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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:50819
Term: ferric oxide
Definition: An iron oxide that has formula Fe2O3.
Chemical ID: MESH:C000499
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases phosphorylationEXP 6480464CTDferric oxide analog results in increased phosphorylation of BAX proteinPMID:22995439
Baxdecreases expressionISOBax (Mus musculus)6480464CTDferric oxide results in decreased expression of BAX proteinPMID:25086211
Baxincreases expressionISOBax (Mus musculus)6480464CTDferric oxide results in increased expression of BAX proteinPMID:26991130
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDbromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]PMID:19421372
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