CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Aatk
apoptosis-associated tyrosine kinase
increases expression
ISO
ferric oxide analog results in increased expression of AATK mRNA
CTD
PMID:25086211
NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
EXP
ferric oxide analog results in increased expression of ABCG1 mRNA
CTD
PMID:38615722
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Acan
aggrecan
increases expression
EXP
ferric oxide analog results in increased expression of ACAN mRNA
CTD
PMID:38615722
NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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Ache
acetylcholinesterase
decreases activity
ISO
ferric oxide results in decreased activity of ACHE protein
CTD
PMID:28993115
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
ISO
ferric oxide analog results in increased expression of ACSS2 mRNA
CTD
PMID:25086211
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Adgre1
adhesion G protein-coupled receptor E1
increases expression
ISO
ferric oxide analog results in increased expression of ADGRE1 mRNA
CTD
PMID:24525745
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Adm
adrenomedullin
increases expression
ISO
ferric oxide analog results in increased expression of ADM mRNA
CTD
PMID:25086211
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adora2b
adenosine A2B receptor
increases expression
ISO
ferric oxide analog results in increased expression of ADORA2B mRNA
CTD
PMID:25086211
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Agtr2
angiotensin II receptor, type 2
decreases expression
EXP
ferric oxide analog results in decreased expression of AGTR2 mRNA
CTD
PMID:38615722
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Ahnak2
AHNAK nucleoprotein 2
increases expression
ISO
ferric oxide analog results in increased expression of AHNAK2 mRNA
CTD
PMID:25086211
NCBI chr 6:131,830,668...131,876,311
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Ahrr
aryl-hydrocarbon receptor repressor
increases expression
ISO EXP
ferric oxide analog results in increased expression of AHRR mRNA
CTD
PMID:24525745 PMID:38615722
NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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Aig1
androgen-induced 1
increases expression
ISO
ferric oxide analog results in increased expression of AIG1 mRNA
CTD
PMID:25086211
NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084
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Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of AKT1 protein
CTD
PMID:24847785
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alas1
5'-aminolevulinate synthase 1
increases expression
EXP
ferric oxide analog results in increased expression of ALAS1 mRNA
CTD
PMID:38615722
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Aldh1a2
aldehyde dehydrogenase 1 family, member A2
decreases expression
EXP
ferric oxide analog results in decreased expression of ALDH1A2 mRNA
CTD
PMID:38615722
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
decreases expression
ISO
ferric oxide analog results in decreased expression of ALDH1L2 mRNA
CTD
PMID:25086211
NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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Angpt1
angiopoietin 1
increases expression
EXP
ferric oxide analog results in increased expression of ANGPT1 mRNA
CTD
PMID:38615722
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Angptl2
angiopoietin-like 2
decreases expression
EXP
ferric oxide analog results in decreased expression of ANGPTL2 mRNA
CTD
PMID:38615722
NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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Ankrd12
ankyrin repeat domain 12
decreases expression
ISO
ferric oxide analog results in decreased expression of ANKRD12 mRNA
CTD
PMID:24525745
NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911
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Anln
anillin, actin binding protein
decreases expression increases expression
ISO
ferric oxide analog results in decreased expression of ANLN mRNA ferric oxide analog results in increased expression of ANLN mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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Anxa3
annexin A3
decreases expression
ISO
ferric oxide analog results in decreased expression of ANXA3 mRNA
CTD
PMID:25086211
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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Aox1
aldehyde oxidase 1
increases expression
EXP
ferric oxide analog results in increased expression of AOX1 mRNA
CTD
PMID:38615722
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Ap5b1
adaptor related protein complex 5 subunit beta 1
decreases expression
ISO
ferric oxide analog results in decreased expression of AP5B1 mRNA
CTD
PMID:25086211
NCBI chr 1:202,876,272...202,880,303
Ensembl chr 1:202,876,272...202,880,289
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Arhgap24
Rho GTPase activating protein 24
increases expression
ISO
ferric oxide analog results in increased expression of ARHGAP24 mRNA
CTD
PMID:25086211
NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
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Atf3
activating transcription factor 3
increases expression
ISO
ferric oxide analog results in increased expression of ATF3 protein
CTD
PMID:24068039
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atg5
autophagy related 5
increases expression
ISO
ferric oxide analog results in increased expression of ATG5 protein
CTD
PMID:24068039
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atosa
atos homolog A
increases expression
ISO
ferric oxide analog results in increased expression of ATOSA mRNA
CTD
PMID:25086211
NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
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B3galnt1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
increases expression
ISO
ferric oxide analog results in increased expression of B3GALNT1 mRNA
CTD
PMID:24525745
NCBI chr 2:153,847,297...153,877,371
Ensembl chr 2:153,846,474...153,877,332
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B3galt2
Beta-1,3-galactosyltransferase 2
decreases expression
EXP
ferric oxide analog results in decreased expression of B3GALT2 mRNA
CTD
PMID:38615722
NCBI chr13:55,389,406...55,398,419
Ensembl chr13:55,389,406...55,398,419
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression decreases expression increases phosphorylation
ISO EXP
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein] ferric oxide results in increased expression of BAX protein ferric oxide results in decreased expression of BAX protein ferric oxide analog results in increased phosphorylation of BAX protein
CTD
PMID:19421372 PMID:22995439 PMID:25086211 PMID:26991130
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
increases phosphorylation increases expression
EXP ISO
ferric oxide analog results in increased phosphorylation of BCL2 protein ferric oxide results in increased expression of BCL2 mRNA ferric oxide analog results in increased expression of BCL2 protein
CTD
PMID:22995439 PMID:25086211 PMID:33554279
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l11
Bcl2-like 11
increases expression
ISO
ferric oxide analog results in increased expression of BCL2L11 mRNA; ferric oxide analog results in increased expression of BCL2L11 protein
CTD
PMID:24525745 PMID:25086211
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bdh2
3-hydroxybutyrate dehydrogenase 2
increases expression
ISO
ferric oxide analog results in increased expression of BDH2 mRNA
CTD
PMID:25086211
NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
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Becn1
beclin 1
decreases expression increases expression
ISO
ferric oxide results in decreased expression of BECN1 protein ferric oxide analog results in increased expression of BECN1 protein
CTD
PMID:24068039 PMID:25086211
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
ferric oxide analog results in increased expression of BHLHE40 mRNA
CTD
PMID:25086211
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Bmp2
bone morphogenetic protein 2
increases expression
EXP
ferric oxide analog results in increased expression of BMP2 mRNA
CTD
PMID:38615722
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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C1s
complement C1s
increases expression
EXP
ferric oxide analog results in increased expression of C1S mRNA
CTD
PMID:38615722
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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Canx
calnexin
decreases expression
ISO
ferric oxide results in decreased expression of CANX protein
CTD
PMID:25086211
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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Car5b
carbonic anhydrase 5B
increases expression
EXP
ferric oxide analog results in increased expression of CAR5B mRNA
CTD
PMID:38615722
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
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Casp3
caspase 3
multiple interactions affects activity increases expression increases cleavage
ISO
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein] ferric oxide affects the activity of CASP3 protein ferric oxide results in increased expression of CASP3 protein modified form ferric oxide results in increased cleavage of CASP3 protein
CTD
PMID:19421372 PMID:26991130 PMID:33554279
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
ISO
ferric oxide results in increased activity of CASP9 protein
CTD
PMID:33554279
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Castor1
cytosolic arginine sensor for mTORC1 subunit 1
increases expression
ISO
ferric oxide analog results in increased expression of CASTOR1 mRNA
CTD
PMID:25086211
NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
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Cat
catalase
decreases activity decreases expression
ISO
ferric oxide results in decreased activity of CAT protein ferric oxide results in decreased expression of CAT protein
CTD
PMID:19699289 PMID:26991130 PMID:28993115
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccdc85b
coiled-coil domain containing 85B
increases expression
ISO
ferric oxide analog results in increased expression of CCDC85B mRNA
CTD
PMID:25086211
NCBI chr 1:202,763,645...202,764,660
Ensembl chr 1:202,763,631...202,764,703
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Ccl11
C-C motif chemokine ligand 11
multiple interactions increases expression
ISO
ferric oxide results in increased expression of and results in increased secretion of CCL11 protein; RAG1 promotes the reaction [ferric oxide analog results in increased expression of CCL11 protein]
CTD
PMID:34982504 PMID:36935073
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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Ccl2
C-C motif chemokine ligand 2
increases secretion increases expression
ISO EXP
ferric oxide results in increased secretion of CCL2 protein ferric oxide analog results in increased expression of CCL2 mRNA
CTD
PMID:24885771 PMID:38615722
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
increases expression
EXP
ferric oxide analog results in increased expression of CCL20 mRNA
CTD
PMID:38615722
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl22
C-C motif chemokine ligand 22
increases secretion
ISO
ferric oxide results in increased secretion of CCL22 protein
CTD
PMID:24885771
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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Ccl3
C-C motif chemokine ligand 3
increases secretion multiple interactions increases expression
ISO
ferric oxide results in increased secretion of CCL3 protein ferric oxide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] ferric oxide results in increased expression of CCL3 protein
CTD
PMID:24885771 PMID:35872045 PMID:36416909
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
decreases expression increases expression increases secretion
ISO
ferric oxide analog results in decreased expression of CCL4 mRNA ferric oxide results in increased expression of CCL4 protein ferric oxide results in increased secretion of CCL4 protein
CTD
PMID:24525745 PMID:24885771 PMID:35872045
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccl5
C-C motif chemokine ligand 5
increases expression
EXP
ferric oxide analog results in increased expression of CCL5 mRNA
CTD
PMID:38615722
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccl7
C-C motif chemokine ligand 7
increases secretion increases expression multiple interactions
ISO EXP
ferric oxide results in increased secretion of CCL7 protein ferric oxide analog results in increased expression of CCL7 mRNA ferric oxide results in increased expression of and results in increased secretion of CCL7 protein; RAG1 inhibits the reaction [ferric oxide analog results in increased expression of CCL7 protein]
CTD
PMID:24885771 PMID:34982504 PMID:36935073 PMID:38615722
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Cd14
CD14 molecule
decreases expression
ISO
ferric oxide analog results in decreased expression of CD14 mRNA
CTD
PMID:25086211
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd274
CD274 molecule
increases expression
ISO
ferric oxide analog results in increased expression of CD274 mRNA
CTD
PMID:25086211
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd74
CD74 molecule
decreases expression
ISO
ferric oxide analog results in decreased expression of CD74 mRNA
CTD
PMID:25086211
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Cd83
CD83 molecule
increases expression
ISO
ferric oxide analog results in increased expression of CD83 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cdh1
cadherin 1
decreases expression
ISO EXP
ferric oxide results in decreased expression of CDH1 protein ferric oxide analog results in decreased expression of CDH1 mRNA
CTD
PMID:34982504 PMID:38615722
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdhr1
cadherin-related family member 1
increases expression
EXP
ferric oxide analog results in increased expression of CDHR1 mRNA
CTD
PMID:38615722
NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
EXP
ferric oxide analog results in increased expression of CDKN1A protein
CTD
PMID:22995439
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
EXP
[ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein
CTD
PMID:24847785
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
decreases expression
ISO
ferric oxide analog results in decreased expression of CDKN2A mRNA
CTD
PMID:24525745
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cep83
centrosomal protein 83
decreases expression
ISO
ferric oxide analog results in decreased expression of CEP83 mRNA
CTD
PMID:24525745
NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
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Clec5a
C-type lectin domain containing 5A
decreases expression
ISO
ferric oxide analog results in decreased expression of CLEC5A mRNA
CTD
PMID:25086211
NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
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Clk4
CDC-like kinase 4
increases expression
ISO
ferric oxide analog results in increased expression of CLK4 mRNA
CTD
PMID:25086211
NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352
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Cntn3
contactin 3
decreases expression
EXP
ferric oxide analog results in decreased expression of CNTN3 mRNA
CTD
PMID:38615722
NCBI chr 4:134,841,268...135,214,460
Ensembl chr 4:134,842,266...135,125,613
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Col3a1
collagen type III alpha 1 chain
decreases expression
EXP
ferric oxide analog results in decreased expression of COL3A1 mRNA
CTD
PMID:38615722
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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Col6a3
collagen type VI alpha 3 chain
increases expression
EXP
ferric oxide analog results in increased expression of COL6A3 mRNA
CTD
PMID:38615722
NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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Col8a1
collagen type VIII alpha 1 chain
decreases expression
EXP
ferric oxide analog results in decreased expression of COL8A1 mRNA
CTD
PMID:38615722
NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424
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Cox6a2
cytochrome c oxidase subunit 6A2
decreases expression
ISO
ferric oxide analog results in decreased expression of COX6A2 mRNA
CTD
PMID:25086211
NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
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Crabp2
cellular retinoic acid binding protein 2
increases expression
EXP
ferric oxide analog results in increased expression of CRABP2 mRNA
CTD
PMID:38615722
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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Csnk1e
casein kinase 1, epsilon
increases expression
ISO
ferric oxide analog results in increased expression of CSNK1E mRNA
CTD
PMID:25086211
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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Cx3cr1
C-X3-C motif chemokine receptor 1
decreases expression
ISO
ferric oxide analog results in decreased expression of CX3CR1 mRNA
CTD
PMID:25086211
NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
ISO EXP
ferric oxide results in increased expression of CXCL1 protein ferric oxide analog results in increased expression of CXCL1 mRNA
CTD
PMID:35872045 PMID:38615722
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
EXP
ferric oxide analog results in increased expression of CXCL10 mRNA
CTD
PMID:38615722
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions increases expression
ISO
ferric oxide results in increased expression of and results in increased secretion of CXCL1 protein ferric oxide results in increased expression of CXCL1 protein
CTD
PMID:34982504 PMID:35872045
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
ferric oxide analog results in increased expression of CXCR4 mRNA
CTD
PMID:25086211
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression
EXP
ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] ferric oxide analog results in increased expression of CYP1A1 mRNA
CTD
PMID:15211619 PMID:38615722
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
EXP
ferric oxide analog results in increased expression of CYP1B1 mRNA
CTD
PMID:38615722
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Ddit3
DNA-damage inducible transcript 3
increases expression decreases expression
ISO
ferric oxide analog results in increased expression of DDIT3 mRNA; ferric oxide analog results in increased expression of DDIT3 protein ferric oxide analog results in decreased expression of DDIT3 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Ddit4
DNA-damage-inducible transcript 4
decreases expression
ISO
ferric oxide analog results in decreased expression of DDIT4 mRNA
CTD
PMID:24525745
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Dgkg
diacylglycerol kinase, gamma
decreases expression
ISO
ferric oxide analog results in decreased expression of DGKG mRNA
CTD
PMID:25086211
NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212
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Dock3
dedicator of cyto-kinesis 3
increases expression
EXP
ferric oxide analog results in increased expression of DOCK3 mRNA
CTD
PMID:38615722
NCBI chr 8:107,552,462...107,903,527
Ensembl chr 8:107,552,463...107,903,514
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Dusp1
dual specificity phosphatase 1
decreases expression
ISO
ferric oxide analog results in decreased expression of DUSP1 mRNA
CTD
PMID:25086211
NCBI chr10:16,680,478...16,683,275
G
Dusp4
dual specificity phosphatase 4
increases expression
ISO
ferric oxide analog results in increased expression of DUSP4 mRNA
CTD
PMID:25086211
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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Eef1a1
eukaryotic translation elongation factor 1 alpha 1
decreases expression
ISO
ferric oxide analog results in decreased expression of EEF1A1 mRNA
CTD
PMID:25086211
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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Egfr
epidermal growth factor receptor
increases phosphorylation
ISO
ferric oxide analog results in increased phosphorylation of EGFR protein
CTD
PMID:24068039
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
decreases expression
ISO
ferric oxide analog results in decreased expression of EGR1 mRNA
CTD
PMID:25086211
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
increases expression
ISO
ferric oxide analog results in increased expression of EGR2 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
decreases expression
ISO
ferric oxide analog results in decreased expression of EIF2AK2 mRNA
CTD
PMID:25086211
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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Eno2
enolase 2
increases expression decreases expression
ISO
ferric oxide analog results in increased expression of ENO2 mRNA ferric oxide analog results in decreased expression of ENO2 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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Epn2
epsin 2
increases expression
ISO
ferric oxide analog results in increased expression of EPN2 mRNA
CTD
PMID:25086211
NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642
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Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
ISO
ferric oxide analog results in increased expression of and results in increased phosphorylation of ERN1 protein
CTD
PMID:25086211
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Esm1
endothelial cell-specific molecule 1
increases expression
EXP
ferric oxide analog results in increased expression of ESM1 mRNA
CTD
PMID:38615722
NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
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Fblim1
filamin binding LIM protein 1
increases expression
ISO
ferric oxide analog results in increased expression of FBLIM1 mRNA
CTD
PMID:25086211
NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
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Filip1
filamin A interacting protein 1
increases expression
EXP
ferric oxide analog results in increased expression of FILIP1 mRNA
CTD
PMID:38615722
NCBI chr 8:80,761,283...80,956,556
Ensembl chr 8:80,764,604...80,922,549
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression increases expression
ISO
ferric oxide analog results in decreased expression of FOS mRNA ferric oxide analog results in increased expression of FOS mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
ferric oxide analog results in increased expression of FOSB mRNA
CTD
PMID:38615722
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
EXP
ferric oxide analog results in increased expression of FOSL1 mRNA
CTD
PMID:38615722
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Fus
Fus RNA binding protein
decreases expression
ISO
ferric oxide analog results in decreased expression of FUS mRNA
CTD
PMID:25086211
NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
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Fyb1
FYN binding protein 1
decreases expression
ISO
ferric oxide analog results in decreased expression of FYB1 mRNA
CTD
PMID:25086211
NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases phosphorylation
EXP
ferric oxide analog results in increased phosphorylation of GADD45A protein
CTD
PMID:22995439
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
ISO
ferric oxide analog results in increased expression of GADD45B mRNA
CTD
PMID:25086211
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
G
Gbp2
guanylate binding protein 2
increases expression
EXP
ferric oxide analog results in increased expression of GBP2 mRNA
CTD
PMID:38615722
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
G
Gja1
gap junction protein, alpha 1
increases expression
ISO
ferric oxide analog results in increased expression of GJA1 mRNA
CTD
PMID:25086211
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gpnmb
glycoprotein nmb
increases expression
EXP
ferric oxide analog results in increased expression of GPNMB mRNA
CTD
PMID:38615722
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
G
Gpr183
G protein-coupled receptor 183
increases expression
ISO
ferric oxide analog results in increased expression of GPR183 mRNA
CTD
PMID:24525745
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
G
Gpr84
G protein-coupled receptor 84
decreases expression increases expression
ISO
ferric oxide analog results in decreased expression of GPR84 mRNA ferric oxide analog results in increased expression of GPR84 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 7:134,443,904...134,446,173
Ensembl chr 7:134,443,936...134,446,178
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
[Benzo(a)pyrene co-treated with ferric oxide] results in increased activity of GSR protein
CTD
PMID:11033230
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gsta1
glutathione S-transferase alpha 1
increases expression
EXP
ferric oxide analog results in increased expression of GSTA1 mRNA
CTD
PMID:38615722
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
ferric oxide analog results in increased expression of GSTP1 mRNA
CTD
PMID:38615722
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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H2ax
H2A.X variant histone
multiple interactions increases expression
ISO
Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein]
CTD
PMID:27270449
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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H2bc8
H2B clustered histone 8
decreases expression
ISO
ferric oxide analog results in decreased expression of H2BC7 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr17:42,708,658...42,709,408
G
H2bc9
H2B clustered histone 9
decreases expression
ISO
ferric oxide analog results in decreased expression of H2BC9 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr17:42,470,593...42,478,590
G
H3c1
H3 clustered histone 1
decreases expression
ISO
ferric oxide analog results in decreased expression of H3C1 mRNA
CTD
PMID:25086211
NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856
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Hbegf
heparin-binding EGF-like growth factor
increases expression
ISO
ferric oxide analog results in increased expression of HBEGF mRNA
CTD
PMID:25086211
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Heatr3
HEAT repeat containing 3
decreases expression
ISO
ferric oxide analog results in decreased expression of HEATR3 mRNA
CTD
PMID:25086211
NCBI chr19:18,892,477...18,930,502
Ensembl chr19:18,893,144...18,930,509
G
Hebp1
heme binding protein 1
increases expression
ISO
ferric oxide analog results in increased expression of HEBP1 mRNA
CTD
PMID:25086211
NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854
G
Hilpda
hypoxia inducible lipid droplet-associated
increases expression
ISO
ferric oxide analog results in increased expression of HILPDA mRNA
CTD
PMID:25086211
NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
G
Hist1h2ail1
histone cluster 1 H2a family member I like 1
decreases expression
ISO
ferric oxide analog results in decreased expression of H3C6 mRNA
CTD
PMID:25086211
NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109
G
Hist1h2bc
histone cluster 1, H2bc
increases expression
ISO
ferric oxide analog results in increased expression of H2BC21 mRNA
CTD
PMID:25086211
NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
G
Hist1h4b
histone cluster 1 H4 family member B
decreases expression
EXP
ferric oxide analog results in decreased expression of HIST1H4B mRNA
CTD
PMID:38615722
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
G
Hist2h2be
histone cluster 2 H2B family member E
decreases expression
ISO
ferric oxide analog results in decreased expression of H2BC11 mRNA
CTD
PMID:25086211
NCBI chr 2:183,780,583...183,783,030
G
Hmox1
heme oxygenase 1
increases expression
ISO EXP
ferric oxide analog results in increased expression of HMOX1 mRNA
CTD
PMID:24525745 PMID:25086211 PMID:38615722
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
increases expression
EXP
ferric oxide analog results in increased expression of HSD11B1 mRNA
CTD
PMID:38615722
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
G
Hsd3b7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
increases expression
ISO
ferric oxide analog results in increased expression of HSD3B7 mRNA
CTD
PMID:25086211
NCBI chr 1:182,412,216...182,415,447
Ensembl chr 1:182,412,151...182,415,442
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA1A mRNA
CTD
PMID:20540983
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA8 mRNA
CTD
PMID:20540983
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspd1
heat shock protein family D (Hsp60) member 1
decreases expression
ISO
ferric oxide results in decreased expression of HSPD1 protein
CTD
PMID:28077287
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Hyal1
hyaluronidase 1
increases expression decreases expression
ISO
ferric oxide analog results in increased expression of HYAL1 mRNA ferric oxide analog results in decreased expression of HYAL1 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
ferric oxide results in increased expression of ICAM1 protein
CTD
PMID:21439359
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Icam2
intercellular adhesion molecule 2
decreases expression
ISO
ferric oxide analog results in decreased expression of ICAM2 mRNA
CTD
PMID:25086211
NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293
G
Id1
inhibitor of DNA binding 1
increases expression
ISO
ferric oxide analog results in increased expression of ID1 mRNA
CTD
PMID:24525745
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Id3
inhibitor of DNA binding 3
increases expression
ISO
ferric oxide analog results in increased expression of ID3 mRNA
CTD
PMID:24525745
NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
G
Il10ra
interleukin 10 receptor subunit alpha
decreases expression
ISO
ferric oxide analog results in decreased expression of IL10RA mRNA
CTD
PMID:25086211
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
G
Il12b
interleukin 12B
multiple interactions
ISO
ferric oxide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]
CTD
PMID:36416909
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il13
interleukin 13
multiple interactions increases expression
ISO
RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL13 protein]
CTD
PMID:36935073
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il17a
interleukin 17A
multiple interactions
ISO
ferric oxide results in increased expression of and results in increased secretion of IL17A protein
CTD
PMID:34982504
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il1b
interleukin 1 beta
increases secretion
ISO
ferric oxide analog results in increased secretion of IL1B protein ferric oxide results in increased secretion of IL1B protein
CTD
PMID:24525745 PMID:24885771
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rl2
interleukin 1 receptor-like 2
increases expression
EXP
ferric oxide analog results in increased expression of IL1RL2 mRNA
CTD
PMID:38615722
NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667
G
Il2
interleukin 2
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL2 protein
CTD
PMID:20540983
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il33
interleukin 33
multiple interactions
ISO
ferric oxide results in increased expression of and results in increased secretion of IL33 protein
CTD
PMID:34982504
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
G
Il4
interleukin 4
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein; ferric oxide inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]
CTD
PMID:20540983 PMID:23147377
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il4i1
interleukin 4 induced 1
decreases expression
ISO
ferric oxide analog results in decreased expression of IL4I1 mRNA
CTD
PMID:25086211
NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562
G
Il5
interleukin 5
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL5 protein; ferric oxide results in increased expression of and results in increased secretion of IL5 protein
CTD
PMID:20540983 PMID:34982504
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
multiple interactions increases expression increases secretion
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL6 protein; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL6 protein] ferric oxide results in increased secretion of IL6 protein ferric oxide analog results in increased secretion of IL6 protein
CTD
PMID:20540983 PMID:24525745 PMID:24885771 PMID:36935073
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf7
interferon regulatory factor 7
decreases expression
ISO
ferric oxide analog results in decreased expression of IRF7 mRNA
CTD
PMID:25086211
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
EXP
ferric oxide analog results in increased phosphorylation of JUN protein
CTD
PMID:22995439
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Klf2
KLF transcription factor 2
decreases expression
ISO
ferric oxide analog results in decreased expression of KLF2 mRNA
CTD
PMID:25086211
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
G
Klf4
KLF transcription factor 4
decreases expression
ISO
ferric oxide analog results in decreased expression of KLF4 mRNA
CTD
PMID:25086211
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
G
Klhl31
kelch-like family member 31
increases expression
EXP
ferric oxide analog results in increased expression of KLHL31 mRNA
CTD
PMID:38615722
NCBI chr 8:78,515,514...78,538,873
Ensembl chr 8:78,515,514...78,538,873
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Lama3
laminin subunit alpha 3
increases expression
EXP
ferric oxide analog results in increased expression of LAMA3 mRNA
CTD
PMID:38615722
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
G
Lamp1
lysosomal-associated membrane protein 1
multiple interactions
EXP
[ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein
CTD
PMID:24847785
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
G
Lamp2
lysosomal-associated membrane protein 2
increases expression
ISO
ferric oxide analog results in increased expression of LAMP2 protein
CTD
PMID:25086211
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
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Lgals3
galectin 3
increases expression
EXP
ferric oxide analog results in increased expression of LGALS3 mRNA
CTD
PMID:38615722
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
G
Lilrb4
leukocyte immunoglobulin like receptor B4
decreases expression
ISO
ferric oxide analog results in decreased expression of LILRB4B mRNA
CTD
PMID:24525745
NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
G
Lima1
LIM domain and actin binding 1
increases expression
ISO
ferric oxide analog results in increased expression of LIMA1 mRNA
CTD
PMID:25086211
NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473
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Lims2
LIM zinc finger domain containing 2
increases expression
ISO
ferric oxide analog results in increased expression of LIMS2 mRNA
CTD
PMID:25086211
NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137
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LOC120095805
U6 spliceosomal RNA
decreases expression
ISO
ferric oxide analog results in decreased expression of RNU6 mRNA
CTD
PMID:24525745
NCBI chr11:16,655,090...16,655,196
Ensembl chr11:16,655,090...16,655,196
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Loxl4
lysyl oxidase-like 4
increases expression
EXP
ferric oxide analog results in increased expression of LOXL4 mRNA
CTD
PMID:38615722
NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322
G
Lst1
leukocyte specific transcript 1
decreases expression
ISO
ferric oxide analog results in decreased expression of LST1 mRNA
CTD
PMID:24525745
NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
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Ly6a
lymphocyte antigen 6 family member A
decreases expression
ISO
ferric oxide analog results in decreased expression of LY6A mRNA
CTD
PMID:24525745
NCBI chr 7:107,177,191...107,189,436
Ensembl chr 7:107,183,469...107,189,981
G
Lypd6
Ly6/Plaur domain containing 6
decreases expression
EXP
ferric oxide analog results in decreased expression of LYPD6 mRNA
CTD
PMID:38615722
NCBI chr 3:34,487,425...34,632,887
Ensembl chr 3:34,496,485...34,630,308
G
Lyz2
lysozyme 2
decreases expression
ISO
ferric oxide analog results in decreased expression of LYZ2 mRNA
CTD
PMID:25086211
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
G
Mafb
MAF bZIP transcription factor B
increases expression
ISO
ferric oxide analog results in increased expression of MAFB mRNA
CTD
PMID:24525745
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
G
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
increases expression
ISO
ferric oxide analog results in increased expression of MAP1LC3A protein
CTD
PMID:25086211
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
ferric oxide analog results in increased expression of MAP1LC3B protein
CTD
PMID:24068039
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO EXP
ferric oxide analog results in increased phosphorylation of MAPK1 protein [ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein
CTD
PMID:24068039 PMID:24847785
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO EXP
ferric oxide analog results in increased phosphorylation of MAPK3 protein [ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK3 protein
CTD
PMID:24068039 PMID:24847785
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mat2a
methionine adenosyltransferase 2A
decreases expression increases expression
ISO
ferric oxide analog results in decreased expression of MAT2A mRNA ferric oxide analog results in increased expression of MAT2A mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
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Mef2c
myocyte enhancer factor 2C
decreases expression
ISO
ferric oxide analog results in decreased expression of MEF2C mRNA
CTD
PMID:25086211
NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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Megf6
multiple EGF-like-domains 6
decreases expression
EXP
ferric oxide analog results in decreased expression of MEGF6 mRNA
CTD
PMID:38615722
NCBI chr 5:164,738,272...164,839,142
Ensembl chr 5:164,738,352...164,839,139
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Mgst1
microsomal glutathione S-transferase 1
increases expression
EXP
ferric oxide analog results in increased expression of MGST1 mRNA
CTD
PMID:38615722
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Mmp12
matrix metallopeptidase 12
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA
CTD
PMID:20540983
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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Mmp19
matrix metallopeptidase 19
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP19 mRNA
CTD
PMID:20540983
NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP2 mRNA
CTD
PMID:20540983
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp23
matrix metallopeptidase 23
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP23 mRNA
CTD
PMID:20540983
NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433
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Mmp7
matrix metallopeptidase 7
increases expression
ISO
ferric oxide results in increased expression of MMP7 protein
CTD
PMID:24885771
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mmp9
matrix metallopeptidase 9
increases expression
EXP
ferric oxide analog results in increased expression of MMP9 mRNA
CTD
PMID:38615722
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mnda
myeloid cell nuclear differentiation antigen
increases expression
EXP
ferric oxide analog results in increased expression of MNDA mRNA
CTD
PMID:38615722
NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
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Msmb
microseminoprotein, beta
affects expression
ISO
ferric oxide affects the expression of MSMB mRNA
CTD
PMID:28077287
NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
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Mt2A
metallothionein 2A
increases expression
EXP
ferric oxide analog results in increased expression of MT2A mRNA
CTD
PMID:38615722
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions increases expression
ISO
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of MYD88 protein] ferric oxide analog results in increased expression of MYD88 mRNA; ferric oxide analog results in increased expression of MYD88 protein; ferric oxide results in increased expression of MYD88 mRNA; ferric oxide results in increased expression of MYD88 protein
CTD
PMID:34982504 PMID:36935073
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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N4bp3
Nedd4 binding protein 3
decreases expression
EXP
ferric oxide analog results in decreased expression of N4BP3 mRNA
CTD
PMID:38615722
NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001
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Naa80
N(alpha)-acetyltransferase 80, NatH catalytic subunit
increases expression
ISO
ferric oxide analog results in increased expression of NAA80 mRNA
CTD
PMID:25086211
NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563
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Nckap5l
NCK-associated protein 5-like
decreases expression
ISO
ferric oxide analog results in decreased expression of NCKAP5L mRNA
CTD
PMID:24525745
NCBI chr 7:130,553,683...130,591,886
Ensembl chr 7:130,555,368...130,591,857
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Ndrg1
N-myc downstream regulated 1
increases expression
ISO
ferric oxide analog results in increased expression of NDRG1 mRNA
CTD
PMID:25086211
NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
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Nedd9
neural precursor cell expressed, developmentally down-regulated 9
increases expression
ISO
ferric oxide analog results in increased expression of NEDD9 mRNA
CTD
PMID:24525745
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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Nfatc2
nuclear factor of activated T-cells 2
increases expression
EXP
ferric oxide analog results in increased expression of NFATC2 mRNA
CTD
PMID:38615722
NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
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Nfkb1
nuclear factor kappa B subunit 1
increases expression
ISO
ferric oxide results in increased expression of NFKB1 mRNA
CTD
PMID:34982504
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nox4
NADPH oxidase 4
increases expression
ISO
ferric oxide results in increased expression of NOX4 protein
CTD
PMID:28077287 PMID:28993115
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Npm3
nucleophosmin/nucleoplasmin, 3
decreases expression
ISO
ferric oxide analog results in decreased expression of NPM3 mRNA
CTD
PMID:25086211
NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
ferric oxide analog results in increased expression of NQO1 mRNA
CTD
PMID:38615722
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nrp1
neuropilin 1
decreases expression
ISO
ferric oxide analog results in decreased expression of NRP1 mRNA
CTD
PMID:25086211
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Nsg1
neuronal vesicle trafficking associated 1
increases expression
EXP
ferric oxide analog results in increased expression of NSG1 mRNA
CTD
PMID:38615722
NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514
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Nt5c2
5'-nucleotidase, cytosolic II
increases expression
ISO
ferric oxide analog results in increased expression of NT5C2 mRNA
CTD
PMID:24525745
NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913
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Nupr1
nuclear protein 1, transcriptional regulator
decreases expression
ISO
ferric oxide analog results in decreased expression of NUPR1 mRNA
CTD
PMID:24525745
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Oas2
2'-5' oligoadenylate synthetase 2
decreases expression
ISO
ferric oxide analog results in decreased expression of OAS2 mRNA
CTD
PMID:25086211
NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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Oasl
2'-5'-oligoadenylate synthetase-like
decreases expression
ISO
ferric oxide analog results in decreased expression of OASL1 mRNA
CTD
PMID:25086211
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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Osgin1
oxidative stress induced growth inhibitor 1
increases expression
EXP
ferric oxide analog results in increased expression of OSGIN1 mRNA
CTD
PMID:38615722
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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Pamr1
peptidase domain containing associated with muscle regeneration 1
increases expression
EXP
ferric oxide analog results in increased expression of PAMR1 mRNA
CTD
PMID:38615722
NCBI chr 3:88,889,061...88,988,615
Ensembl chr 3:88,889,046...88,988,606
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Pappa
pappalysin
increases expression
EXP
ferric oxide analog results in increased expression of PAPPA mRNA
CTD
PMID:38615722
NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
ferric oxide analog results in increased cleavage of PARP1 protein ferric oxide results in increased cleavage of PARP1 protein ferric oxide results in decreased expression of and results in increased cleavage of PARP1 protein
CTD
PMID:26991130 PMID:27270449 PMID:28993115
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pate4
prostate and testis expressed 4
affects expression
ISO
ferric oxide affects the expression of PATE4 mRNA
CTD
PMID:28077287
NCBI chr 8:33,988,812...33,991,552
Ensembl chr 8:33,988,812...33,991,552 Ensembl chr 8:33,988,812...33,991,552
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Pcdh7
protocadherin 7
decreases expression
ISO
ferric oxide analog results in decreased expression of PCDH7 mRNA
CTD
PMID:25086211
NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051 Ensembl chr14:52,475,610...52,902,051
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Pcsk5
proprotein convertase subtilisin/kexin type 5
decreases expression
EXP
ferric oxide analog results in decreased expression of PCSK5 mRNA
CTD
PMID:38615722
NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
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Pde2a
phosphodiesterase 2A
decreases expression
EXP
ferric oxide analog results in decreased expression of PDE2A mRNA
CTD
PMID:38615722
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
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Per2
period circadian regulator 2
increases expression
ISO
ferric oxide analog results in increased expression of PER2 mRNA
CTD
PMID:25086211
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Pes1
pescadillo ribosomal biogenesis factor 1
decreases expression
ISO
ferric oxide analog results in decreased expression of PES1 mRNA
CTD
PMID:25086211
NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134
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Phlda1
pleckstrin homology-like domain, family A, member 1
increases expression
ISO
ferric oxide analog results in increased expression of PHLDA1 mRNA
CTD
PMID:25086211
NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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Pla2g7
phospholipase A2 group VII
increases expression
EXP
ferric oxide analog results in increased expression of PLA2G7 mRNA
CTD
PMID:38615722
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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Plekhf1
pleckstrin homology and FYVE domain containing 1
increases expression
ISO
ferric oxide analog results in increased expression of PLEKHF1 mRNA
CTD
PMID:25086211
NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
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Plk2
polo-like kinase 2
increases expression
ISO
ferric oxide analog results in increased expression of PLK2 mRNA
CTD
PMID:25086211
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Plk3
polo-like kinase 3
increases expression
ISO
ferric oxide analog results in increased expression of PLK3 mRNA
CTD
PMID:25086211
NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
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Plpbp
pyridoxal phosphate binding protein
increases expression
ISO
ferric oxide analog results in increased expression of PLPBP mRNA
CTD
PMID:25086211
NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
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Plppr4
phospholipid phosphatase related 4
decreases expression
EXP
ferric oxide analog results in decreased expression of PLPPR4 mRNA
CTD
PMID:38615722
NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302
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Ppm1e
protein phosphatase, Mg2+/Mn2+ dependent, 1E
increases expression
EXP
ferric oxide analog results in increased expression of PPM1E mRNA
CTD
PMID:38615722
NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
decreases expression
ISO
ferric oxide analog results in decreased expression of PPP1R15A mRNA
CTD
PMID:24525745
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Prf1
perforin 1
decreases expression
ISO
ferric oxide analog results in decreased expression of PRF1 mRNA
CTD
PMID:24525745
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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Prmt6
protein arginine methyltransferase 6
decreases expression
ISO
ferric oxide analog results in decreased expression of PRMT6 mRNA
CTD
PMID:25086211
NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648
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Prr18
proline rich 18
increases expression
ISO
ferric oxide analog results in increased expression of PRR18 mRNA
CTD
PMID:25086211
NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:52,400,215...52,404,309
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Prr33
proline rich 33
decreases expression
ISO
ferric oxide analog results in decreased expression of PRR33 mRNA
CTD
PMID:25086211
NCBI chr 1:197,644,903...197,650,774
Ensembl chr 1:197,644,902...197,650,714
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Ptgr1
prostaglandin reductase 1
increases expression
EXP
ferric oxide analog results in increased expression of PTGR1 mRNA
CTD
PMID:38615722
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Ptgs1
prostaglandin-endoperoxide synthase 1
increases expression
EXP
ferric oxide analog results in increased expression of PTGS1 mRNA
CTD
PMID:38615722
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Rab15
RAB15, member RAS oncogene family
increases expression
ISO
ferric oxide analog results in increased expression of RAB15 mRNA
CTD
PMID:25086211
NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942
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Rad50
RAD50 double strand break repair protein
decreases expression
ISO
ferric oxide analog results in decreased expression of RAD50 mRNA
CTD
PMID:24525745
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Rag1
recombination activating 1
multiple interactions
ISO
RAG1 inhibits the reaction [ferric oxide analog results in increased expression of CCL7 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of CCL11 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL13 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL6 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of TNF protein]
CTD
PMID:36935073
NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
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Rbak
RB-associated KRAB zinc finger
increases expression
ISO
ferric oxide analog results in increased expression of RBAK mRNA
CTD
PMID:24525745
NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934
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Rcan1
regulator of calcineurin 1
increases expression
ISO
ferric oxide analog results in increased expression of RCAN1 mRNA
CTD
PMID:25086211
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
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Rcbtb2
RCC1 and BTB domain containing protein 2
increases expression
ISO
ferric oxide analog results in increased expression of RCBTB2 mRNA
CTD
PMID:24525745
NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750
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Rgs16
regulator of G-protein signaling 16
increases expression
EXP
ferric oxide analog results in increased expression of RGS16 mRNA
CTD
PMID:38615722
NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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Rilpl1
Rab interacting lysosomal protein-like 1
decreases expression
ISO
ferric oxide analog results in decreased expression of RILPL1 mRNA
CTD
PMID:24525745
NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938
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Ripk1
receptor interacting serine/threonine kinase 1
multiple interactions
EXP
[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein
CTD
PMID:24847785
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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Ripk3
receptor-interacting serine-threonine kinase 3
multiple interactions
EXP
[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK3 protein
CTD
PMID:24847785
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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RT1-A2
RT1 class Ia, locus A2
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-T23 mRNA
CTD
PMID:20540983
NCBI chr20:4,870,939...4,910,183
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RT1-Db1
RT1 class II, locus Db1
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-EB1 mRNA
CTD
PMID:20540983
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Rusc2
RUN and SH3 domain containing 2
increases expression
ISO
ferric oxide analog results in increased expression of RUSC2 mRNA
CTD
PMID:25086211
NCBI chr 5:57,628,397...57,675,524
Ensembl chr 5:57,629,904...57,675,524
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Samd9l
sterile alpha motif domain containing 9 like
decreases expression
ISO
ferric oxide analog results in decreased expression of SAMD9L mRNA
CTD
PMID:25086211
NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415
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Scara5
scavenger receptor class A, member 5
increases expression
EXP
ferric oxide analog results in increased expression of SCARA5 mRNA
CTD
PMID:38615722
NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373
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Sema3a
semaphorin 3A
increases expression
EXP
ferric oxide analog results in increased expression of SEMA3A mRNA
CTD
PMID:38615722
NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
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Sema3d
semaphorin 3D
decreases expression
EXP
ferric oxide analog results in decreased expression of SEMA3D mRNA
CTD
PMID:38615722
NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930
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Serpinb1a
serpin family B member 1A
decreases expression
ISO
ferric oxide analog results in decreased expression of SERPINB1A mRNA
CTD
PMID:24525745
NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
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Skil
SKI-like proto-oncogene
increases expression
ISO
ferric oxide analog results in increased expression of SKIL mRNA
CTD
PMID:24525745
NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
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Slamf8
SLAM family member 8
increases expression
ISO
ferric oxide analog results in increased expression of SLAMF8 mRNA
CTD
PMID:24525745
NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211
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Slc11a1
solute carrier family 11 member 1
increases expression
ISO
ferric oxide analog results in increased expression of SLC11A1 mRNA
CTD
PMID:25086211
NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
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Slc30a3
solute carrier family 30 member 3
increases expression
EXP
ferric oxide analog results in increased expression of SLC30A3 mRNA
CTD
PMID:38615722
NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720
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Slc46a3
solute carrier family 46, member 3
decreases expression
ISO
ferric oxide analog results in decreased expression of SLC46A3 mRNA
CTD
PMID:25086211
NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092
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Slc7a5
solute carrier family 7 member 5
decreases expression
EXP
ferric oxide analog results in decreased expression of SLC7A5 mRNA
CTD
PMID:38615722
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slco2a1
solute carrier organic anion transporter family, member 2a1
increases expression
EXP
ferric oxide analog results in increased expression of SLCO2A1 mRNA
CTD
PMID:38615722
NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
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Slpi
secretory leukocyte peptidase inhibitor
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA
CTD
PMID:20540983
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Sod1
superoxide dismutase 1
increases expression
ISO
ferric oxide analog results in increased expression of SOD1 protein
CTD
PMID:24068039
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
increases expression
ISO
ferric oxide analog results in increased expression of SOD2 protein; ferric oxide results in increased expression of SOD2 protein
CTD
PMID:24068039 PMID:25086211 PMID:26991130
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spata24
spermatogenesis associated 24
decreases expression
ISO
ferric oxide analog results in decreased expression of SPATA24 mRNA
CTD
PMID:24525745
NCBI chr18:27,249,047...27,257,129
Ensembl chr18:27,248,609...27,257,124
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Spock2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
increases expression
EXP
ferric oxide analog results in increased expression of SPOCK2 mRNA
CTD
PMID:38615722
NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272
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Spta1
spectrin, alpha, erythrocytic 1
increases expression
EXP
ferric oxide analog results in increased expression of SPTA1 mRNA
CTD
PMID:38615722
NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371
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Srxn1
sulfiredoxin 1
increases expression
EXP
ferric oxide analog results in increased expression of SRXN1 mRNA
CTD
PMID:38615722
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Stmn2
stathmin 2
increases expression
EXP
ferric oxide analog results in increased expression of STMN2 mRNA
CTD
PMID:38615722
NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011
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Synpo2
synaptopodin 2
increases expression
EXP
ferric oxide analog results in increased expression of SYNPO2 mRNA
CTD
PMID:38615722
NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267
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Tatdn2
TatD DNase domain containing 2
decreases expression
ISO
ferric oxide analog results in decreased expression of TATDN2 mRNA
CTD
PMID:24525745
NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897
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Tbc1d2
TBC1 domain family, member 2
increases expression decreases expression
ISO
ferric oxide analog results in increased expression of TBC1D2 mRNA ferric oxide analog results in decreased expression of TBC1D2 mRNA
CTD
PMID:24525745 PMID:25086211
NCBI chr 5:60,884,114...60,931,717
Ensembl chr 5:60,884,124...60,931,352
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Tbxas1
thromboxane A synthase 1
increases expression
ISO
ferric oxide analog results in increased expression of TBXAS1 mRNA
CTD
PMID:24525745
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Tf
transferrin
increases expression
EXP
ferric oxide results in increased expression of TF mRNA
CTD
PMID:16428268
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfrc
transferrin receptor
decreases expression
ISO EXP
ferric oxide analog results in decreased expression of TFRC mRNA
CTD
PMID:25086211 PMID:38615722
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfa
transforming growth factor alpha
increases expression
EXP
ferric oxide analog results in increased expression of TGFA mRNA
CTD
PMID:38615722
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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Tgfbi
transforming growth factor, beta induced
increases expression
ISO
ferric oxide analog results in increased expression of TGFBI mRNA
CTD
PMID:24525745
NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
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Tgm2
transglutaminase 2
increases expression
ISO
ferric oxide analog results in increased expression of TGM2 mRNA
CTD
PMID:25086211
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Thbs2
thrombospondin 2
decreases expression
EXP
ferric oxide analog results in decreased expression of THBS2 mRNA
CTD
PMID:38615722
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
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Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TIMP1 mRNA
CTD
PMID:20540983
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Timp2
TIMP metallopeptidase inhibitor 2
increases expression
ISO
ferric oxide results in increased expression of TIMP2 protein
CTD
PMID:24885771
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tlr2
toll-like receptor 2
increases expression multiple interactions
ISO
ferric oxide analog results in increased expression of TLR2 mRNA; ferric oxide analog results in increased expression of TLR2 protein; ferric oxide results in increased expression of TLR2 mRNA; ferric oxide results in increased expression of TLR2 protein oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TLR2 protein]
CTD
PMID:24525745 PMID:34982504 PMID:36935073
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
multiple interactions increases expression
ISO
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TLR4 protein] ferric oxide analog results in increased expression of TLR4 mRNA; ferric oxide analog results in increased expression of TLR4 protein; ferric oxide results in increased expression of TLR4 mRNA; ferric oxide results in increased expression of TLR4 protein
CTD
PMID:34982504 PMID:36935073
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr5
toll-like receptor 5
increases expression
EXP
ferric oxide analog results in increased expression of TLR5 mRNA
CTD
PMID:38615722
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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Tmem176a
transmembrane protein 176A
decreases expression
ISO
ferric oxide analog results in decreased expression of TMEM176A mRNA
CTD
PMID:25086211
NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
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Tnf
tumor necrosis factor
multiple interactions increases expression increases secretion
ISO
[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TNF protein; ferric oxide results in increased expression of and results in increased secretion of TNF protein; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TNF protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of TNF protein] ferric oxide analog results in increased expression of TNF mRNA; ferric oxide analog results in increased expression of TNF protein; ferric oxide results in increased expression of TNF mRNA ferric oxide results in increased secretion of TNF protein ferric oxide analog results in increased secretion of TNF protein
CTD
PMID:20540983 PMID:24068039 PMID:24525745 PMID:24885771 PMID:34982504 PMID:36935073 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnni3
troponin I3, cardiac type
increases expression
ISO
ferric oxide results in increased expression of TNNI3 protein
CTD
PMID:28993115
NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Tox3
TOX high mobility group box family member 3
decreases expression
EXP
ferric oxide analog results in decreased expression of TOX3 mRNA
CTD
PMID:38615722
NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148
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Tp53
tumor protein p53
increases phosphorylation multiple interactions
EXP
ferric oxide analog results in increased phosphorylation of TP53 protein [ferric oxide analog co-treated with Acrolein] results in increased expression of TP53 protein
CTD
PMID:22995439 PMID:24847785
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
ferric oxide analog results in increased expression of TRP53INP1 mRNA
CTD
PMID:25086211
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Tpr
translocated promoter region, nuclear basket protein
decreases expression
ISO
ferric oxide analog results in decreased expression of TPR mRNA
CTD
PMID:24525745
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Traf6
TNF receptor associated factor 6
increases expression
ISO
ferric oxide analog results in increased expression of TRAF6 mRNA; ferric oxide analog results in increased expression of TRAF6 protein; ferric oxide results in increased expression of TRAF6 mRNA; ferric oxide results in increased expression of TRAF6 protein
CTD
PMID:34982504 PMID:36935073
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Trib3
tribbles pseudokinase 3
decreases expression
ISO
ferric oxide analog results in decreased expression of TRIB3 mRNA
CTD
PMID:24525745
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Tslp
thymic stromal lymphopoietin
multiple interactions
ISO
ferric oxide results in increased expression of and results in increased secretion of TSLP protein
CTD
PMID:34982504
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Ttpal
alpha tocopherol transfer protein like
decreases expression
ISO
ferric oxide analog results in decreased expression of TTPAL mRNA
CTD
PMID:25086211
NCBI chr 3:152,278,246...152,296,550
Ensembl chr 3:152,278,303...152,296,513
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Tubb2b
tubulin, beta 2B class IIb
increases expression
ISO
ferric oxide analog results in increased expression of TUBB2B mRNA
CTD
PMID:24525745
NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638
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Uchl1
ubiquitin C-terminal hydrolase L1
increases expression
EXP
ferric oxide analog results in increased expression of UCHL1 mRNA
CTD
PMID:38615722
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
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Wdfy3
WD repeat and FYVE domain containing 3
increases expression
ISO
ferric oxide analog results in increased expression of WDFY3 mRNA
CTD
PMID:24525745
NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482
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Yipf7
Yip1 domain family, member 7
increases expression
ISO
ferric oxide analog results in increased expression of YIPF7 mRNA
CTD
PMID:25086211
NCBI chr14:38,571,045...38,599,070
Ensembl chr14:38,571,066...38,599,055
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Zbtb2
zinc finger and BTB domain containing 2
decreases expression
ISO
ferric oxide analog results in decreased expression of ZBTB2 mRNA
CTD
PMID:24525745
NCBI chr 1:40,827,457...40,846,733
Ensembl chr 1:40,827,457...40,846,594
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Zc3h13
zinc finger CCCH type containing 13
increases expression
ISO
ferric oxide analog results in increased expression of ZC3H13 mRNA
CTD
PMID:24525745
NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
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Zfp36
zinc finger protein 36
increases expression
ISO
ferric oxide analog results in increased expression of ZFP36 mRNA
CTD
PMID:24525745
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of BAX protein
CTD
PMID:30098274
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of BCL2 protein
CTD
PMID:30098274
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP3 protein; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 mRNA; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 protein modified form
CTD
PMID:24935781 PMID:30098274
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP9 protein
CTD
PMID:30098274
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Fadd
Fas associated via death domain
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of FADD protein
CTD
PMID:30098274
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fas
Fas cell surface death receptor
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FAS protein
CTD
PMID:30098274
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FOS protein
CTD
PMID:30098274
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Hmox1
heme oxygenase 1
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of HMOX1 protein
CTD
PMID:30098274
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1b
interleukin 1 beta
increases secretion
EXP ISO
Ferrosoferric Oxide analog results in increased secretion of IL1B protein Ferrosoferric Oxide results in increased secretion of IL1B protein
CTD
PMID:22939914 PMID:24885771
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases secretion
EXP ISO
Ferrosoferric Oxide analog results in increased secretion of IL6 protein Ferrosoferric Oxide results in increased secretion of IL6 protein
CTD
PMID:22939914 PMID:24885771
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of JUN protein
CTD
PMID:30098274
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK1 protein
CTD
PMID:30098274
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK3 protein
CTD
PMID:30098274
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK8 protein
CTD
PMID:30098274
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK9 protein
CTD
PMID:30098274
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of NQO1 protein
CTD
PMID:30098274
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of PARP1 protein
CTD
PMID:30098274
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of PTGS2 protein
CTD
PMID:30098274
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rras
RAS related
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of RRAS protein
CTD
PMID:30098274
NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357
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Tnf
tumor necrosis factor
increases secretion
EXP
Ferrosoferric Oxide analog results in increased secretion of TNF protein
CTD
PMID:22939914
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions
ISO
[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of TP53 protein
CTD
PMID:30098274
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]
CTD
PMID:19421372
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
multiple interactions
ISO
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]
CTD
PMID:19421372
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Icam1
intercellular adhesion molecule 1
increases expression
ISO
ferrous oxide results in increased expression of ICAM1 protein
CTD
PMID:21439359
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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