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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thioflavine T
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Accession:CHEBI:76023 term browser browse the term
Definition:An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.
Synonyms:exact_synonym: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
 related_synonym: 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride;   C.I. 49005;   C.I. Basic Yellow 1;   Formula=C17H19ClN2S;   InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1;   InChIKey=JADVWWSKYZXRGX-UHFFFAOYSA-M;   SMILES=C=1(C=2C=CC(N(C)C)=CC2)SC=3C=C(C)C=CC3[N+]1C.[Cl-];   ThT;   Thioflavin T;   basic yellow 1
 alt_id: CHEBI:88013
 xref: CAS:2390-54-7
 xref_mesh: MESH:C009462
 xref: PMID:22976818;   PMID:23069995;   PMID:23151310;   PMID:23215453;   PMID:23454128;   PMID:23458420;   PMID:23479447;   PMID:23517370;   PMID:23662608;   PMID:23747341;   PMID:23807235;   PMID:23844566;   PMID:23903702;   PMID:23909872;   PMID:23934820;   PMID:24002823;   PMID:25483916;   PMID:25712665;   PMID:25794693;   PMID:26087242;   Patent:WO2006006172;   Patent:WO2007011834;   Reaxys:3922452;   Wikipedia:Thioflavin_T


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 NCBI chr12:19,407,359...19,413,713 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        dye 1312
          histological dye 166
            thioflavine T 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      halogen 18112
                        chlorine atom 17940
                          chlorine molecular entity 17940
                            elemental chlorine 8442
                              monoatomic chlorine 8426
                                chloride 8426
                                  chloride salt 8426
                                    organic chloride salt 898
                                      thioflavine T 1
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