Slc24a3 (solute carrier family 24 member 3)

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Gene: Slc24a3 (solute carrier family 24 member 3) Rattus norvegicus

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Symbol:

Slc24a3

Name:

solute carrier family 24 member 3

RGD ID:

69256

Description:

Enables calcium, potassium:sodium antiporter activity. Involved in monoatomic cation transport. Located in cell periphery. Orthologous to human SLC24A3 (solute carrier family 24 member 3); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

na(+)/K(+)/Ca(2+)-exchange protein 3; Nckx3; potassium-dependent sodium-calcium exchanger NCKX3 (SLC24A3); sodium/potassium/calcium exchanger 3; solute carrier family 24 (sodium/potassium/calcium exchanger) member 3; solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; solute carrier family 24, member 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Slc24a3^{Tn(sb-T2/Bart3)2.188Mcwi} Slc24a3^{Tn(sb-T2/Bart3)2.178Mcwi}

Genetic Models:

F344-Slc24a3^{Tn(sb-T2/Bart3)2.178Mcwi} F344-Slc24a3^{Tn(sb-T2/Bart3)2.188Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	153,005,418 - 153,504,497 (+)	NCBI		GRCr8
mRatBN7.2	3	132,552,119 - 133,051,192 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	132,551,595 - 133,051,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	136,458,426 - 136,960,748 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	145,042,522 - 145,544,835 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	142,745,677 - 143,247,999 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	139,333,942 - 139,835,728 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	139,695,028 - 139,833,967 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	145,760,074 - 146,259,491 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	133,734,890 - 134,249,326 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	133,640,575 - 134,153,200 (+)	NCBI
Celera	3	131,419,773 - 131,916,131 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

familial hyperinsulinemic hypoglycemia 1 (ISO)

Salivary Gland Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-hydroxypropanoic acid (ISO)

2-methoxyethanol (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chlordecone (ISO)

choline (ISO)

cisplatin (EXP,ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

mercury dichloride (EXP)

methimazole (EXP)

N,N-diethyl-m-toluamide (EXP)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

permethrin (EXP)

progesterone (EXP,ISO)

rac-lactic acid (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP,ISO)

toluene (EXP)

topotecan (EXP)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (IEA,ISO)

calcium ion transmembrane transport (IBA,IEA,ISO)

intracellular calcium ion homeostasis (IBA,IEA,ISO,NAS)

monoatomic cation transport (IDA)

negative regulation of gene expression (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

potassium ion transmembrane transport (IEA,ISO)

sodium ion transmembrane transport (IEA,ISO)

Cellular Component

cell periphery (IDA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

antiporter activity (IEA)

calcium channel activity (IBA)

calcium, potassium:sodium antiporter activity (IBA,IDA,IEA,ISO)

symporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.	Dong H, etal., Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1226-35. Epub 2006 Apr 14.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.	Kiedrowski L, etal., Neuroreport 2002 Aug 27;13(12):1529-32.
4.	Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3.	Kraev A, etal., J Biol Chem 2001 Jun 22;276(25):23161-72.
5.	Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.	Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats.	Yang H, etal., Mol Reprod Dev. 2010 Nov;77(11):971-7. doi: 10.1002/mrd.21245.

Additional References at PubMed

PMID:19464262	PMID:19474185	PMID:21321244	PMID:26631410	PMID:28602864

Genomics

Comparative Map Data

Slc24a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	153,005,418 - 153,504,497 (+)	NCBI		GRCr8
mRatBN7.2	3	132,552,119 - 133,051,192 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	132,551,595 - 133,051,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	136,458,426 - 136,960,748 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	145,042,522 - 145,544,835 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	142,745,677 - 143,247,999 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	139,333,942 - 139,835,728 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	139,695,028 - 139,833,967 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	145,760,074 - 146,259,491 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	133,734,890 - 134,249,326 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	133,640,575 - 134,153,200 (+)	NCBI
Celera	3	131,419,773 - 131,916,131 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

SLC24A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	19,212,642 - 19,722,926 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	19,212,642 - 19,722,926 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	19,193,286 - 19,703,570 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	19,141,290 - 19,651,541 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	19,141,289 - 19,651,540	NCBI
Celera	20	19,267,475 - 19,777,636 (+)	NCBI		Celera
Cytogenetic Map	20	p11.23	NCBI
HuRef	20	19,155,790 - 19,666,236 (+)	NCBI		HuRef
CHM1_1	20	19,262,244 - 19,704,077 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	19,264,159 - 19,774,968 (+)	NCBI		T2T-CHM13v2.0

Slc24a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	145,009,695 - 145,484,086 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	145,009,674 - 145,484,086 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	145,167,775 - 145,642,166 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	145,167,754 - 145,642,166 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	145,068,347 - 145,467,689 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	144,934,052 - 145,333,394 (+)	NCBI		MGSCv36	mm8
Celera	2	146,442,567 - 146,852,275 (+)	NCBI		Celera
Cytogenetic Map	2	G1	NCBI
cM Map	2	71.08	NCBI

Slc24a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	27,477,819 - 27,928,383 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	27,477,801 - 27,930,108 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC24A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	20,097,895 - 20,610,669 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	20,094,738 - 20,607,505 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	19,168,820 - 19,680,706 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	19,137,943 - 19,648,235 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	19,137,938 - 19,646,475 (+)	Ensembl	panpan1.1		panPan2

SLC24A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	3,593,562 - 4,014,366 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	3,593,513 - 3,784,467 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	3,620,103 - 3,818,880 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	4,000,491 - 4,482,100 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	4,000,493 - 4,482,430 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	3,595,752 - 4,077,406 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	3,699,250 - 4,181,348 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	3,977,410 - 4,458,938 (-)	NCBI		UU_Cfam_GSD_1.0

Slc24a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	152,206,337 - 152,654,468 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	639,532 - 1,085,830 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	637,715 - 1,085,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC24A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	27,270,093 - 27,780,526 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	27,270,232 - 27,780,535 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	31,405,580 - 31,468,072 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC24A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	48,238,872 - 48,736,517 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666078	3,017,793 - 3,516,931 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc24a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	19,808,255 - 20,297,056 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	19,808,186 - 20,298,772 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc24a3
2647 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	191
Count of miRNA genes:	147
Interacting mature miRNAs:	165
Transcripts:	ENSRNOT00000012683
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	115638168	135181505	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

D3Rat85

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	133,042,352 - 133,042,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,826,887 - 139,827,106	NCBI	Rnor6.0
Rnor_5.0	3	146,250,650 - 146,250,869	UniSTS	Rnor5.0
RGSC_v3.4	3	134,240,485 - 134,240,704	UniSTS	RGSC3.4
RGSC_v3.1	3	134,146,057 - 134,146,277	RGD
Celera	3	131,907,298 - 131,907,517	UniSTS
FHH x ACI Map	3	81.3799	UniSTS
FHH x ACI Map	3	81.3799	RGD
Cytogenetic Map	3	q41	UniSTS

D3Got97

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	133,006,585 - 133,006,885 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,791,762 - 139,792,061	NCBI	Rnor6.0
Rnor_5.0	3	146,215,525 - 146,215,824	UniSTS	Rnor5.0
RGSC_v3.4	3	134,203,881 - 134,204,181	RGD	RGSC3.4
RGSC_v3.4	3	134,203,882 - 134,204,181	UniSTS	RGSC3.4
RGSC_v3.1	3	134,109,454 - 134,109,754	RGD
Celera	3	131,871,677 - 131,871,976	UniSTS
Cytogenetic Map	3	q41	UniSTS

D3Got240

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	132,954,388 - 132,954,605 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,741,825 - 139,742,041	NCBI	Rnor6.0
Rnor_5.0	3	146,164,940 - 146,165,156	UniSTS	Rnor5.0
RGSC_v3.4	3	134,151,226 - 134,151,442	UniSTS	RGSC3.4
Celera	3	131,819,702 - 131,819,918	UniSTS
Cytogenetic Map	3	q41	UniSTS

BE115278

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	132,683,693 - 132,683,843 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,470,660 - 139,470,809	NCBI	Rnor6.0
Rnor_5.0	3	145,896,571 - 145,896,720	UniSTS	Rnor5.0
RGSC_v3.4	3	133,867,704 - 133,867,853	UniSTS	RGSC3.4
Celera	3	131,551,007 - 131,551,156	UniSTS
RH 3.4 Map	3	1178.6	UniSTS
Cytogenetic Map	3	q41	UniSTS

UniSTS:225330

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	132,583,428 - 132,583,591 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,365,125 - 139,365,287	NCBI	Rnor6.0
Rnor_5.0	3	145,791,227 - 145,791,389	UniSTS	Rnor5.0
RGSC_v3.4	3	133,766,199 - 133,766,361	UniSTS	RGSC3.4
Celera	3	131,451,011 - 131,451,173	UniSTS
Cytogenetic Map	3	q41	UniSTS

Slc24a3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	133,049,999 - 133,050,949 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	139,834,536 - 139,835,485	NCBI	Rnor6.0
Rnor_5.0	3	146,258,299 - 146,259,248	UniSTS	Rnor5.0
Celera	3	131,914,939 - 131,915,888	UniSTS
Cytogenetic Map	3	q41	UniSTS

Genetic Models

This gene Slc24a3 is modified in the following models/strains:

F344-Slc24a3^{Tn(sb-T2/Bart3)2.178Mcwi} F344-Slc24a3^{Tn(sb-T2/Bart3)2.188Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY009158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000089098 ⟹ ENSRNOP00000071351

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	132,906,557 - 133,051,192 (+)	Ensembl
Rnor_6.0 Ensembl	3	139,695,028 - 139,833,967 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115668 ⟹ ENSRNOP00000093366

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	132,551,595 - 133,051,192 (+)	Ensembl

RefSeq Acc Id:

NM_053505 ⟹ NP_445957

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	153,005,418 - 153,504,497 (+)	NCBI
mRatBN7.2	3	132,552,119 - 133,051,192 (+)	NCBI
Rnor_6.0	3	139,333,942 - 139,835,728 (+)	NCBI
Rnor_5.0	3	145,760,074 - 146,259,491 (+)	NCBI
RGSC_v3.4	3	133,734,890 - 134,249,326 (+)	RGD
Celera	3	131,419,773 - 131,916,131 (+)	NCBI

Sequence:

show sequence

CGGCCGCCCGCGACCCGAGCGGACGCGCCCGGCAGGGACGCCGCCCGGCCGTCCGAGGATGCCG
CCGCCGGGCGACCAGGACCGCGCGCGCCGCCGCAGCCGCCGCCGGCGGAGGGACCTTCTGCTGA
GCCAGCTCTGCTTCCTGGCTTCGGTGGCGCTGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCA
GAAGGAACTTGACCTCATGGATCTCATCGGGGAAGATAGAAAATGGATGGTGGGGAGGAAGCTG
ATGCAGGTGAATGATACACTGACTTCTGAAGATGCAGGACTCCGGAGCAGCAAGAACTGCACAG
AGCCAGCCCTGCATGAATTCCCCAGGGACATCTTCTCCAATGAAGACCGACGACAAGGAGCGGT
GGTACTCCACGTGCTCTGTGCCATGTATATGTTCTATGCACTGGCCATCGTGTGCGATGACTTC
TTCGTCCCATCCTTGGAAAAGATCTGTGAGCGCCTCCACCTCAGTGAAGATGTGGCAGGAGCCA
CCTTCATGGCAGCAGGCAGCTCGGCCCCGGAGCTCTTCACATCGGTCATAGGAGTCTTCATCAC
AAAGGGGGATGTGGGAGTCGGCACCATCGTGGGCTCTGCTGTGTTCAACATCCTGTGCATCATT
GGCGTCTGCGGGCTCTTTGCAGGACAGGTCGTGGCTCTTTCTTCCTGGTGCCTGCTGAGGGATT
CCATCTACTACACACTGTCTGTGGTCGCACTCATTGTGTTCATTTATGATGAAAAGGTTTCTTG
GTGGGAATCTCTAGTCCTTGTGCTGATGTACCTCATCTATATCATCATCATGAAATACAATGCG
TGCATACACCAGTGCTTCGAAAGGAGGACGAAAGGTGCTGGGAACATGGTCAACGGACTGGCCA
ACAACGCCGAAATCGATGACAGCAGCAACTGCGATGCCACTGTGGTGCTACTTAAGAAAGCCAA
TTTCCACCGCAAAGCGTCAGTGATCATGGTGGATGAGCTGCTGTCTGCCTACCCACACCAGCTC
TCTTTCTCTGAGGCTGGCCTTCGAATAATGATCACAAGCCACTTTCCTCCCAAGACCCGGCTCT
CCATGGCCAGTCGCATGTTAATCAATGAGAGACAAAGACTGATAAACAGCAGGGCATATACCAA
TGGGGAATCTGAAGTGGCCATCAAAATCCCAATTAAGCACACTGTGGAGAATGGAACAGGGCCC
AGCAGTGCCCCAGACAGGGGTGTGAATGGAACCCGGAGGGACGACATAGTTGCTGAGGCTGACA
ATGAGACAGAGAACGAGAATGAAGACGAGAACAATGAGAATGACGAGGAGGAGGATGAAGATGA
TGATGAAGGCCCCTACACGCCATTCGACCCCCCCTCTGGCAAACTGGAAACTGTGAAATGGGCA
TTCACCTGGCCCCTGAGTTTTGTCTTGTACTTCACTGTCCCCAACTGTAACAAGCCCCACTGGG
AGAAGTGGTTTATGGTGACGTTTGCTTCCTCTACACTGTGGATTGCAGCCTTCTCCTACATGAT
GGTGTGGATGGTTACCATCATCGGCTACACCCTAGGGATCCCTGATGTCATCATGGGGATCACC
TTCCTGGCTGCCGGAACCAGCGTGCCCGACTGCATGGCCAGCCTCATTGTAGCCAGACAAGGGA
TGGGGGACATGGCTGTGTCCAATTCCATTGGGAGCAACGTGTTTGACATCTTGATTGGGCTTGG
CCTTCCCTGGGCTCTGCAGACTCTGGCTGTGGATTATGGATCCTATATTCGGCTGAACAGCAGA
GGGCTCATCTACTCCGTGGGCTTGCTCCTGGCCTCTGTCTTTGTCACGGTGTTTGGCGTTCACC
TGAACAAGTGGCAGCTGGACAAGAAGCTGGGCTGTGGATGCCTCTTCCTGTATGGCGTGTTCCT
CTGCTTCTCCATCATGACGGAGTTCAACGTGTTCACCTTTGTGAACTTGCCCATGTGTGGGGAC
TAATGATTGACCAGGTCACCTGCCGAGGCCCAGGTCCTTCTTTTCTGTGCAATACGAGACCCGG
CCGCACCCGAGTCATGCGGCCCCTCAACGGCCGCGGCGTCCGTCTCTCCCGTGCTGTCTGCGGG
CCTGTCCTGGTGGTCTAGGCTCTCCCTGCCACCTCCTTTGCTCCCAAACTCCCTTGGTCCTACC
TCCCAGCCAGCCCCCCTCACCCACCCACCCCATTCCTGTGTCTTCTTCCGTGTGAAGACGTCCA
CCATCCACATGAATTTTCAAGCTCCATATTTGAACGGTGACTGAGATTCTAGAACAAAACTGGC
TGCTAACTGGCCCAAGCCAGGCACAACTTACTCCAATCCCTCCTCCTTTTTTTAAGTTATTTCA
CAGAAGATACCCTAATTTATGACCAGAGACTTTGAGGAAACAGGAGAGGGTCCGCTGATGGCAG
GAAGTATTGGGTTTGTTTTGTTTGGGAGTGATTCCTAGGTTACCGGGTTTGGGAAATGGTTTAA
TTTGAGGGGGTTCATTGTTTCTTTACTTTTCTTTCAGAGACAGAGGACTCCCCTCGAGTCTTCT
CTCACTGGGCTCTGGCTTAATAGATGGTCCACAGATTGTACTGTCTCCTGGGGGAGAATCCAGG
CACGTTGGGAATTTAATAATTAGTTGGGAAACCACTGAGCGAGACCACCAGGAATAGATGCATG
ACATGACATTTTTCTGCTCAAGGACACATCACTAAAGTCCTGAAGGCTTCACCTGGGGGTGGGG
GGTGTAAGGTGTTAGAGGAAGAAACCTGCTTCTCACATGTTCACTATGCCCATCTCCCTCCCAA
CTAGGTTCTTTCTAGTTTTTCAAGCAATAGTTCTCGCCTGCCTAAGGCCTTTGACAGGAAGACC
CTGACTAACTGTAAGGCACCAGGCAGTCAACGACAGAAACTTCCCCAGTGTGTGAGTCCTTGAC
ATGTGCTCTTGTTGCTTGGCATTTGTGGTGACAGGGAGTGACCCCAGAGGCTATCACTGTGCTC
TGGACAGAAGTTACAGACACTGGTTTCTTGGAAAATGAAGAGAAGCACATTTTGCACAGATGTC
GTCAATGAAGTCCCAATTTGCCACTTGGTATCGAGTACACTGGACCCTGACAGCTGGCTCTTGA
GCAAACATCCTTCCTCACAGGATGCCACCAATAAGCTAGCCAGTTTCATCCCTCCCGTCCCAGA
GGGATGGCCAGGGAGGGAGGAAGCAGAGAACTGCTGCATTGAAAACCACAGAATGGGTTCACCT
CAGACTGGCTCAAGGGCACAAGTTATTGTGAACATTTCGCCAATCACTGCTCAACCGCCCTGCT
AGATTTTTCTATGATGCTGAATTATTATGCAGAATAACTCCACCAAGTTGAGATACACCCATGC
TTGTTACACTTGTATTTATTGAAACTGTGGATTCTTGCCCGCCCGTGCTCTCCCTTGTATTTAC
TTTAAGCACTGATCACTTATCATCCACTCGGTATGGTTTTCCCAGTCCCTTGTACACATCCTGG
TTTGAATTGTAAAAAATAACCTGCTACAGACTGGTTGAACGTTTCTGTCTGAGCTGCAAGCCAA
GGGGTGGCGTCAACCGAGGACCAGGAGTGGAAATCACCCATTTGGGCTCTCAGAGCTAAGACAC
ACTTACTGATTTGGTTGCACATTTTGCACTGGTTTATGGCGATTGTTTTCTTGGACGAATGGTG
TAAAATAAACTTCTCTGTTCTGTATCCTCCCTCAAA

hide sequence

RefSeq Acc Id:

XM_039106001 ⟹ XP_038961929

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	153,046,987 - 153,504,497 (+)	NCBI
mRatBN7.2	3	132,593,668 - 133,049,651 (+)	NCBI

RefSeq Acc Id:

XM_063284741 ⟹ XP_063140811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	153,046,987 - 153,504,497 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445957	(Get FASTA)	NCBI Sequence Viewer
	XP_038961929	(Get FASTA)	NCBI Sequence Viewer
	XP_063140811	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG32680	(Get FASTA)	NCBI Sequence Viewer
	EDL95148	(Get FASTA)	NCBI Sequence Viewer
	EDL95149	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071351.2
	ENSRNOP00000093366.1
GenBank Protein	Q9EPQ0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445957 ⟸ NM_053505

- UniProtKB:

Q9EPQ0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPPPGDQDRARRRSRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLIGEDRKWMVGR
KLMQVNDTLTSEDAGLRSSKNCTEPALHEFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCD
DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILC
IIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKY
NACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPH
QLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGT
GPSSAPDRGVNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPYTPFDPPSGKLETVK
WAFTWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMG
ITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLN
SRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMTEFNVFTFVNLPMC
GD

hide sequence

Ensembl Acc Id:

ENSRNOP00000071351 ⟸ ENSRNOT00000089098

RefSeq Acc Id:	XP_038961929 ⟸ XM_039106001
- Peptide Label:	isoform X2
- UniProtKB:	Q9EPQ0 (UniProtKB/Swiss-Prot), A6K770 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000093366 ⟸ ENSRNOT00000115668

RefSeq Acc Id:	XP_063140811 ⟸ XM_063284741
- Peptide Label:	isoform X1
- UniProtKB:	Q9EPQ0 (UniProtKB/Swiss-Prot)

Protein Domains

Sodium/calcium exchanger membrane region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9EPQ0-F1-model_v2	AlphaFold	Q9EPQ0	1-624	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69256	AgrOrtholog
BioCyc Gene	G2FUF-47590	BioCyc
Ensembl Genes	ENSRNOG00000060687	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000089098.2	UniProtKB/TrEMBL
	ENSRNOT00000115668.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1420.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	K/Na/Ca-exchanger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NaCa_Exmemb	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NCX_ion-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:85267	UniProtKB/Swiss-Prot
NCBI Gene	85267	ENTREZGENE
PANTHER	PTHR10846	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SODIUM/POTASSIUM/CALCIUM EXCHANGER 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Na_Ca_ex	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc24a3	PhenoGen
RatGTEx	ENSRNOG00000060687	RatGTEx
UniProt	A0A0G2K092_RAT	UniProtKB/TrEMBL
	A0A8I6AJI6_RAT	UniProtKB/TrEMBL
	A6K770	ENTREZGENE, UniProtKB/TrEMBL
	A6K771_RAT	UniProtKB/TrEMBL
	NCKX3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Slc24a3	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3		solute carrier family 24, member 3	Name updated	1299863	APPROVED
2002-06-10	Slc24a3	solute carrier family 24, member 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA highly expressed in brain, especially in thalamic nuclei, hippocampal CA1 neurons, and in layer IV of the cerebral cortex	68852
gene_process	transports one calcium and one potassium in exchange for four sodium ions	68852
gene_protein	predicted protein contains 644 aa residues	68852

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations