Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridine orange free base
go back to main search page
Accession:CHEBI:87346 term browser browse the term
Definition:A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.
Synonyms:exact_synonym: N(3),N(3),N(6),N(6)-tetramethylacridine-3,6-diamine
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Di(dimethylamino)acridine;   Acridine Orange;   Acridine Orange Base;   Brilliant Acridine Orange E;   C.I. 46005B;   C.I. Solvent Orange 15;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14/h5-11H,1-4H3;   InChIKey=DPKHZNPWBDQZCN-UHFFFAOYSA-N;   N,N,N',N'-Tetramethyl-3,6-acridinediamine;   SMILES=CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   Solvent Orange 15
 xref: CAS:494-38-2
 xref_mesh: MESH:D000165
 xref: PMID:24988915;   PMID:25025314;   PMID:25542136;   PMID:26016416;   PMID:26034308;   PMID:26163789;   Reaxys:20916;   Wikipedia:Acridine_orange


show annotations for term's descendants           Sort by:
 
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        dye 1296
          histological dye 149
            acridine orange free base 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterotricyclic compound 14571
                                      dibenzopyridine 154
                                        acridines 121
                                          aminoacridines 17
                                            acridine orange free base 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.