Clk4 (CDC-like kinase 4) - Rat Genome Database

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Gene: Clk4 (CDC-like kinase 4) Rattus norvegicus
Analyze
Symbol: Clk4
Name: CDC-like kinase 4
RGD ID: 1310274
Description: Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to be active in nucleus. Orthologous to human CLK4 (CDC like kinase 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDC like kinase 4; dual specificity protein kinase CLK4; LOC287269
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,024,364 - 36,042,366 (+)NCBIGRCr8
mRatBN7.21035,523,382 - 35,541,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,524,755 - 35,541,352 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,217,344 - 40,235,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01039,707,659 - 39,725,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,211,040 - 35,228,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,715,565 - 36,733,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,715,565 - 36,733,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,487,184 - 36,505,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,782,792 - 36,800,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11036,783,840 - 36,801,409 (+)NCBI
Celera1034,879,664 - 34,897,233 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9307018   PMID:19168442  


Genomics

Comparative Map Data
Clk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,024,364 - 36,042,366 (+)NCBIGRCr8
mRatBN7.21035,523,382 - 35,541,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,524,755 - 35,541,352 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,217,344 - 40,235,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01039,707,659 - 39,725,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,211,040 - 35,228,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,715,565 - 36,733,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,715,565 - 36,733,133 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,487,184 - 36,505,103 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,782,792 - 36,800,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11036,783,840 - 36,801,409 (+)NCBI
Celera1034,879,664 - 34,897,233 (+)NCBICelera
Cytogenetic Map10q22NCBI
CLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,602,664 - 178,627,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,602,664 - 178,630,615 (-)EnsemblGRCh38hg38GRCh38
GRCh375178,029,665 - 178,054,051 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365177,962,271 - 177,986,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 345177,962,271 - 177,986,660NCBI
Celera5173,657,123 - 173,681,183 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5172,756,811 - 172,777,551 (-)NCBIHuRef
CHM1_15177,462,038 - 177,486,420 (-)NCBICHM1_1
T2T-CHM13v2.05179,154,636 - 179,179,025 (-)NCBIT2T-CHM13v2.0
Clk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,153,941 - 51,172,597 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,152,557 - 51,172,593 (+)EnsemblGRCm39 Ensembl
GRCm381151,263,114 - 51,281,770 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,261,730 - 51,281,766 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,076,673 - 51,095,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,106,594 - 51,125,187 (+)NCBIMGSCv36mm8
Celera1155,822,951 - 55,841,544 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.02NCBI
Clk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554081,719,963 - 1,747,878 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554081,726,283 - 1,747,314 (+)NCBIChiLan1.0ChiLan1.0
CLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,542,784 - 173,567,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,682,324 - 171,709,226 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05173,760,420 - 173,784,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,017,365 - 181,041,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,017,365 - 181,037,919 (-)Ensemblpanpan1.1panPan2
CLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1112,960,161 - 2,986,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,965,256 - 2,986,658 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha113,104,085 - 3,130,619 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,936,551 - 2,963,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,943,500 - 2,963,082 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,907,231 - 2,933,752 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0112,985,795 - 3,012,306 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,227,084 - 3,253,609 (+)NCBIUU_Cfam_GSD_1.0
Clk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,055,729 - 113,081,781 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493664767,000 - 88,149 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493664762,478 - 83,947 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,693,669 - 79,753,712 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,729,460 - 79,752,945 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,341,286 - 81,367,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,290,716 - 80,313,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,288,120 - 80,313,255 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607511,602,496 - 11,625,658 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473341,713,524 - 41,752,822 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clk4
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:96
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000005048
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000005048   ⟹   ENSRNOP00000005048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,524,755 - 35,541,352 (+)Ensembl
Rnor_6.0 Ensembl1036,715,565 - 36,733,133 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119764   ⟹   ENSRNOP00000079861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1035,528,096 - 35,541,279 (+)Ensembl
RefSeq Acc Id: NM_001013041   ⟹   NP_001013059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,024,458 - 36,042,028 (+)NCBI
mRatBN7.21035,523,473 - 35,541,043 (+)NCBI
Rnor_6.01036,715,565 - 36,733,135 (+)NCBI
Rnor_5.01036,487,184 - 36,505,103 (+)NCBI
RGSC_v3.41036,782,792 - 36,800,362 (+)RGD
Celera1034,879,664 - 34,897,233 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399428   ⟹   NP_001386357
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,025,740 - 36,042,366 (+)NCBI
mRatBN7.21035,524,755 - 35,541,381 (+)NCBI
RefSeq Acc Id: NM_001399429   ⟹   NP_001386358
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,025,740 - 36,042,366 (+)NCBI
mRatBN7.21035,524,755 - 35,541,381 (+)NCBI
RefSeq Acc Id: XM_006246237   ⟹   XP_006246299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,029,614 - 36,042,366 (+)NCBI
mRatBN7.21035,528,629 - 35,541,384 (+)NCBI
Rnor_6.01036,720,771 - 36,733,473 (+)NCBI
Rnor_5.01036,487,184 - 36,505,103 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767672   ⟹   XP_008765894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,029,615 - 36,042,366 (+)NCBI
mRatBN7.21035,528,630 - 35,541,384 (+)NCBI
Rnor_6.01036,720,771 - 36,733,473 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085381   ⟹   XP_038941309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,025,667 - 36,042,366 (+)NCBI
mRatBN7.21035,524,702 - 35,541,384 (+)NCBI
RefSeq Acc Id: XM_039085382   ⟹   XP_038941310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,024,378 - 36,042,366 (+)NCBI
mRatBN7.21035,523,382 - 35,541,384 (+)NCBI
RefSeq Acc Id: XM_039085383   ⟹   XP_038941311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,029,614 - 36,042,366 (+)NCBI
mRatBN7.21035,523,457 - 35,541,384 (+)NCBI
RefSeq Acc Id: XM_063268583   ⟹   XP_063124653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,024,364 - 36,042,366 (+)NCBI
RefSeq Acc Id: XM_063268584   ⟹   XP_063124654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,029,614 - 36,042,366 (+)NCBI
RefSeq Acc Id: XM_063268585   ⟹   XP_063124655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,025,708 - 36,042,366 (+)NCBI
RefSeq Acc Id: NP_001013059   ⟸   NM_001013041
- Peptide Label: isoform 3
- UniProtKB: Q6AYK7 (UniProtKB/TrEMBL),   A6HE53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246299   ⟸   XM_006246237
- Peptide Label: isoform X3
- UniProtKB: F7ETQ4 (UniProtKB/TrEMBL),   A6HE49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765894   ⟸   XM_008767672
- Peptide Label: isoform X3
- UniProtKB: F7ETQ4 (UniProtKB/TrEMBL),   A6HE49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005048   ⟸   ENSRNOT00000005048
RefSeq Acc Id: XP_038941310   ⟸   XM_039085382
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941311   ⟸   XM_039085383
- Peptide Label: isoform X4
- UniProtKB: Q6AYK7 (UniProtKB/TrEMBL),   A6HE53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941309   ⟸   XM_039085381
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000079861   ⟸   ENSRNOT00000119764
RefSeq Acc Id: NP_001386358   ⟸   NM_001399429
- Peptide Label: isoform 2
- UniProtKB: F7ETQ4 (UniProtKB/TrEMBL),   A6HE49 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386357   ⟸   NM_001399428
- Peptide Label: isoform 1
- UniProtKB: A0A8I5ZNT1 (UniProtKB/TrEMBL),   A6HE48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124653   ⟸   XM_063268583
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZNT1 (UniProtKB/TrEMBL),   A6HE48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124655   ⟸   XM_063268585
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063124654   ⟸   XM_063268584
- Peptide Label: isoform X4
- UniProtKB: A6HE53 (UniProtKB/TrEMBL),   Q6AYK7 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYK7-F1-model_v2 AlphaFold Q6AYK7 1-301 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697159
Promoter ID:EPDNEW_R7683
Type:single initiation site
Name:Clk4_1
Description:CDC-like kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01036,715,533 - 36,715,593EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310274 AgrOrtholog
BioCyc Gene G2FUF-25203 BioCyc
Ensembl Genes ENSRNOG00000003714 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005048 ENTREZGENE
  ENSRNOT00000005048.6 UniProtKB/TrEMBL
  ENSRNOT00000119764 ENTREZGENE
  ENSRNOT00000119764.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113075 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:287269 UniProtKB/TrEMBL
MGC_CLONE MGC:93919 IMAGE-MGC_LOAD
NCBI Gene 287269 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE CLK4 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE DOA-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Clk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003714 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZNT1 ENTREZGENE, UniProtKB/TrEMBL
  A6HE48 ENTREZGENE, UniProtKB/TrEMBL
  A6HE49 ENTREZGENE, UniProtKB/TrEMBL
  A6HE53 ENTREZGENE, UniProtKB/TrEMBL
  A6HE54_RAT UniProtKB/TrEMBL
  F7ETQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYK7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-13 Clk4  CDC-like kinase 4  Clk4  CDC like kinase 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Clk4  CDC like kinase 4  Clk4_predicted  CDC like kinase 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Clk4_predicted  CDC like kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED