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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azure B
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Accession:CHEBI:87639 term browser browse the term
Definition:An organic chloride salt having 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium as the counterion. It is used in making azure eosin stains for blood smear staining and is an active metabolite of methylene blue.
Synonyms:exact_synonym: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride
 related_synonym: 3-(Dimethylamino)-7-(methylimino)-3H-phenothiazine hydrochloride;   3-Methylamino-7-dimethylaminophenzathonium chloride;   C.I. 52010;   Formula=C15H16ClN3S;   InChI=1S/C15H16N3S.ClH/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12;/h4-9,16H,1-3H3;1H/q+1;/p-1;   InChIKey=KFZNPGQYVZZSNV-UHFFFAOYSA-M;   SMILES=[Cl-].CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   Trimethylthionine chloride;   methylene azure B
 xref: CAS:531-55-5
 xref_mesh: MESH:C025819
 xref: PMID:24122875;   PMID:24161345;   PMID:24682678;   PMID:24953877;   PMID:25162947;   PMID:25445435;   PMID:25613051;   PMID:25965774;   PMID:26241827;   Reaxys:3922630



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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        dye 1366
          histological dye 246
            azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      halogen 18546
                        chlorine atom 18335
                          chlorine molecular entity 18309
                            elemental chlorine 8473
                              monoatomic chlorine 8447
                                chloride 8447
                                  chloride salt 8447
                                    organic chloride salt 930
                                      azure B 2
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