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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:51619
Term: 5(6)-carboxy-2',7'-dichlorofluorescein
Definition: null
Chemical ID: MESH:C053897
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects transportEXP 6480464CTDABCC2 protein affects the transport of 56-carboxy-2' 7'-dichlorofluorescein

PMID:21240898 PMID:21341280
Abcc2increases exportEXP 6480464CTDABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein

PMID:24909372
Abcc2increases transportEXP 6480464CTDABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein

PMID:24907646
Abcc2multiple interactionsEXP 6480464CTD[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein] Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Pravastatin promotes the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein] Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein] Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein]

PMID:23562342 PMID:24907646 PMID:24909372
Abcc2increases exportISORGD:6195696480464CTDABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein analog

PMID:25862123 PMID:27450509
Abcc2increases transportISORGD:6195696480464CTDABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein

PMID:24973091 PMID:31348918
Abcc2multiple interactionsISORGD:6195696480464CTD4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein]] Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein] cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 56-carboxy-2' 7'-dichlorofluorescein] pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Probenecid inhibits the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein analog] Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 56-carboxy-2' 7'-dichlorofluorescein] Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 56-carboxy-2' 7'-dichlorofluorescein analog]

PMID:19326901 PMID:23562342 PMID:24973091 PMID:25862123 PMID:27450509 PMID:31348918
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