Terc (telomerase RNA component) - Rat Genome Database

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Gene: Terc (telomerase RNA component) Rattus norvegicus
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Symbol: Terc
Name: telomerase RNA component
RGD ID: 727802
Description: Predicted to enable DNA polymerase binding activity; WD40-repeat domain binding activity; and template for synthesis of G-rich strand of telomere DNA activity. Predicted to contribute to telomerase RNA reverse transcriptase activity. Involved in negative regulation of cell differentiation. Predicted to be located in Cajal body and cytoplasm. Predicted to be part of box H/ACA telomerase RNP complex and telomerase catalytic core complex. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 1; cervix uteri carcinoma in situ; melanoma; and prostate cancer. Orthologous to human TERC (telomerase RNA component); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; aflatoxin B1.
Type: ncrna (Ensembl: misc_RNA)
RefSeq Status: VALIDATED
Previously known as: telomerase RNA; Tr
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,744,148 - 114,744,535 (+)NCBIGRCr8
mRatBN7.22112,815,654 - 112,816,041 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2119,466,989 - 119,467,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,579,552 - 117,579,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02112,290,386 - 112,290,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02116,432,723 - 116,433,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02136,126,300 - 136,126,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42117,234,446 - 117,234,833 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12117,179,407 - 117,179,795 (+)NCBI
Celera2107,993,694 - 107,994,082 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Expression of telomerase subunits in gastric cancer. Chen F, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):741-3. doi: 10.1007/BF02896189.
2. Secondary structure of vertebrate telomerase RNA. Chen JL, etal., Cell 2000 Mar 3;100(5):503-14.
3. Telomerase RNA as a detection marker in the serum of breast cancer patients. Chen XQ, etal., Clin Cancer Res. 2000 Oct;6(10):3823-6.
4. High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. Dome JS, etal., J Clin Oncol. 2005 Dec 20;23(36):9138-45. Epub 2005 Sep 19.
5. Gene amplifications associated with the development of hormone-resistant prostate cancer. Edwards J, etal., Clin Cancer Res. 2003 Nov 1;9(14):5271-81.
6. Detection of telomerase in urine by 3 methods: evaluation of diagnostic accuracy for bladder cancer. Eissa S, etal., J Urol. 2007 Sep;178(3 Pt 1):1068-72. Epub 2007 Jul 20.
7. Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Heselmeyer-Haddad K, etal., Am J Pathol. 2005 Apr;166(4):1229-38.
8. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. Hopman AH, etal., J Pathol. 2006 Dec;210(4):412-9.
9. The effect on melanoma risk of genes previously associated with telomere length. Iles MM, etal., J Natl Cancer Inst. 2014 Sep 17;106(10). pii: dju267. doi: 10.1093/jnci/dju267. Print 2014 Oct.
10. Telomere length, telomerase activity and telomerase RNA expression during mouse mammary tumor progression. Kiyozuka Y, etal., Int J Mol Med. 1998 Oct;2(4):437-44.
11. Detection of human telomerase RNA in the tumour-surrounding mucosa of bladder carcinomas as a marker for premalignant transformation. Leuenroth S, etal., BJU Int. 2005 Sep;96(4):553-7.
12. Telomerase regulation of myofibroblast differentiation. Liu T, etal., Am J Respir Cell Mol Biol. 2006 May;34(5):625-33. Epub 2006 Jan 19.
13. Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. Montanaro L, etal., J Pathol. 2006 Sep;210(1):10-8.
14. Expression of telomerase mRNA component (hTR) in transitional cell carcinoma of the upper urinary tract. Nakanishi K, etal., Cancer. 1999 Nov 15;86(10):2109-16.
15. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
16. Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer. Novakovic S, etal., Oncol Rep. 2004 Jan;11(1):245-52.
17. Up-regulation of telomerase in primary cultured rat hepatocytes. Nozawa K, etal., J Biochem (Tokyo) 1999 Aug;126(2):361-7.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion. Ozaki S, etal., Hepatology. 1999 Oct;30(4):914-9. doi: 10.1002/hep.510300419.
20. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. Poremba C, etal., J Pathol. 2002 Oct;198(2):181-9.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue. Rohde V, etal., Clin Cancer Res. 2000 Dec;6(12):4803-9.
25. Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours. Wisman GB, etal., Int J Oncol. 2003 Nov;23(5):1451-9.
Additional References at PubMed
PMID:9334263   PMID:9335332   PMID:11381263   PMID:15235603   PMID:15367665   PMID:17145779   PMID:17554309   PMID:17982445  


Genomics

Comparative Map Data
Terc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,744,148 - 114,744,535 (+)NCBIGRCr8
mRatBN7.22112,815,654 - 112,816,041 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2119,466,989 - 119,467,376 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,579,552 - 117,579,939 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02112,290,386 - 112,290,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02116,432,723 - 116,433,110 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02136,126,300 - 136,126,687 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42117,234,446 - 117,234,833 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12117,179,407 - 117,179,795 (+)NCBI
Celera2107,993,694 - 107,994,082 (+)NCBICelera
Cytogenetic Map2q24NCBI
TERC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383169,764,610 - 169,765,060 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3169,764,520 - 169,765,060 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl3169,764,610 - 169,765,047 (-)EnsemblGRCh38hg38GRCh38
GRCh373169,482,398 - 169,482,848 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363170,965,092 - 170,965,542 (-)NCBINCBI36Build 36hg18NCBI36
Celera3167,881,540 - 167,881,990 (-)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3166,852,038 - 166,852,488 (-)NCBIHuRef
CHM1_13169,445,476 - 169,445,926 (-)NCBICHM1_1
T2T-CHM13v2.03172,548,562 - 172,549,012 (-)NCBIT2T-CHM13v2.0
Terc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,321,753 - 96,322,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,321,753 - 96,322,149 (-)EnsemblGRCm39 Ensembl
GRCm38396,414,437 - 96,414,833 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,414,437 - 96,414,859 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl396,414,437 - 96,414,833 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,218,360 - 96,218,756 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,499,842 - 96,500,238 (-)NCBIMGSCv36mm8
Celera397,832,081 - 97,832,477 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.82NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat

Markers in Region
RH142549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,816,146 - 112,816,258 (+)MAPPERmRatBN7.2
Rnor_6.02116,433,216 - 116,433,327NCBIRnor6.0
Rnor_5.02136,126,793 - 136,126,904UniSTSRnor5.0
RGSC_v3.42117,234,939 - 117,235,050UniSTSRGSC3.4
Celera2107,994,188 - 107,994,299UniSTS
RH 3.4 Map2686.6UniSTS
Cytogenetic Map2q24UniSTS
RH143059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,815,731 - 112,815,985 (+)MAPPERmRatBN7.2
Rnor_6.02116,432,801 - 116,433,054NCBIRnor6.0
Rnor_5.02136,126,378 - 136,126,631UniSTSRnor5.0
RGSC_v3.42117,234,524 - 117,234,777UniSTSRGSC3.4
Celera2107,993,772 - 107,994,026UniSTS
RH 3.4 Map2713.7UniSTS
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 24 8 16 8 8 4 8 8
Low 1 12 19 19 2 19 8 8 14 16 10 1 8
Below cutoff 1 13 7 7 1 7 17 11 8 2

Sequence


RefSeq Acc Id: ENSRNOT00000084300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)Ensembl
RefSeq Acc Id: NR_001567
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,744,148 - 114,744,535 (+)NCBI
mRatBN7.22112,815,654 - 112,816,041 (+)NCBI
Rnor_6.02116,432,723 - 116,433,110 (+)NCBI
Rnor_5.02136,126,300 - 136,126,687 (+)NCBI
RGSC_v3.42117,234,446 - 117,234,833 (+)RGD
Celera2107,993,694 - 107,994,082 (+)RGD
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727802 AgrOrtholog
BioCyc Gene G2FUF-53449 BioCyc
Ensembl Genes ENSRNOG00000051777 Ensembl
NCBI Gene 378461 ENTREZGENE
PhenoGen Terc PhenoGen
RatGTEx ENSRNOG00000051777 RatGTEx
RNAcentral URS00001ED027 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Terc  telomerase RNA component  Terc  telomerase RNA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Terc  telomerase RNA  Tr    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution based on the similarities of the secondary structure of the telomerase RNA of vertebrates and ciliate organisms, it appears that its global architecture, but not its actual sequence, is strongly conserved evolutionarily 1299554
gene_regulation transcription is upregulated in rat hepatocytes in response to growth in serum-free medium 1299555