RGD Reference Report - c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. - Rat Genome Database

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c-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma.

Authors: Kim, CH  Koh, YW  Han, JH  Kim, JW  Lee, JS  Baek, SJ  Hwang, HS  Choi, EC 
Citation: Kim CH, etal., Head Neck. 2010 Dec;32(12):1655-64. doi: 10.1002/hed.21383.
RGD ID: 8548612
Pubmed: PMID:20848408   (View Abstract at PubMed)
DOI: DOI:10.1002/hed.21383   (Journal Full-text)

BACKGROUND: Hepatocyte growth factor (HGF) can promote proliferation, invasion, and angiogenesis in various tumor cells. However, the prognosis according to expression of HGF/c-Met has not been reported in patients with squamous cell carcinoma of the oral tongue (SCCOT). METHODS: Tumors from 61 patients with SCCOT were evaluated for the expression of HGF and c-Met by immunohistochemistry. For Western blot, we used fresh normal and cancer tissues from 3 patients with SCCOT. RESULTS: The positive rates of HGF and c-Met immunostaining in SCCOT were 57.3% and 54.1%, respectively. The c-Met staining was significantly correlated with lymph node metastasis (p = .005), tumor classification (p = .004), and recurrence (p = .018). Survival was significantly affected in patients with positive c-Met expression (p = .003). HGF and c-Met were strongly expressed in cancer tissues on Western blot. CONCLUSION: The c-Met expression may play an important role in the progression and the survival outcome of patients with SCCOT.

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)
Met  (MET proto-oncogene, receptor tyrosine kinase)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)
Met  (met proto-oncogene)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)
MET  (MET proto-oncogene, receptor tyrosine kinase)

Additional Information