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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thioflavine T
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Accession:CHEBI:76023 term browser browse the term
Definition:An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.
Synonyms:exact_synonym: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
 related_synonym: 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride;   C.I. 49005;   C.I. Basic Yellow 1;   Formula=C17H19ClN2S;   InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1;   InChIKey=JADVWWSKYZXRGX-UHFFFAOYSA-M;   SMILES=C=1(C=2C=CC(N(C)C)=CC2)SC=3C=C(C)C=CC3[N+]1C.[Cl-];   ThT;   Thioflavin T;   basic yellow 1
 alt_id: CHEBI:88013
 xref: CAS:2390-54-7
 xref_mesh: MESH:C009462
 xref: PMID:21451522;   PMID:22976818;   PMID:23069995;   PMID:23151310;   PMID:23215453;   PMID:23454128;   PMID:23458420;   PMID:23479447;   PMID:23517370;   PMID:23662608;   PMID:23747341;   PMID:23807235;   PMID:23844566;   PMID:23903702;   PMID:23909872;   PMID:23934820;   PMID:24002823;   PMID:25483916;   PMID:25712665;   PMID:25794693;   PMID:26087242;   Patent:WO2006006172;   Patent:WO2007011834;   Reaxys:3922452;   Wikipedia:Thioflavin_T



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thioflavine T term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        dye 1366
          histological dye 246
            thioflavine T 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      halogen 18546
                        chlorine atom 18335
                          chlorine molecular entity 18309
                            elemental chlorine 8473
                              monoatomic chlorine 8447
                                chloride 8447
                                  chloride salt 8447
                                    organic chloride salt 930
                                      thioflavine T 1
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