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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thioflavine T
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Accession:CHEBI:76023 term browser browse the term
Definition:An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.
Synonyms:exact_synonym: 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
 related_synonym: 2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzothiazolium chloride;   C.I. 49005;   C.I. Basic Yellow 1;   Formula=C17H19ClN2S;   InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1;   InChIKey=JADVWWSKYZXRGX-UHFFFAOYSA-M;   SMILES=C=1(C=2C=CC(N(C)C)=CC2)SC=3C=C(C)C=CC3[N+]1C.[Cl-];   ThT;   Thioflavin T;   basic yellow 1
 alt_id: CHEBI:88013
 xref: CAS:2390-54-7
 xref_mesh: MESH:C009462
 xref: PMID:21451522;   PMID:22976818;   PMID:23069995;   PMID:23151310;   PMID:23215453;   PMID:23454128;   PMID:23458420;   PMID:23479447;   PMID:23517370;   PMID:23662608;   PMID:23747341;   PMID:23807235;   PMID:23844566;   PMID:23903702;   PMID:23909872;   PMID:23934820;   PMID:24002823;   PMID:25483916;   PMID:25712665;   PMID:25794693;   PMID:26087242;   Patent:WO2006006172;   Patent:WO2007011834;   Reaxys:3922452;   Wikipedia:Thioflavin_T


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thioflavine T term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding		 ISO [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [thioflavin T binds to ACHE protein] inhibits the reaction [ACHE protein results in increased hydrolysis of Acetylthiocholine]; thioflavin T binds to and results in decreased activity of ACHE protein; thioflavin T inhibits the reaction [hopeahainol A binds to ACHE protein] CTD PMID:18423506 PMID:18602908 PMID:20493829 PMID:27297626 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19886
      application 19720
        dye 2962
          histological dye 258
            thioflavine T 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  main group element atom 19856
                    p-block element atom 19856
                      halogen 18691
                        chlorine atom 18504
                          chlorine molecular entity 18504
                            elemental chlorine 8529
                              monoatomic chlorine 8514
                                chloride 8514
                                  chloride salt 8514
                                    organic chloride salt 1068
                                      thioflavine T 1
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