Gene: Cx3cr1 (C-X3-C motif chemokine receptor 1) Rattus norvegicus
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Symbol:
Cx3cr1
Name:
C-X3-C motif chemokine receptor 1
RGD ID:
620137
Description:
Exhibits C-X3-C chemokine receptor activity. Involved in several processes, including positive regulation of neurogenesis; regulation of gene expression; and regulation of signal transduction. Localizes to several cellular components, including cell surface; neuronal cell body membrane; and perinuclear region of cytoplasm. Used to study glomerulonephritis; hepatopulmonary syndrome; and status epilepticus. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); borna disease; portal hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif chemokine receptor 1); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
C-X3-C CKR-1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CX3C chemokine receptor 1; fractalkine receptor; Rbs11
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CX3CR1 (C-X3-C motif chemokine receptor 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cx3cr1 (chemokine (C-X3-C motif) receptor 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cx3cr1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cx3cr1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
CX3CR1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Cx3cr1 (C-X3-C motif chemokine receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CX3CR1 (C-X3-C motif chemokine receptor 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Cx3cr1 (chemokine (C-X3-C motif) receptor 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
npr-20
Alliance
DIOPT (Ensembl Compara|InParanoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 8 128,740,756 - 128,754,514 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 128,740,756 - 128,754,514 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 127,941,653 - 127,955,411 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 125,033,630 - 125,047,335 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 8 125,053,366 - 125,067,072 (-) NCBI Celera 8 118,932,179 - 118,945,873 (-) NCBI Celera Cytogenetic Map 8 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
anti-basement membrane glomerulonephritis IEP 4891946 mRNA, protein:increased expression:glomerulus RGD arteriosclerosis ISO RGD:1552004 4891900 RGD arthus reaction ISO RGD:1552004 9068463 RGD asthma ISO RGD:1552004 4891882 RGD asthma no_association ISO RGD:1352124 4891904 DNA:polymorphisms: :p.V249I, p.T280M (human) RGD asthma ISO RGD:1352124 4891895 DNA:SNPs: :p.V249I, rs2669849 (human) RGD atherosclerosis ISO RGD:1552004 9479739 RGD atopic dermatitis ISO RGD:1352124 9491761 protein:decreased expression:blood, leukocyte RGD atopic dermatitis ISO RGD:1552004 9491393 RGD borna disease IEP 4891998 mRNA:increased expression:brain RGD Chronic Mesangial Proliferative Glomerulonephritis IEP 9491783 RGD congestive heart failure IEP 9491792 mRNA, protein:increased expression: paraventricular nucleus of hypothalamus RGD conjunctivitis ISO RGD:1552004 9491751 RGD corneal neovascularization ISO RGD:1552004 9365153 RGD Coronary Disease ISO RGD:1352124 4891901 DNA:polymorphism: :p.V249I (human) RGD cystitis IEP 4891972 protein:increased expression:urinary bladder urothelium RGD diabetes mellitus ISO RGD:1552004 9491759 RGD Experimental Arthritis IEP 4891969 protein:increased expression:spinal cord RGD Experimental Arthritis IEP 4892002 RGD Experimental Autoimmune Encephalomyelitis IMP 9491767 RGD Experimental Autoimmune Encephalomyelitis IEP 4891973 RGD Experimental Autoimmune Neuritis IEP 4891968 RGD Experimental Autoimmune Uveitis IEP 9479740 RGD Experimental Autoimmune Uveitis ISO RGD:1552004 9491397 RGD Experimental Diabetes Mellitus IEP 4891992 mRNA:increased expression:kidney RGD glaucoma ISO RGD:1552004 9384823 RGD glomerulonephritis IMP 4892027 RGD glomerulonephritis IEP 4891995 mRNA:increased expression:glomerulus RGD Graft vs Host Disease severity ISO RGD:1352124 4892014 RGD Hearing Loss ISO RGD:1552004 9491762 mRNA, protein:increased expression:cochlea RGD hepatopulmonary syndrome treatment IMP 9491778 RGD Herpes Simplex Encephalitis ISO RGD:1552004 8661752 RGD Hyperalgesia IEP 9491779 associated with Arthritis, Experimental, protein:increased expression:lumbar spinal cord RGD Hyperalgesia IMP 9387859 RGD Hyperalgesia ISO RGD:1552004 9354422 associated with Inflammation RGD Hyperalgesia IMP 4891942 associated with Sciatic Neuropathy RGD Hyperalgesia IMP 4892020 associated with Bone Neoplasms RGD Hyperalgesia ISO RGD:1552004 4891885 RGD Inflammation IEP 9491768 associated with Temporomandibular Joint Disorders RGD Inflammation ISO RGD:1552004 9375525 RGD Intervertebral Disc Displacement IEP 4891907 protein:increased expression:spinal cord RGD Intimal Hyperplasia ISO RGD:1552004 8661636 RGD macular degeneration ISO RGD:1552004 9491385 RGD macular degeneration ISO RGD:1352124 9479078 DNA:missense mutation:cds:p.T280M (human) RGD macular degeneration no_association ISO RGD:1352124 9491392 DNA:missense mutations:cds:p.V249I, p.T280M (rs3732379, rs3732378) (human) RGD macular degeneration ISO RGD:1352124 9491390 DNA:missense mutations:cds:p.V249I, p.T280M (human) RGD macular degeneration no_association ISO RGD:1352124 9491395 DNA:missense mutation:cds:p.V249I (human) RGD macular degeneration ISO RGD:1352124 9491395 DNA:missense mutation:cds:p.V249I (human) RGD Memory Disorders IMP 9491766 RGD Microscopic Polyangiitis ISO RGD:1352124 9491765 protein:increased expression:blood, T cell RGD Myocardial Reperfusion Injury ISO RGD:1352124 4892017 protein:decreased expression:blood, monocyte RGD Neoplasm Metastasis susceptibility ISO RGD:1352124 4892015 associated with Breast Neoplasms RGD nephrosis IEP 4891946 RGD obesity ISO RGD:1352124 4891903 DNA:SNP: :p.T280M (human) RGD optic nerve glioma onset ISO RGD:1552004 9491391 associated with Neurofibromatosis 1 RGD otitis media susceptibility ISO RGD:1352124 9491764 DNA:missense mutation:cds:p.T280M (human) RGD Pain IMP 4892020 associated with Bone Neoplasms RGD Parkinsonian Disorders IMP 4891964 RGD portal hypertension IEP 9491791 RGD prion disease IEP 4892001 protein:increased expression:microglial cell RGD psoriasis ISO RGD:1352124 9491384 DNA:SNP, missense mutation:intron, cds: , p.T280M (human) RGD pulmonary embolism treatment IEP 9491777 RGD pulmonary hypertension ISO RGD:1352124 4891896 associated with Scleroderma, Systemic, DNA:polymorphisms: :p.V249I, p.T280M (human) RGD pulmonary hypertension IEP 4891893 mRNA, protein:increased expression:lung RGD respiratory syncytial virus infectious disease ISO RGD:1552004 4892016 RGD respiratory syncytial virus infectious disease severity ISO RGD:1552004 4892018 RGD retinal degeneration ISO RGD:1552004 9479077 RGD retinal vasculitis ISO RGD:1352124 9491394 DNA:missense mutations, haplotypes:cds:p.V249I, p.T280M (human) RGD retinitis ISO RGD:1552004 8661224 RGD sciatic neuropathy treatment IEP 9491396 RGD sciatic neuropathy IEP 1358720 RGD sciatic neuropathy ISO RGD:1552004 9354422 RGD Sepsis ISO RGD:1352124 4144897 protein:increased expression:lung, macrophage RGD status epilepticus treatment IMP 9491789 RGD systemic lupus erythematosus severity ISO RGD:1352124 6893428 mRNA:increased expression:blood, mononuclear cell RGD systemic scleroderma ISO RGD:1552004 9479741 RGD systemic scleroderma ISO RGD:1352124 4891896 DNA:polymorphisms: :p.V249I, p.T280M (human) RGD systemic scleroderma ISO RGD:1352124 4891898 protein:increased expression:lung, skin RGD transient cerebral ischemia IEP 9491776 mRNA, protein:decreased expression:hippocampus RGD uveitis IEP 4891945 associated with Endotoxemia, mRNA, protein:increased expression:retina RGD Viral Bronchiolitis ISO RGD:1352124 4891891 RGD Viral Bronchiolitis ISO RGD:1352124 4891905 DNA:SNP: :p.T280M (human) RGD
Imported Annotations - CTD
Chloracne ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17101203 Coronary Disease ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD human immunodeficiency virus infectious disease ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD retinal degeneration ISO RGD:1352124 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20361964
Imported Annotations - MGI
coronary artery disease ISS RGD:1352124 13592920 OMIM:300464 more ... MouseDO Imported Annotations - OMIM
age related macular degeneration 12 ISO RGD:1352124 7240710 OMIM Coronary Disease susceptibility ISO RGD:1352124 7240710 OMIM human immunodeficiency virus infectious disease susceptibility ISO RGD:1352124 7240710 OMIM
1,2-dichloroethane increases expression ISO RGD:1552004 6480464 ethylene dichloride results in increased expression of CX3CR1 mRNA CTD PMID:28960355 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552004 6480464 Tetrachlorodibenzodioxin affects the expression of CX3CR1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1552004 6480464 Tetrachlorodibenzodioxin results in increased expression of CX3CR1 mRNA CTD PMID:26377647 , PMID:29673856 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine increases expression ISO RGD:1352124 6480464 Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 2-butoxyethanol decreases expression ISO RGD:1552004 6480464 n-butoxyethanol results in decreased expression of CX3CR1 mRNA CTD PMID:19812364 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1552004 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CX3CR1 mRNA CTD PMID:20188158 4,4'-sulfonyldiphenol increases expression ISO RGD:1552004 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of CX3CR1 mRNA CTD PMID:30951980 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of CX3CR1 mRNA CTD PMID:24780913 acetamide increases expression EXP 6480464 acetamide results in increased expression of CX3CR1 mRNA CTD PMID:31881176 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CX3CR1 mRNA CTD PMID:25378103 aflatoxin B1 decreases expression ISO RGD:1352124 6480464 Aflatoxin B1 results in decreased expression of CX3CR1 mRNA CTD PMID:32234424 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CX3CR1 mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of CX3CR1 mRNA CTD PMID:30779732 benzo[a]pyrene decreases expression ISO RGD:1552004 6480464 Benzo(a)pyrene results in decreased expression of CX3CR1 mRNA CTD PMID:21569818 benzo[a]pyrene decreases expression ISO RGD:1352124 6480464 Benzo(a)pyrene results in decreased expression of CX3CR1 mRNA CTD PMID:32234424 benzo[a]pyrene affects methylation ISO RGD:1352124 6480464 Benzo(a)pyrene affects the methylation of CX3CR1 3' UTR, Benzo(a)pyrene affects the methylation of CX3CR1 exon CTD PMID:27901495 benzo[b]fluoranthene affects expression ISO RGD:1552004 6480464 benzo(b)fluoranthene affects the expression of CX3CR1 mRNA CTD PMID:26377693 Benzo[ghi]perylene increases expression ISO RGD:1552004 6480464 1, 12-benzoperylene results in increased expression of CX3CR1 mRNA CTD PMID:26377693 Benzo[k]fluoranthene increases expression ISO RGD:1552004 6480464 benzo(k)fluoranthene results in increased expression of CX3CR1 mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1552004 6480464 Diethylhexyl Phthalate results in increased expression of CX3CR1 mRNA CTD PMID:28085963 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CX3CR1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1552004 6480464 bisphenol A results in increased expression of CX3CR1 mRNA CTD PMID:29248573 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CX3CR1 mRNA CTD PMID:30816183 bisphenol F increases expression ISO RGD:1552004 6480464 bisphenol F results in increased expression of CX3CR1 mRNA CTD PMID:30951980 buta-1,3-diene decreases expression ISO RGD:1552004 6480464 1, 3-butadiene results in decreased expression of CX3CR1 mRNA CTD PMID:29038090 cadmium atom decreases expression ISO RGD:1352124 6480464 Cadmium results in decreased expression of CX3CR1 mRNA CTD PMID:24376830 cannabidiol decreases expression ISO RGD:1552004 6480464 Cannabidiol results in decreased expression of CX3CR1 mRNA CTD PMID:21542829 carbon nanotube affects expression ISO RGD:1552004 6480464 Nanotubes, Carbon affects the expression of CX3CR1 mRNA, Nanotubes, Carbon analog affects the expression of CX3CR1 mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:1552004 6480464 Nanotubes, Carbon analog results in decreased expression of CX3CR1 mRNA CTD PMID:25620056 ceric oxide affects expression EXP 6480464 ceric oxide affects the expression of CX3CR1 mRNA CTD PMID:29463257 choline affects expression ISO RGD:1352124 6480464 Choline affects the expression of CX3CR1 mRNA CTD PMID:17616785 choline multiple interactions ISO RGD:1552004 6480464 [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 , PMID:23439872 crocidolite asbestos increases expression ISO RGD:1552004 6480464 Asbestos, Crocidolite results in increased expression of CX3CR1 mRNA CTD PMID:29507420 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of CX3CR1 protein CTD PMID:16651033 dextran sulfate multiple interactions ISO RGD:1552004 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CX3CR1 mRNA CTD PMID:29950665 diazinon decreases expression ISO RGD:1352124 6480464 Diazinon results in decreased expression of CX3CR1 mRNA CTD PMID:24356939 dioxygen increases expression ISO RGD:1352124 6480464 Oxygen deficiency results in increased expression of CX3CR1 mRNA, Oxygen deficiency results in increased expression of CX3CR1 protein CTD PMID:17476338 dioxygen decreases expression ISO RGD:1552004 6480464 Oxygen deficiency results in decreased expression of CX3CR1 mRNA CTD PMID:24205000 disodium selenite decreases expression ISO RGD:1352124 6480464 Sodium Selenite results in decreased expression of CX3CR1 mRNA CTD PMID:18175754 divanadium pentaoxide increases expression ISO RGD:1352124 6480464 vanadium pentoxide results in increased expression of CX3CR1 mRNA CTD PMID:17459161 doxorubicin decreases expression ISO RGD:1352124 6480464 Doxorubicin results in decreased expression of CX3CR1 mRNA CTD PMID:29803840 entinostat increases expression ISO RGD:1352124 6480464 entinostat results in increased expression of CX3CR1 mRNA CTD PMID:27188386 ethanol affects expression ISO RGD:1552004 6480464 Ethanol affects the expression of CX3CR1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1552004 6480464 Ethanol results in increased expression of CX3CR1 mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:1552004 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of CX3CR1 mRNA CTD PMID:30517762 ferric oxide decreases expression ISO RGD:1552004 6480464 ferric oxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25086211 folic acid multiple interactions ISO RGD:1552004 6480464 [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 , PMID:23439872 gamma-hexachlorocyclohexane decreases expression ISO RGD:1352124 6480464 Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA CTD PMID:24356939 GW 501516 decreases expression ISO RGD:1352124 6480464 GW 501516 results in decreased expression of CX3CR1 mRNA CTD PMID:19850645 L-methionine multiple interactions ISO RGD:1552004 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CX3CR1 mRNA CTD PMID:20938992 lead diacetate increases expression ISO RGD:1552004 6480464 lead acetate results in increased expression of CX3CR1 mRNA CTD PMID:21829687 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of CX3CR1 mRNA CTD PMID:21846543 mechlorethamine multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA] CTD PMID:28184907 mechlorethamine increases expression EXP 6480464 Mechlorethamine results in increased expression of CX3CR1 mRNA, Mechlorethamine results in increased expression of CX3CR1 protein CTD PMID:26273949 , PMID:28184907 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of CX3CR1 mRNA CTD PMID:19564919 monosodium L-glutamate increases expression ISO RGD:1552004 6480464 Sodium Glutamate results in increased expression of CX3CR1 mRNA CTD PMID:22078008 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine increases expression ISO RGD:1352124 6480464 N more ... CTD PMID:19013360 nickel atom decreases expression ISO RGD:1352124 6480464 Nickel results in decreased expression of CX3CR1 mRNA CTD PMID:23195993 nickel atom increases expression ISO RGD:1352124 6480464 Nickel results in increased expression of CX3CR1 mRNA CTD PMID:25583101 O-methyleugenol decreases expression ISO RGD:1352124 6480464 methyleugenol results in decreased expression of CX3CR1 mRNA CTD PMID:32234424 ochratoxin A increases expression ISO RGD:1352124 6480464 ochratoxin A metabolite results in increased expression of CX3CR1 mRNA, ochratoxin A results in increased expression of CX3CR1 mRNA CTD PMID:24356939 paracetamol multiple interactions ISO RGD:1552004 6480464 [MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CR1 mRNA CTD PMID:22575169 paracetamol increases expression ISO RGD:1352124 6480464 Acetaminophen results in increased expression of CX3CR1 mRNA CTD PMID:26690555 paraquat decreases response to substance ISO RGD:1552004 6480464 CX3CR1 protein results in decreased susceptibility to Paraquat CTD PMID:23299473 pentane-2,3-dione increases expression EXP 6480464 2, 3-pentanedione results in increased expression of CX3CR1 mRNA CTD PMID:25710175 phenobarbital increases expression ISO RGD:1352124 6480464 Phenobarbital results in increased expression of CX3CR1 mRNA CTD PMID:19084549 quercetin multiple interactions ISO RGD:1552004 6480464 Quercetin affects the reaction [CX3CR1 protein affects the activity of PTGS2 protein] more ... CTD PMID:20361964 silicon dioxide decreases expression ISO RGD:1352124 6480464 Silicon Dioxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO RGD:1552004 6480464 Silicon Dioxide results in increased expression of CX3CR1 mRNA CTD PMID:29341224 silicon dioxide decreases expression ISO RGD:1552004 6480464 Silicon Dioxide results in decreased expression of CX3CR1 mRNA CTD PMID:19073995 simvastatin decreases expression ISO RGD:1352124 6480464 Simvastatin results in decreased expression of CX3CR1 mRNA CTD PMID:18359719 sodium arsenite affects methylation ISO RGD:1352124 6480464 sodium arsenite affects the methylation of CX3CR1 gene CTD PMID:28589171 Soman increases expression EXP 6480464 Soman results in increased expression of CX3CR1 mRNA CTD PMID:19281266 succimer multiple interactions ISO RGD:1552004 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CX3CR1 mRNA CTD PMID:21641980 tetrachloromethane increases expression ISO RGD:1552004 6480464 Carbon Tetrachloride results in increased expression of CX3CR1 mRNA CTD PMID:23288052 tetrachloromethane multiple interactions ISO RGD:1552004 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of CX3CR1 mRNA CTD PMID:30517762 titanium dioxide multiple interactions ISO RGD:1552004 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CX3CR1 mRNA CTD PMID:29950665 trichloroethene multiple interactions ISO RGD:1552004 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of CX3CR1 mRNA] CTD PMID:15363585 valproic acid increases methylation ISO RGD:1352124 6480464 Valproic Acid results in increased methylation of CX3CR1 gene CTD PMID:29154799 valproic acid multiple interactions EXP 6480464 Valproic Acid inhibits the reaction [Mechlorethamine results in increased expression of CX3CR1 mRNA] CTD PMID:28184907
Biological Process autocrine signaling IGI UniProtKB:O55145 13673777 PMID:12729461 ARUK-UCL calcium-mediated signaling IBA PANTHER:PTN001200797 more ... 13792537 PMID:21873635 GO_Central cell adhesion ISO RGD:1552004 1624291 UniProtKB:P78423 (MGI:6162594 , PMID:10187784) RGD MGI:6162594 , PMID:10187784 cell chemotaxis IMP 13673824 PMID:10415068 ARUK-UCL cell chemotaxis IBA MGI:103567 more ... 13792537 PMID:21873635 GO_Central cellular response to lipopolysaccharide IEP 4892028 RGD cellular response to lipopolysaccharide ISO RGD:1552004 1624291 UniProtKB:P05067 (MGI:6162390 , PMID:23499256) RGD MGI:6162390 , PMID:23499256 cellular response to transforming growth factor beta stimulus IEP 4892023 RGD central nervous system maturation ISO RGD:1552004 1624291 (MGI:5576986, PMID:24487234) RGD MGI:5576986 , PMID:24487234 cerebral cortex cell migration ISO RGD:1552004 1624291 MGI:2670351 (MGI:3639805 , PMID:16732273) RGD MGI:3639805 , PMID:16732273 chemokine-mediated signaling pathway IMP 13673824 PMID:10415068 ARUK-UCL chemotaxis IBA MGI:103011 more ... 13792537 PMID:21873635 GO_Central chemotaxis ISO RGD:1352124 1624291 UniProtKB:O55145 (PMID:16019082) RGD PMID:16019082 cytokine-mediated signaling pathway ISO RGD:1552004 1624291 (MGI:3833195, PMID:18971423) RGD MGI:3833195 , PMID:18971423 immune response IBA MGI:103011 more ... 13792537 PMID:21873635 GO_Central leukocyte tethering or rolling ISO RGD:1552004 1624291 UniProtKB:O00585 more ... RGD MGI:6162594 , PMID:10187784 macrophage chemotaxis ISO RGD:1552004 1624291 MGI:3608773 (MGI:3777228 , PMID:18322241) RGD MGI:3777228 , PMID:18322241 memory IMP 9491766 ; 9491776 RGD microglial cell activation IMP 9491776 RGD microglial cell activation involved in immune response ISO RGD:1552004 1624291 MGI:2670351 (MGI:3639805 , PMID:16732273) RGD MGI:3639805 , PMID:16732273 modulation of chemical synaptic transmission ISO RGD:1552004 1624291 (MGI:5576986, PMID:24487234) RGD MGI:5576986 , PMID:24487234 multiple spine synapse organization, single dendrite ISO RGD:1552004 1624291 (MGI:5576986, PMID:24487234) RGD MGI:5576986 , PMID:24487234 negative regulation of angiogenesis ISO RGD:1552004 1624291 MGI:3608773 (MGI:3777228 , PMID:18322241) RGD MGI:3777228 , PMID:18322241 negative regulation of apoptotic signaling pathway IGI UniProtKB:P78423 4892026 PMID:10869418 ARUK-UCL negative regulation of cell migration IMP 4891970 RGD negative regulation of chronic inflammatory response to non-antigenic stimulus IMP 9491776 RGD negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO RGD:1552004 1624291 MGI:2670351 (MGI:3833195 , PMID:18971423) RGD MGI:3833195 , PMID:18971423 negative regulation of hippocampal neuron apoptotic process IGI UniProtKB:P78423 4892026 PMID:10869418 ARUK-UCL negative regulation of interleukin-1 beta production IMP 9491804 PMID:20018408 ARUK-UCL negative regulation of long-term synaptic potentiation IMP 9491766 RGD phospholipase C-activating G protein-coupled receptor signaling pathway ISO RGD:1552004 1624291 (MGI:6162594, PMID:10187784) RGD MGI:6162594 , PMID:10187784 positive regulation of angiogenesis IMP 4892022 ; 9491778 RGD positive regulation of cytosolic calcium ion concentration IBA MGI:1096320 more ... 13792537 PMID:21873635 GO_Central positive regulation of I-kappaB phosphorylation IGI UniProtKB:P78423 4892026 PMID:10869418 ARUK-UCL positive regulation of microglial cell migration IMP 13673824 PMID:10415068 ARUK-UCL positive regulation of neuroblast proliferation IMP 9491804 RGD positive regulation of neurogenesis ISO RGD:1552004 1624291 (MGI:6189288, PMID:20018408) RGD MGI:6189288 , PMID:20018408 positive regulation of NF-kappaB transcription factor activity IGI UniProtKB:P78423 4892026 PMID:10869418 ARUK-UCL positive regulation of protein kinase B signaling IGI UniProtKB:P78423 4892026 PMID:10869418 ARUK-UCL regulation of nitric oxide biosynthetic process ISO RGD:1552004 1624291 UniProtKB:P05067 (MGI:6162390 , PMID:23499256) RGD MGI:6162390 , PMID:23499256 regulation of tumor necrosis factor production ISO RGD:1552004 1624291 UniProtKB:P05067 (MGI:6162390 , PMID:23499256) RGD MGI:6162390 , PMID:23499256 response to ischemia IGI UniProtKB:O55145 13673875 PMID:12059974 ARUK-UCL social behavior ISO RGD:1552004 1624291 (MGI:5576986, PMID:24487234) RGD MGI:5576986 , PMID:24487234 synapse maturation ISO RGD:1552004 1624291 (MGI:5576986, PMID:24487234) RGD MGI:5576986 , PMID:24487234 Cellular Component cell surface ISO RGD:1352124 1624291 (PMID:28791023) RGD PMID:28791023 cell surface ISO RGD:1552004 1624291 (MGI:6162594, PMID:10187784) RGD MGI:6162594 , PMID:10187784 cell surface IDA 13673824 PMID:10415068 ARUK-UCL cell surface IDA 4892001 PMID:11870871 ARUK-UCL dendritic tree IDA 4892026 PMID:10869418 ARUK-UCL external side of plasma membrane IBA MGI:103011 more ... 13792537 PMID:21873635 GO_Central integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 neuron projection IDA 4892026 RGD neuronal cell body membrane IDA 4892026 RGD perinuclear region of cytoplasm IDA 4892001 ; 4891944 RGD Molecular Function C-C chemokine binding IBA MGI:104616 more ... 13792537 PMID:21873635 GO_Central C-C chemokine receptor activity IBA MGI:103011 more ... 13792537 PMID:21873635 GO_Central C-X3-C chemokine binding ISO RGD:1352124 1624291 (PMID:23125415) RGD PMID:23125415 C-X3-C chemokine binding ISO RGD:1552004 1624291 UniProtKB:P78423 (MGI:6162594 , PMID:10187784) RGD MGI:6162594 , PMID:10187784 C-X3-C chemokine binding ISS UniProtKB:P49238 1600115 GO_REF:0000024 UniProt GO_REF:0000024 C-X3-C chemokine receptor activity IDA 4892025 RGD chemokine binding IBA MGI:104616 more ... 13792537 PMID:21873635 GO_Central chemokine receptor activity IMP 13673824 PMID:10415068 ARUK-UCL cytokine receptor activity ISO RGD:1552004 1624291 (MGI:3833195, PMID:18971423) RGD MGI:3833195 , PMID:18971423 G protein-coupled receptor activity ISO RGD:1552004 1624291 (MGI:6162594, PMID:10187784) RGD MGI:6162594 , PMID:10187784 protein binding ISO RGD:1352124 1624291 UniProtKB:P78423 , UniProtKB:Q9P0B6 (PMID:32296183), (PMID:9931005) RGD PMID:32296183 , PMID:9931005
Gene-Chemical Interaction Annotations
