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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16004972 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
increases export multiple interactions |
ISO |
ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16156793 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions |
ISO |
ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride] [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] |
CTD |
PMID:25865432 PMID:34896433 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions increases transport |
ISO |
abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] |
CTD |
PMID:25865432 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases abundance decreases export decreases activity multiple interactions increases export increases transport |
ISO |
ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; [bisphenol A results in decreased activity of ABCG2 protein] which results in decreased transport of bisbenzimide ethoxide trihydrochloride; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of bisbenzimide ethoxide trihydrochloride; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] |
CTD |
PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 PMID:27475308 PMID:34073890 PMID:34717915 PMID:34896433 More...
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases export |
ISO |
KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride |
CTD |
PMID:25841332 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride |
CTD |
PMID:19239227 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport multiple interactions increases export increases transport |
EXP ISO |
ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein 4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog] ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog [ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein] |
CTD |
PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 PMID:24909372 PMID:24973091 PMID:25862123 PMID:27450509 PMID:31348918 More...
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions increases transport |
EXP ISO |
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] |
CTD |
PMID:24907646 PMID:31348918 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions increases uptake increases transport |
ISO |
Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] ABCC5 protein results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein |
CTD |
PMID:31348918 PMID:35066093 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions increases transport |
ISO |
quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] |
CTD |
PMID:21244849 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] |
CTD |
PMID:16049127 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases response to substance |
ISO |
BAX protein results in increased susceptibility to Acridine Orange |
CTD |
PMID:16177561 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
[Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA |
CTD |
PMID:16814760 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Acridine Orange results in increased stability of and results in increased activity of TP53 protein |
CTD |
PMID:16177561 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases response to substance |
ISO |
BAX protein results in increased susceptibility to Acridine Orange |
CTD |
PMID:16177561 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
[Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA |
CTD |
PMID:16814760 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Acridine Orange results in increased stability of and results in increased activity of TP53 protein |
CTD |
PMID:16177561 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions increases expression |
ISO |
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein] Benzophenoneidum results in increased expression of ALDH1A1 protein |
CTD |
PMID:28722353 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Ano6 |
anoctamin 6 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of ANO6 protein |
CTD |
PMID:28722353 |
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NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
Benzophenoneidum results in increased expression of ARAF protein |
CTD |
PMID:28722353 |
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NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Atp6ap2 |
ATPase H+ transporting accessory protein 2 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of ATP6AP2 protein |
CTD |
PMID:28722353 |
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NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
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G |
Ccdc22 |
coiled-coil domain containing 22 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of CCDC22 protein |
CTD |
PMID:28722353 |
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NCBI chr X:14,898,296...14,910,244
Ensembl chr X:14,898,296...14,910,244
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G |
Ccdc39 |
coiled-coil domain 39 molecular ruler complex subunit |
increases expression |
ISO |
Benzophenoneidum results in increased expression of CCDC39 protein |
CTD |
PMID:28722353 |
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NCBI chr 2:116,665,651...116,703,354
Ensembl chr 2:116,665,261...116,703,350
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G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Benzophenoneidum results in increased expression of CD44 protein |
CTD |
PMID:28722353 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Chtf18 |
chromosome transmission fidelity factor 18 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of CHTF18 protein |
CTD |
PMID:28722353 |
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NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050
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G |
Commd1 |
copper metabolism domain containing 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of COMMD1 protein |
CTD |
PMID:28722353 |
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NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
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G |
Cops7b |
COP9 signalosome subunit 7B |
increases expression |
ISO |
Benzophenoneidum results in increased expression of COPS7B protein |
CTD |
PMID:28722353 |
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NCBI chr 9:87,238,132...87,263,967
Ensembl chr 9:87,238,375...87,263,967
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G |
Cul3 |
cullin 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of CUL3 protein |
CTD |
PMID:28722353 |
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NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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G |
Dynlt1 |
dynein light chain Tctex-type 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of DYNLT1 protein |
CTD |
PMID:28722353 |
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NCBI chr 1:46,887,017...46,893,956
Ensembl chr 1:46,887,017...46,893,881
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G |
Eif4g3 |
eukaryotic translation initiation factor 4 gamma, 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of EIF4G3 protein |
CTD |
PMID:28722353 |
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NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363
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G |
Fastkd2 |
FAST kinase domains 2 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of FASTKD2 protein |
CTD |
PMID:28722353 |
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NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation |
EXP |
Benzophenoneidum results in increased phosphorylation of H2AX protein |
CTD |
PMID:37527026 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hook3 |
hook microtubule-tethering protein 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of HOOK3 protein |
CTD |
PMID:28722353 |
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NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of HSD17B7 protein |
CTD |
PMID:28722353 |
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NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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G |
Htt |
huntingtin |
increases expression |
ISO |
Benzophenoneidum results in increased expression of HTT protein |
CTD |
PMID:28722353 |
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NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070
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G |
Iqgap3 |
IQ motif containing GTPase activating protein 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of IQGAP3 protein |
CTD |
PMID:28722353 |
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NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956
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G |
Kifap3 |
kinesin-associated protein 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of KIFAP3 protein |
CTD |
PMID:28722353 |
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NCBI chr13:76,127,702...76,264,654
Ensembl chr13:76,127,696...76,264,650
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein |
CTD |
PMID:28722353 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of MAP2K4 protein |
CTD |
PMID:28722353 |
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NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Mbd3 |
methyl-CpG binding domain protein 3 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of MBD3 protein |
CTD |
PMID:28722353 |
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NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
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G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
EXP |
Benzophenoneidum results in increased expression of MKI67 protein |
CTD |
PMID:37527026 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Noa1 |
nitric oxide associated 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of NOA1 protein |
CTD |
PMID:28722353 |
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NCBI chr14:30,835,264...30,851,294
Ensembl chr14:30,835,247...30,851,293
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G |
Nup62 |
nucleoporin 62 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of NUP62 protein |
CTD |
PMID:28722353 |
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NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
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G |
Plcg1 |
phospholipase C, gamma 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of PLCG1 protein |
CTD |
PMID:28722353 |
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NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Ppp4r1 |
protein phosphatase 4, regulatory subunit 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of PPP4R1 protein |
CTD |
PMID:28722353 |
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NCBI chr 9:105,391,271...105,450,626
Ensembl chr 9:105,391,412...105,450,633
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Prim2 |
DNA primase subunit 2 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of PRIM2 protein |
CTD |
PMID:28722353 |
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NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
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Prom1 |
prominin 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of PROM1 protein |
CTD |
PMID:28722353 |
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NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
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Prorp |
protein only RNase P catalytic subunit |
increases expression |
ISO |
Benzophenoneidum results in increased expression of PRORP protein |
CTD |
PMID:28722353 |
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NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416
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Shmt1 |
serine hydroxymethyltransferase 1 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of SHMT1 protein |
CTD |
PMID:28722353 |
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NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820
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Srsf11 |
serine and arginine rich splicing factor 11 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of SRSF11 protein |
CTD |
PMID:28722353 |
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NCBI chr 2:247,074,623...247,101,460
Ensembl chr 2:247,074,631...247,101,425
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Tbc1d15 |
TBC1 domain family, member 15 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of TBC1D15 protein |
CTD |
PMID:28722353 |
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NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175
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Tfam |
transcription factor A, mitochondrial |
increases expression |
ISO |
Benzophenoneidum results in increased expression of TFAM protein |
CTD |
PMID:28722353 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Usp24 |
ubiquitin specific peptidase 24 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of USP24 protein |
CTD |
PMID:28722353 |
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NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311
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Washc5 |
WASH complex subunit 5 |
increases expression |
ISO |
Benzophenoneidum results in increased expression of WASHC5 protein |
CTD |
PMID:28722353 |
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NCBI chr 7:90,884,192...90,936,096
Ensembl chr 7:90,884,197...90,936,103
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Lig1 |
DNA ligase 1 |
decreases activity |
ISO |
Aurintricarboxylic Acid results in decreased activity of LIG1 protein |
CTD |
PMID:15134906 |
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NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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Ogg1 |
8-oxoguanine DNA glycosylase |
decreases activity |
ISO |
Aurintricarboxylic Acid results in decreased activity of OGG1 protein |
CTD |
PMID:26218629 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Gpt |
glutamic--pyruvic transaminase |
increases activity |
EXP |
Azure A results in increased activity of GPT protein |
CTD |
PMID:33775737 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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App |
amyloid beta precursor protein |
multiple interactions |
ISO |
[Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein |
CTD |
PMID:30500345 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Bace1 |
beta-secretase 1 |
decreases activity |
ISO |
Azure B results in decreased activity of BACE1 protein |
CTD |
PMID:30500345 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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Casp3 |
caspase 3 |
multiple interactions |
ISO |
brilliant green results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:26177467 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7 |
caspase 7 |
multiple interactions |
ISO |
brilliant green results in increased cleavage of and results in increased activity of CASP7 protein |
CTD |
PMID:26177467 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
brilliant green results in decreased expression of CCND1 protein |
CTD |
PMID:26177467 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
decreases expression |
ISO |
brilliant green results in decreased expression of IKBKE protein |
CTD |
PMID:26177467 |
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NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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Lonp1 |
lon peptidase 1, mitochondrial |
increases expression |
ISO |
brilliant green results in increased expression of LONP1 mRNA |
CTD |
PMID:21215310 |
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NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Txn1 |
thioredoxin 1 |
increases oxidation |
ISO |
brilliant green results in increased oxidation of TXN protein |
CTD |
PMID:21215310 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txn2 |
thioredoxin 2 |
decreases expression affects response to substance multiple interactions |
ISO |
brilliant green results in decreased expression of TXN2 protein TXN2 protein affects the susceptibility to brilliant green brilliant green results in increased oxidation of and results in increased degradation of TXN2 protein |
CTD |
PMID:21215310 |
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NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases export multiple interactions increases secretion |
ISO |
ABCB1 protein results in increased export of fluorexon Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon] [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon] |
CTD |
PMID:10571255 PMID:12235267 PMID:16442095 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export increases export increases import affects transport multiple interactions |
ISO |
ABCC1 protein affects the export of fluorexon ABCC1 protein results in increased export of fluorexon ABCC1 protein results in increased import of fluorexon ABCC1 protein affects the transport of fluorexon [Glycyrrhetinic Acid affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [Indomethacin affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [matairesinol affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; [verlukast affects the activity of ABCC1 protein] which results in increased abundance of fluorexon; Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon] |
CTD |
PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18204840 PMID:18955043 PMID:26454883 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export increases abundance multiple interactions affects transport |
ISO |
ABCC2 protein affects the export of fluorexon ABCC2 protein alternative form results in increased abundance of fluorexon robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon] ABCC2 protein affects the transport of fluorexon |
CTD |
PMID:15670588 PMID:15848949 PMID:22027652 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc6 |
ATP binding cassette subfamily C member 6 |
affects transport |
ISO |
ABCC6 affects the transport of fluorexon |
CTD |
PMID:14667841 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abcb11 |
ATP binding cassette subfamily B member 11 |
affects export multiple interactions |
ISO |
ABCB11 protein affects the export of calcein AM ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM] |
CTD |
PMID:10617675 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a |
ATP binding cassette subfamily B member 1A |
affects export increases export multiple interactions increases activity increases transport increases secretion |
ISO EXP |
ABCB1 protein affects the export of calcein AM ABCB1 protein results in increased export of calcein AM ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM] 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]] calcein AM results in increased activity of ABCB1 protein mutant form |
CTD |
PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 PMID:19549930 PMID:21321059 PMID:21783720 PMID:29174985 PMID:30217652 PMID:37259354 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases transport multiple interactions |
ISO |
ABCC1 protein results in increased transport of calcein AM [ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MLN 8237 results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [verlukast results in decreased activity of ABCC1 protein] which results in decreased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM] |
CTD |
PMID:19239227 PMID:19647055 PMID:27376922 PMID:34896433 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects transport multiple interactions increases transport increases export |
ISO EXP |
ABCC2 protein affects the transport of calcein AM Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM] [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM] |
CTD |
PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3 |
ATP binding cassette subfamily C member 3 |
affects transport multiple interactions increases transport |
ISO |
ABCC3 protein affects the transport of calcein AM Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM] |
CTD |
PMID:15210835 PMID:15979871 PMID:19647055 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc6 |
ATP binding cassette subfamily C member 6 |
multiple interactions |
ISO |
Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] |
CTD |
PMID:15210835 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM |
CTD |
PMID:19239227 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
multiple interactions increases uptake |
ISO |
Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] |
CTD |
PMID:30863990 |
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Akap9 |
A-kinase anchoring protein 9 |
increases expression |
ISO |
4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA |
CTD |
PMID:19502547 |
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NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
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G |
Ankrd37 |
ankyrin repeat domain 37 |
increases expression |
ISO |
4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA |
CTD |
PMID:19502547 |
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NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
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Ar |
androgen receptor |
multiple interactions affects localization |
ISO |
4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein 4-methyl-7-diethylaminocoumarin affects the localization of AR protein |
CTD |
PMID:28478275 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases activity |
ISO |
4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein |
CTD |
PMID:19502547 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Pfkm |
phosphofructokinase, muscle |
increases expression |
ISO |
4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA |
CTD |
PMID:19502547 |
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NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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G |
Psph |
phosphoserine phosphatase |
increases expression |
ISO |
4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA |
CTD |
PMID:19502547 |
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NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
4-methyl-7-diethylaminocoumarin affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein |
CTD |
PMID:19502547 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Asic5 |
acid sensing ion channel subunit family member 5 |
decreases activity |
ISO |
DAPI results in decreased activity of ASIC5 protein |
CTD |
PMID:21828194 |
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NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Dithiazanine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Eosine Yellowish-(YS) inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] |
CTD |
PMID:15897899 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] |
CTD |
PMID:15897899 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] |
CTD |
PMID:15897899 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccne2 |
cyclin E2 |
multiple interactions |
ISO |
Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] |
CTD |
PMID:15897899 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cd59b |
CD59b molecule |
increases mutagenesis |
ISO |
Ethidium results in increased mutagenesis of CD59 protein |
CTD |
PMID:17045307 |
|
NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
multiple interactions |
ISO |
[Pyruvic Acid co-treated with Uridine co-treated with Ethidium] inhibits the reaction [Rotenone inhibits the reaction [arsenite results in increased expression of ERO1A protein]] |
CTD |
PMID:37659621 |
|
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Gja1 |
gap junction protein, alpha 1 |
increases uptake |
EXP |
GJA1 protein results in increased uptake of Ethidium |
CTD |
PMID:26926986 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] |
CTD |
PMID:8875956 PMID:10571731 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
decreases expression |
ISO |
Ethidium results in decreased expression of COX1 protein |
CTD |
PMID:18823003 |
|
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G |
Mt-co2 |
mitochondrially encoded cytochrome c oxidase II |
decreases expression |
ISO |
Ethidium results in decreased expression of COX2 mRNA |
CTD |
PMID:22712077 |
|
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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G |
Mt-cyb |
mitochondrially encoded cytochrome b |
decreases expression |
ISO |
Ethidium results in decreased expression of CYTB mRNA |
CTD |
PMID:22712077 |
|
NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
decreases expression |
ISO |
Ethidium results in decreased expression of ND1 mRNA |
CTD |
PMID:22712077 |
|
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G |
Mt-nd4 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 |
decreases expression |
ISO |
Ethidium results in decreased expression of ND4 mRNA |
CTD |
PMID:22712077 |
|
NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
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G |
Nrf1 |
nuclear respiratory factor 1 |
increases expression |
ISO |
Ethidium results in increased expression of NRF1 mRNA |
CTD |
PMID:22712077 |
|
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
P2rx7 |
purinergic receptor P2X 7 |
decreases transport increases transport |
ISO |
P2RX7 gene polymorphism results in decreased transport of Ethidium P2RX7 protein results in increased transport of Ethidium |
CTD |
PMID:16263709 |
|
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Ethidium inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RELA protein] |
CTD |
PMID:35032610 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions increases uptake affects uptake |
ISO |
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium] SLC22A1 protein affects the uptake of Ethidium |
CTD |
PMID:19357179 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
affects uptake multiple interactions increases uptake |
ISO |
SLC22A2 protein affects the uptake of Ethidium 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium] |
CTD |
PMID:19357179 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
increases uptake multiple interactions |
ISO |
SLC22A3 protein results in increased uptake of Ethidium 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium] |
CTD |
PMID:19357179 |
|
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Sting1 |
stimulator of interferon response cGAMP interactor 1 |
multiple interactions |
ISO |
Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of STING1 protein] |
CTD |
PMID:35032610 |
|
NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335
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G |
Tfam |
transcription factor A, mitochondrial |
increases expression |
ISO |
Ethidium results in increased expression of TFAM mRNA |
CTD |
PMID:22712077 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Ethidium inhibits the reaction [cyanoginosin LR results in increased expression of TNF mRNA] |
CTD |
PMID:35032610 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
Ethidium affects the activity of TP53 protein |
CTD |
PMID:35435491 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Fast Green FCF inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
|
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects export |
ISO |
ABCC1 protein affects the export of Fluo-3 |
CTD |
PMID:15948026 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases secretion |
EXP |
Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] |
CTD |
PMID:9794919 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcb7 |
ATP binding cassette subfamily B member 7 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ABCB7 protein |
CTD |
PMID:27129696 |
|
NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Anxa4 |
annexin A4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ANXA4 protein |
CTD |
PMID:27129696 |
|
NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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G |
Arhgap6 |
Rho GTPase activating protein 6 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ARHGAP6 protein |
CTD |
PMID:27129696 |
|
NCBI chr X:24,953,464...25,490,003
Ensembl chr X:24,953,464...25,488,663
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G |
Azi2 |
5-azacytidine induced 2 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to AZI2 protein |
CTD |
PMID:27129696 |
|
NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847
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G |
Capzb |
capping actin protein of muscle Z-line subunit beta |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CAPZB protein |
CTD |
PMID:27129696 |
|
NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
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G |
Cd109 |
CD109 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD109 protein |
CTD |
PMID:27129696 |
|
NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194
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G |
Cd180 |
CD180 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD180 protein |
CTD |
PMID:27129696 |
|
NCBI chr 2:33,855,940...33,870,046
Ensembl chr 2:33,855,991...33,899,936
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G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of CD86 protein |
CTD |
PMID:19665512 |
|
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cd93 |
CD93 molecule |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CD93 protein |
CTD |
PMID:27129696 |
|
NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378
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G |
Cdc20 |
cell division cycle 20 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to CDC20 protein |
CTD |
PMID:27129696 |
|
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Copa |
COPI coat complex subunit alpha |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to COPA protein |
CTD |
PMID:27129696 |
|
NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dcaf4 |
DDB1 and CUL4 associated factor 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to DCAF4 protein |
CTD |
PMID:27129696 |
|
NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982
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G |
Dot1l |
DOT1 like histone lysine methyltransferase |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to DOT1L protein |
CTD |
PMID:27129696 |
|
NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475
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G |
Elac1 |
elaC ribonuclease Z 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ELAC1 protein |
CTD |
PMID:27129696 |
|
NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
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G |
Enpp7 |
ectonucleotide pyrophosphatase/phosphodiesterase 7 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to ENPP7 protein |
CTD |
PMID:27129696 |
|
NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589
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G |
Flrt3 |
fibronectin leucine rich transmembrane protein 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to FLRT3 protein |
CTD |
PMID:27129696 |
|
NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841
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G |
Fn1 |
fibronectin 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to FN1 protein |
CTD |
PMID:27129696 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein |
CTD |
PMID:27871981 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to HSPA5 protein |
CTD |
PMID:27129696 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to HSPA9 protein |
CTD |
PMID:27129696 |
|
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein |
CTD |
PMID:29198882 PMID:36870414 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IKBKB protein |
CTD |
PMID:27129696 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikzf4 |
IKAROS family zinc finger 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IKZF4 protein |
CTD |
PMID:27129696 |
|
NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein |
CTD |
PMID:36870414 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17re |
interleukin 17 receptor E |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IL17RE protein |
CTD |
PMID:27129696 |
|
NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206
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G |
Il31ra |
interleukin 31 receptor A |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to IL31RA protein |
CTD |
PMID:27129696 |
|
NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767
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G |
Il4 |
interleukin 4 |
multiple interactions increases expression |
ISO |
[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] |
CTD |
PMID:27871981 PMID:29198882 PMID:36870414 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Lypd3 |
Ly6/Plaur domain containing 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to LYPD3 protein |
CTD |
PMID:27129696 |
|
NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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G |
Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to MAP3K20 protein |
CTD |
PMID:27129696 |
|
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:27129696 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:27129696 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:27129696 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
ISO |
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27129696 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mt2A |
metallothionein 2A |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA |
CTD |
PMID:20491607 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mybpc1 |
myosin binding protein C1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to MYBPC1 protein |
CTD |
PMID:27129696 |
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NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein |
CTD |
PMID:27871981 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]] |
CTD |
PMID:20491607 PMID:27871981 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Plce1 |
phospholipase C, epsilon 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PLCE1 protein |
CTD |
PMID:27129696 |
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NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
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G |
Postn |
periostin |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to POSTN protein |
CTD |
PMID:27129696 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Pprc1 |
PPARG related coactivator 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PPRC1 protein |
CTD |
PMID:27129696 |
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NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
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G |
Prkcb |
protein kinase C, beta |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein |
CTD |
PMID:31958493 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Psd4 |
pleckstrin and Sec7 domain containing 4 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PSD4 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571
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G |
Psmd14 |
proteasome 26S subunit, non-ATPase 14 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to PSMD14 protein |
CTD |
PMID:27129696 |
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NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] |
CTD |
PMID:27871981 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Scn5a |
sodium voltage-gated channel alpha subunit 5 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SCN5A protein |
CTD |
PMID:27129696 |
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NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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G |
Skor1 |
SKI family transcriptional corepressor 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SKOR1 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:63,599,153...63,609,727
Ensembl chr 8:63,599,165...63,607,756
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions increases uptake |
ISO |
Taurocholic Acid promotes the reaction [SLC10A1 protein results in increased uptake of Fluorescein-5-isothiocyanate] |
CTD |
PMID:32209977 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc38a10 |
solute carrier family 38, member 10 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to SLC38A10 protein |
CTD |
PMID:27129696 |
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NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions increases phosphorylation |
ISO |
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]] |
CTD |
PMID:27871981 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat5a |
signal transducer and activator of transcription 5A |
multiple interactions increases phosphorylation |
ISO |
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] |
CTD |
PMID:27871981 |
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NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Stat6 |
signal transducer and activator of transcription 6 |
increases phosphorylation multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] |
CTD |
PMID:27871981 |
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NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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G |
Trpa1 |
transient receptor potential cation channel, subfamily A, member 1 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to TRPA1 protein |
CTD |
PMID:27129696 |
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NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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G |
Tslp |
thymic stromal lymphopoietin |
increases expression multiple interactions |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of TSLP protein diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] |
CTD |
PMID:27871981 |
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NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Txn1 |
thioredoxin 1 |
increases expression |
ISO |
Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA |
CTD |
PMID:20491607 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Usp3 |
ubiquitin specific peptidase 3 |
affects binding |
ISO |
Fluorescein-5-isothiocyanate binds to USP3 protein |
CTD |
PMID:27129696 |
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NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:35901927 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]] |
CTD |
PMID:35901927 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2 protein] |
CTD |
PMID:35901927 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2L1 protein] |
CTD |
PMID:35901927 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Cat |
catalase |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of CAT protein] |
CTD |
PMID:35901927 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of GPX1 protein] |
CTD |
PMID:35901927 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:35901927 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
gallein inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:35901927 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] |
CTD |
PMID:27160165 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases uptake increases transport |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] |
CTD |
PMID:31348918 PMID:32305507 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
malachite green results in decreased activity of BCHE protein |
CTD |
PMID:16036213 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Ccnb1 |
cyclin B1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein |
CTD |
PMID:12616621 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] |
CTD |
PMID:10906429 PMID:12616621 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
EXP |
malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] |
CTD |
PMID:10906429 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein |
CTD |
PMID:12616621 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein |
CTD |
PMID:12616621 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Kcna3 |
potassium voltage-gated channel subfamily A member 3 |
decreases activity multiple interactions |
ISO |
malachite green results in decreased activity of KCNA3 protein [malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium |
CTD |
PMID:21362439 |
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NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity multiple interactions |
ISO |
malachite green results in decreased activity of KCNH2 protein [malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium |
CTD |
PMID:21362439 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Khnyn |
KH and NYN domain containing |
affects response to substance |
ISO |
KHNYN gene SNP affects the susceptibility to malachite green |
CTD |
PMID:25622337 |
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NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] |
CTD |
PMID:10906429 PMID:11831363 PMID:12616621 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Rnf150 |
ring finger protein 150 |
affects response to substance |
ISO |
RNF150 gene SNP affects the susceptibility to malachite green |
CTD |
PMID:25622337 |
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NCBI chr19:25,006,978...25,229,273
Ensembl chr19:25,006,611...25,228,678
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G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
Merbromin results in decreased activity of CA2 protein |
CTD |
PMID:16858005 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Merbromin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
Methylene Blue results in decreased activity of ACHE protein |
CTD |
PMID:33844597 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] |
CTD |
PMID:31173149 |
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NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] |
CTD |
PMID:31428839 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] |
CTD |
PMID:31428839 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] |
CTD |
PMID:31173149 |
|
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] |
CTD |
PMID:11919648 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
ISO |
Methylene Blue results in increased activity of G6PD protein |
CTD |
PMID:1901343 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] |
CTD |
PMID:24556215 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA |
CTD |
PMID:24556215 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] |
CTD |
PMID:24556215 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Glrx |
glutaredoxin |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA |
CTD |
PMID:24556215 |
|
NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680
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G |
Glrx2 |
glutaredoxin 2 |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA |
CTD |
PMID:24556215 |
|
NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] |
CTD |
PMID:17290048 |
|
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA] Methylene Blue results in increased expression of HMOX1 protein |
CTD |
PMID:24556215 PMID:25943564 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] |
CTD |
PMID:31428839 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Il17a |
interleukin 17A |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] |
CTD |
PMID:31428839 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] |
CTD |
PMID:31428839 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
|
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Maob |
monoamine oxidase B |
multiple interactions decreases activity |
ISO |
Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] Methylene Blue results in decreased activity of MAOB protein |
CTD |
PMID:21554916 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Mapt |
microtubule-associated protein tau |
decreases expression multiple interactions decreases phosphorylation increases expression |
ISO |
Methylene Blue results in decreased expression of MAPT protein [Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] Methylene Blue results in decreased phosphorylation of MAPT protein modified form Methylene Blue results in increased expression of MAPT mRNA |
CTD |
PMID:16930453 PMID:24556215 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] |
CTD |
PMID:25943564 PMID:31428839 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO EXP |
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:24556215 PMID:31428839 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA] Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein] |
CTD |
PMID:24556215 PMID:31428839 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] |
CTD |
PMID:24556215 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pgd |
phosphogluconate dehydrogenase |
increases activity |
ISO |
Methylene Blue results in increased activity of PGD protein |
CTD |
PMID:1901343 |
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NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Prdx6 |
peroxiredoxin 6 |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA |
CTD |
PMID:24556215 |
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NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO |
Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] |
CTD |
PMID:31173149 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions increases activity |
ISO |
oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] |
CTD |
PMID:19686715 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] |
CTD |
PMID:11744139 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
Methylene Blue affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
ISO |
Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] |
CTD |
PMID:24556215 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Txn2 |
thioredoxin 2 |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA |
CTD |
PMID:24556215 |
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NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
ISO |
Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] |
CTD |
PMID:24556215 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Txnrd2 |
thioredoxin reductase 2 |
multiple interactions |
ISO |
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA |
CTD |
PMID:24556215 |
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NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases export multiple interactions |
ISO |
ABCB1 protein results in increased export of mitotracker green FM LCL161 inhibits the reaction [ABCB1 protein results in increased export of mitotracker green FM] |
CTD |
PMID:32497533 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Gstp1 |
glutathione S-transferase pi 1 |
affects metabolic processing |
ISO |
GSTP1 protein affects the metabolism of monobromobimane |
CTD |
PMID:15355982 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
monodansylcadaverine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:16170020 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
decreases expression |
ISO |
monodansylcadaverine results in decreased expression of BAD protein |
CTD |
PMID:16170020 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
monodansylcadaverine results in increased expression of BCL2L11 protein |
CTD |
PMID:16170020 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
monodansylcadaverine results in decreased expression of BIRC5 protein |
CTD |
PMID:16170020 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Ccl25 |
C-C motif chemokine ligand 25 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] |
CTD |
PMID:22341560 |
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NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] |
CTD |
PMID:22341560 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] |
CTD |
PMID:22341560 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
ISO |
monodansylcadaverine results in decreased expression of GSK3B protein |
CTD |
PMID:16170020 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]; monodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:20733350 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
monodansylcadaverine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL12B protein] |
CTD |
PMID:22341560 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein] |
CTD |
PMID:22341560 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il3 |
interleukin 3 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] |
CTD |
PMID:22341560 |
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NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] |
CTD |
PMID:22341560 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] |
CTD |
PMID:22341560 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein] |
CTD |
PMID:22341560 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22341560 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22341560 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:22341560 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein] |
CTD |
PMID:22341560 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Tgm2 |
transglutaminase 2 |
decreases activity |
ISO |
monodansylcadaverine results in decreased activity of TGM2 protein |
CTD |
PMID:16382148 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Ticam2 |
TIR domain containing adaptor molecule 2 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] |
CTD |
PMID:22341560 |
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NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein] |
CTD |
PMID:22341560 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp4 |
TIMP metallopeptidase inhibitor 4 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP4 protein] |
CTD |
PMID:22341560 |
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NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] |
CTD |
PMID:22341560 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] |
CTD |
PMID:22341560 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Zfp143 |
zinc finger protein 143 |
multiple interactions |
ISO |
monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein] |
CTD |
PMID:20733350 |
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NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
pararosaniline results in decreased activity of BCHE protein |
CTD |
PMID:16036213 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
decreases expression decreases activity |
ISO |
pararosaniline results in decreased expression of NR3C1 protein pararosaniline results in decreased activity of NR3C1 protein |
CTD |
PMID:19255438 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO |
Propidium binds to and results in decreased activity of ACHE protein; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein] Propidium results in decreased activity of ACHE protein |
CTD |
PMID:10421444 PMID:25522658 PMID:27238725 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Bche |
butyrylcholinesterase |
decreases activity |
ISO |
Propidium results in decreased activity of BCHE protein |
CTD |
PMID:31173753 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
Propidium results in decreased expression of CCL2 protein |
CTD |
PMID:20116850 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
decreases expression |
ISO |
Propidium results in decreased expression of CCL3 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
decreases expression |
ISO |
Propidium results in decreased expression of CCL4 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
Propidium results in decreased expression of CCL5 protein |
CTD |
PMID:20116850 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Il6r |
interleukin 6 receptor |
decreases expression |
ISO |
Propidium results in decreased expression of IL6R protein modified form |
CTD |
PMID:20116850 |
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NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Propidium results in decreased expression of VEGFA protein |
CTD |
PMID:20116850 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases uptake increases export |
ISO EXP |
3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5,7-dimethoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5,7-dimethoxyflavone inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 5-hydroxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-methoxyflavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; [zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of Rhodamine 123; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; betulin inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; biochanin A inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; biochanin A promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; daidzein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; flavone inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; formononetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; glycitein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; kaempferol inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Quercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Quercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; quercitrin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; tangeretin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; tangeretin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] [P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of Rhodamine 123; [Verapamil results in decreased activity of ABCB1 protein] inhibits the reaction [P-glycoprotein inducer and activator TX5 results in increased export of Rhodamine 123] |
CTD |
PMID:25058526 PMID:27816545 PMID:30391378 PMID:31756430 PMID:33321149 PMID:34217736 PMID:34896433 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions increases export |
ISO |
abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123] |
CTD |
PMID:27816545 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
rhodamine 6G results in decreased activity of ACHE protein |
CTD |
PMID:33844597 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity |
ISO |
Rose Bengal results in decreased activity of ABCB1 protein |
CTD |
PMID:20041016 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
EXP |
Rose Bengal results in decreased activity of CYP19A1 protein |
CTD |
PMID:18310892 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of CYP3A4 protein |
CTD |
PMID:20041016 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
decreases response to substance |
EXP |
GSTA3 protein results in decreased susceptibility to Rose Bengal |
CTD |
PMID:1740415 |
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NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Iyd |
iodotyrosine deiodinase |
decreases activity |
ISO |
Rose Bengal results in decreased activity of IYD protein |
CTD |
PMID:24012475 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Klkb1 |
kallikrein B1 |
multiple interactions decreases response to substance |
ISO |
7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] |
CTD |
PMID:25339356 |
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NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases activity |
ISO |
Rose Bengal results in decreased activity of UGT1A6 protein |
CTD |
PMID:20041016 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Direct Red 81 inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Ahr |
aryl hydrocarbon receptor |
affects localization multiple interactions |
ISO EXP |
sudan III affects the localization of AHR protein [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein |
CTD |
PMID:15585952 PMID:15788368 PMID:22287322 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] |
CTD |
PMID:22287322 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression increases activity multiple interactions |
ISO EXP |
sudan III results in increased expression of CYP1A1 mRNA sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein sudan III results in increased activity of CYP1A1 protein [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:18418879 PMID:20308224 PMID:22287322 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
sudan III results in increased expression of CYP1A2 protein |
CTD |
PMID:20308224 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
EXP |
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein sudan III results in decreased expression of CYP2B1 mRNA |
CTD |
PMID:15788368 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
multiple interactions decreases expression |
EXP |
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein sudan III results in decreased expression of CYP2B2 mRNA |
CTD |
PMID:15788368 |
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NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases expression |
EXP |
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein sudan III results in decreased expression of CYP2C11 mRNA |
CTD |
PMID:15788368 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases expression |
EXP |
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein sudan III results in decreased expression of CYP3A2 mRNA |
CTD |
PMID:15788368 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions decreases expression |
EXP |
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein sudan III results in decreased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:15788368 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
decreases expression |
EXP |
sudan III results in decreased expression of CYP4A1 mRNA |
CTD |
PMID:15585952 |
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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G |
Cyp4a2 |
cytochrome P450, family 4, subfamily a, polypeptide 2 |
decreases expression |
EXP |
sudan III results in decreased expression of CYP4A2 mRNA |
CTD |
PMID:15585952 |
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NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
decreases expression |
EXP |
sudan III results in decreased expression of CYP4A3 mRNA |
CTD |
PMID:15585952 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
sudan III results in increased expression of NQO1 mRNA |
CTD |
PMID:20308224 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:22287322 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression multiple interactions |
ISO EXP |
sudan III results in decreased expression of PPARA protein sudan III results in decreased expression of PPARA mRNA [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein] |
CTD |
PMID:15585952 PMID:15788368 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Rxra |
retinoid X receptor alpha |
decreases expression |
ISO |
sudan III results in decreased expression of RXRA protein |
CTD |
PMID:15585952 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
EXP |
Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein |
CTD |
PMID:18418879 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases transport |
EXP |
ABCC2 protein results in increased transport of Texas red |
CTD |
PMID:32212926 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Ache |
acetylcholinesterase |
multiple interactions affects binding |
ISO |
[Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] |
CTD |
PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ache |
acetylcholinesterase |
decreases activity |
ISO |
Tolonium Chloride results in decreased activity of ACHE protein |
CTD |
PMID:33844597 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
App |
amyloid beta precursor protein |
decreases secretion |
ISO |
Tolonium Chloride results in decreased secretion of APP protein modified form |
CTD |
PMID:36027949 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bace1 |
beta-secretase 1 |
multiple interactions |
ISO |
Tolonium Chloride results in decreased expression of and results in decreased activity of BACE1 protein |
CTD |
PMID:36027949 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Cdk5 |
cyclin-dependent kinase 5 |
decreases expression |
ISO |
Tolonium Chloride results in decreased expression of CDK5 protein |
CTD |
PMID:36027949 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Tolonium Chloride results in decreased expression of FYN protein |
CTD |
PMID:36027949 |
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NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression increases phosphorylation |
ISO |
Tolonium Chloride results in decreased expression of GSK3B protein Tolonium Chloride results in increased phosphorylation of GSK3B protein |
CTD |
PMID:36027949 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Tolonium Chloride results in decreased expression of and results in decreased phosphorylation of MAPT protein |
CTD |
PMID:36027949 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
decreases phosphorylation |
ISO |
Tolonium Chloride results in decreased phosphorylation of PPP2CA protein |
CTD |
PMID:36027949 |
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NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Psen1 |
presenilin 1 |
decreases expression |
ISO |
Tolonium Chloride results in decreased expression of PSEN1 protein modified form |
CTD |
PMID:36027949 |
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NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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