 6;271(36):21695-8.
23. The conservation and regulation of rat DSP-PP gene. Ritchie HH, etal., Connect Tissue Res 2002;43(2-3):331-7.
24. Cloning and sequence determination of rat dentin sialoprotein, a novel dentin protein. Ritchie HH, etal., J Biol Chem 1994 Feb 4;269(5):3698-702.
25. Expression of Notch signalling-related genes in normal and differentiating rat dental pulp cells. Sun H, etal., Aust Endod J. 2010 Aug;36(2):54-8.
26. Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. Sun Y, etal., Int J Oral Maxillofac Surg. 2010 Mar;39(3):272-81. doi: 10.1016/j.ijom.2009.12.017. Epub 2010 Jan 25.
27. Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head. Sun Y, etal., J Histochem Cytochem. 2010 Nov;58(11):1033-43. doi: 10.1369/jhc.2010.956771. Epub 2010 Aug 2.
28. Expression of mineralized tissue associated proteins: dentin sialoprotein and phosphophoryn in rodent hair follicles. Tang XN, etal., J Dermatol Sci. 2011 Nov;64(2):92-8. doi: 10.1016/j.jdermsci.2011.08.009. Epub 2011 Aug 27.
29. Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. Thyagarajan T, etal., J Biol Chem 2001 Apr 6;276(14):11016-20. Epub 2000 Dec 14.
30. An ex vivo culture model for orthodontically induced root resorption. Wan Hassan WN, etal., J Dent. 2012 May;40(5):406-15. doi: 10.1016/j.jdent.2012.02.002. Epub 2012 Feb 8.
31. Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Xiao S, etal., Nat Genet. 2001 Feb;27(2):201-4.
32. Expression of Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs) in the reparative dentin of rat molars. Xie X, etal., Dent Traumatol. 2014 Aug;30(4):285-95. doi: 10.1111/edt.12093. Epub 2014 Feb 6.
33. Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors. Xu T, etal., J Mol Histol. 2014 Feb;45(1):11-9. doi: 10.1007/s10735-013-9533-4. Epub 2013 Aug 22.
34. Lymphocyte enhancer-binding factor 1: an essential factor in odontoblastic differentiation of dental pulp cells enzymatically isolated from rat incisors. Yokose S and Naka T, J Bone Miner Metab. 2010 Apr 28.
35. Differential expression between "DSP-only" and DSP-PP523 transcripts in rat molar teeth. Zhu YQ, etal., Arch Oral Biol. 2017 May 31;82:33-37. doi: 10.1016/j.archoralbio.2017.04.031.
36. Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I. Zurick KM, etal., J Biomed Mater Res A. 2012 Sep;100(9):2492-8. doi: 10.1002/jbm.a.34159. Epub 2012 May 21.
Additional References at PubMed
PMID:9395101   PMID:10403786   PMID:10978503   PMID:11566357   PMID:11856645   PMID:15193538   PMID:16014627   PMID:16046405   PMID:16937369   PMID:17286598   PMID:17698853   PMID:19001636  
PMID:20387077   PMID:22798071   PMID:23161527   PMID:23611378   PMID:23900597   PMID:25027178   PMID:25138274   PMID:25583546   PMID:26972716   PMID:33647395  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2145,565,562 - 5,571,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,565,629 - 5,571,672 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,534,670 - 5,540,793 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0146,834,894 - 6,841,017 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0145,533,249 - 5,539,381 (-)NCBIRnor_WKY
Rnor_6.0146,926,972 - 6,933,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,914,385 - 6,920,492 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,674,662 - 6,680,769 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,674,663 - 6,680,769 (-)NCBI
Celera145,704,631 - 5,710,738 (-)NCBICelera
Cytogenetic Map14p22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38487,608,529 - 87,616,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl487,608,529 - 87,616,873 (+)EnsemblGRCh38hg38GRCh38
GRCh37488,529,681 - 88,538,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,748,705 - 88,757,049 (+)NCBINCBI36Build 36hg18NCBI36
Build 34488,886,859 - 88,895,204NCBI
Celera485,818,035 - 85,826,406 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,275,661 - 84,283,858 (+)NCBIHuRef
CHM1_1488,506,445 - 88,514,787 (+)NCBICHM1_1
T2T-CHM13v2.0490,935,096 - 90,943,283 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395104,318,569 - 104,327,993 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,318,578 - 104,327,993 (+)EnsemblGRCm39 Ensembl
GRCm385104,170,703 - 104,180,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,170,712 - 104,180,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,599,731 - 104,609,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,411,005 - 104,420,429 (+)NCBIMGSCv36mm8
Celera5101,476,457 - 101,494,758 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.59NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554742,254,842 - 2,259,303 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1490,630,300 - 90,635,681 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0479,903,923 - 79,909,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13211,017,440 - 11,022,780 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,932,307 - 30,937,641 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,069,800 - 11,075,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,069,800 - 11,075,121 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,152,952 - 11,158,287 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,978,595 - 10,983,939 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,970,188 - 28,976,515 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244052852,036,925 - 2,043,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905458,298 - 463,346 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936905458,062 - 463,359 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8131,319,983 - 131,472,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,318,187 - 131,444,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,512,001 - 140,540,005 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1735,993,669 - 35,999,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603714,694,483 - 14,700,534 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248724,096,001 - 4,102,392 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dspp
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000002943, ENSRNOT00000002946, ENSRNOT00000002947
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
Below cutoff 10 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002943   ⟹   ENSRNOP00000002943
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,565,629 - 5,571,672 (-)Ensembl
Rnor_6.0 Ensembl146,926,976 - 6,933,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000002946   ⟹   ENSRNOP00000002946
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,567,092 - 5,571,672 (-)Ensembl
Rnor_6.0 Ensembl146,928,502 - 6,933,070 (-)Ensembl
RefSeq Acc Id: NM_012790   ⟹   NP_036922
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2145,565,562 - 5,571,669 (-)NCBI
Rnor_6.0146,926,972 - 6,933,079 (-)NCBI
Rnor_5.0146,914,385 - 6,920,492 (-)NCBI
RGSC_v3.4146,674,662 - 6,680,769 (-)RGD
Celera145,704,631 - 5,710,738 (-)RGD
RefSeq Acc Id: XM_039091624   ⟹   XP_038947552
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2145,565,778 - 5,571,660 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036922   ⟸   NM_012790
- Peptide Label: precursor
- UniProtKB: E9PTW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002946   ⟸   ENSRNOT00000002946
RefSeq Acc Id: ENSRNOP00000002943   ⟸   ENSRNOT00000002943
RefSeq Acc Id: XP_038947552   ⟸   XM_039091624
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62598-F1-model_v2 AlphaFold Q62598 1-687 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2525 AgrOrtholog
BioCyc Gene G2FUF-16500 BioCyc
Ensembl Genes ENSRNOG00000002168 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002943.6 UniProtKB/TrEMBL
  ENSRNOP00000002946.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002943.8 UniProtKB/TrEMBL
  ENSRNOT00000002946.8 UniProtKB/TrEMBL
KEGG Report rno:25254 UniProtKB/TrEMBL
PhenoGen Dspp PhenoGen
UniProt DSPP_RAT UniProtKB/Swiss-Prot
UniProt Secondary P70578 UniProtKB/Swiss-Prot
  Q9R057 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dspp  dentin sialophosphoprotein    dentin sailophosphoprotein  Name updated 1299863 APPROVED
2002-06-10 Dspp  dentin sailophosphoprotein      Symbol and Name status set to approved 70586 APPROVED
2002-01-14 Dspp  dentin sailophosphoprotein      Correction to spelling of name 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog are associated with Dentinogenesis imperfecta I and II 728746
gene_process may play a role in formation of dentin and bone 62422
gene_transcript may be encoded, at least in part, by transcripts encoding both Dsp and phosphophoryn (PP) 728746