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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azure B
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Accession:CHEBI:87639 term browser browse the term
Definition:An organic chloride salt having 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium as the counterion. It is used in making azure eosin stains for blood smear staining and is an active metabolite of methylene blue.
Synonyms:exact_synonym: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride
 related_synonym: 3-(Dimethylamino)-7-(methylimino)-3H-phenothiazine hydrochloride;   3-Methylamino-7-dimethylaminophenzathonium chloride;   C.I. 52010;   Formula=C15H16ClN3S;   InChI=1S/C15H16N3S.ClH/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12;/h4-9,16H,1-3H3;1H/q+1;/p-1;   InChIKey=KFZNPGQYVZZSNV-UHFFFAOYSA-M;   SMILES=[Cl-].CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   Trimethylthionine chloride;   methylene azure B
 xref: CAS:531-55-5
 xref_mesh: MESH:C025819
 xref: PMID:24122875;   PMID:24161345;   PMID:24682678;   PMID:24953877;   PMID:25162947;   PMID:25445435;   PMID:25613051;   PMID:25965774;   PMID:26241827;   Reaxys:3922630


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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        dye 1296
          histological dye 149
            azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      halogen 18012
                        chlorine atom 17793
                          chlorine molecular entity 17793
                            elemental chlorine 8372
                              monoatomic chlorine 8353
                                chloride 8353
                                  chloride salt 8353
                                    organic chloride salt 664
                                      azure B 2
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