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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:emodin
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Accession:CHEBI:42223 term browser browse the term
Definition:A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Synonyms:exact_synonym: 1,3,8-trihydroxy-6-methylanthra-9,10-quinone
 related_synonym: 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione;   1,3,8-trihydroxy-6-methyl-9,10-anthraquinone;   3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE;   Formula=C15H10O5;   InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3;   InChIKey=RHMXXJGYXNZAPX-UHFFFAOYSA-N;   SMILES=Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1;   Schuttgelb
 alt_id: CHEBI:42221;   CHEBI:4782
 xref: Beilstein:1888141;   CAS:518-82-1;   DrugBank:DB07715;   KEGG:C10343;   KNApSAcK:C00000555;   LINCS:LSM-18994;   LIPID_MAPS_instance:LMPK13040008
 xref_mesh: MESH:D004642
 xref: PDBeChem:EMO;   PMID:12563347;   PMID:12657721;   PMID:16077936;   PMID:16388516;   PMID:16959273;   PMID:17019678;   PMID:17022020;   PMID:17340270;   PMID:18193729;   PMID:18387517;   PMID:18473931;   PMID:19089830;   PMID:19409890;   PMID:19505457;   PMID:19799875;   PMID:19921750;   PMID:20139316;   PMID:21834668;   PMID:22020806;   PMID:22137788;   PMID:22144110;   PMID:22271272;   PMID:22378302;   PMID:22426603;   PMID:22452333;   PMID:22484343;   Reaxys:1888141;   Wikipedia:Emodin
 cyclic_relationship: is_conjugate_acid_of CHEBI:77659


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emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
multiple interactions
decreases expression
EXP
ISO
Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein
CTD PMID:28161596, PMID:30517764 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
CTD PMID:19549930, PMID:24380838 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Emodin results in increased expression of ABCB1B mRNA CTD PMID:19549930 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Emodin results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein
CTD PMID:19549930, PMID:28161596, PMID:30517764 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein
CTD PMID:19549930, PMID:28161596, PMID:30517764 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]
CTD PMID:28161596, PMID:30517764 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression EXP Emodin results in increased expression of ABCC6 mRNA CTD PMID:19549930 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Emodin results in decreased expression of ACTA1 mRNA CTD PMID:16045814 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:15288473, PMID:27989784 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:14644660, PMID:17869316 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
CTD PMID:15288473, PMID:16045814, PMID:17077332, PMID:23848338, PMID:27032576 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ar androgen receptor multiple interactions ISO Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein] CTD PMID:23212659 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg2 arginase 2 decreases expression ISO Emodin results in decreased expression of ARG2 mRNA CTD PMID:21319176 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Emodin results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:12,573,604...12,602,407
Ensembl chr 7:12,574,198...12,601,674
JBrowse link
G Atm ATM serine/threonine kinase increases expression
increases phosphorylation
ISO Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein
CTD PMID:16045814, PMID:20855424 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bag5 BAG cochaperone 5 decreases expression ISO Emodin results in decreased expression of BAG5 mRNA CTD PMID:16045814 NCBI chr 6:136,180,640...136,185,651
Ensembl chr 6:136,182,006...136,185,651
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Emodin affects the expression of BAX protein
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]
CTD PMID:19549930, PMID:27032576 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]
CTD PMID:19549930, PMID:23848338, PMID:27032576 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bfar bifunctional apoptosis regulator decreases expression ISO Emodin results in decreased expression of BFAR mRNA CTD PMID:16045814 NCBI chr10:1,464,658...1,471,152
NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Bid BH3 interacting domain death agonist increases degradation
multiple interactions
ISO Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]
CTD PMID:27032576 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein CTD PMID:23848338 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Canx calnexin decreases expression ISO Emodin results in decreased expression of CANX mRNA CTD PMID:16045814 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp1 caspase 1 increases expression ISO Emodin results in increased expression of CASP1 mRNA CTD PMID:15612046 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 decreases expression ISO Emodin results in decreased expression of CASP12 mRNA CTD PMID:21319176 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 increases expression
affects expression
increases cleavage
multiple interactions
increases activity
ISO
EXP
Emodin results in increased expression of CASP3 protein
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]
CTD PMID:19549930, PMID:23848338, PMID:25448808, PMID:27032576 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein] CTD PMID:27032576 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression ISO Emodin results in increased expression of CASP9 mRNA CTD PMID:21319176 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
affects expression
ISO
EXP
Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein
CTD PMID:19549930, PMID:22271272, PMID:26139382 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Emodin results in decreased expression of CCNB2 mRNA CTD PMID:16045814 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
EXP Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]
CTD PMID:27989784 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Emodin results in decreased expression of CDK13 mRNA CTD PMID:16045814 NCBI chr17:49,833,194...49,922,932
Ensembl chr17:49,833,400...49,921,550
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Emodin results in decreased expression of CDK4 mRNA CTD PMID:16045814 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Emodin results in increased expression of CDKN1C mRNA CTD PMID:21319176 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 decreases expression ISO Emodin results in decreased expression of CELSR3 mRNA CTD PMID:16045814 NCBI chr 8:117,620,293...117,648,034
Ensembl chr 8:117,620,317...117,648,028
JBrowse link
G Chia chitinase, acidic multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA] CTD PMID:22484343 NCBI chr 2:208,750,348...208,797,388
Ensembl chr 2:208,749,996...208,797,402
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO Emodin results in decreased expression of CIDEC mRNA CTD PMID:21319176 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL1A1 mRNA CTD PMID:15288473 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL3A1 mRNA CTD PMID:15288473 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cops5 COP9 signalosome subunit 5 multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein CTD PMID:17077332 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO Emodin results in increased expression of CSNK2A1 mRNA CTD PMID:21319176 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862
JBrowse link
G Csnk2b casein kinase 2 beta increases expression ISO Emodin results in increased expression of CSNK2B mRNA CTD PMID:21319176 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
JBrowse link
G Ctsd cathepsin D decreases expression ISO Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA] CTD PMID:18590720 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] CTD PMID:18590720 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases expression ISO Emodin results in increased expression of CYLD mRNA CTD PMID:21319176 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein
CTD PMID:11502733, PMID:14644660, PMID:17012224, PMID:27633141 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
decreases activity
ISO [CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein
CTD PMID:27633141, PMID:27989148, PMID:30672276 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
ISO Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein
CTD PMID:11502733, PMID:14990334, PMID:27633141 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP
ISO
Emodin results in decreased expression of CYP27A1 mRNA CTD PMID:28161596, PMID:30517764 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation
multiple interactions
ISO CYP2C19 protein results in increased oxidation of Emodin
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CTD PMID:27989148 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Emodin CTD PMID:30672276 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein CTD PMID:28161596 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Emodin results in decreased expression of CYP7B1 mRNA CTD PMID:30517764 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein CTD PMID:26972667 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Emodin results in increased expression of DDIT3 protein CTD PMID:19549930 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Emodin results in increased expression of DNAJB1 mRNA CTD PMID:16045814 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 increases expression ISO Emodin results in increased expression of DYNC1H1 mRNA CTD PMID:21319176 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Emodin results in increased expression of E2F5 mRNA CTD PMID:16045814 NCBI chr 2:88,350,764...88,366,913
Ensembl chr 2:88,351,361...88,366,115
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Emodin results in increased expression of EI24 mRNA CTD PMID:16045814 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha decreases expression ISO Emodin results in decreased expression of EIF2B1 mRNA CTD PMID:16045814 NCBI chr12:37,444,136...37,452,391
Ensembl chr12:37,444,072...37,465,398
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Emodin results in increased activity of ESR1 protein CTD PMID:19161236 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Emodin results in increased activity of ESR2 protein CTD PMID:19161236 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Emodin results in decreased expression of FABP5 mRNA CTD PMID:15612046 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Emodin results in increased expression of FADD mRNA CTD PMID:21319176 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein
CTD PMID:19549930, PMID:27032576 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein] CTD PMID:27032576 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Emodin results in decreased expression of FN1 mRNA CTD PMID:15288473 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Emodin results in increased expression of FOXO1 mRNA CTD PMID:16045814 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA] CTD PMID:30517764 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Emodin results in increased expression of GAS2 mRNA CTD PMID:16045814 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Emodin results in increased expression of GCNT2 mRNA CTD PMID:15612046 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Golga3 golgin A3 increases expression ISO Emodin results in increased expression of GOLGA3 mRNA CTD PMID:21319176 NCBI chr12:52,510,509...52,558,606
Ensembl chr12:52,512,970...52,558,606
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Emodin results in increased expression of GPX1 mRNA CTD PMID:16045814 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA] CTD PMID:30517764 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:22271272 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
CTD PMID:20855424 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Emodin results in decreased expression of HACD3 mRNA CTD PMID:16045814 NCBI chr 8:70,471,572...70,509,874
Ensembl chr 8:70,471,572...70,509,874
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 increases expression ISO Emodin results in increased expression of H1F9 mRNA CTD PMID:21319176 NCBI chr10:82,775,691...82,776,487
Ensembl chr10:82,775,691...82,776,487
JBrowse link
G Hk2 hexokinase 2 increases expression ISO Emodin results in increased expression of HK2 mRNA CTD PMID:21319176 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein] CTD PMID:26139382, PMID:30517764 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
affects glucuronidation
EXP
ISO
Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin
CTD PMID:32538071 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Emodin results in increased expression of HSPA5 protein CTD PMID:19549930 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein] CTD PMID:18590720 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 increases expression ISO Emodin results in increased expression of IGSF11 mRNA CTD PMID:21319176 NCBI chr11:64,286,691...64,421,248
Ensembl chr11:64,286,694...64,421,248
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA] CTD PMID:30517764 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:22484343 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 increases expression ISO Emodin results in increased expression of IL15 mRNA CTD PMID:15612046 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein] CTD PMID:26139382, PMID:30517764 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:22484343 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:18590720, PMID:23848338, PMID:26139382, PMID:30517764 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Emodin results in decreased expression of ITPR1 mRNA CTD PMID:16045814 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Jag1 jagged canonical Notch ligand 1 multiple interactions
decreases expression
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]
Emodin results in decreased expression of JAG1 protein
CTD PMID:27989784 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jak1 Janus kinase 1 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]
CTD PMID:23848338 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]
CTD PMID:23848338 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein CTD PMID:17077332 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Krt19 keratin 19 decreases expression ISO Emodin results in decreased expression of KRT19 mRNA CTD PMID:16045814 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Laptm5 lysosomal protein transmembrane 5 increases expression ISO Emodin results in increased expression of LAPTM5 mRNA CTD PMID:15612046 NCBI chr 5:149,015,793...149,069,719
Ensembl chr 5:149,047,681...149,069,719
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Emodin results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G LOC100363405 hypothetical LOC100363405 increases expression ISO Emodin results in increased expression of ZFP37 mRNA CTD PMID:21319176 NCBI chr 5:77,265,335...77,294,739
Ensembl chr 5:77,266,842...77,294,765
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein CTD PMID:23212659 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 decreases expression ISO Emodin results in decreased expression of MACF1 mRNA CTD PMID:16045814 NCBI chr 5:141,039,455...141,363,524
Ensembl chr 5:141,039,468...141,363,524
JBrowse link
G Maob monoamine oxidase B decreases activity EXP Emodin results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:15288473 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]
CTD PMID:15288473, PMID:26972667, PMID:27032576 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Emodin results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:14729614 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]
CTD PMID:15288473, PMID:26972667, PMID:27032576 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Emodin results in decreased expression of MAPT mRNA CTD PMID:16045814 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
increases expression
ISO Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA
CTD PMID:21319176, PMID:23848338 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Emodin results in increased expression of MGMT mRNA CTD PMID:19549930 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Emodin results in decreased expression of MITF protein CTD PMID:26972667 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:18590720 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA] CTD PMID:22484343 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression
EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein
CTD PMID:17886230, PMID:19549930 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mylk myosin light chain kinase increases activity EXP Emodin results in increased activity of MYLK protein CTD PMID:15133857 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO Emodin results in increased expression of NCOA2 mRNA CTD PMID:21319176 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA] CTD PMID:26139382 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Emodin results in increased expression of NFKB1 protein CTD PMID:19549930 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:16045814, PMID:22484343 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nkx6-2 NK6 homeobox 2 increases expression ISO Emodin results in increased expression of NKX6-2 mRNA CTD PMID:15612046 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2
CTD PMID:18590720, PMID:23615023 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions
decreases response to substance
EXP Emodin results in decreased expression of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin
CTD PMID:27989784 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Emodin results in increased expression of NR0B2 mRNA CTD PMID:30517764 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein CTD PMID:26972667 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein CTD PMID:30517764 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions
ISO Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]
CTD PMID:23848338, PMID:27032576 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdcl phosducin-like decreases expression ISO Emodin results in decreased expression of PDCL mRNA CTD PMID:16045814 NCBI chr 3:21,602,349...21,609,821
Ensembl chr 3:21,601,816...21,609,853
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] CTD PMID:15288473 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions
decreases expression
EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein
CTD PMID:15288473 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Emodin results in decreased expression of PECAM1 protein CTD PMID:23848338 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Emodin results in increased expression of PIK3C3 mRNA CTD PMID:16045814 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression EXP Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA
CTD PMID:25448808 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Emodin results in increased expression of PPM1D mRNA CTD PMID:16045814 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Emodin results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:66,673,060...66,783,501
Ensembl chr 3:66,673,071...66,780,075
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Emodin results in increased expression of PRDX6 mRNA CTD PMID:16045814 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkca protein kinase C, alpha affects localization EXP Emodin affects the localization of PRKCA protein CTD PMID:15133857 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta decreases expression
affects expression
ISO
EXP
Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein
CTD PMID:16045814, PMID:19549930 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prm3 protamine 3 increases expression ISO Emodin results in increased expression of PRM3 mRNA CTD PMID:21319176 NCBI chr10:4,951,557...4,952,071
Ensembl chr10:4,951,557...4,952,071
JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression EXP Emodin affects the expression of PTK2 protein CTD PMID:19549930 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression
multiple interactions
ISO Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr 4:157,239,141...157,263,890
Ensembl chr 4:157,239,142...157,263,890
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]
CTD PMID:15288473, PMID:16045814 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rag1 recombination activating 1 decreases expression ISO Emodin results in decreased expression of RAG1 mRNA CTD PMID:15612046 NCBI chr 3:91,206,394...91,217,491
Ensembl chr 3:91,206,394...91,217,491
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO Emodin results in decreased expression of RARB mRNA CTD PMID:22609528 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Emodin results in decreased expression of RB1 mRNA CTD PMID:16045814 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Emodin results in increased expression of RCN2 mRNA CTD PMID:16045814 NCBI chr 8:60,709,851...60,726,938
Ensembl chr 8:60,709,851...60,726,936
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
EXP
ISO
Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]
CTD PMID:18590720, PMID:19549930, PMID:22484343, PMID:30517764 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Emodin results in decreased expression of RHOA mRNA CTD PMID:16045814 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO Emodin results in decreased expression of ROCK2 mRNA CTD PMID:16045814 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Emodin results in decreased expression of SAE1 mRNA CTD PMID:16045814 NCBI chr 1:78,277,524...78,333,281
Ensembl chr 1:78,277,515...78,333,321
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] CTD PMID:14534369 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]
CTD PMID:28161596, PMID:30517764 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Emodin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO Emodin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA] CTD PMID:30517764 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Smcp sperm mitochondria-associated cysteine-rich protein increases expression ISO Emodin results in increased expression of SMCP mRNA CTD PMID:21319176 NCBI chr 2:192,775,425...192,780,631
Ensembl chr 2:192,775,437...192,780,631
JBrowse link
G Snu13 small nuclear ribonucleoprotein 13 decreases expression ISO Emodin results in decreased expression of SNU13 mRNA CTD PMID:15612046 NCBI chr 7:123,282,754...123,287,721
Ensembl chr 7:123,282,754...123,287,721
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects activity
ISO
EXP
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein
CTD PMID:21382473, PMID:23615023 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Emodin results in decreased phosphorylation of SRC protein CTD PMID:23848338 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression ISO Emodin results in increased expression of ST8SIA1 mRNA CTD PMID:16045814 NCBI chr 4:177,065,266...177,195,942
Ensembl chr 4:177,065,168...177,196,180
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
multiple interactions
ISO Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Emodin results in decreased expression of STIP1 mRNA CTD PMID:16045814 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Supt20h SPT20 homolog, SAGA complex component increases expression ISO Emodin results in increased expression of SUPT20H mRNA CTD PMID:16045814 NCBI chr 2:143,892,609...143,925,733
Ensembl chr 2:143,892,567...143,925,633
JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO Emodin results in decreased expression of TAOK3 mRNA CTD PMID:16045814 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Tbcc tubulin folding cofactor C decreases expression ISO Emodin results in decreased expression of TBCC mRNA CTD PMID:16045814 NCBI chr 9:16,405,187...16,406,338
Ensembl chr 9:16,405,185...16,406,338
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Emodin results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:176,124,846...176,144,531
Ensembl chr 3:176,125,482...176,144,531
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] CTD PMID:15288473, PMID:19474275, PMID:27989784 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]
Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]
CTD PMID:14534369, PMID:15313406, PMID:18590720, PMID:26139382 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
increases activity
ISO Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein
CTD PMID:20855424 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 affects expression EXP Emodin affects the expression of TP53 protein CTD PMID:19549930 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Emodin results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression
decreases expression
ISO Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA
CTD PMID:16045814, PMID:21319176 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Emodin results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link
G Tsga13 testis specific, 13 increases expression ISO Emodin results in increased expression of TSGA13 mRNA CTD PMID:21319176 NCBI chr 4:58,195,424...58,216,712
Ensembl chr 4:58,195,355...58,216,711
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Emodin results in decreased expression of TUBB3 mRNA CTD PMID:16045814 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Txnl4b thioredoxin-like 4B decreases expression ISO Emodin results in decreased expression of TXNL4B mRNA CTD PMID:16045814 NCBI chr19:42,101,081...42,110,223
Ensembl chr19:42,101,902...42,107,601
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Emodin results in decreased expression of TXNRD1 mRNA CTD PMID:16045814 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tyr tyrosinase decreases activity ISO Emodin results in decreased activity of TYR protein CTD PMID:26972667 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein CTD PMID:26972667 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO Emodin results in increased expression of UBE2I mRNA CTD PMID:21319176 NCBI chr10:14,618,615...14,639,274
Ensembl chr10:14,620,531...14,630,151
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Emodin CTD PMID:14557274, PMID:24854283 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Emodin CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO
EXP
Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein CTD PMID:32538071 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Emodin results in decreased expression of VDAC1 mRNA CTD PMID:16045814 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein CTD PMID:23848338 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression
multiple interactions
EXP Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]
CTD PMID:27989784 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects expression EXP Emodin affects the expression of XRCC1 protein CTD PMID:19549930 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              emodin 204
                isoskyrin 0
                questin 0
                skyrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        cyclic ketone 13813
                                          quinone 8338
                                            acenoquinone 7497
                                              anthraquinone 469
                                                hydroxyanthraquinones 461
                                                  trihydroxyanthraquinone 207
                                                    emodin 204
                                                      isoskyrin 0
                                                      questin 0
                                                      skyrin 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.