RGD Reference Report - c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. - Rat Genome Database

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c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.

Authors: Kim, CH  Koh, YW  Han, JH  Kim, JW  Lee, JS  Baek, SJ  Hwang, HS  Choi, EC 
Citation: Kim CH, etal., Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
RGD ID: 8548612
Pubmed: PMID:20848408   (View Abstract at PubMed)
DOI: DOI:10.1002/hed.21383   (Journal Full-text)

BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HGFHumantongue squamous cell carcinoma  IEP protein:increased expression:tongue:RGD 
HgfRattongue squamous cell carcinoma  ISOHGF (Homo sapiens)protein:increased expression:tongue:RGD 
HgfMousetongue squamous cell carcinoma  ISOHGF (Homo sapiens)protein:increased expression:tongue:RGD 
METHumantongue squamous cell carcinoma  IEP protein:increased expression:tongue:RGD 
MetRattongue squamous cell carcinoma  ISOMET (Homo sapiens)protein:increased expression:tongue:RGD 
MetMousetongue squamous cell carcinoma  ISOMET (Homo sapiens)protein:increased expression:tongue:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)
Met  (MET proto-oncogene, receptor tyrosine kinase)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)
Met  (met proto-oncogene)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)
MET  (MET proto-oncogene, receptor tyrosine kinase)


Additional Information