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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:emodin
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Accession:CHEBI:42223 term browser browse the term
Definition:A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Synonyms:exact_synonym: 1,3,8-trihydroxy-6-methylanthra-9,10-quinone
 related_synonym: 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione;   1,3,8-trihydroxy-6-methyl-9,10-anthraquinone;   3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE;   Formula=C15H10O5;   InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3;   InChIKey=RHMXXJGYXNZAPX-UHFFFAOYSA-N;   SMILES=Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1;   Schuttgelb
 alt_id: CHEBI:42221;   CHEBI:4782
 xref: Beilstein:1888141;   CAS:518-82-1;   DrugBank:DB07715;   KEGG:C10343;   KNApSAcK:C00000555;   LINCS:LSM-18994;   LIPID_MAPS_instance:LMPK13040008
 xref_mesh: MESH:D004642
 xref: PDBeChem:EMO;   PMID:12563347;   PMID:12657721;   PMID:16077936;   PMID:16388516;   PMID:16959273;   PMID:17019678;   PMID:17022020;   PMID:17340270;   PMID:18193729;   PMID:18387517;   PMID:18473931;   PMID:19089830;   PMID:19409890;   PMID:19505457;   PMID:19799875;   PMID:19921750;   PMID:20139316;   PMID:21834668;   PMID:22020806;   PMID:22137788;   PMID:22144110;   PMID:22271272;   PMID:22378302;   PMID:22426603;   PMID:22452333;   PMID:22484343;   Reaxys:1888141;   Wikipedia:Emodin
 cyclic_relationship: is_conjugate_acid_of CHEBI:77659


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emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
multiple interactions
decreases expression
EXP
ISO
Emodin results in increased expression of ABCB11 mRNA; Emodin results in increased expression of ABCB11 protein
dorsomorphin inhibits the reaction [Emodin results in decreased expression of ABCB11 mRNA]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]
Emodin results in decreased expression of ABCB11 mRNA; Emodin results in decreased expression of ABCB11 protein
CTD PMID:28161596 PMID:30517764 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
Emodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
Emodin results in increased expression of ABCB1A mRNA
ABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]
CTD PMID:19549930 PMID:24380838 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Emodin results in increased expression of ABCB1B mRNA CTD PMID:19549930 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Emodin results in decreased expression of ABCB4 mRNA CTD PMID:28161596 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA
Emodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 protein
CTD PMID:19549930 PMID:28161596 PMID:30517764 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
Emodin results in increased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA
Emodin results in decreased expression of ABCC3 mRNA; Emodin results in decreased expression of ABCC3 protein
CTD PMID:19549930 PMID:28161596 PMID:30517764 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of ABCC4 mRNA; Emodin results in decreased expression of ABCC4 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC4 mRNA]
CTD PMID:28161596 PMID:30517764 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression EXP Emodin results in increased expression of ABCC6 mRNA CTD PMID:19549930 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Emodin results in decreased expression of ACTA1 mRNA CTD PMID:16045814 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP Emodin results in decreased expression of ACTA2 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]
CTD PMID:15288473 PMID:27989784 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]; Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Emodin binds to and results in increased activity of AHR protein
Emodin binds to and results in increased activity of AHR protein; Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:14644660 PMID:17869316 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; SB 203580 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [Emodin results in decreased phosphorylation of AKT1 protein]
Emodin results in decreased expression of AKT1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
CTD PMID:15288473 PMID:16045814 PMID:17077332 PMID:23848338 PMID:27032576 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ar androgen receptor multiple interactions ISO Emodin inhibits the reaction [cobaltous chloride results in increased expression of AR protein] CTD PMID:23212659 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg2 arginase 2 decreases expression ISO Emodin results in decreased expression of ARG2 mRNA CTD PMID:21319176 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO Emodin results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Atm ATM serine/threonine kinase increases expression
increases phosphorylation
ISO Emodin results in increased expression of ATM mRNA
Emodin results in increased phosphorylation of ATM protein
CTD PMID:16045814 PMID:20855424 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bag5 BAG cochaperone 5 decreases expression ISO Emodin results in decreased expression of BAG5 mRNA CTD PMID:16045814 NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
decreases expression
multiple interactions
ISO
EXP
Emodin affects the expression of BAX protein
Emodin results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; SB 203580 affects the reaction [Emodin affects the expression of BAX protein]; U 0126 affects the reaction [Emodin affects the expression of BAX protein]
CTD PMID:19549930 PMID:27032576 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of BCL2 mRNA; Emodin results in decreased expression of BCL2 protein
Emodin affects the expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; SB 203580 affects the reaction [Emodin affects the expression of BCL2 protein]; U 0126 affects the reaction [Emodin affects the expression of BCL2 protein]
CTD PMID:19549930 PMID:23848338 PMID:27032576 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bfar bifunctional apoptosis regulator decreases expression ISO Emodin results in decreased expression of BFAR mRNA CTD PMID:16045814 NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038
JBrowse link
G Bid BH3 interacting domain death agonist increases degradation
multiple interactions
ISO Emodin results in increased degradation of BID protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; SB 203580 promotes the reaction [Emodin results in increased degradation of BID protein]
CTD PMID:27032576 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Emodin results in decreased expression of BIRC5 mRNA; Emodin results in decreased expression of BIRC5 protein CTD PMID:23848338 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Canx calnexin decreases expression ISO Emodin results in decreased expression of CANX mRNA CTD PMID:16045814 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp1 caspase 1 increases expression ISO Emodin results in increased expression of CASP1 mRNA CTD PMID:15612046 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 decreases expression ISO Emodin results in decreased expression of CASP12 mRNA CTD PMID:21319176 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases expression
affects expression
increases cleavage
multiple interactions
increases activity
ISO
EXP
Emodin results in increased expression of CASP3 protein
Emodin affects the expression of CASP3 protein modified form
Emodin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Emodin results in increased activity of CASP3 protein]; Emodin results in increased cleavage of and results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of CASP3 protein]; U 0126 promotes the reaction [Emodin results in increased cleavage of CASP3 protein]
CTD PMID:19549930 PMID:23848338 PMID:25448808 PMID:27032576 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; SB 203580 promotes the reaction [Emodin results in increased activity of CASP8 protein]; U 0126 promotes the reaction [Emodin results in increased activity of CASP8 protein] CTD PMID:27032576 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO Emodin results in increased expression of CASP9 mRNA CTD PMID:21319176 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
affects expression
ISO
EXP
Emodin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Emodin promotes the reaction [Cisplatin results in decreased activity of CAT protein]
Emodin affects the expression of CAT protein
CTD PMID:19549930 PMID:22271272 PMID:26139382 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Emodin results in decreased expression of CCNB2 mRNA CTD PMID:16045814 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
EXP Emodin results in increased expression of CDH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]
CTD PMID:27989784 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk13 cyclin-dependent kinase 13 decreases expression ISO Emodin results in decreased expression of CDK13 mRNA CTD PMID:16045814 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Emodin results in decreased expression of CDK4 mRNA CTD PMID:16045814 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Emodin results in increased expression of CDKN1C mRNA CTD PMID:21319176 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 decreases expression ISO Emodin results in decreased expression of CELSR3 mRNA CTD PMID:16045814 NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354
JBrowse link
G Chia chitinase, acidic multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of CHIA mRNA] CTD PMID:22484343 NCBI chr 2:193,614,374...193,656,532
Ensembl chr 2:193,614,114...193,656,533
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO Emodin results in decreased expression of CIDEC mRNA CTD PMID:21319176 NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL1A1 mRNA CTD PMID:15288473 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] CTD PMID:19474275 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Emodin results in decreased expression of COL3A1 mRNA CTD PMID:15288473 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cops5 COP9 signalosome subunit 5 multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein CTD PMID:17077332 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression ISO Emodin results in increased expression of CSNK2A1 mRNA CTD PMID:21319176 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Csnk2b casein kinase 2 beta increases expression ISO Emodin results in increased expression of CSNK2B mRNA CTD PMID:21319176 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Ctsd cathepsin D decreases expression ISO Emodin results in decreased expression of CTSD mRNA CTD PMID:16045814 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA] CTD PMID:18590720 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CXCL2 mRNA] CTD PMID:18590720 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase increases expression ISO Emodin results in increased expression of CYLD mRNA CTD PMID:21319176 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression
ISO Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Emodin results in decreased activity of CYP1A1 protein
Emodin results in increased expression of CYP1A1 mRNA; Emodin results in increased expression of CYP1A1 protein
CTD PMID:11502733 PMID:14644660 PMID:17012224 PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
decreases activity
ISO [CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP1A2 protein results in increased hydroxylation of Emodin
CYP1A2 protein results in increased oxidation of Emodin
Emodin results in decreased activity of CYP1A2 protein
CTD PMID:27633141 PMID:27989148 PMID:30672276 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
ISO Emodin results in increased expression of CYP1B1 mRNA; Emodin results in increased expression of CYP1B1 protein
Emodin results in decreased activity of CYP1B1 protein
CTD PMID:11502733 PMID:14990334 PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP
ISO
Emodin results in decreased expression of CYP27A1 mRNA CTD PMID:28161596 PMID:30517764 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Emodin results in decreased activity of CYP2C9 protein CTD PMID:27633141 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation
multiple interactions
ISO CYP2C19 protein results in increased oxidation of Emodin
[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CTD PMID:27989148 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
increases oxidation
ISO [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite
CYP3A4 protein results in increased hydroxylation of Emodin
CYP3A4 protein results in increased oxidation of Emodin
CTD PMID:27989148 PMID:30672276 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Emodin CTD PMID:30672276 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Emodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 protein CTD PMID:28161596 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Emodin results in decreased expression of CYP7B1 mRNA CTD PMID:30517764 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Emodin results in decreased expression of CYP8B1 mRNA; Emodin results in decreased expression of CYP8B1 protein CTD PMID:28161596 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dct dopachrome tautomerase decreases expression ISO Emodin results in decreased expression of DCT mRNA; Emodin results in decreased expression of DCT protein CTD PMID:26972667 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Emodin results in increased expression of DDIT3 protein CTD PMID:19549930 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO Emodin results in decreased expression of DHFR mRNA CTD PMID:16045814 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Emodin results in increased expression of DNAJB1 mRNA CTD PMID:16045814 NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 increases expression ISO Emodin results in increased expression of DYNC1H1 mRNA CTD PMID:21319176 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Emodin results in increased expression of E2F5 mRNA CTD PMID:16045814 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Emodin results in increased expression of EI24 mRNA CTD PMID:16045814 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha decreases expression ISO Emodin results in decreased expression of EIF2B1 mRNA CTD PMID:16045814 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Emodin results in increased activity of ESR1 protein CTD PMID:19161236 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Emodin results in increased activity of ESR2 protein CTD PMID:19161236 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Emodin results in decreased expression of FABP5 mRNA CTD PMID:15612046 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Emodin results in increased expression of FADD mRNA CTD PMID:21319176 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]; U 0126 promotes the reaction [Emodin results in increased expression of FAS protein]
Emodin results in decreased expression of FAS protein
CTD PMID:19549930 PMID:27032576 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]; SB 203580 promotes the reaction [Emodin results in increased expression of FASLG protein]; U 0126 promotes the reaction [Emodin results in increased expression of FASLG protein] CTD PMID:27032576 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Emodin results in decreased expression of FN1 mRNA CTD PMID:15288473 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO Emodin results in increased expression of FOXO1 mRNA CTD PMID:16045814 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GADD45A mRNA] CTD PMID:30517764 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Emodin results in increased expression of GAS2 mRNA CTD PMID:16045814 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Emodin results in increased expression of GCNT2 mRNA CTD PMID:15612046 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Golga3 golgin A3 increases expression ISO Emodin results in increased expression of GOLGA3 mRNA CTD PMID:21319176 NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Emodin results in increased expression of GPX1 mRNA CTD PMID:16045814 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPX2 mRNA] CTD PMID:30517764 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO Emodin promotes the reaction [Cisplatin results in decreased activity of GSR protein] CTD PMID:22271272 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Emodin results in decreased expression of GSTM3 mRNA CTD PMID:16045814 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO Emodin results in increased expression of H2AX protein modified form
TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
CTD PMID:20855424 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression ISO Emodin results in decreased expression of HACD3 mRNA CTD PMID:16045814 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of HIF1A mRNA] CTD PMID:21382473 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hils1 histone linker H1 domain, spermatid-specific 1 increases expression ISO Emodin results in increased expression of H1F9 mRNA CTD PMID:21319176 NCBI chr10:79,913,525...79,914,321
Ensembl chr10:79,913,480...79,914,321
JBrowse link
G Hk2 hexokinase 2 increases expression ISO Emodin results in increased expression of HK2 mRNA CTD PMID:21319176 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 protein] CTD PMID:26139382 PMID:30517764 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
affects glucuronidation
EXP
ISO
Emodin results in decreased expression of HNF4A protein
Emodin results in decreased expression of HNF4A mRNA; Emodin results in decreased expression of HNF4A protein
HNF4A gene SNP affects the glucuronidation of Emodin
CTD PMID:32538071 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Emodin results in increased expression of HSPA5 protein CTD PMID:19549930 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ICAM1 protein] CTD PMID:18590720 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 increases expression ISO Emodin results in increased expression of IGSF11 mRNA CTD PMID:21319176 NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL10 mRNA] CTD PMID:30517764 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:22484343 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 increases expression ISO Emodin results in increased expression of IL15 mRNA CTD PMID:15612046 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL1B protein] CTD PMID:26139382 PMID:30517764 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:22484343 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:22484343 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 mRNA]; Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of IL6 protein]
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:18590720 PMID:23848338 PMID:26139382 PMID:30517764 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Emodin results in decreased expression of ITPR1 mRNA CTD PMID:16045814 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Jag1 jagged canonical Notch ligand 1 multiple interactions
decreases expression
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]
Emodin results in decreased expression of JAG1 protein
CTD PMID:27989784 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jak1 Janus kinase 1 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK1 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK1 protein]
CTD PMID:23848338 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation
multiple interactions
ISO Emodin results in decreased phosphorylation of JAK2 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]
CTD PMID:23848338 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein CTD PMID:17077332 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Krt19 keratin 19 decreases expression ISO Emodin results in decreased expression of KRT19 mRNA CTD PMID:16045814 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Laptm5 lysosomal protein transmembrane 5 increases expression ISO Emodin results in increased expression of LAPTM5 mRNA CTD PMID:15612046 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Emodin results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G LOC100363405 hypothetical LOC100363405 increases expression ISO Emodin results in increased expression of ZFP37 mRNA CTD PMID:21319176 NCBI chr 5:74,930,335...74,960,075
Ensembl chr 5:74,863,483...74,960,101
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Emodin co-treated with cobaltous chloride] results in increased expression of LRP1 protein CTD PMID:23212659 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 decreases expression ISO Emodin results in decreased expression of MACF1 mRNA CTD PMID:16045814 NCBI chr 5:135,623,729...135,949,097
Ensembl chr 5:135,623,742...135,945,905
JBrowse link
G Maob monoamine oxidase B decreases activity EXP Emodin results in decreased activity of MAOB protein CTD PMID:15120460 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein] CTD PMID:15288473 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein] CTD PMID:15288473 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]
Emodin results in decreased phosphorylation of MAPK1 protein
Emodin results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK1 protein]
CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Emodin results in increased expression of MAPK10 mRNA CTD PMID:15612046 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] CTD PMID:14729614 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]
Emodin results in decreased phosphorylation of MAPK3 protein
Emodin results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with TO-901317] inhibits the reaction [Emodin results in increased phosphorylation of MAPK3 protein]
CTD PMID:15288473 PMID:26972667 PMID:27032576 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Emodin results in decreased expression of MAPT mRNA CTD PMID:16045814 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
increases expression
ISO Emodin results in decreased expression of MCL1 mRNA; Emodin results in decreased expression of MCL1 protein
Emodin results in increased expression of MCL1 mRNA
CTD PMID:21319176 PMID:23848338 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Emodin results in increased expression of MGMT mRNA CTD PMID:19549930 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Emodin results in decreased expression of MITF protein CTD PMID:26972667 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of MPO protein] CTD PMID:18590720 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Emodin inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA] CTD PMID:22484343 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
affects expression
EXP Emodin inhibits the reaction [AGT protein results in increased expression of MYC protein]
Emodin affects the expression of MYC protein
CTD PMID:17886230 PMID:19549930 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mylk myosin light chain kinase increases activity EXP Emodin results in increased activity of MYLK protein CTD PMID:15133857 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 increases expression ISO Emodin results in increased expression of NCOA2 mRNA CTD PMID:21319176 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NFE2L2 protein]; Emodin promotes the reaction [Tobacco Smoke Pollution results in increased expression of NFE2L2 mRNA] CTD PMID:26139382 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Emodin results in increased expression of NFKB1 protein CTD PMID:19549930 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
ISO Emodin results in increased expression of NFKBIA mRNA
Emodin inhibits the reaction [Ovalbumin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD PMID:16045814 PMID:22484343 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkx6-2 NK6 homeobox 2 increases expression ISO Emodin results in increased expression of NKX6-2 mRNA CTD PMID:15612046 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects expression
EXP Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]
Emodin affects the expression of NOS2
CTD PMID:18590720 PMID:23615023 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 decreases expression
multiple interactions
decreases response to substance
EXP Emodin results in decreased expression of NOTCH1 protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein]
NOTCH1 protein results in decreased susceptibility to Emodin
CTD PMID:27989784 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Emodin results in increased expression of NR0B2 mRNA CTD PMID:30517764 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Emodin results in increased expression of NR1H3 mRNA; Emodin results in increased expression of NR1H3 protein CTD PMID:26972667 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Emodin results in decreased expression of NR1H4 mRNA; Emodin results in decreased expression of NR1H4 protein CTD PMID:30517764 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions
ISO Emodin results in increased activity of PARP1 protein
Emodin results in increased cleavage of PARP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; [U 0126 co-treated with Emodin] results in increased cleavage of PARP1 protein; SB 203580 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Emodin results in increased cleavage of PARP1 protein]
CTD PMID:23848338 PMID:27032576 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Emodin inhibits the reaction [AGT protein results in increased expression of PCNA protein] CTD PMID:17886230 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcl phosducin-like decreases expression ISO Emodin results in decreased expression of PDCL mRNA CTD PMID:16045814 NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]; Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein] CTD PMID:15288473 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions
decreases expression
EXP Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]
Emodin results in decreased expression of PDGFRB protein
CTD PMID:15288473 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Emodin results in decreased expression of PECAM1 protein CTD PMID:23848338 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression ISO Emodin results in increased expression of PIK3C3 mRNA CTD PMID:16045814 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 affects expression EXP Emodin affects the expression of PIK3R1 protein CTD PMID:19549930 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Emodin results in increased expression of PPARG protein
Emodin results in increased stability of and results in increased expression of PPARG mRNA
CTD PMID:25448808 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO Emodin results in increased expression of PPM1D mRNA CTD PMID:16045814 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppp1r1c protein phosphatase 1, regulatory (inhibitor) subunit 1C decreases expression ISO Emodin results in decreased expression of PPP1R1C mRNA CTD PMID:15612046 NCBI chr 3:64,616,700...64,719,696
Ensembl chr 3:64,616,700...64,724,104
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO Emodin results in increased expression of PRDX6 mRNA CTD PMID:16045814 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prkca protein kinase C, alpha affects localization EXP Emodin affects the localization of PRKCA protein CTD PMID:15133857 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcd protein kinase C, delta decreases expression
affects expression
ISO
EXP
Emodin results in decreased expression of PRKCD mRNA
Emodin affects the expression of PRKCD protein
CTD PMID:16045814 PMID:19549930 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prm3 protamine 3 increases expression ISO Emodin results in increased expression of PRM3 mRNA CTD PMID:21319176 NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985
JBrowse link
G Ptk2 protein tyrosine kinase 2 affects expression EXP Emodin affects the expression of PTK2 protein CTD PMID:19549930 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases expression
multiple interactions
ISO Emodin results in increased expression of PTPN6 protein
PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression
multiple interactions
ISO
EXP
Emodin results in decreased expression of RAF1 mRNA
Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]
CTD PMID:15288473 PMID:16045814 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rag1 recombination activating 1 decreases expression ISO Emodin results in decreased expression of RAG1 mRNA CTD PMID:15612046 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO Emodin results in decreased expression of RARB mRNA CTD PMID:22609528 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Emodin results in decreased expression of RB1 mRNA CTD PMID:16045814 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rcn2 reticulocalbin 2 increases expression ISO Emodin results in increased expression of RCN2 mRNA CTD PMID:16045814 NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
EXP
ISO
Emodin affects the expression of and affects the localization of RELA protein; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]
Emodin results in decreased localization of RELA protein
Emodin inhibits the reaction [Ovalbumin affects the localization of RELA protein]
CTD PMID:18590720 PMID:19549930 PMID:22484343 PMID:30517764 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Emodin results in decreased expression of RHOA mRNA CTD PMID:16045814 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO Emodin results in decreased expression of ROCK1 mRNA CTD PMID:16045814 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases expression ISO Emodin results in decreased expression of ROCK2 mRNA CTD PMID:16045814 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Emodin results in decreased expression of SAE1 mRNA CTD PMID:16045814 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] CTD PMID:14534369 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
EXP
ISO
Emodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 protein
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]
CTD PMID:28161596 PMID:30517764 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Emodin results in decreased activity of SLC22A6 protein CTD PMID:29045746 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO Emodin results in decreased activity of SLC22A8 protein CTD PMID:29045746 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA] CTD PMID:30517764 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smcp sperm mitochondria-associated cysteine-rich protein increases expression ISO Emodin results in increased expression of SMCP mRNA CTD PMID:21319176 NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001
JBrowse link
G Snu13 small nuclear ribonucleoprotein 13 decreases expression ISO Emodin results in decreased expression of SNU13 mRNA CTD PMID:15612046 NCBI chr 7:113,565,903...113,570,871
Ensembl chr 7:113,565,295...113,570,872
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD1 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD1 mRNA] CTD PMID:21382473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects activity
ISO
EXP
Emodin inhibits the reaction [Oxygen deficiency results in decreased activity of SOD2 protein]; Emodin inhibits the reaction [Oxygen deficiency results in decreased expression of SOD2 mRNA]
Emodin affects the activity of SOD2 protein
CTD PMID:21382473 PMID:23615023 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation ISO Emodin results in decreased phosphorylation of SRC protein CTD PMID:23848338 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression ISO Emodin results in increased expression of ST8SIA1 mRNA CTD PMID:16045814 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
JBrowse link
G Stat3 signal transducer and activator of transcription 3 affects localization
multiple interactions
ISO Emodin affects the localization of STAT3 protein
Emodin inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; PTPN6 mutant form inhibits the reaction [Emodin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]
CTD PMID:23848338 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Emodin results in decreased expression of STIP1 mRNA CTD PMID:16045814 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO Emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Supt20h SPT20 homolog, SAGA complex component increases expression ISO Emodin results in increased expression of SUPT20H mRNA CTD PMID:16045814 NCBI chr 2:138,897,316...138,930,495
Ensembl chr 2:138,897,416...138,930,495
JBrowse link
G Taok3 TAO kinase 3 decreases expression ISO Emodin results in decreased expression of TAOK3 mRNA CTD PMID:16045814 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tbcc tubulin folding cofactor C decreases expression ISO Emodin results in decreased expression of TBCC mRNA CTD PMID:16045814 NCBI chr 9:14,098,875...14,100,026
Ensembl chr 9:14,098,868...14,100,042
JBrowse link
G Tcfl5 transcription factor like 5 increases expression ISO Emodin results in increased expression of TCFL5 mRNA CTD PMID:15612046 NCBI chr 3:167,734,471...167,754,174
Ensembl chr 3:167,734,473...167,754,282
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases activity
EXP 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of NOTCH1 protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; 2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin results in decreased activity of TGFB1 protein]; Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of and affects the localization of NOTCH1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Emodin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; NOTCH1 protein inhibits the reaction [Emodin results in decreased activity of TGFB1 protein] CTD PMID:15288473 PMID:19474275 PMID:27989784 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]
Emodin inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]; Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]; Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]]
CTD PMID:14534369 PMID:15313406 PMID:18590720 PMID:26139382 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions
increases activity
ISO Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate]; TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form]
Emodin results in increased activity of TOP2A protein
CTD PMID:20855424 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 affects expression EXP Emodin affects the expression of TP53 protein CTD PMID:19549930 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp63 tumor protein p63 increases expression ISO Emodin results in increased expression of TRP63 mRNA CTD PMID:15612046 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Traf2 Tnf receptor-associated factor 2 increases expression
decreases expression
ISO Emodin results in increased expression of TRAF2 mRNA
Emodin results in decreased expression of TRAF2 mRNA
CTD PMID:16045814 PMID:21319176 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 increases expression ISO Emodin results in increased expression of TRPV2 mRNA CTD PMID:15612046 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
G Tsga13 testis specific, 13 increases expression ISO Emodin results in increased expression of TSGA13 mRNA CTD PMID:21319176 NCBI chr 4:59,501,773...59,522,925
Ensembl chr 4:59,501,774...59,522,818
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO Emodin results in decreased expression of TUBB3 mRNA CTD PMID:16045814 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Txnl4b thioredoxin-like 4B decreases expression ISO Emodin results in decreased expression of TXNL4B mRNA CTD PMID:16045814 NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression ISO Emodin results in decreased expression of TXNRD1 mRNA CTD PMID:16045814 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tyr tyrosinase decreases activity ISO Emodin results in decreased activity of TYR protein CTD PMID:26972667 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO Emodin results in decreased expression of TYRP1 mRNA; Emodin results in decreased expression of TYRP1 protein CTD PMID:26972667 NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO Emodin results in increased expression of UBE2I mRNA CTD PMID:21319176 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Emodin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Emodin CTD PMID:14557274 PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Emodin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases expression ISO
EXP
Emodin results in decreased expression of UGT2B7 mRNA; Emodin results in decreased expression of UGT2B7 protein CTD PMID:32538071 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Emodin results in decreased expression of VDAC1 mRNA CTD PMID:16045814 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Emodin results in decreased expression of VEGFA mRNA; Emodin results in decreased expression of VEGFA protein CTD PMID:23848338 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression
multiple interactions
EXP Emodin results in decreased expression of VIM protein
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]; Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; NOTCH1 protein inhibits the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]]
CTD PMID:27989784 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects expression EXP Emodin affects the expression of XRCC1 protein CTD PMID:19549930 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            antineoplastic agent 17316
              emodin 206
                isoskyrin 0
                questin 0
                skyrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        cyclic ketone 15393
                                          quinone 8376
                                            acenoquinone 7507
                                              anthraquinone 476
                                                hydroxyanthraquinones 466
                                                  trihydroxyanthraquinone 212
                                                    emodin 206
                                                      isoskyrin 0
                                                      questin 0
                                                      skyrin 0
paths to the root