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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prostaglandin E2
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Accession:CHEBI:15551 term browser browse the term
Definition:Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Synonyms:exact_synonym: (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
 related_synonym: (15S)-prostaglandin E2;   (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid;   (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate;   (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate;   (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid;   (Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid;   Cervidil;   Cerviprime;   Cerviprost;   Dinoproston;   Dinoprostone;   Enzaprost E;   Formula=C20H32O5;   Glandin-E2;   InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1;   InChIKey=XEYBRNLFEZDVAW-ARSRFYASSA-N;   Minprositin E2;   Minprostin E2;   PGE2;   Prepidil;   Propess;   Prostarmon E;   Prostenone;   Prostin;   Prostin E2;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)CC(=O)[C@@H]1C\\C=C/CCCC(O)=O;   U 12062;   U-12,062;   dinoprostona;   dinoprostonum
 alt_id: CHEBI:10910;   CHEBI:10911;   CHEBI:114125;   CHEBI:26323;   CHEBI:4625;   CHEBI:8512
 xref: Beilstein:2224724;   CAS:363-24-6;   DrugBank:DB00917;   Drug_Central:913;   FooDB:FDB022498;   HMDB:HMDB0001220;   KEGG:C00584;   KEGG:D00079;   LINCS:LSM-42919;   LIPID_MAPS_instance:LMFA03010003
 xref_mesh: MESH:D015232
 xref: PDBeChem:P2E;   PMID:11279302;   PMID:12746806;   PMID:12859290;   PMID:14499495;   PMID:14535055;   PMID:14703707;   PMID:15542928;   PMID:15661432;   PMID:16405508;   PMID:16787416;   PMID:16978535;   PMID:20671299;   PMID:2403792;   PMID:24501112;   PMID:32898608;   PMID:33271839;   PMID:33559528;   PMID:33685091;   PMID:33715333;   PMID:33782420;   PMID:33811074;   PMID:33958485;   PMID:34065827;   PMID:34071686;   PMID:34102274;   PMID:6317292;   PMID:7224729;   PMID:74611;   PMID:7836930;   PMID:9276764;   Patent:DE2011969;   Patent:GB851827;   Patent:NL6505799;   Patent:US3598858;   Reaxys:2224724;   Wikipedia:Prostaglandin_E2
 cyclic_relationship: is_conjugate_acid_of CHEBI:606564


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prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases export
affects export		 ISO ABCC4 protein results in increased export of Dinoprostone
ABCC4 gene SNP affects the export of Dinoprostone		 CTD PMID:22155354 PMID:27659809 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone] CTD PMID:14738173 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
decreases expression		 EXP 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Dinoprostone results in decreased expression of ACTA1 mRNA] CTD PMID:18030065 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Dinoprostone results in increased expression of ACTA2 protein CTD PMID:27697457 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Dinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adm adrenomedullin decreases expression ISO Dinoprostone results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone] CTD PMID:17369603 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance		 EXP Dexamethasone inhibits the reaction [AGT protein alternative form results in increased abundance of Dinoprostone] CTD PMID:4030047 PMID:6421564 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone] CTD PMID:21334316 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation		 ISO
EXP		 Dinoprostone results in increased phosphorylation of AKT1 protein
Dinoprostone results in increased phosphorylation of and results in increased activity of AKT1 protein; oxodiperoxo(pyridine-2-carboxylate)vanadate(V) inhibits the reaction [Dinoprostone results in decreased phosphorylation of AKT1 protein]
Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]
taiwanin C inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]		 CTD PMID:16396944 PMID:17805209 PMID:18056380 PMID:23747687 PMID:25094029 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone CTD PMID:21193584 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Anxa1 annexin A1 multiple interactions ISO ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone] CTD PMID:21777521 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions EXP Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of APOA1 mRNA] CTD PMID:15816358 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein increases abundance
increases expression
multiple interactions
increases secretion		 EXP
ISO		 APP protein modified form results in increased abundance of Dinoprostone
Dinoprostone results in increased expression of APP protein modified form
PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone]; resveratrol inhibits the reaction [APP protein results in increased secretion of Dinoprostone]
[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone]
APP protein modified form results in increased secretion of Dinoprostone
CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; Dronabinol inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; L 685458 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]		 CTD PMID:16685418 PMID:20171164 PMID:23261590 PMID:28721267 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp1 aquaporin 1 increases response to substance ISO AQP1 results in increased susceptibility to Dinoprostone CTD PMID:20018876 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions		 ISO
EXP		 Dinoprostone results in increased expression of AREG mRNA; Dinoprostone results in increased expression of AREG protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]; U 0126 inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]		 CTD PMID:15284208 PMID:15509566 PMID:16888076 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions
increases phosphorylation		 ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] CTD PMID:12164941 PMID:22188298 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Dinoprostone results in decreased expression of SIRT1 mRNA]; ATF3 protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Dinoprostone promotes the reaction [ATF3 protein binds to SIRT1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of ATF3 protein]		 CTD PMID:30409902 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions		 EXP AVP protein results in increased abundance of Dinoprostone
Dexamethasone inhibits the reaction [AVP protein results in increased abundance of Dinoprostone]		 CTD PMID:4030047 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]] CTD PMID:25432964 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 [BAX binds to Dinoprostone] which results in increased localization of BAX
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein]		 CTD PMID:16396944 PMID:17369862 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of BCL2 protein
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]		 CTD PMID:9443418 PMID:25432964 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Dinoprostone affects the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein] CTD PMID:16396944 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Dinoprostone results in increased expression of BIRC3 protein CTD PMID:12837940 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein] CTD PMID:21268125 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP [KNG1 protein co-treated with Dinoprostone] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Dinoprostone promotes the reaction [Capsaicin results in increased secretion of CALCA protein]; Dinoprostone promotes the reaction [Protons results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12044622 PMID:14991081 PMID:18296611 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions		 ISO
EXP		 Dinoprostone results in decreased activity of CASP3 protein
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]
Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]		 CTD PMID:12837940 PMID:16396944 PMID:20335659 PMID:25094029 PMID:25432964 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]] CTD PMID:25432964 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein] CTD PMID:25094029 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases abundance		 EXP
ISO		 CAT protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]
CAT protein results in decreased abundance of Dinoprostone
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [CAT protein results in decreased abundance of Dinoprostone]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]		 CTD PMID:10899936 PMID:11286988 PMID:25432964 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbs cystathionine beta synthase multiple interactions ISO CBS protein inhibits the reaction [Rotenone results in increased abundance of Dinoprostone] CTD PMID:25086357 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of CCL12 mRNA] CTD PMID:28434932 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Dinoprostone results in increased expression of CCL17 mRNA CTD PMID:16303787 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]
Dinoprostone results in decreased expression of CCL2 mRNA
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]		 CTD PMID:16303787 PMID:16784723 PMID:21913898 PMID:25432964 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO [Dinoprostone co-treated with IL1B] results in increased expression of CCL20; Dinoprostone promotes the reaction [IL23A results in increased expression of CCL20]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]		 CTD PMID:17667525 PMID:19273625 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Dinoprostone results in increased expression of CCL22 mRNA CTD PMID:16303787 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] CTD PMID:16784723 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]
Dinoprostone results in decreased expression of CCL3 mRNA
Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]		 CTD PMID:9863660 PMID:16303787 PMID:17667525 PMID:21913898 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression
multiple interactions		 ISO Dinoprostone results in decreased expression of CCL4 protein
Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]
Dinoprostone results in decreased expression of CCL4 mRNA		 CTD PMID:16303787 PMID:17667525 PMID:21913898 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
multiple interactions		 ISO Dinoprostone results in decreased expression of CCL5 mRNA
Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]		 CTD PMID:10495789 PMID:16303787 PMID:16784723 PMID:17667525 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA] CTD PMID:28434932 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 ISO taiwanin C inhibits the reaction [Dinoprostone results in increased expression of CCND1 protein] CTD PMID:30884126 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO Dinoprostone results in decreased expression of CCR5 mRNA; Dinoprostone results in decreased expression of CCR5 protein CTD PMID:16303787 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 multiple interactions ISO [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6 CTD PMID:19273625 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of CCR7 mRNA; Dinoprostone results in increased expression of CCR7 protein
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein		 CTD PMID:16303787 PMID:18952292 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of CD68 protein] CTD PMID:25432964 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions		 ISO Dinoprostone results in decreased expression of CDH1 protein
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein]		 CTD PMID:30208247 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]] CTD PMID:25432964 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
increases secretion		 EXP
ISO		 bifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; bifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]
butylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; Dibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; Diethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]		 CTD PMID:21251947 PMID:21871944 PMID:25016925 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO Dinoprostone results in increased expression of COL10A1 mRNA; Dinoprostone results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Dinoprostone results in decreased expression of COL1A1 mRNA CTD PMID:8971655 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression
multiple interactions		 ISO
EXP		 Dinoprostone results in increased expression of COL2A1 mRNA; Dinoprostone results in increased expression of COL2A1 protein
Indomethacin inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]		 CTD PMID:27050768 PMID:35446470 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cp ceruloplasmin increases secretion EXP CP protein results in increased secretion of Dinoprostone CTD PMID:17727827 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO [nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein] CTD PMID:12164941 PMID:23526216 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Dinoprostone promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; Dinoprostone promotes the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:9066782 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein		 CTD PMID:15180965 PMID:18952292 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 increases localization
multiple interactions
increases expression		 ISO Dinoprostone results in increased localization of CTNNB1 protein
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein]		 CTD PMID:18395713 PMID:30208247 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]] CTD PMID:21913898 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Dinoprostone results in increased expression of CXCR4 mRNA; Dinoprostone results in increased expression of CXCR4 protein CTD PMID:16303787 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Dinoprostone results in increased expression of CYP11A1 mRNA CTD PMID:19001523 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Dinoprostone results in increased expression of CYP17A1 mRNA CTD PMID:19001523 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO
EXP		 2-methoxyoestrone-3-O-sulphamate inhibits the reaction [Dinoprostone results in increased activity of CYP19A1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ATF3 protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; bakuchiol inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; Chlordan inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; Chlordan inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Dinoprostone inhibits the reaction [NR2F2 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 mRNA]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 protein]; Dinoprostone promotes the reaction [NR5A1 protein binds to CYP19A1 promoter]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]
Dinoprostone results in increased expression of CYP19A1 mRNA; Dinoprostone results in increased expression of CYP19A1 protein		 CTD PMID:15862962 PMID:16024248 PMID:19001523 PMID:20351196 PMID:20678559 More... NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]
Dinoprostone results in increased expression of CYP1B1 mRNA; Dinoprostone results in increased expression of CYP1B1 protein		 CTD PMID:20093341 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Dinoprostone promotes the reaction [DDIT3 protein binds to CXCL8 promoter] CTD PMID:17709599 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO DUSP1 mutant form inhibits the reaction [trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]] CTD PMID:21911040 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Edn1 endothelin 1 multiple interactions
increases secretion		 EXP
ISO		 [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]
EDN1 protein results in increased secretion of Dinoprostone		 CTD PMID:16384872 PMID:21811393 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]; Indomethacin promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor increases secretion
increases phosphorylation
multiple interactions
increases expression		 ISO EGFR protein results in increased secretion of Dinoprostone
Dinoprostone results in increased phosphorylation of EGFR protein
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form]; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]		 CTD PMID:16213893 PMID:17805209 PMID:20850495 PMID:30208247 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:30409902 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO EPHX2 gene mutant form affects the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]] CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ereg epiregulin increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of EREG mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA]; U 0126 inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA]		 CTD PMID:16888076 PMID:18444251 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation ISO Dinoprostone results in increased phosphorylation of ESR1 protein CTD PMID:20093341 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
increases expression		 ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA protein]; Dinoprostone promotes the reaction [ESRRA protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 mRNA]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 protein]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 protein]
Dinoprostone results in increased expression of ESRRA mRNA; Dinoprostone results in increased expression of ESRRA protein		 CTD PMID:20351196 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
increases secretion		 EXP
ISO		 [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]
F2 protein results in increased secretion of Dinoprostone
tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]]		 CTD PMID:21811393 PMID:26385185 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression		 ISO Dinoprostone results in increased expression of FAS
Dinoprostone results in decreased expression of FAS mRNA		 CTD PMID:10357836 PMID:15491851 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression
increases response to substance
multiple interactions		 ISO Dinoprostone results in increased expression of FASLG
FASLG results in increased susceptibility to Dinoprostone
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]		 CTD PMID:15491851 PMID:25432964 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Dinoprostone promotes the reaction [Celecoxib results in decreased activity of FASN protein] CTD PMID:19159447 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fcer2 Fc epsilon receptor II decreases expression ISO Dinoprostone results in decreased expression of FCER2 protein CTD PMID:1328389 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476 		JBrowse link
G Fgf20 fibroblast growth factor 20 increases abundance ISO FGF20 protein results in increased abundance of Dinoprostone CTD PMID:12360478 NCBI chr16:52,030,549...52,038,201
Ensembl chr16:52,010,194...52,038,204 		JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]; FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone; SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone] CTD PMID:16144964 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases secretion
multiple interactions		 EXP FGF7 protein results in increased secretion of Dinoprostone
Indomethacin inhibits the reaction [FGF7 protein results in increased secretion of Dinoprostone]		 CTD PMID:16169897 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Dinoprostone results in increased expression of FOS mRNA CTD PMID:10864209 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gast gastrin multiple interactions EXP Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide increases abundance EXP GHRL results in increased abundance of Dinoprostone CTD PMID:16868036 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Glra3 glycine receptor, alpha 3 multiple interactions
increases response to substance		 ISO Dinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]
GLRA3 results in increased susceptibility to Dinoprostone		 CTD PMID:15131310 NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Dinoprostone inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31444509 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]] CTD PMID:25432964 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
affects secretion		 ISO [GPX2 protein affects the activity of PTGS2 protein] which affects the metabolism of Dinoprostone; [GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone
GPX2 protein affects the secretion of Dinoprostone		 CTD PMID:18479189 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases response to substance ISO GRIN2A results in increased susceptibility to Dinoprostone CTD PMID:9113374 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D increases response to substance ISO GRIN2D results in increased susceptibility to Dinoprostone CTD PMID:9113374 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases phosphorylation ISO Dinoprostone results in increased phosphorylation of GSK3A protein CTD PMID:20578217 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases expression
multiple interactions		 ISO Dinoprostone results in increased phosphorylation of GSK3B protein
Dinoprostone results in decreased expression of GSK3B protein
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein]		 CTD PMID:18395713 PMID:20578217 PMID:30208247 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects chemical synthesis ISO GSTM2 protein affects the chemical synthesis of Dinoprostone CTD PMID:10905636 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 affects chemical synthesis ISO GSTM3 protein affects the chemical synthesis of Dinoprostone CTD PMID:10905636 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions
increases abundance		 EXP [HCRT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone
HCRT results in increased abundance of Dinoprostone		 CTD PMID:18378017 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hgf hepatocyte growth factor increases abundance EXP HGF protein results in increased abundance of Dinoprostone CTD PMID:14751415 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]
[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of HIF1A mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]		 CTD PMID:18832182 PMID:20042640 PMID:20335389 PMID:23526216 PMID:28434932 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of HK2 mRNA
Dinoprostone promotes the reaction [nickel chloride results in increased expression of HK2 mRNA]		 CTD PMID:27452194 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]
[chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [N-bromotaurine results in decreased abundance of Dinoprostone]; [chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [N-chlorotaurine results in decreased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [copper protoporphyrin IX promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]		 CTD PMID:18157587 PMID:19428335 PMID:22155307 PMID:23942037 PMID:24003391 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase affects abundance
increases metabolic processing
multiple interactions		 ISO HPGD protein affects the abundance of Dinoprostone
HPGD protein results in increased metabolism of Dinoprostone
[Dinoprostone co-treated with NAD] binds to HPGD protein		 CTD PMID:18500342 PMID:19584167 PMID:20448048 PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP]]; HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP] CTD PMID:9187264 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases activity		 ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased activity of HSD11B1 protein]; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]; Dinoprostone promotes the reaction [HSD11B1 protein affects the oxidation of Hydrocortisone]; PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein] CTD PMID:17761898 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Dinoprostone results in decreased activity of HSD11B2 protein CTD PMID:10377029 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO Dinoprostone results in increased expression of HSD3B2 mRNA CTD PMID:19001523 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dinoprostone results in increased expression of ICAM1 mRNA; Dinoprostone results in increased expression of ICAM1 protein		 CTD PMID:10495789 PMID:16777358 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases abundance		 ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; NFE2L2 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; Probucol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]
[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; Indomethacin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; nimesulide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]
Dinoprostone results in decreased expression of IFNG protein		 CTD PMID:9743329 PMID:12911628 PMID:14623498 PMID:15177302 PMID:15788148 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon increases expression ISO Dinoprostone results in increased expression of IGHE protein CTD PMID:15788148
G Il10 interleukin 10 decreases expression
multiple interactions
decreases abundance
increases abundance		 ISO Dinoprostone results in decreased expression of IL10; Dinoprostone results in decreased expression of IL10 protein
Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; IL10 protein inhibits the reaction [Endotoxins results in increased abundance of Dinoprostone]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]
Dinoprostone promotes the reaction [Zymosan results in increased expression of IL10 mRNA]; Dinoprostone promotes the reaction [Zymosan results in increased expression of IL10 protein]; IL10 gene mutant form promotes the reaction [Silicon Dioxide results in increased abundance of Dinoprostone]
IL10 protein results in decreased abundance of Dinoprostone
IL10 protein results in increased abundance of Dinoprostone		 CTD PMID:7582491 PMID:11301049 PMID:12548226 PMID:14975940 PMID:16303787 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il11 interleukin 11 multiple interactions
increases abundance		 ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:11369638 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
increases secretion		 ISO [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
Dinoprostone results in increased expression of IL12B mRNA; Dinoprostone results in increased expression of IL12B protein
Dinoprostone results in increased secretion of IL12B protein
CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]; Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]		 CTD PMID:10614771 PMID:11369638 PMID:15180965 PMID:16303787 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 decreases expression ISO Dinoprostone results in decreased expression of IL12RB1 protein CTD PMID:9743329 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 decreases expression ISO Dinoprostone results in decreased expression of IL12RB2 mRNA CTD PMID:9743329 NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289 		JBrowse link
G Il13 interleukin 13 increases secretion ISO Dinoprostone results in increased secretion of IL13 protein CTD PMID:15788148 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO [Dinoprostone co-treated with IL23A] results in increased expression of IL17F; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [IL1B results in increased expression of IL17F] CTD PMID:19273625 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Il17ra interleukin 17 receptor A multiple interactions ISO IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone] CTD PMID:22359662 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174 		JBrowse link
G Il1a interleukin 1 alpha increases abundance
increases secretion
multiple interactions		 ISO
EXP		 IL1A protein results in increased abundance of Dinoprostone
IL1A protein results in increased secretion of Dinoprostone
[IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone
mofezolac inhibits the reaction [IL1A protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1A protein results in increased abundance of Dinoprostone]		 CTD PMID:8218930 PMID:11351503 PMID:15167967 PMID:16169897 PMID:21513769 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases chemical synthesis
increases expression
increases secretion
increases abundance		 ISO
EXP		 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; 1-Butanol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; [[Oligomycins co-treated with IL1B protein] results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6; [Dinoprostone co-treated with IL1B] results in increased expression of CCL20; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; [Triclosan co-treated with Cetylpyridinium] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Acetaminophen inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; BAY 11-7085 inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Celecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; ciglitazone promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Cycloheximide inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dactinomycin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone promotes the reaction [IL1B results in increased expression of IL17F]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Glucosamine analog inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Glucosamine inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; HMOX1 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; L 745337 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Oligomycins promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; prolinedithiocarbamate inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; PTGS2 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Quercetin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; sargachromanol G inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; sauchinone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; SC 560 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Tamoxifen promotes the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]]; Triclosan inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]
Dinoprostone results in increased expression of IL1B protein
2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; CAT protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Dinoprostone inhibits the reaction [IL1B protein results in increased abundance of copper bis(3,5-diisopropylsalicylate)]; Glucosamine inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; GW0072 inhibits the reaction [[IL1B protein co-treated with Rosiglitazone] results in increased secretion of Dinoprostone]; IL1B protein promotes the reaction [PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; IL1B protein promotes the reaction [Rosiglitazone results in increased secretion of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrrolidine dithiocarbamic acid inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased abundance of and results in increased secretion of Dinoprostone]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]
IL1B protein results in increased abundance of Dinoprostone; IL1B results in increased abundance of Dinoprostone
Dinoprostone results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]		 CTD PMID:1515551 PMID:7582491 PMID:8662662 PMID:9266823 PMID:10614771 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases activity
increases expression		 ISO Dinoprostone results in increased activity of IL1R1 protein
Dinoprostone results in increased expression of IL1R1 mRNA		 CTD PMID:19273625 PMID:19407222 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Dinoprostone inhibits the reaction [IL1RN protein results in decreased expression of IL6 protein]; IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]] CTD PMID:8520508 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Dinoprostone results in decreased expression of IL2; Dinoprostone results in decreased expression of IL2 protein CTD PMID:2948675 PMID:2989362 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il22 interleukin 22 decreases expression ISO Dinoprostone results in decreased expression of IL22 CTD PMID:19273625 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions
increases expression		 ISO [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6; [Dinoprostone co-treated with IL23A] results in increased expression of IL17F; Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]; Dinoprostone promotes the reaction [IL23A results in increased expression of CCL20]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]
Dinoprostone results in increased expression of IL23A mRNA
CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]; Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]
Dinoprostone results in increased expression of IL23A protein		 CTD PMID:15180965 PMID:19273625 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Dinoprostone results in decreased expression of IL2RA CTD PMID:2948675 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma decreases expression ISO Dinoprostone results in decreased expression of IL2RG CTD PMID:19812686 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il4 interleukin 4 increases secretion
increases response to substance
decreases secretion
multiple interactions		 ISO Dinoprostone results in increased secretion of IL4 protein; IL4 protein results in increased secretion of Dinoprostone
IL4 protein results in increased susceptibility to Dinoprostone
IL4 results in decreased secretion of Dinoprostone
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; luliconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]		 CTD PMID:12370375 PMID:15788148 PMID:18952292 PMID:19767084 PMID:23688403 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases secretion ISO Dinoprostone results in increased secretion of IL5 protein CTD PMID:15788148 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 [Dinoprostone co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; Dinoprostone inhibits the reaction [IL1RN protein results in decreased expression of IL6 protein]; Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]]
Dinoprostone results in increased expression of IL6 protein
Dexamethasone inhibits the reaction [Dinoprostone results in increased expression of IL6 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Lipopolysaccharides promotes the reaction [Dinoprostone results in increased expression of IL6 protein]
[IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [IL6 protein results in increased expression of PTGS2 mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; Celecoxib inhibits the reaction [IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone		 CTD PMID:7536779 PMID:8520508 PMID:15180965 PMID:15379866 PMID:16303787 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression ISO prostaglandin E2 increases expression of Irak3 protein in alveolar macrophages RGD PMID:20439918 RGD:36049799 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP		 ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]		 CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Dinoprostone CTD PMID:14984413 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO Dinoprostone results in decreased phosphorylation of and results in decreased activity of JAK3 protein CTD PMID:19812686 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein] CTD PMID:30409902 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kng1 kininogen 1 increases abundance
multiple interactions
increases secretion		 EXP KNG1 protein alternative form results in increased abundance of Dinoprostone; KNG1 protein results in increased abundance of Dinoprostone
[KNG1 protein co-treated with Dinoprostone] results in increased secretion of CALCA protein; [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Dinoprostone promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Streptozocin promotes the reaction [KNG1 protein modified form results in increased secretion of Dinoprostone]		 CTD PMID:4030047 PMID:11166334 PMID:12791437 PMID:18234883 PMID:20832942 More... NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of LDHA mRNA]
Dinoprostone results in increased expression of LDHA mRNA		 CTD PMID:27452194 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lep leptin increases abundance
increases expression
increases secretion		 EXP LEP protein results in increased abundance of Dinoprostone
Dinoprostone results in increased expression of LEP protein
Dinoprostone results in increased secretion of LEP protein		 CTD PMID:11060898 PMID:16015682 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO MAP3K8 protein affects the reaction [arsenite results in increased secretion of Dinoprostone] CTD PMID:19808956 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 Dinoprostone results in increased activity of MAPK1 protein
gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK1 protein]
Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK1 protein]
Dinoprostone results in decreased phosphorylation of MAPK1 protein		 CTD PMID:16888076 PMID:17805209 PMID:18030065 PMID:18056380 PMID:19201774 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity
multiple interactions
increases phosphorylation		 ISO
EXP		 Dinoprostone results in increased activity of MAPK14 protein
L-826266 inhibits the reaction [Dinoprostone results in increased activity of MAPK14 protein]
Dinoprostone results in increased phosphorylation of MAPK14 protein		 CTD PMID:16644903 PMID:18030065 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 Dinoprostone results in increased activity of MAPK3 protein
gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK3 protein]
Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK3 protein]
Dinoprostone results in decreased phosphorylation of MAPK3 protein		 CTD PMID:16888076 PMID:17805209 PMID:18030065 PMID:18056380 PMID:19201774 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions		 ISO Dinoprostone results in increased activity of MAPK8 protein
L-826266 inhibits the reaction [Dinoprostone results in increased activity of MAPK8 protein]		 CTD PMID:16644903 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein] CTD PMID:25094029 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] CTD PMID:28434932 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases secretion
multiple interactions		 ISO Dinoprostone results in increased expression of MMP9 mRNA; Dinoprostone results in increased expression of MMP9 protein
Dinoprostone results in increased secretion of MMP9 protein
15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; 15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Fenofibrate inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; Fenofibrate inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]		 CTD PMID:16330497 PMID:19880272 PMID:25094029 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:22039321 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]] CTD PMID:22363816 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc1 mucin 1, cell surface associated multiple interactions ISO [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein CTD PMID:18952292 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression		 ISO
EXP		 Dinoprostone results in increased expression of MYC; Dinoprostone results in increased expression of MYC protein
Dinoprostone results in decreased expression of MYC		 CTD PMID:1315190 PMID:8667251 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions		 EXP Dinoprostone results in increased expression of MYH7 protein
Colforsin inhibits the reaction [Dinoprostone results in increased expression of MYH7 protein]		 CTD PMID:18851973 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; NFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone] CTD PMID:23942037 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects activity		 ISO [L-335677 co-treated with 6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with L-826266 co-treated with L-161982] inhibits the reaction [Dinoprostone affects the activity of NFKB1 protein] CTD PMID:18297109 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]		 CTD PMID:22188298 PMID:25432964 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions
increases secretion		 EXP Acetaminophen affects the reaction [NGF protein results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [NGF protein results in increased secretion of Dinoprostone] CTD PMID:21811393 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases response to substance		 ISO
EXP		 [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone; honokiol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone]
[Ozone results in increased expression of NOS2 protein] which results in increased abundance of Dinoprostone; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]
NOS2 results in increased susceptibility to Dinoprostone
Dinoprostone inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Dinoprostone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]		 CTD PMID:11919077 PMID:15491851 PMID:16325209 PMID:16944022 PMID:21147091 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A increases expression
increases abundance
multiple interactions		 EXP Dinoprostone results in increased expression of NPPA mRNA; Dinoprostone results in increased expression of NPPA protein
NPPA protein results in increased abundance of Dinoprostone
Colforsin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein]		 CTD PMID:3070145 PMID:18030065 PMID:18851973 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B increases expression EXP Dinoprostone results in increased expression of NPPB mRNA CTD PMID:18030065 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 multiple interactions ISO Dinoprostone inhibits the reaction [NR2F2 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [NR2F2 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of NR4A2
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]		 CTD PMID:16293616 PMID:22188298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO Dinoprostone promotes the reaction [NR5A1 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions
increases expression		 ISO Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]
Dinoprostone results in increased expression of NRG1 mRNA		 CTD PMID:16357062 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions EXP Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of ORM1 mRNA] CTD PMID:15816358 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]] CTD PMID:25432964 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]] CTD PMID:26691871 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein] CTD PMID:19289254 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
increases abundance		 ISO 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Dinoprostone] CTD PMID:19201774 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Dinoprostone results in decreased expression of PKLR mRNA CTD PMID:10357836 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression ISO Dinoprostone results in increased expression of PLA2G2A protein CTD PMID:15964894 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]
[Cadmium results in increased activity of PLA2G4A protein] which results in increased abundance of Dinoprostone		 CTD PMID:15212812 PMID:15878913 PMID:20850495 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g5 phospholipase A2, group V multiple interactions ISO PLA2G5 protein promotes the reaction [Zymosan results in increased metabolism of Dinoprostone] CTD PMID:14761945 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] CTD PMID:17640750 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] CTD PMID:17640750 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone] CTD PMID:19748995 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B multiple interactions
increases expression
decreases expression		 EXP fulvestrant inhibits the reaction [Dinoprostone results in decreased expression of PPP1R9B protein]; PTGER1 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein] CTD PMID:17408863 PMID:18726914 PMID:23054057 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of PRKACA protein CTD PMID:22188298 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkce protein kinase C, epsilon affects response to substance EXP PRKCE protein affects the susceptibility to Dinoprostone CTD PMID:18509033 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prl prolactin multiple interactions ISO Dinoprostone promotes the reaction [[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA] CTD PMID:7506205 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prodh proline dehydrogenase multiple interactions ISO [PRODH results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone CTD PMID:18794809 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305 		JBrowse link
G Psen2 presenilin 2 multiple interactions ISO [PSEN2 protein mutant form results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone CTD PMID:16331303 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Pten phosphatase and tensin homolog increases activity
decreases phosphorylation
multiple interactions		 EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; Dinoprostone results in increased activity of PTEN protein
Dinoprostone results in decreased phosphorylation of PTEN protein
dioctanoyl-phosphatidylinositol 4,5-bisphosphate inhibits the reaction [Dinoprostone results in decreased phosphorylation of PTEN protein]; oxodiperoxo(pyridine-2-carboxylate)vanadate(V) inhibits the reaction [Dinoprostone results in increased activity of PTEN protein]		 CTD PMID:18056380 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO Dinoprostone binds to and results in increased activity of PTGDR protein; Dinoprostone inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:27636113 NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679 		JBrowse link
G Ptger1 prostaglandin E receptor 1 increases response to substance
increases activity
multiple interactions		 ISO
EXP		 PTGER1 protein results in increased susceptibility to Dinoprostone; PTGER1 results in increased susceptibility to Dinoprostone
Dinoprostone results in increased activity of PTGER1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased abundance of Inositol Phosphates; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of PRKACA protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Dinoprostone binds to and results in increased activity of PTGER1 protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]
PTGER1 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]		 CTD PMID:11375261 PMID:15126118 PMID:15311063 PMID:17408863 PMID:20335389 More... NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases expression
increases activity		 ISO
EXP		 [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein]; Dinoprostone binds to and results in increased activity of PTGER2 protein; Dinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER2 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]; PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]
PTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]		 CTD PMID:15131310 PMID:15930264 PMID:17408863 PMID:17709599 PMID:17761898 More... NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
affects response to substance
increases activity
affects binding
increases expression		 ISO
EXP		 [Dinoprostone results in increased activity of PTGER3 protein] which results in decreased abundance of Cyclic AMP; Dinoprostone binds to and results in increased activity of PTGER3 protein
PTGER3 affects the susceptibility to Dinoprostone
PTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]
Dinoprostone binds to PTGER3 protein; Dinoprostone binds to PTGER3 protein alternative form
Dinoprostone results in increased expression of PTGER3 mRNA
Dinoprostone binds to and results in increased activity of PTGER3 protein; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER3 protein]		 CTD PMID:10357836 PMID:11375261 PMID:12535167 PMID:14636300 PMID:15937517 More... NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions
increases activity
increases expression		 ISO
EXP		 Dinoprostone binds to and results in decreased activity of PTGER4 protein
Dinoprostone results in increased activity of PTGER4 protein
[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP]
Dinoprostone results in increased expression of PTGER4 mRNA
PTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]		 CTD PMID:10800959 PMID:12009843 PMID:17408863 PMID:23526216 PMID:30208247 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptges prostaglandin E synthase increases abundance
multiple interactions		 ISO
EXP		 PTGES results in increased abundance of Dinoprostone
[GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone; [IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [Lithium Chloride results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; [Tetrachlorodibenzodioxin results in increased expression of PTGES mRNA] which results in increased chemical synthesis of Dinoprostone; PTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased abundance of Dinoprostone]
[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone; [Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]
[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone		 CTD PMID:17369862 PMID:18479189 PMID:19393675 PMID:19428335 PMID:19692487 More... NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO
EXP		 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone]; [Lipopolysaccharides results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone
2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone]; [Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone; PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone]		 CTD PMID:19934399 PMID:20171164 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
increases chemical synthesis		 ISO
EXP		 Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]; PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]
[mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; [resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]
[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone results in decreased susceptibility to [resveratrol results in decreased activity of PTGS1 protein]		 CTD PMID:10594344 PMID:16354411 PMID:16894348 PMID:19066340 PMID:19751497 More... NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases chemical synthesis
increases expression
multiple interactions
increases abundance
affects abundance		 ISO
EXP		 PTGS2 protein results in increased chemical synthesis of Dinoprostone
Dinoprostone results in increased expression of PTGS2
3-caffeoyl-4-dicaffeoylquinic acid inhibits the reaction [phorbolol myristate acetate promotes the reaction [PTGS2 protein results in increased abundance of Dinoprostone]]; 4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; [Acetaminophen results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [Cadmium results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Cadmium results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [GPX2 protein affects the activity of PTGS2 protein] which affects the metabolism of Dinoprostone; [IL6 protein results in increased expression of PTGS2 mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [KT 5720 co-treated with Dinoprostone] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; [Lipids results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; [Melitten results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Mycoplasma arthritidis mitogen results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [nonylphenol results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Zymosan results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Capsaicin inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Capsaicin inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; capsazepine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Carthamus yellow inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein]; Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein]; Dinoprostone inhibits the reaction [copper protoporphyrin IX inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Drugs, Chinese Herbal inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Glucosamine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; nimesulide inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; phorbolol myristate acetate promotes the reaction [PTGS2 protein results in increased abundance of Dinoprostone]; piperine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Selenium deficiency promotes the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
[Thiamine deficiency results in increased expression of PTGS2 mRNA] which results in increased expression of Dinoprostone
PTGS2 protein mutant form results in increased abundance of Dinoprostone metabolite; PTGS2 protein results in increased abundance of Dinoprostone
Dinoprostone results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone results in increased expression of PTGS2 mRNA; Dinoprostone results in increased expression of PTGS2 protein
PTGS2 protein affects the abundance of Dinoprostone metabolite
[DuP 697 results in decreased expression of PTGS2] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Dinoprostone]; [HCRT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprostone; [nimesulide results in decreased expression of PTGS2 protein] which results in decreased abundance of Dinoprostone; [o,p'-DDT results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprostone; [PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; ciglitazone promotes the reaction [[PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Dinoprostone results in decreased susceptibility to [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein]; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]; endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; IL1B protein promotes the reaction [PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Meloxicam inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone; pyrrolidine dithiocarbamic acid inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Troglitazone inhibits the reaction [[PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; wuzi yanzong analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
1-phenyl-6,7-dihydroxy-isochroman inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased abundance of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [[Oligomycins co-treated with IL1B protein] results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; [Bupivacaine results in increased expression of PTGS2] which results in increased abundance of Dinoprostone; [Celecoxib analog results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Dronabinol results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Etodolac results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone; [Genistein inhibits the reaction [Fluorouracil results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [Hydrogen Peroxide results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of and results in increased secretion of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Melitten results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Meloxicam results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nickel sulfate co-treated with Dinoprostone] results in increased expression of PTGS2 protein; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Particulate Matter results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; [PRODH results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; [PSEN2 protein mutant form results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [PTGS2 co-treated with Dinoprostone] results in increased expression of VEGFA; [PTGS2 protein results in increased chemical synthesis of Dinoprostone] which results in decreased susceptibility to Fenretinide; [PTGS2 protein results in increased chemical synthesis of Dinoprostone] which results in decreased susceptibility to Tamoxifen; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [SC 791 results in decreased activity of PTGS2 protein] inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased abundance of Dinoprostone]; [Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [TGFB1 results in increased expression of PTGS2] which results in increased abundance of Dinoprostone; [TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone; [Tobacco Smoke Pollution results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Vehicle Emissions results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; acadesine inhibits the reaction [[Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone]; arzanol inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Celecoxib inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Cycloheximide inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dexamethasone inhibits the reaction [[Particulate Matter results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [[Vehicle Emissions results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]; Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; DUSP1 mutant form inhibits the reaction [trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]]; Etodolac inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Ibuprofen inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]; Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; nimesulide inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; oleuropein inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone; PTGS2 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; Resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; SB 203580 inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]]; trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]		 CTD PMID:7575673 PMID:8621535 PMID:8662662 PMID:9266823 PMID:9321948 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases activity EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; [Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein CTD PMID:18056380 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases activity EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; [Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein; Dinoprostone results in increased activity of RAPGEF3 protein CTD PMID:18056380 NCBI chr 7:128,875,772...128,898,203
Ensembl chr 7:128,875,773...128,898,521 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein]
Dinoprostone inhibits the reaction [copper protoporphyrin IX inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]]; Dinoprostone promotes the reaction [Lipopolysaccharides affects the localization of RELA protein]		 CTD PMID:22188298 PMID:24003391 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions ISO [Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein CTD PMID:10432392 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Retn resistin increases secretion ISO RETN protein results in increased secretion of Dinoprostone CTD PMID:23827175 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of RORC
Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]		 CTD PMID:19273625 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Dinoprostone results in increased expression of RUNX2 mRNA; Dinoprostone results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]
1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; ATF3 protein affects the reaction [Dinoprostone results in decreased expression of SIRT1 mRNA]; Dinoprostone promotes the reaction [ATF3 protein binds to SIRT1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]]
Dinoprostone results in decreased expression of SIRT1 mRNA; Dinoprostone results in decreased expression of SIRT1 protein		 CTD PMID:20335659 PMID:20844277 PMID:23257246 PMID:30409902 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of SLC16A3 mRNA] CTD PMID:27452194 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Slc22a22 solute carrier family 22 member 22 increases transport
affects binding		 ISO SLC22A22 protein results in increased transport of Dinoprostone
Dinoprostone binds to SLC22A22 protein		 CTD PMID:20448048 NCBI chr 7:88,720,425...88,750,111
Ensembl chr 7:88,720,427...88,750,111 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Dinoprostone results in decreased expression of SLC22A6 protein CTD PMID:19605544 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake		 ISO SLC22A7 protein results in increased transport of Dinoprostone
SLC22A7 protein results in increased uptake of Dinoprostone		 CTD PMID:12065749 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport
affects transport
decreases expression		 ISO
EXP		 SLC22A8 protein results in increased transport of Dinoprostone
SLC22A8 protein affects the transport of Dinoprostone
Dinoprostone results in decreased expression of SLC22A8 protein		 CTD PMID:11306713 PMID:15100168 PMID:19605544 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression		 ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of SLC2A1 mRNA]
Dinoprostone results in increased expression of SLC2A1 mRNA		 CTD PMID:27452194 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions
increases transport		 ISO Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone] CTD PMID:14514642 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] CTD PMID:29396848 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Dinoprostone results in increased expression of SOX9 mRNA; Dinoprostone results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
decreases expression
increases expression		 ISO Dinoprostone inhibits the reaction [NR2F2 protein binds to STAR promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter]; Dinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter]
Dinoprostone results in decreased expression of STAR mRNA
Dinoprostone results in increased expression of STAR mRNA; Dinoprostone results in increased expression of STAR protein		 CTD PMID:19001523 PMID:19253104 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]] CTD PMID:21268125 PMID:25432964 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Dinoprostone promotes the reaction [Kallidin results in increased secretion of TAC1 protein]; Dinoprostone promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:11166334 PMID:16039053 PMID:18234883 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Dinoprostone results in decreased expression of TBX21 mRNA CTD PMID:19273625 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO Dinoprostone results in decreased expression of TFRC protein CTD PMID:2989362 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 [TGFB1 results in increased expression of PTGS2] which results in increased abundance of Dinoprostone
Dinoprostone inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]
Dinoprostone results in decreased expression of TGFB1 mRNA
[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]		 CTD PMID:8877289 PMID:16489006 PMID:28434932 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA] CTD PMID:28434932 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] CTD PMID:28434932 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA] CTD PMID:28434932 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA] CTD PMID:28434932 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO Dinoprostone results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions		 ISO Dinoprostone results in increased expression of TIMP1 mRNA; Dinoprostone results in increased expression of TIMP1 protein
Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]		 CTD PMID:16330497 PMID:25432964 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone; Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] CTD PMID:20040740 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases abundance
increases secretion		 ISO
EXP		 1-carboxyheptylimidazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; [Triclosan co-treated with Cetylpyridinium] inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; pyrrolidine dithiocarbamic acid promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]]; sorbinil inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased metabolism of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]
Dinoprostone results in decreased expression of TNF protein
TNF protein results in increased abundance of Dinoprostone; TNF results in increased abundance of Dinoprostone
[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF protein]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]
Benzo(a)pyrene promotes the reaction [TNF protein results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone metabolite]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; TNF protein promotes the reaction [Benzo(a)pyrene results in increased abundance of Dinoprostone]
TNF protein results in increased abundance of Dinoprostone; TNF protein results in increased abundance of Dinoprostone metabolite		 CTD PMID:1515551 PMID:1993070 PMID:7536779 PMID:9298541 PMID:9576062 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases expression
increases secretion		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]
Dinoprostone results in increased expression of TNFRSF11B mRNA		 CTD PMID:25234201 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases activity ISO Dinoprostone results in increased activity of TNFRSF1A protein CTD PMID:19407222 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases response to substance ISO TRPC7 results in increased susceptibility to Dinoprostone CTD PMID:16790996 NCBI chr17:7,708,911...7,833,435
Ensembl chr17:7,709,583...7,833,435 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] CTD PMID:18234883 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP UCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone] CTD PMID:14514642 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases chemical synthesis EXP UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprostone CTD PMID:3864191 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Dinoprostone results in increased phosphorylation of VASP protein CTD PMID:18182247 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [[Cisplatin co-treated with ciglitazone] results in decreased expression of VEGFA] which results in decreased abundance of Dinoprostone; [nickel sulfate co-treated with Dinoprostone] results in increased secretion of VEGFA protein; [PTGS2 co-treated with Dinoprostone] results in increased expression of VEGFA CTD PMID:12821125 PMID:18832182 PMID:21681689 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Dinoprostone results in decreased expression of VEGFC mRNA; Dinoprostone results in decreased expression of VEGFC protein CTD PMID:18509974 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vgf VGF nerve growth factor inducible increases abundance EXP VGF results in increased abundance of Dinoprostone CTD PMID:20805684 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Dinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
13,14-dihydro-15-oxo-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions		 ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2		 CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
15-dehydro-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases chemical synthesis ISO HPGD protein results in increased chemical synthesis of 15-ketoprostaglandin E2 CTD PMID:20448048 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions
increases metabolic processing
increases reduction		 EXP
ISO		 15-ketoprostaglandin E2 inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]; Indomethacin inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2]
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin E2] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin E2		 CTD PMID:23878198 PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
8-epi-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 affects response to substance ISO PTGER4 protein affects the susceptibility to 8-isoprostaglandin E2 CTD PMID:22565502 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            oxytocic 249
              prostaglandin E2 233
                13,14-dihydro-15-oxo-prostaglandin E2 1
                15-dehydro-prostaglandin E2 2
                2-[(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oyl]-sn-glycero-3-phosphocholine 0
                2-[(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oyl]-sn-glycero-3-phosphoethanolamine 0
                20-hydroxyprostaglandin E2 0
                8-epi-prostaglandin E2 1
                nitroproston 0
                prostaglandin E2 1-glyceryl ester 0
                prostaglandin E2 2-glyceryl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbon oxoacid 18666
                                    carboxylic acid 18663
                                      monocarboxylic acid 18013
                                        fatty acid 16829
                                          fatty acid derivative 8981
                                            icosanoid 471
                                              prostanoid 407
                                                prostaglandin 399
                                                  prostaglandins E 236
                                                    prostaglandin E2 233
                                                      13,14-dihydro-15-oxo-prostaglandin E2 1
                                                      15-dehydro-prostaglandin E2 2
                                                      2-[(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oyl]-sn-glycero-3-phosphocholine 0
                                                      2-[(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oyl]-sn-glycero-3-phosphoethanolamine 0
                                                      20-hydroxyprostaglandin E2 0
                                                      8-epi-prostaglandin E2 1
                                                      nitroproston 0
                                                      prostaglandin E2 1-glyceryl ester 0
                                                      prostaglandin E2 2-glyceryl ester 0
paths to the root