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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridine orange free base
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Accession:CHEBI:87346 term browser browse the term
Definition:A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.
Synonyms:exact_synonym: N(3),N(3),N(6),N(6)-tetramethylacridine-3,6-diamine
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Di(dimethylamino)acridine;   Acridine Orange;   Acridine Orange Base;   Brilliant Acridine Orange E;   C.I. 46005B;   C.I. Solvent Orange 15;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14/h5-11H,1-4H3;   InChIKey=DPKHZNPWBDQZCN-UHFFFAOYSA-N;   N,N,N',N'-Tetramethyl-3,6-acridinediamine;   SMILES=CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   Solvent Orange 15
 xref: CAS:494-38-2
 xref_mesh: MESH:D000165
 xref: PMID:24988915;   PMID:25025314;   PMID:25542136;   PMID:26016416;   PMID:26034308;   PMID:26163789;   Reaxys:20916;   Wikipedia:Acridine_orange



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acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        dye 2973
          histological dye 255
            acridine orange free base 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteropolycyclic compound 18301
                                    organic heterotricyclic compound 15641
                                      dibenzopyridine 175
                                        acridines 138
                                          aminoacridines 17
                                            acridine orange free base 3
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