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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorescent dye
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Accession:CHEBI:51121 term browser browse the term
Synonyms:related_synonym: fluorescent dyes


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2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] CTD PMID:16004972 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases export
multiple interactions
ISO ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]
CTD PMID:16156793 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO bisbenzimide ethoxide trihydrochloride inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride
ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride
abamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
abamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases transport
ISO abamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride] CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases abundance
decreases export
decreases activity
multiple interactions
increases export
increases transport
ISO ABCG2 protein results in decreased abundance of bisbenzimide ethoxide trihydrochloride
ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride
bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCG2 protein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride; Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; danofloxacin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Genistein promotes the reaction [ABCG2 protein polymorphism results in decreased export of bisbenzimide ethoxide trihydrochloride]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; Reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Tobacco Smoke Pollution inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]; verlukast inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
CTD PMID:12869632 PMID:19239227 PMID:26850786 PMID:26907376 PMID:27450509 PMID:27475308 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases export ISO KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [MYC protein results in increased expression of ABCG2 protein] which results in increased export of bisbenzimide ethoxide trihydrochloride CTD PMID:19239227 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
3,4-dihydrocoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO 3,4-dihydrocoumarin affects the expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:22,569,999...22,588,143
Ensembl chr19:22,569,999...22,588,137
JBrowse link
G Egf epidermal growth factor increases expression ISO 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of EPHX1 mRNA CTD PMID:22016648 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO 3,4-dihydrocoumarin results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PCK1 mRNA CTD PMID:22016648 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pon1 paraoxonase 1 affects metabolic processing ISO PON1 SNP affects the metabolism of 3,4-dihydrocoumarin CTD PMID:25027835 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO 3,4-dihydrocoumarin results in increased expression of PRDX1 mRNA CTD PMID:22016648 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PSMB8 mRNA CTD PMID:22016648 NCBI chr20:3,990,809...3,993,772
Ensembl chr20:3,990,613...3,993,769
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737
JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO 3,4-dihydrocoumarin results in decreased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases export
increases transport
EXP
ISO
ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 PMID:24909372 PMID:24973091 PMID:25862123 PMID:27450509 PMID:31348918 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases transport
EXP
ISO
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:24907646 PMID:31348918 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases transport
ISO Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein] CTD PMID:31348918 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
5-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases transport
ISO quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] CTD PMID:21244849 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
5-chloromethylfluorescein diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione] CTD PMID:16049127 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
6-carboxyfluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases export ISO ABCC1 protein results in increased export of 6-carboxyfluorescein CTD PMID:17940500 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
ISO ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]
CTD PMID:11477083 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases import
ISO 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein] CTD PMID:28629854 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases import
multiple interactions
ISO SLC22A8 protein results in increased import of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]
CTD PMID:28629854 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
9-aminoacridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding ISO Aminacrine binds to ACHE protein CTD PMID:31176713 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Aminacrine CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G H2ax H2A.X variant histone decreases phosphorylation
multiple interactions
ISO Aminacrine results in decreased phosphorylation of H2AX protein
[Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]
CTD PMID:26928355 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Aminacrine results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Aminacrine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aminacrine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Aminacrine results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
acridine orange term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
acridine orange free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases response to substance ISO BAX protein results in increased susceptibility to Acridine Orange CTD PMID:16177561 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Acridine Orange binds to Platinum Compounds] which results in increased expression of GSTP1 mRNA; [Acridine Orange binds to Platinum] which results in increased expression of GSTP1 mRNA CTD PMID:16814760 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Acridine Orange results in increased stability of and results in increased activity of TP53 protein CTD PMID:16177561 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression
ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
Benzophenoneidum results in increased expression of ALDH1A1 protein
CTD PMID:28722353 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:1,369,534...1,391,603
Ensembl chr  X:1,379,194...1,390,873
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:15,742,978...15,754,925
Ensembl chr  X:15,742,978...15,754,925
JBrowse link
G Ccdc39 coiled-coil domain containing 39 increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 2:120,278,605...120,367,829
Ensembl chr 2:120,278,605...120,316,600
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791
JBrowse link
G Commd1 copper metabolism domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr14:107,664,321...107,759,974
Ensembl chr14:107,664,255...107,760,191
JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 9:93,607,199...93,633,064
Ensembl chr 9:93,607,477...93,633,064
JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr 1:47,206,892...47,213,785
Ensembl chr 1:47,206,895...47,213,749
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 5:156,343,663...156,564,037
Ensembl chr 5:156,396,695...156,564,037
JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 9:70,448,386...70,471,420
Ensembl chr 9:70,450,444...70,470,550
JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr16:70,710,347...70,818,789 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 2:187,447,477...187,489,630
Ensembl chr 2:187,447,501...187,489,630
JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr13:82,072,497...82,217,256
Ensembl chr13:82,072,497...82,217,252
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr 7:12,179,046...12,186,251
Ensembl chr 7:12,179,203...12,186,656
JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171
JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr 9:113,515,312...113,573,308
Ensembl chr 9:113,534,326...113,573,307
JBrowse link
G Prim2 DNA primase subunit 2 increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr 6:76,079,880...76,171,298
Ensembl chr 6:76,079,880...76,171,296
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 2:264,837,463...264,864,296
Ensembl chr 2:264,837,472...264,864,265
JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr 7:58,164,190...58,219,804
Ensembl chr 7:58,164,198...58,219,790
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 5:125,896,725...126,030,411
Ensembl chr 5:125,896,725...126,030,401
JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr 7:99,625,379...99,677,237
Ensembl chr 7:99,625,619...99,677,268
JBrowse link
aurintricarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lig1 DNA ligase 1 decreases activity ISO Aurintricarboxylic Acid results in decreased activity of LIG1 protein CTD PMID:15134906 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases activity ISO Aurintricarboxylic Acid results in decreased activity of OGG1 protein CTD PMID:26218629 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
C3-thiacarbocyanine cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
calcein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export
multiple interactions
increases secretion
ISO ABCB1 protein results in increased export of fluorexon
Amiodarone inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Reserpine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
[carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; [Verapamil results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Miconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Reserpine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Troleandomycin inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of fluorexon]
CTD PMID:10571255 PMID:12235267 PMID:16442095 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects export
increases export
increases import
affects transport
multiple interactions
ISO ABCC1 protein affects the export of fluorexon
ABCC1 protein results in increased export of fluorexon
ABCC1 protein results in increased import of fluorexon
ABCC1 protein affects the transport of fluorexon
Mefloquine inhibits the reaction [ABCC1 protein affects the export of fluorexon]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon]; Quercetin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; robinetin inhibits the reaction [ABCC1 protein affects the export of fluorexon]; Silymarin inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein affects the export of fluorexon]; verlukast inhibits the reaction [ABCC1 protein results in increased export of fluorexon]; Vincristine inhibits the reaction [ABCC1 protein affects the transport of fluorexon]
CTD PMID:10685512 PMID:15670588 PMID:16004972 PMID:16156793 PMID:18955043 PMID:26454883 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases abundance
multiple interactions
affects transport
ISO ABCC2 protein affects the export of fluorexon
ABCC2 protein alternative form results in increased abundance of fluorexon
robinetin inhibits the reaction [ABCC2 protein affects the export of fluorexon]
ABCC2 protein affects the transport of fluorexon
CTD PMID:15670588 PMID:15848949 PMID:22027652 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects transport ISO ABCC6 affects the transport of fluorexon CTD PMID:14667841 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects export
multiple interactions
ISO ABCB11 protein affects the export of calcein AM
ditekiren inhibits the reaction [ABCB11 protein affects the export of calcein AM]
CTD PMID:10617675 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects export
increases export
multiple interactions
increases activity
increases transport
increases secretion
ISO
EXP
ABCB1 protein affects the export of calcein AM
ABCB1 protein results in increased export of calcein AM
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Endosulfan co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [phosalone co-treated with Verapamil] inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; [Verapamil binds to and results in decreased activity of ABCB1 protein] inhibits the reaction [sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]]; ABCB1 protein affects the reaction [Mifepristone results in decreased transport of calcein AM]; ABCB1 protein affects the reaction [zosuquidar trihydrochloride results in decreased transport of calcein AM]; Atorvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; deoxynivalenol inhibits the reaction [valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]]; Diazinon inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Diazinon promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Diazinon promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Endosulfan inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Endosulfan promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; fenoxycarb inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; fenvalerate inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; phosalone inhibits the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; phosalone inhibits the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; propiconazole inhibits the reaction [phosalone inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Endosulfan inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; propiconazole promotes the reaction [Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]; Reserpine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; sodium arsenite promotes the reaction [ABCB1 protein results in increased secretion of calcein AM]; spinosad inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; valspodar inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of calcein AM]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]; Verapamil promotes the reaction [propiconazole inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]]
calcein AM results in increased activity of ABCB1 protein mutant form
CTD PMID:10617675 PMID:12711602 PMID:15616150 PMID:16121039 PMID:19223659 PMID:19549930 PMID:21321059 PMID:21783720 PMID:29174985 PMID:30217652 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases transport
multiple interactions
ISO ABCC1 protein results in increased transport of calcein AM
[ABCC1 protein results in increased susceptibility to Silver Nitrate] which results in decreased export of calcein AM; [ABCC1 protein results in increased susceptibility to Silver] which results in decreased export of calcein AM; [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; verlukast inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; zearalenol metabolite inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]
CTD PMID:19239227 PMID:19647055 PMID:27376922 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
increases transport
increases export
ISO
EXP
ABCC2 protein affects the transport of calcein AM
Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
[MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM; Atorvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; verlukast inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
CTD PMID:15210835 PMID:15616150 PMID:19239227 PMID:19647055 PMID:19952419 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects transport
multiple interactions
increases transport
ISO ABCC3 protein affects the transport of calcein AM
Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Hydrocortisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]; verlukast inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; zearalenol inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]; Zearalenone inhibits the reaction [ABCC3 protein results in increased transport of calcein AM]
CTD PMID:15210835 PMID:15979871 PMID:19647055 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [MYC protein results in increased expression of ABCC1 protein] which results in increased export of calcein AM; [MYC protein results in increased expression of ABCC2 protein] which results in increased export of calcein AM CTD PMID:19239227 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
cascade blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
increases uptake
ISO Bleomycin inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Docetaxel inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Irinotecan inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Methotrexate inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Tamoxifen inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Teniposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue]; Thiotepa inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
coumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aass aminoadipate-semialdehyde synthase decreases expression EXP coumarin results in decreased expression of AASS mRNA CTD PMID:18480146 NCBI chr 4:50,152,005...50,208,935
Ensembl chr 4:50,152,452...50,200,328
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 affects expression EXP coumarin affects the expression of ABCB11 mRNA CTD PMID:16963487 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP coumarin results in increased expression of ABCC3 mRNA CTD PMID:18480146 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression EXP coumarin results in increased expression of ACAA1 mRNA CTD PMID:18480146 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression EXP coumarin affects the expression of ACAA2 mRNA CTD PMID:16963487 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [haloxon results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein] CTD PMID:10421444 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase affects expression EXP coumarin affects the expression of ACLY mRNA CTD PMID:16963487 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aco1 aconitase 1 affects expression EXP coumarin affects the expression of ACO1 mRNA CTD PMID:16963487 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP coumarin results in increased expression of ACOT4 mRNA CTD PMID:18480146 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 increases expression ISO coumarin results in increased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases expression ISO coumarin analog results in decreased expression of AIFM1 mRNA CTD PMID:32578917 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP coumarin results in increased expression of AKR1B8 mRNA CTD PMID:18480146 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression EXP coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression EXP coumarin affects the expression of AKR1D1 mRNA CTD PMID:16963487 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP coumarin results in increased expression of AKR7A3 mRNA CTD PMID:18480146 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO coumarin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32578917 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP coumarin results in increased expression of ALDH1A1 mRNA CTD PMID:18480146 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression EXP coumarin results in increased expression of ALOX5 mRNA CTD PMID:18480146 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Anxa7 annexin A7 increases expression EXP coumarin results in increased expression of ANXA7 mRNA CTD PMID:18480146 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287
JBrowse link
G Apbb3 amyloid beta precursor protein binding family B member 3 decreases expression EXP coumarin results in decreased expression of APBB3 mRNA CTD PMID:18480146 NCBI chr18:29,497,865...29,504,995
Ensembl chr18:29,497,863...29,504,995
JBrowse link
G Apcs amyloid P component, serum decreases expression EXP coumarin results in decreased expression of APCS mRNA CTD PMID:18480146 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Arg1 arginase 1 affects expression EXP coumarin affects the expression of ARG1 mRNA CTD PMID:16963487 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP coumarin results in increased expression of ASNS mRNA CTD PMID:18480146 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 increases expression EXP coumarin results in increased expression of ATPIF1 mRNA CTD PMID:18480146 NCBI chr 5:150,719,570...150,723,287
Ensembl chr 5:150,719,569...150,723,321
JBrowse link
G Atrn attractin decreases expression EXP coumarin results in decreased expression of ATRN mRNA CTD PMID:18480146 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP coumarin results in decreased expression of AVPR1A mRNA CTD PMID:18480146 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding affects expression EXP coumarin affects the expression of AZGP1 mRNA CTD PMID:16963487 NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO coumarin analog results in increased expression of BAD mRNA CTD PMID:32578917 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO coumarin analog results in increased expression of BAK1 protein CTD PMID:31199928 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO coumarin analog results in increased expression of BAX mRNA; coumarin results in increased expression of BAX protein CTD PMID:15964220 PMID:32578917 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO coumarin analog results in increased expression of BBC3 protein CTD PMID:31199928 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP coumarin results in decreased expression of BBOX1 mRNA CTD PMID:18480146 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO coumarin analog results in decreased expression of BCL2 mRNA; coumarin results in decreased expression of BCL2 protein CTD PMID:15964220 PMID:32578917 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 increases expression EXP coumarin results in increased expression of BHLHA15 mRNA CTD PMID:18480146 NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression
affects expression
EXP coumarin results in decreased expression of BHMT mRNA
coumarin affects the expression of BHMT mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO coumarin analog results in increased expression of BID mRNA CTD PMID:32578917 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO coumarin analog results in decreased expression of BIRC5 mRNA CTD PMID:32578917 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP coumarin results in decreased expression of CA3 mRNA CTD PMID:18480146 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Capn1 calpain 1 decreases expression ISO coumarin analog results in decreased expression of CAPN1 mRNA CTD PMID:32578917 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO coumarin results in decreased activity of CA1 protein CTD PMID:22077347 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 increases expression
decreases activity
EXP
ISO
coumarin results in increased expression of CA2 mRNA
coumarin results in decreased activity of CA2 protein
CTD PMID:18480146 PMID:22077347 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
ISO coumarin analog results in increased cleavage of CASP3 protein
coumarin analog results in increased expression of CASP3 mRNA
CTD PMID:32578917 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases expression ISO coumarin analog results in increased expression of CASP8 mRNA CTD PMID:32578917 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression ISO coumarin analog results in increased expression of CASP9 mRNA CTD PMID:32578917 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]
coumarin analog results in decreased activity of CAT protein
CTD PMID:21630391 PMID:32578917 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP coumarin results in increased expression of CBR1 mRNA CTD PMID:18480146 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Ccnb2 cyclin B2 decreases expression EXP coumarin results in decreased expression of CCNB2 mRNA CTD PMID:18480146 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO coumarin analog results in decreased expression of CCND1 mRNA CTD PMID:32578917 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of CCNE1 mRNA
coumarin analog results in decreased expression of CCNE1 mRNA
CTD PMID:18480146 PMID:32578917 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 increases expression EXP coumarin results in increased expression of CCNE2 mRNA CTD PMID:18480146 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdh1 cadherin 1 increases expression ISO coumarin analog results in increased expression of CDH1 mRNA; coumarin analog results in increased expression of CDH1 protein CTD PMID:32578917 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO coumarin analog results in decreased expression of CDH2 mRNA CTD PMID:32578917 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO coumarin analog results in decreased expression of CDK2 mRNA CTD PMID:32578917 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO coumarin analog results in decreased expression of CDK4 mRNA CTD PMID:32578917 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO coumarin analog results in increased expression of CDKN1A mRNA CTD PMID:32578917 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP coumarin results in decreased expression of CDKN3 mRNA CTD PMID:18480146 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP coumarin affects the expression of CDO1 mRNA CTD PMID:16963487 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO coumarin results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cisd3 CDGSH iron sulfur domain 3 increases expression EXP coumarin results in increased expression of CISD3 mRNA CTD PMID:18480146 NCBI chr10:85,628,579...85,631,656
Ensembl chr10:85,628,491...85,631,657
JBrowse link
G Cldn3 claudin 3 decreases expression ISO coumarin analog results in decreased expression of CLDN3 mRNA CTD PMID:32578917 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Cldn4 claudin 4 decreases expression ISO coumarin analog results in decreased expression of CLDN4 mRNA CTD PMID:32578917 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Coq6 coenzyme Q6 monooxygenase increases expression EXP coumarin results in increased expression of COQ6 mRNA CTD PMID:18480146 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP coumarin results in increased expression of CREG mRNA CTD PMID:18480146 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP coumarin results in increased expression of CRELD2 mRNA CTD PMID:18480146 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP coumarin results in decreased expression of CRYAB mRNA CTD PMID:18480146 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cryl1 crystallin, lambda 1 increases expression EXP coumarin results in increased expression of CRYL1 mRNA CTD PMID:18480146 NCBI chr15:37,543,727...37,663,586
Ensembl chr15:37,543,727...37,663,584
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP coumarin results in decreased expression of CSAD mRNA CTD PMID:18480146 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP coumarin results in decreased expression of CSRP1 mRNA CTD PMID:18480146 NCBI chr13:52,553,843...52,575,054
Ensembl chr13:52,553,775...52,575,051
JBrowse link
G Ctf1 cardiotrophin 1 increases expression EXP coumarin results in increased expression of CTF1 mRNA CTD PMID:18480146 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cth cystathionine gamma-lyase affects expression EXP coumarin affects the expression of CTH mRNA CTD PMID:16963487 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO coumarin analog results in decreased expression of CTNNB1 mRNA CTD PMID:32578917 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsb cathepsin B increases expression ISO coumarin analog results in increased expression of CTSB mRNA CTD PMID:32578917 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression EXP coumarin results in decreased expression of CXCL12 mRNA CTD PMID:18480146 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyb561 cytochrome b-561 increases expression EXP coumarin results in increased expression of CYB561 mRNA CTD PMID:18480146 NCBI chr10:94,136,993...94,147,567
Ensembl chr10:94,136,993...94,147,621
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO coumarin analog results in increased expression of CYCS mRNA CTD PMID:32578917 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
affects expression
EXP coumarin results in decreased expression of CYP1A2 mRNA
coumarin affects the expression of CYP1A2 mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases hydroxylation
increases hydroxylation
ISO CYP2A13 gene polymorphism results in decreased hydroxylation of coumarin
CYP2A13 protein results in increased hydroxylation of coumarin
CTD PMID:17922361 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 affects metabolic processing
increases hydroxylation
ISO
EXP
CYP2A5 protein affects the metabolism of coumarin
CYP2A6 protein results in increased hydroxylation of coumarin
CTD PMID:10646973 PMID:12919726 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP coumarin results in decreased expression of CYP2C mRNA CTD PMID:18480146 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects localization EXP coumarin affects the localization of CYP2E1 protein CTD PMID:28803882 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects expression EXP coumarin affects the expression of CYP3A2 mRNA CTD PMID:16963487 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP coumarin results in decreased expression of CYP51 mRNA CTD PMID:18480146 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP coumarin results in decreased expression of CYP7A1 mRNA CTD PMID:18480146 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP coumarin results in increased expression of DDIT4L mRNA CTD PMID:18480146 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit increases expression EXP coumarin results in increased expression of DDOST mRNA CTD PMID:18480146 NCBI chr 5:156,668,924...156,676,036
Ensembl chr 5:156,668,712...156,676,035
JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP coumarin results in decreased expression of DDX31 mRNA CTD PMID:18480146 NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 increases expression EXP coumarin results in increased expression of DNAJB11 mRNA CTD PMID:18480146 NCBI chr11:81,741,342...81,757,806
Ensembl chr11:81,741,297...81,757,813
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression EXP coumarin affects the expression of DNAJB9 mRNA CTD PMID:16963487 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP coumarin results in increased expression of DNAJC3 mRNA CTD PMID:18480146 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dscc1 DNA replication and sister chromatid cohesion 1 increases expression EXP coumarin results in increased expression of DSCC1 mRNA CTD PMID:18480146 NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression EXP coumarin affects the expression of ECI1 mRNA CTD PMID:16963487 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 increases expression EXP coumarin results in increased expression of EEF1E1 mRNA CTD PMID:18480146 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 increases expression EXP coumarin results in increased expression of ELL3 mRNA CTD PMID:18480146 NCBI chr 3:113,400,395...113,405,869
Ensembl chr 3:113,401,734...113,405,829
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression EXP coumarin results in increased expression of EME2 mRNA CTD PMID:18480146 NCBI chr10:14,253,552...14,257,017
Ensembl chr10:14,254,252...14,256,930
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO coumarin results in increased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G F9 coagulation factor IX increases response to substance ISO F9 exon polymorphism results in increased susceptibility to coumarin; F9 protein mutant form results in increased susceptibility to coumarin CTD PMID:11307814 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP coumarin results in decreased expression of FADS1 mRNA CTD PMID:18480146 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fam111a FAM111 trypsin like peptidase A increases expression EXP coumarin results in increased expression of FAM111A mRNA CTD PMID:18480146 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527
JBrowse link
G Fasn fatty acid synthase affects expression EXP coumarin affects the expression of FASN mRNA CTD PMID:16963487 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression EXP coumarin results in increased expression of FEN1 mRNA CTD PMID:18480146 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fgg fibrinogen gamma chain affects expression EXP coumarin affects the expression of FGG mRNA CTD PMID:16963487 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fggy FGGY carbohydrate kinase domain containing decreases expression EXP coumarin results in decreased expression of FGGY mRNA CTD PMID:18480146 NCBI chr 5:114,516,860...114,901,571
Ensembl chr 5:114,516,889...114,901,564
JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 increases expression EXP coumarin results in increased expression of FKBP11 mRNA CTD PMID:18480146 NCBI chr 7:140,398,253...140,402,664
Ensembl chr 7:140,398,199...140,437,467
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP coumarin results in decreased expression of FMO1 mRNA CTD PMID:18480146 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP coumarin results in increased expression of GAS5 mRNA CTD PMID:18480146 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gckr glucokinase regulator decreases expression EXP coumarin results in decreased expression of GCKR mRNA CTD PMID:18480146 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP coumarin results in increased expression of GCLC mRNA CTD PMID:18480146 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression EXP coumarin results in increased expression of GCLM mRNA CTD PMID:18480146 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP coumarin results in increased expression of GJB2 mRNA CTD PMID:18480146 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Gk glycerol kinase decreases expression EXP coumarin results in decreased expression of GK mRNA CTD PMID:18480146 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Glb1 galactosidase, beta 1 increases expression EXP coumarin results in increased expression of GLB1 mRNA CTD PMID:18480146 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gldc glycine decarboxylase decreases expression EXP coumarin results in decreased expression of GLDC mRNA CTD PMID:18480146 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093
JBrowse link
G Gpr108 G protein-coupled receptor 108 decreases expression EXP coumarin results in decreased expression of GPR108 mRNA CTD PMID:18480146 NCBI chr 9:9,704,300...9,714,767
Ensembl chr 9:9,704,346...9,714,755
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP coumarin affects the expression of GPX1 mRNA CTD PMID:16963487 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP coumarin results in increased expression of GSR mRNA CTD PMID:18480146 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO coumarin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO
EXP
coumarin results in increased expression of GSTA3 protein CTD PMID:9794803 PMID:11309284 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP
ISO
coumarin results in increased expression of GSTA5 protein
coumarin results in increased expression of GSTA1 protein
CTD PMID:9794803 PMID:11309284 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO coumarin results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression EXP
ISO
coumarin results in increased expression of GSTM3 protein
coumarin results in increased expression of GSTM5 protein
CTD PMID:9794803 PMID:11309284 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO
EXP
coumarin results in increased expression of GSTP1 protein CTD PMID:9794803 PMID:11309284 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP coumarin results in increased expression of GSTT1 mRNA; coumarin results in increased expression of GSTT1 protein CTD PMID:9794803 PMID:9855024 PMID:10413528 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP coumarin results in decreased expression of HAL mRNA CTD PMID:18480146 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP coumarin results in decreased expression of HAO2 mRNA CTD PMID:18480146 NCBI chr 2:200,785,492...200,808,868
Ensembl chr 2:200,778,122...200,808,857
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions EXP coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein] CTD PMID:19647726 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO coumarin analog results in increased expression of HIF1A mRNA CTD PMID:32578917 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP coumarin results in increased expression of HMGCR mRNA CTD PMID:18480146 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] CTD PMID:21232530 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression EXP coumarin results in increased expression of HSP90B1 mRNA CTD PMID:18480146 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP coumarin results in increased expression of HSPA1B mRNA CTD PMID:18480146 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP coumarin results in increased expression of HYOU1 mRNA CTD PMID:18480146 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP coumarin results in decreased expression of IGFALS mRNA CTD PMID:18480146 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of IL1B mRNA
coumarin analog results in decreased expression of IL1B protein
CTD PMID:15135310 PMID:32578917 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
EXP
ISO
coumarin results in increased expression of IL6 mRNA
coumarin analog results in decreased expression of IL6 mRNA; coumarin analog results in decreased expression of IL6 protein
CTD PMID:15135310 PMID:32578917 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression EXP coumarin results in increased expression of ISYNA1 mRNA CTD PMID:18480146 NCBI chr16:20,589,497...20,592,333
Ensembl chr16:20,589,481...20,592,449
JBrowse link
G Josd2 Josephin domain containing 2 increases expression EXP coumarin results in increased expression of JOSD2 mRNA CTD PMID:18480146 NCBI chr 1:100,473,426...100,477,352
Ensembl chr 1:100,473,643...100,477,351
JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 increases expression EXP coumarin results in increased expression of KCNK2 mRNA CTD PMID:18480146 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476
JBrowse link
G Kdr kinase insert domain receptor increases expression ISO coumarin analog results in increased expression of KDR mRNA CTD PMID:32578917 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kif20a kinesin family member 20A decreases expression EXP coumarin results in decreased expression of KIF20A mRNA CTD PMID:18480146 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression EXP coumarin results in decreased expression of KLF2 mRNA CTD PMID:18480146 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Krt19 keratin 19 decreases expression EXP coumarin results in decreased expression of KRT19 mRNA CTD PMID:18480146 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Kynu kynureninase decreases expression EXP coumarin results in decreased expression of KYNU mRNA CTD PMID:18480146 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lad1 ladinin 1 increases expression EXP coumarin results in increased expression of LAD1 mRNA CTD PMID:18480146 NCBI chr13:52,645,257...52,659,619
Ensembl chr13:52,645,257...52,659,619
JBrowse link
G Lmf2 lipase maturation factor 2 increases expression EXP coumarin results in increased expression of LMF2 mRNA CTD PMID:18480146 NCBI chr 7:130,322,018...130,326,470
Ensembl chr 7:130,322,020...130,326,470
JBrowse link
G Lrp3 LDL receptor related protein 3 affects expression EXP coumarin affects the expression of LRP3 mRNA CTD PMID:16963487 NCBI chr 1:91,447,308...91,462,603
Ensembl chr 1:91,448,361...91,462,603
JBrowse link
G Mat1a methionine adenosyltransferase 1A affects expression EXP coumarin affects the expression of MAT1A mRNA CTD PMID:16963487 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression EXP coumarin results in decreased expression of MBL2 mRNA CTD PMID:18480146 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 increases expression EXP coumarin results in increased expression of MCM2 mRNA CTD PMID:18480146 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP coumarin results in increased expression of MCM3 mRNA CTD PMID:18480146 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression EXP coumarin results in increased expression of MCM4 mRNA CTD PMID:18480146 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP coumarin results in increased expression of MCM5 mRNA CTD PMID:18480146 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO coumarin analog results in decreased expression of MDM2 mRNA CTD PMID:32578917 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgp matrix Gla protein decreases expression ISO coumarin results in decreased expression of MGP mRNA CTD PMID:19350115 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression EXP coumarin results in increased expression of MGST2 mRNA CTD PMID:18480146 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 decreases expression EXP coumarin results in decreased expression of MGST3 mRNA CTD PMID:18480146 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO coumarin analog results in decreased expression of MMP2 mRNA CTD PMID:32578917 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO coumarin analog results in decreased expression of MMP9 mRNA
coumarin analog results in decreased expression of and results in decreased activity of MMP9 protein
CTD PMID:32578917 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mms22l MMS22-like, DNA repair protein increases expression EXP coumarin results in increased expression of MMS22L mRNA CTD PMID:18480146 NCBI chr 5:38,844,502...38,960,989
Ensembl chr 5:38,844,488...38,961,035
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP coumarin affects the expression of MSMO1 mRNA CTD PMID:16963487 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mt1 metallothionein 1 increases expression EXP coumarin results in increased expression of MT1A mRNA CTD PMID:18480146 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A increases expression EXP coumarin results in increased expression of MT2A mRNA CTD PMID:18480146 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression EXP coumarin results in decreased expression of NECTIN2 mRNA CTD PMID:18480146 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects activity
increases activity
ISO coumarin affects the activity of NFE2L2 protein
coumarin results in increased activity of NFE2L2 protein
CTD PMID:11309284 PMID:30114225 PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nol3 nucleolar protein 3 increases expression EXP coumarin results in increased expression of NOL3 mRNA CTD PMID:18480146 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nol8 nucleolar protein 8 increases expression EXP coumarin results in increased expression of NOL8 mRNA CTD PMID:18480146 NCBI chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
JBrowse link
G Nop56 NOP56 ribonucleoprotein increases expression EXP coumarin results in increased expression of NOP56 mRNA CTD PMID:18480146 NCBI chr 3:122,803,726...122,808,564
Ensembl chr 3:122,803,772...122,808,558
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP
ISO
coumarin results in increased expression of NOS2 mRNA
coumarin analog results in increased expression of NOS2 mRNA; coumarin analog results in increased expression of NOS2 protein
CTD PMID:15135310 PMID:32578917 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO
EXP
coumarin results in increased expression of NQO1 mRNA; coumarin results in increased expression of NQO1 protein CTD PMID:11309284 PMID:17311802 PMID:18480146 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP coumarin results in increased expression of NR0B2 mRNA CTD PMID:18480146 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP coumarin results in increased expression of NR1D2 mRNA CTD PMID:18480146 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP coumarin results in decreased expression of NREP mRNA CTD PMID:18480146 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Nrtn neurturin increases expression EXP coumarin results in increased expression of NRTN mRNA CTD PMID:18480146 NCBI chr 9:10,299,881...10,306,599
Ensembl chr 9:10,305,470...10,306,597
JBrowse link
G Ntng1 netrin G1 decreases expression EXP coumarin results in decreased expression of NTNG1 mRNA CTD PMID:18480146 NCBI chr 2:212,695,464...213,073,046
Ensembl chr 2:212,696,624...212,852,870
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP coumarin results in increased expression of NUPR1 mRNA CTD PMID:18480146 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog decreases expression EXP coumarin results in decreased expression of OAF mRNA CTD PMID:18480146 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP coumarin results in decreased expression of OAT mRNA CTD PMID:18480146 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Ogn osteoglycin decreases expression EXP coumarin results in decreased expression of OGN mRNA CTD PMID:18480146 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
decreases expression
increases cleavage
multiple interactions
ISO coumarin results in decreased activity of PARP1 protein
coumarin analog results in decreased expression of PARP1 mRNA
coumarin analog results in increased cleavage of PARP1 protein
[coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]
CTD PMID:17669606 PMID:31199928 PMID:32578917 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression EXP coumarin results in increased expression of PCK2 mRNA CTD PMID:18480146 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO coumarin analog results in increased expression of PCNA mRNA CTD PMID:32578917 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP coumarin results in decreased expression of PDE4B mRNA CTD PMID:18480146 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP coumarin results in increased expression of PDIA3 mRNA CTD PMID:18480146 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP coumarin results in increased expression of PDIA4 mRNA CTD PMID:18480146 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP coumarin results in decreased expression of PDK2 mRNA CTD PMID:18480146 NCBI chr10:82,838,270...82,852,758
Ensembl chr10:82,839,153...82,852,660
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP coumarin results in increased expression of PLA2G12A mRNA CTD PMID:18480146 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit increases expression EXP coumarin results in increased expression of POLD1 mRNA CTD PMID:18480146 NCBI chr 1:100,538,066...100,554,105
Ensembl chr 1:100,537,900...100,554,488
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit increases expression EXP coumarin results in increased expression of POLD2 mRNA CTD PMID:18480146 NCBI chr14:86,111,416...86,117,578
Ensembl chr14:86,111,294...86,117,578
JBrowse link
G Polr1e RNA polymerase I subunit E increases expression EXP coumarin results in increased expression of POLR1E mRNA CTD PMID:18480146 NCBI chr 5:60,572,573...60,588,097
Ensembl chr 5:60,572,577...60,588,240
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP coumarin results in increased expression of PTGR1 mRNA CTD PMID:18480146 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G R3hdm1 R3H domain containing 1 increases expression EXP coumarin results in increased expression of R3HDM1 mRNA CTD PMID:18480146 NCBI chr13:44,812,567...44,950,762
Ensembl chr13:44,812,567...44,950,762
JBrowse link
G R3hdm2 R3H domain containing 2 decreases expression EXP coumarin results in decreased expression of R3HDM2 mRNA CTD PMID:18480146 NCBI chr 7:70,677,226...70,805,255
Ensembl chr 7:70,697,050...70,805,221
JBrowse link
G Rab3d RAB3D, member RAS oncogene family increases expression EXP coumarin results in increased expression of RAB3D mRNA CTD PMID:18480146 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294
JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression EXP coumarin results in increased expression of RBM3 mRNA CTD PMID:18480146 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340
JBrowse link
G Rbp1 retinol binding protein 1 decreases expression EXP coumarin results in decreased expression of RBP1 mRNA CTD PMID:18480146 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G RGD1560171 similar to PRO0149 protein increases expression EXP coumarin results in increased expression of RGD1560171 mRNA CTD PMID:18480146 NCBI chr  X:143,681,714...143,683,171
Ensembl chr  X:143,682,099...143,682,917
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase decreases expression EXP coumarin results in decreased expression of RGD1564865 mRNA CTD PMID:18480146 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132
JBrowse link
G Rgn regucalcin decreases expression EXP coumarin results in decreased expression of RGN mRNA CTD PMID:18480146 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rgs8 regulator of G-protein signaling 8 decreases expression EXP coumarin results in decreased expression of RGS8 mRNA CTD PMID:18480146 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog decreases expression EXP coumarin results in decreased expression of RPRM mRNA CTD PMID:18480146 NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718
JBrowse link
G RT1-Ba RT1 class II, locus Ba increases expression EXP coumarin results in increased expression of RT1-BA mRNA CTD PMID:18480146 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-DMa RT1 class II, locus DMa increases expression EXP coumarin results in increased expression of HLA-DMA mRNA CTD PMID:18480146 NCBI chr20:3,935,512...3,938,915
Ensembl chr20:5,240,975...5,244,386
JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP coumarin results in increased expression of RT1-EC2 mRNA CTD PMID:18480146
G Saraf store-operated calcium entry-associated regulatory factor increases expression EXP coumarin results in increased expression of SARAF mRNA CTD PMID:18480146 NCBI chr16:61,735,189...61,753,438
Ensembl chr16:61,735,181...61,753,476
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP coumarin results in decreased expression of SCD1 mRNA CTD PMID:18480146 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP coumarin results in increased expression of SDF2L1 mRNA CTD PMID:18480146 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase increases expression EXP coumarin results in increased expression of SEL1L mRNA CTD PMID:18480146 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Sema6d semaphorin 6D increases expression EXP coumarin results in increased expression of SEMA6D mRNA CTD PMID:18480146 NCBI chr 3:116,899,906...116,958,059
Ensembl chr 3:116,899,878...116,958,050
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP coumarin results in increased expression of SLC17A1 mRNA CTD PMID:18480146 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc17a3 solute carrier family 17 member 3 increases expression EXP coumarin results in increased expression of SLC17A3 mRNA CTD PMID:18480146 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP coumarin results in increased expression of SLC1A2 mRNA CTD PMID:18480146 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP coumarin affects the expression of SLC27A2 mRNA CTD PMID:16963487 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression EXP coumarin results in decreased expression of SLC28A2 mRNA CTD PMID:18480146 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382
JBrowse link
G Slc35e3 solute carrier family 35, member E3 increases expression EXP coumarin results in increased expression of SLC35E3 mRNA CTD PMID:18480146 NCBI chr 7:60,765,077...60,778,136
Ensembl chr 7:60,765,079...60,778,136
JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression EXP coumarin results in decreased expression of SLC6A13 mRNA CTD PMID:18480146 NCBI chr 4:153,874,942...153,912,185
Ensembl chr 4:153,874,852...153,912,155
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression EXP coumarin results in increased expression of SLC6A9 mRNA CTD PMID:18480146 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B increases expression EXP coumarin results in increased expression of SMPDL3B mRNA CTD PMID:18480146 NCBI chr 5:150,925,150...150,946,994
Ensembl chr 5:150,925,370...150,949,931
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO coumarin analog results in decreased expression of SNAI2 mRNA CTD PMID:32578917 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression EXP coumarin results in increased expression of SRXN1 mRNA CTD PMID:18480146 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases activity ISO coumarin results in increased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 affects expression EXP coumarin affects the expression of SULT1B1 mRNA CTD PMID:16963487 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP coumarin results in decreased expression of SULT1C1 mRNA CTD PMID:18480146 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression EXP coumarin results in decreased expression of SULT1E1 mRNA CTD PMID:18480146 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression EXP coumarin results in decreased expression of SYCP3 mRNA CTD PMID:18480146 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251
JBrowse link
G Syne4 spectrin repeat containing nuclear envelope family member 4 increases expression EXP coumarin results in increased expression of SYNE4 mRNA CTD PMID:18480146 NCBI chr 1:88,772,729...88,777,044
Ensembl chr 1:88,772,904...88,776,999
Ensembl chr 1:88,772,904...88,776,999
JBrowse link
G Tfrc transferrin receptor increases expression EXP coumarin results in increased expression of TFRC mRNA CTD PMID:18480146 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO coumarin analog results in increased expression of TGFB1 mRNA CTD PMID:32578917 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thra thyroid hormone receptor alpha increases expression EXP coumarin results in increased expression of THRA mRNA CTD PMID:18480146 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrsp thyroid hormone responsive affects expression
decreases expression
EXP coumarin affects the expression of THRSP mRNA
coumarin results in decreased expression of THRSP mRNA
CTD PMID:16963487 PMID:18480146 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO coumarin analog results in increased expression of TIMP2 mRNA CTD PMID:32578917 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression ISO coumarin analog results in increased expression of TIMP4 mRNA CTD PMID:32578917 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link
G Tmed3 transmembrane p24 trafficking protein 3 increases expression EXP coumarin results in increased expression of TMED3 mRNA CTD PMID:18480146 NCBI chr 8:97,075,194...97,083,107
Ensembl chr 8:97,075,160...97,083,120
JBrowse link
G Tnf tumor necrosis factor increases expression EXP
ISO
coumarin results in increased expression of TNF mRNA
coumarin analog results in increased expression of TNF protein
CTD PMID:15135310 PMID:32578917 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP coumarin results in decreased expression of TNFRSF9 mRNA CTD PMID:18480146 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tp53 tumor protein p53 increases expression ISO coumarin analog results in increased expression of TP53 mRNA; coumarin analog results in increased expression of TP53 protein CTD PMID:32578917 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO coumarin analog results in increased expression of TRADD mRNA CTD PMID:32578917 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 increases expression EXP coumarin results in increased expression of TRPC2 mRNA CTD PMID:18480146 NCBI chr 1:167,180,103...167,192,456
Ensembl chr 1:167,169,442...167,192,801
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression EXP coumarin results in decreased expression of TSC22D1 mRNA CTD PMID:18480146 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Tst thiosulfate sulfurtransferase affects expression EXP coumarin affects the expression of TST mRNA CTD PMID:16963487 NCBI chr 7:119,616,323...119,623,072
Ensembl chr 7:119,616,324...119,623,072
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression EXP coumarin results in increased expression of TTC39A mRNA CTD PMID:18480146 NCBI chr 5:129,024,505...129,083,226
Ensembl chr 5:129,043,675...129,082,442
Ensembl chr 5:129,043,675...129,082,442
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP coumarin results in increased expression of TXNRD1 mRNA CTD PMID:18480146 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP coumarin results in increased expression of UGDH mRNA CTD PMID:18480146 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP coumarin results in decreased expression of UGT2B mRNA CTD PMID:18480146 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP coumarin results in decreased expression of UST5R mRNA CTD PMID:18480146 NCBI chr 1:224,457,895...224,533,994
Ensembl chr 1:224,457,900...224,533,219
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO coumarin analog results in increased expression of VEGFA mRNA CTD PMID:32578917 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression ISO coumarin analog results in decreased expression of VIM protein CTD PMID:32578917 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 decreases response to substance
increases response to substance
ISO VKORC1 gene mutant form results in decreased susceptibility to coumarin
VKORC1 gene mutant form results in increased susceptibility to coumarin; VKORC1 promoter SNP results in increased susceptibility to coumarin
CTD PMID:17849045 PMID:18278162 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP coumarin results in increased expression of WEE1 mRNA CTD PMID:18480146 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
G Yrdc yrdC N(6)-threonylcarbamoyltransferase domain containing increases expression EXP coumarin results in increased expression of YRDC mRNA CTD PMID:18480146 NCBI chr 5:142,845,265...142,850,110
Ensembl chr 5:142,845,114...142,850,111
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO coumarin analog results in decreased expression of ZEB1 mRNA CTD PMID:32578917 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zfp444 zinc finger protein 444 increases expression EXP coumarin results in increased expression of ZFP444 mRNA CTD PMID:18480146 NCBI chr 1:71,380,856...71,400,781
Ensembl chr 1:71,379,559...71,400,388
JBrowse link
G Zfp593 zinc finger protein 593 increases expression EXP coumarin results in increased expression of ZNF593 mRNA CTD PMID:18480146 NCBI chr 5:152,462,522...152,464,850
Ensembl chr 5:152,462,522...152,464,850
JBrowse link
G Zwint ZW10 interacting kinetochore protein increases expression EXP coumarin results in increased expression of ZWINT mRNA CTD PMID:18480146 NCBI chr20:17,075,781...17,091,715
Ensembl chr20:17,075,771...17,091,766
JBrowse link
coumarin 460 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap9 A-kinase anchoring protein 9 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of AKAP9 mRNA CTD PMID:19502547 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO 4-methyl-7-diethylaminocoumarin binds to and results in increased activity of AR protein
4-methyl-7-diethylaminocoumarin affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO 4-methyl-7-diethylaminocoumarin results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Pfkm phosphofructokinase, muscle increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PFKM mRNA CTD PMID:19502547 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Psph phosphoserine phosphatase increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of PSPH mRNA CTD PMID:19502547 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methyl-7-diethylaminocoumarin results in increased expression of VEGFA protein CTD PMID:19502547 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
DAPI term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asic5 acid sensing ion channel subunit family member 5 decreases activity ISO DAPI results in decreased activity of ASIC5 protein CTD PMID:21828194 NCBI chr 2:180,935,392...180,964,365
Ensembl chr 2:180,936,688...180,964,365
JBrowse link
dithiazanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dithiazanine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
erythrosin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Erythrosine results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Erythrosine results in increased expression of CCND1 protein CTD PMID:8927716 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases activity ISO Erythrosine results in increased activity of CDK2 protein CTD PMID:8927716 PMID:9168006 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity EXP Erythrosine results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Erythrosine results in decreased activity of CYP3A4 protein CTD PMID:20041016 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Erythrosine results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Erythrosine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO Erythrosine results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Erythrosine results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Erythrosine results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Erythrosine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Erythrosine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Tp53 tumor protein p53 increases activity ISO Erythrosine results in increased activity of TP53 protein CTD PMID:9168006 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Erythrosine promotes the reaction [TRH protein results in increased expression of TSHB protein] CTD PMID:2160137 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO Erythrosine results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO Erythrosine results in decreased activity of UGT2B7 protein CTD PMID:20041016 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Erythrosine results in increased expression of VEGFA protein CTD PMID:20025956 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
ethidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA] CTD PMID:15897899 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA] CTD PMID:15897899 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE1 mRNA] CTD PMID:15897899 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 multiple interactions ISO Ethidium inhibits the reaction [Estradiol results in increased expression of CCNE2 mRNA] CTD PMID:15897899 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Ethidium results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Gja1 gap junction protein, alpha 1 increases uptake EXP GJA1 protein results in increased uptake of Ethidium CTD PMID:26926986 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethidium inhibits the reaction [sodium arsenate results in increased expression of IL1A protein]; Ethidium inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:8875956 PMID:10571731 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Ethidium results in decreased expression of COX1 protein CTD PMID:18823003 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Ethidium results in decreased expression of COX2 mRNA CTD PMID:22712077 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b decreases expression ISO Ethidium results in decreased expression of CYTB mRNA CTD PMID:22712077 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 decreases expression ISO Ethidium results in decreased expression of ND1 mRNA CTD PMID:22712077 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 decreases expression ISO Ethidium results in decreased expression of ND4 mRNA CTD PMID:22712077 NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Ethidium results in increased expression of NRF1 mRNA CTD PMID:22712077 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases transport
increases transport
ISO P2RX7 gene polymorphism results in decreased transport of Ethidium
P2RX7 protein results in increased transport of Ethidium
CTD PMID:16263709 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
SLC22A1 protein affects the uptake of Ethidium
CTD PMID:19357179 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects uptake
multiple interactions
increases uptake
ISO SLC22A2 protein affects the uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Ethidium inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO SLC22A3 protein results in increased uptake of Ethidium
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]
CTD PMID:19357179 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Ethidium results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
Fluo-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export ISO ABCC1 protein affects the export of Fluo-3 CTD PMID:15948026 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases secretion
EXP Adenosine Triphosphate promotes the reaction [ABCC2 protein results in increased secretion of Fluo-3]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased secretion of Fluo-3] CTD PMID:9794919 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
fluorescein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein] CTD PMID:23850985 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fluorescein results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake
multiple interactions
ISO SLCO1B3 protein results in increased uptake of Fluorescein
bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]
CTD PMID:27989701 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco3a1 solute carrier organic anion transporter family, member 3a1 increases uptake
multiple interactions
ISO SLCO3A1 protein results in increased uptake of Fluorescein
Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]
CTD PMID:28887287 NCBI chr 1:135,790,854...136,073,640
Ensembl chr 1:135,790,810...136,073,540
JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:26,314,561...26,845,242
Ensembl chr  X:26,315,878...26,376,467
JBrowse link
G Azi2 5-azacytidine induced 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 8:126,411,030...126,435,581
Ensembl chr 8:126,411,829...126,434,579
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Cd109 CD109 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 8:85,951,420...86,065,411
Ensembl chr 8:85,951,191...86,065,409
JBrowse link
G Cd180 CD180 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr 2:32,820,275...32,833,223
Ensembl chr 2:32,820,322...32,833,125
JBrowse link
G Cd86 CD86 molecule increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd93 CD93 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 3:142,778,798...142,783,774
Ensembl chr 3:142,778,770...142,783,774
JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Copa COPI coat complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr13:90,467,285...90,508,894
Ensembl chr13:90,467,265...90,508,932
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr 6:107,001,763...107,027,466
Ensembl chr 6:107,001,763...107,027,456
JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr 7:11,786,105...11,824,742
Ensembl chr 7:11,786,105...11,824,742
JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:69,706,522...69,723,869
Ensembl chr18:69,706,522...69,723,869
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 3:134,684,446...134,696,586
Ensembl chr 3:134,683,065...134,696,654
JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
CTD PMID:27871981 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr 7:3,061,422...3,098,142
Ensembl chr 7:3,061,469...3,074,359
JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 4:145,413,157...145,426,608
Ensembl chr 4:145,413,230...145,426,603
JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr 2:44,333,347...44,408,005
Ensembl chr 2:44,336,006...44,394,709
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 PMID:29198882 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 1:81,499,856...81,504,306
Ensembl chr 1:81,499,821...81,504,318
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 3:58,965,025...59,120,507
Ensembl chr 3:58,965,552...59,067,369
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:27129696 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:27129696 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein
CTD PMID:27129696 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mybpc1 myosin binding protein C1 affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr 7:29,086,159...29,171,909
Ensembl chr 7:29,086,156...29,171,783
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]
CTD PMID:20491607 PMID:27871981 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Postn periostin affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Pprc1 PPARG related coactivator 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 3:1,478,432...1,515,094
Ensembl chr 3:1,478,525...1,514,934
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 8:68,029,930...68,040,504
Ensembl chr 8:68,030,621...68,038,533
JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr10:109,284,054...109,333,907
Ensembl chr10:109,284,957...109,333,899
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]] CTD PMID:27871981 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]
CTD PMID:27871981 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]
CTD PMID:27871981 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 8:72,207,970...72,284,871
Ensembl chr 8:72,207,972...72,284,873
JBrowse link
gallein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein] CTD PMID:27160165 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
lucifer yellow dye term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases uptake
increases transport
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Novobiocin inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]; Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow] CTD PMID:31348918 PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
malachite green cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO malachite green results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:10906429 PMID:12616621 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions
ISO malachite green results in decreased activity of KCNA3 protein
[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 2:209,766,767...209,768,344
Ensembl chr 2:209,766,512...209,769,711
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO malachite green results in decreased activity of KCNH2 protein
[malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium
CTD PMID:21362439 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Khnyn KH and NYN domain containing affects response to substance ISO KHNYN gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr15:34,551,570...34,563,729
Ensembl chr15:34,552,410...34,561,727
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Rnf150 ring finger protein 150 affects response to substance ISO RNF150 gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr19:24,044,210...24,264,508
Ensembl chr19:24,044,103...24,265,444
JBrowse link
merbromin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Car2 carbonic anhydrase 2 decreases activity ISO Merbromin results in decreased activity of CA2 protein CTD PMID:16858005 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Merbromin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
methylene blue term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of ATP1A2 protein] CTD PMID:31173149 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] CTD PMID:31428839 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein] CTD PMID:31428839 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased phosphorylation of CACNA1C protein] CTD PMID:31173149 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA] CTD PMID:11919648 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity ISO Methylene Blue results in increased activity of G6PD protein CTD PMID:1901343 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA] CTD PMID:24556215 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA CTD PMID:24556215 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein] CTD PMID:24556215 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glrx glutaredoxin multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA CTD PMID:24556215 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Glrx2 glutaredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA CTD PMID:24556215 NCBI chr13:60,529,057...60,552,115
Ensembl chr13:60,529,932...60,537,916
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17290048 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Methylene Blue inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
[Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]
Methylene Blue results in increased expression of HMOX1 protein
CTD PMID:24556215 PMID:25943564 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] CTD PMID:31428839 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] CTD PMID:31428839 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity
ISO Methylene Blue inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
Methylene Blue results in decreased activity of MAOB protein
CTD PMID:21554916 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapt microtubule-associated protein tau decreases expression
multiple interactions
decreases phosphorylation
increases expression
ISO Methylene Blue results in decreased expression of MAPT protein
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLC mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GCLM mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of GLRX2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of HMOX1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA; Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA]; Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA]; Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP mRNA]; Methylene Blue inhibits the reaction [MAPT protein mutant form results in increased expression of GFAP protein]
Methylene Blue results in decreased phosphorylation of MAPT protein modified form
Methylene Blue results in increased expression of MAPT mRNA
CTD PMID:16930453 PMID:24556215 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Methylene Blue inhibits the reaction [Paraquat results in increased expression of MPO protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:25943564 PMID:31428839 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
[Methylene Blue co-treated with MAPT protein mutant form] affects the localization of NFE2L2 protein; [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NFE2L2 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]
CTD PMID:24556215 PMID:31428839 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Methylene Blue co-treated with [MAPT protein mutant form results in increased expression of NOS2 mRNA]
Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]
CTD PMID:24556215 PMID:31428839 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [Methylene Blue results in increased expression of NQO1 mRNA] CTD PMID:24556215 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO Methylene Blue results in increased activity of PGD protein CTD PMID:1901343 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of PRDX6 mRNA CTD PMID:24556215 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Methylene Blue inhibits the reaction [Sodium Cyanide results in increased activity of and affects the localization of PRKCE protein] CTD PMID:31173149 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases activity
ISO oxophenylarsine inhibits the reaction [Methylene Blue results in increased activity of SLC2A1 protein] CTD PMID:19686715 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein] CTD PMID:11744139 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form results in increased expression of TXN mRNA] CTD PMID:24556215 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXN2 mRNA CTD PMID:24556215 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO Methylene Blue affects the reaction [MAPT protein mutant form affects the expression of TXNRD1 mRNA] CTD PMID:24556215 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions ISO [Methylene Blue co-treated with MAPT protein mutant form] results in increased expression of TXNRD2 mRNA CTD PMID:24556215 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
monobromobimane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing ISO GSTP1 protein affects the metabolism of monobromobimane CTD PMID:15355982 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
monodansylcadaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO monodansylcadaverine results in decreased phosphorylation of AKT1 protein CTD PMID:16170020 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression ISO monodansylcadaverine results in decreased expression of BAD protein CTD PMID:16170020 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO monodansylcadaverine results in increased expression of BCL2L11 protein CTD PMID:16170020 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO monodansylcadaverine results in decreased expression of BIRC5 protein CTD PMID:16170020 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO monodansylcadaverine results in decreased expression of GSK3B protein CTD PMID:16170020 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]; monodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:20733350 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il12b interleukin 12B multiple interactions ISO monodansylcadaverine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL12B protein] CTD PMID:22341560 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il2 interleukin 2 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein] CTD PMID:22341560 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il3 interleukin 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] CTD PMID:22341560 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein] CTD PMID:22341560 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:22341560 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:22341560 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] CTD PMID:22341560 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein] CTD PMID:22341560 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Tgm2 transglutaminase 2 decreases activity ISO monodansylcadaverine results in decreased activity of TGM2 protein CTD PMID:16382148 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:40,555,106...40,572,569
Ensembl chr18:40,555,106...40,572,241
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein] CTD PMID:22341560 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP4 protein] CTD PMID:22341560 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO monodansylcadaverine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO monodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:174,702,310...174,738,133
Ensembl chr 1:174,702,373...174,738,126
JBrowse link
pararosaniline free base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO pararosaniline results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO pararosaniline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
decreases activity
ISO pararosaniline results in decreased expression of NR3C1 protein
pararosaniline results in decreased activity of NR3C1 protein
CTD PMID:19255438 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
phloxine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tslp thymic stromal lymphopoietin multiple interactions ISO Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes] RGD PMID:29310423 RGD:38549374 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
propidium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO Propidium binds to and results in decreased activity of ACHE protein; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
Propidium results in decreased activity of ACHE protein
CTD PMID:10421444 PMID:25522658 PMID:27238725 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Propidium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Propidium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Propidium results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Propidium results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Propidium results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Propidium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Propidium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
rhodamine 123 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases export
ISO 5-oxo-hexahydroquinoline analog inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Rhodamine 123] CTD PMID:25058526 PMID:27816545 PMID:30391378 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
ISO abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Rhodamine 123] CTD PMID:27816545 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
rose bengal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Rose Bengal results in decreased activity of ABCB1 protein CTD PMID:20041016 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity EXP Rose Bengal results in decreased activity of CYP19A1 protein CTD PMID:18310892 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Rose Bengal results in decreased activity of CYP3A4 protein CTD PMID:20041016 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Rose Bengal CTD PMID:1740415 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Iyd iodotyrosine deiodinase decreases activity ISO Rose Bengal results in decreased activity of IYD protein CTD PMID:24012475 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rose Bengal results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Klkb1 kallikrein B1 multiple interactions
decreases response to substance
ISO 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal]; splitomicin inhibits the reaction [KLKB1 gene mutant form results in decreased susceptibility to Rose Bengal] CTD PMID:25339356 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO Rose Bengal results in decreased activity of UGT1A6 protein CTD PMID:20041016 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO
EXP
sudan III affects the localization of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952 PMID:15788368 PMID:22287322 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO
EXP
sudan III results in increased expression of CYP1A1 mRNA
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
sudan III results in increased activity of CYP1A1 protein
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
CTD PMID:18418879 PMID:20308224 PMID:22287322 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA
CTD PMID:15788368 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA
CTD PMID:15788368 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA
CTD PMID:15788368 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein
sudan III results in decreased expression of CYP3A2 mRNA
CTD PMID:15788368 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein
sudan III results in decreased expression of CYP3A23-3A1 mRNA
CTD PMID:15788368 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 decreases expression EXP sudan III results in decreased expression of CYP4A2 mRNA CTD PMID:15585952 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP sudan III results in decreased expression of CYP4A3 mRNA CTD PMID:15585952 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO
EXP
sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952 PMID:15788368 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
texas red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases transport EXP ABCC2 protein results in increased transport of Texas red CTD PMID:32212926 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
thioflavine T term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        dye 1309
          fluorescent dye 467
            (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene 0
            5(6)-carboxyfluorescein 0
            9-aminoacridine 8
            Alexa Fluor 633 0
            Alexa Fluor 647 0
            PicoGreen 0
            SYBR Green I 0
            coumarin + 267
            dimethylindole red 0
            eosin b 0
            erythrosin 0
            erythrosin B 18
            fluorescein + 67
            fluorescein isothiocyanate + 56
            fluorochrome + 219
            phloxine O 1
            squaraine dye + 0
paths to the root