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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rose bengal(2-)
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Accession:CHEBI:52904 term browser browse the term
Definition:The anionic form of a fluorescent dye derived from a polyhalogenated fluorescin.
Synonyms:exact_synonym: 2,3,4,5-tetrachloro-6-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
 related_synonym: Formula=C20H2Cl4I4O5;   InChI=1S/C20H4Cl4I4O5/c21-10-8(9(20(31)32)11(22)13(24)12(10)23)7-3-1-5(25)16(29)14(27)18(3)33-19-4(7)2-6(26)17(30)15(19)28/h1-2,29H,(H,31,32)/p-2;   InChIKey=VDNLFJGJEQUWRB-UHFFFAOYSA-L;   SMILES=[O-]C(=O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1-c1c2cc(I)c([O-])c(I)c2oc2c(I)c(=O)c(I)cc12;   rose bengal anion;   rose bengal dianion
 xref: Beilstein:1445395
 xref_mesh: MESH:D012395
 cyclic_relationship: is_conjugate_base_of CHEBI:87202



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rose bengal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Rose Bengal results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity EXP Rose Bengal results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Rose Bengal results in decreased activity of CYP3A4 protein CTD PMID:20041016 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Rose Bengal CTD PMID:1740415 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Rose Bengal results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Klkb1 kallikrein B1 multiple interactions
decreases response to substance
ISO 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] CTD PMID:25339356 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO Rose Bengal results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        dye 1364
          xanthene dye 80
            rose bengal(2-) 8
              rose bengal 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  oxacycle 17684
                                    dibenzopyran 243
                                      xanthenes 237
                                        xanthene dye 80
                                          rose bengal(2-) 8
                                            rose bengal 8
paths to the root