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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridine orange
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Accession:CHEBI:51739 term browser browse the term
Definition:Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.
Synonyms:exact_synonym: N,N,N',N'-tetramethylacridine-3,6-diamine hydrochloride
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Bis(dimethylamino)acridine hydrochloride;   C.I. 46005;   Formula=C17H19N3.ClH;   Formula=C17H20ClN3;   InChI=1S/C17H19N3.ClH/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;/h5-11H,1-4H3;1H;   InChIKey=VSTHNGLPHBTRMB-UHFFFAOYSA-N;   N3,N3,N6,N6-tetramethyl-3,6-Acridinediamine hydrochloride(1:1);   Rhoduline Orange;   SMILES=[H+].[Cl-].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   basic orange 14
 xref: Beilstein:3575587;   CAS:494-38-2;   CAS:65-61-2;   KEGG:C19315
 xref_mesh: MESH:D000165
 xref: Wikipedia:Acridine_orange


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        dye 1309
          histological dye 160
            acridine orange 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      dibenzopyridine 155
                                        acridines 122
                                          aminoacridines 17
                                            acridine orange cation 3
                                              acridine orange 3
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