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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acridine orange
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Accession:CHEBI:51739 term browser browse the term
Definition:Fluorescent dye useful for cell cycle determination. It is cell-permeable, and interacts with DNA and RNA by intercalation or electrostatic attractions respectively.
Synonyms:exact_synonym: N,N,N',N'-tetramethylacridine-3,6-diamine hydrochloride
 related_synonym: 3,6-Bis(dimethylamino)acridine;   3,6-Bis(dimethylamino)acridine hydrochloride;   C.I. 46005;   Formula=C17H19N3.ClH;   Formula=C17H20ClN3;   InChI=1S/C17H19N3.ClH/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;/h5-11H,1-4H3;1H;   InChIKey=VSTHNGLPHBTRMB-UHFFFAOYSA-N;   N3,N3,N6,N6-tetramethyl-3,6-Acridinediamine hydrochloride(1:1);   Rhoduline Orange;   SMILES=[H+].[Cl-].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C;   basic orange 14
 xref: Beilstein:3575587;   CAS:494-38-2;   CAS:65-61-2;   KEGG:C19315
 xref_mesh: MESH:D000165
 xref: Wikipedia:Acridine_orange



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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19729
        dye 3006
          histological dye 257
            acridine orange 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18900
                                  organic heteropolycyclic compound 18315
                                    organic heterotricyclic compound 15859
                                      dibenzopyridine 175
                                        acridines 138
                                          aminoacridines 17
                                            acridine orange cation 3
                                              acridine orange 3
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