RGD Reference Report - Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. - Rat Genome Database

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Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer.

Authors: Thang, Phung Manh  Takano, Atsushi  Yoshitake, Yoshihiro  Shinohara, Masanori  Murakami, Yoshinori  Daigo, Yataro 
Citation: Thang PM, etal., Int J Oncol. 2016 Oct;49(4):1385-93. doi: 10.3892/ijo.2016.3649. Epub 2016 Aug 5.
RGD ID: 28867233
Pubmed: (View Article at PubMed) PMID:27499128
DOI: Full-text: DOI:10.3892/ijo.2016.3649

Oral cavity carcinoma (OCC) is one of the most common causes of cancer-related death worldwide and has poor clinical outcome after standard therapies. Therefore, new prognostic biomarkers and therapeutic targets for OCC are urgently needed. We selected cell division cycle associated 1 (CDCA1) as a candidate OCC biomarker. Immunohistochemical analysis confirmed that CDCA1 protein was expressed in 67 of 99 OCC tissues (67.7%), but not in healthy oral epithelia. CDCA1 expression was significantly associated with poor prognosis in OCC patients (P=0.0244). Knockdown of CDCA1 by siRNAs significantly increased apoptosis of tumor cells. These data suggest that CDCA1 represents a novel prognostic biomarker and therapeutic target for OCC.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nuf2  (NUF2 component of NDC80 kinetochore complex)

Genes (Mus musculus)
Nuf2  (NUF2, NDC80 kinetochore complex component)

Genes (Homo sapiens)
NUF2  (NUF2 component of NDC80 kinetochore complex)


Additional Information