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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:51232
Term: 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole
Definition: A bibenzimidazole that has formula C27H28N6O.
Chemical ID: MESH:C017807
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases transportISOAbcb1a (Mus musculus)6480464CTDABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloridePMID:25865432
Abcb1aincreases transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloridePMID:25865432
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDabamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]PMID:25865432
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[zosuquidar trihydrochloride results in decreased activity of ABCB1 protein] which results in decreased export of bisbenzimide ethoxide trihydrochloride; abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]PMID:25865432 PMID:34896433
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