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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iron group molecular entity
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Accession:CHEBI:33744 term browser browse the term
Synonyms:related_synonym: iron group molecular entities



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ferbam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO ferbam results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
ferric ammonium citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 increases activity
decreases activity
ISO ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein
CTD PMID:11054110 PMID:18073202 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Aco2 aconitase 2 multiple interactions
increases activity
ISO ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein
CTD PMID:16625280 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]] CTD PMID:32283200 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein] CTD PMID:24862973 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Anxa3 annexin A3 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein] CTD PMID:19515424 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein] CTD PMID:19515424 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:17191120 PMID:26318285 PMID:27481217 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein] CTD PMID:12807743 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO ferric ammonium citrate results in decreased expression of COL1A1 mRNA CTD PMID:19735707 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
decreases phosphorylation
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:26318285 PMID:27481217 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:32283200 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Erp29 endoplasmic reticulum protein 29 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein] CTD PMID:19515424 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions
ISO ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]
CTD PMID:25858758 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein] CTD PMID:32283200 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]
CTD PMID:12393473 PMID:19913091 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein] CTD PMID:19515424 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein] CTD PMID:19515424 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression
ISO Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]
CTD PMID:12393473 PMID:16439612 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein] CTD PMID:19515424
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein] CTD PMID:19515424 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein] CTD PMID:24862973 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein] CTD PMID:24862973 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]; ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]] CTD PMID:32283200 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ireb2 iron responsive element binding protein 2 decreases expression
decreases activity
EXP
ISO
ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein
CTD PMID:11054110 PMID:17469137 PMID:18073202 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein] CTD PMID:17350462 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein
CTD PMID:17191120 PMID:25858758 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO ferric ammonium citrate results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein
CTD PMID:17191120 PMID:25858758 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein] CTD PMID:19515424 NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA] CTD PMID:9826428 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Oga O-GlcNAcase multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein] CTD PMID:24862973 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein] CTD PMID:19515424 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein] CTD PMID:19515424 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein] CTD PMID:19515424 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein] CTD PMID:19515424 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] CTD PMID:24862973 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein] CTD PMID:19515424 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A1 mRNA CTD PMID:11054110 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO ferric ammonium citrate results in increased expression of SLC11A2 mRNA CTD PMID:11054110 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression
multiple interactions
EXP
ISO
ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]
CTD PMID:19913091 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA] CTD PMID:24862973 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tf transferrin multiple interactions ISO ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron] CTD PMID:11335103 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfr2 transferrin receptor 2 decreases expression ISO ferric ammonium citrate results in decreased expression of TFR2 protein CTD PMID:25633564 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
ISO ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA
CTD PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein] CTD PMID:24862973 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpd52l1 TPD52 like 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein] CTD PMID:19515424 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein] CTD PMID:19515424 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein] CTD PMID:32283200 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
ferric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatk apoptosis-associated tyrosine kinase increases expression ISO ferric oxide analog results in increased expression of AATK mRNA CTD PMID:25086211 NCBI chr10:105,290,750...105,327,219
Ensembl chr10:105,291,585...105,327,112
JBrowse link
G Ache acetylcholinesterase decreases activity ISO ferric oxide results in decreased activity of ACHE protein CTD PMID:28993115 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO ferric oxide analog results in increased expression of ACSS2 mRNA CTD PMID:25086211 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 increases expression ISO ferric oxide analog results in increased expression of ADGRE1 mRNA CTD PMID:24525745 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adm adrenomedullin increases expression ISO ferric oxide analog results in increased expression of ADM mRNA CTD PMID:25086211 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO ferric oxide analog results in increased expression of ADORA2B mRNA CTD PMID:25086211 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 increases expression ISO ferric oxide analog results in increased expression of AHNAK2 mRNA CTD PMID:25086211 NCBI chr 6:131,830,668...131,876,311 JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO ferric oxide analog results in increased expression of AHRR mRNA CTD PMID:24525745 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Aig1 androgen-induced 1 increases expression ISO ferric oxide analog results in increased expression of AIG1 mRNA CTD PMID:25086211 NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of AKT1 protein CTD PMID:24847785 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO ferric oxide analog results in decreased expression of ALDH1L2 mRNA CTD PMID:25086211 NCBI chr 7:20,254,196...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G Ankrd12 ankyrin repeat domain 12 decreases expression ISO ferric oxide analog results in decreased expression of ANKRD12 mRNA CTD PMID:24525745 NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911
JBrowse link
G Anln anillin, actin binding protein decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of ANLN mRNA
ferric oxide analog results in increased expression of ANLN mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
JBrowse link
G Anxa3 annexin A3 decreases expression ISO ferric oxide analog results in decreased expression of ANXA3 mRNA CTD PMID:25086211 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Ap5b1 adaptor related protein complex 5 subunit beta 1 decreases expression ISO ferric oxide analog results in decreased expression of AP5B1 mRNA CTD PMID:25086211 NCBI chr 1:202,876,272...202,880,303
Ensembl chr 1:202,876,272...202,880,289
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 increases expression ISO ferric oxide analog results in increased expression of ARHGAP24 mRNA CTD PMID:25086211 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO ferric oxide analog results in increased expression of ATF3 protein CTD PMID:24068039 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atg5 autophagy related 5 increases expression ISO ferric oxide analog results in increased expression of ATG5 protein CTD PMID:24068039 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G B3galnt1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) increases expression ISO ferric oxide analog results in increased expression of B3GALNT1 mRNA CTD PMID:24525745 NCBI chr 2:153,847,297...153,877,371
Ensembl chr 2:153,846,474...153,877,332
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]
ferric oxide results in increased expression of BAX protein
ferric oxide results in decreased expression of BAX protein
ferric oxide analog results in increased phosphorylation of BAX protein
CTD PMID:19421372 PMID:22995439 PMID:25086211 PMID:26991130 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation
increases expression
EXP
ISO
ferric oxide analog results in increased phosphorylation of BCL2 protein
ferric oxide analog results in increased expression of BCL2 protein
CTD PMID:22995439 PMID:25086211 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO ferric oxide analog results in increased expression of BCL2L11 mRNA; ferric oxide analog results in increased expression of BCL2L11 protein CTD PMID:24525745 PMID:25086211 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 increases expression ISO ferric oxide analog results in increased expression of BDH2 mRNA CTD PMID:25086211 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072
JBrowse link
G Becn1 beclin 1 decreases expression
increases expression
ISO ferric oxide results in decreased expression of BECN1 protein
ferric oxide analog results in increased expression of BECN1 protein
CTD PMID:24068039 PMID:25086211 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO ferric oxide analog results in increased expression of BHLHE40 mRNA CTD PMID:25086211 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Canx calnexin decreases expression ISO ferric oxide results in decreased expression of CANX protein CTD PMID:25086211 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]
ferric oxide results in increased cleavage of CASP3 protein
CTD PMID:19421372 PMID:26991130 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 increases expression ISO ferric oxide analog results in increased expression of CASTOR1 mRNA CTD PMID:25086211 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
JBrowse link
G Cat catalase decreases activity
decreases expression
ISO ferric oxide results in decreased activity of CAT protein
ferric oxide results in decreased expression of CAT protein
CTD PMID:19699289 PMID:26991130 PMID:28993115 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc85b coiled-coil domain containing 85B increases expression ISO ferric oxide analog results in increased expression of CCDC85B mRNA CTD PMID:25086211 NCBI chr 1:202,763,645...202,764,631 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO ferric oxide results in increased secretion of CCL2 protein CTD PMID:24885771 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases secretion ISO ferric oxide results in increased secretion of CCL22 protein CTD PMID:24885771 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO ferric oxide results in increased secretion of CCL3 protein CTD PMID:24885771 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression
increases secretion
ISO ferric oxide analog results in decreased expression of CCL4 mRNA
ferric oxide results in increased secretion of CCL4 protein
CTD PMID:24525745 PMID:24885771 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases secretion ISO ferric oxide results in increased secretion of CCL7 protein CTD PMID:24885771 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cd14 CD14 molecule decreases expression ISO ferric oxide analog results in decreased expression of CD14 mRNA CTD PMID:25086211 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd274 CD274 molecule increases expression ISO ferric oxide analog results in increased expression of CD274 mRNA CTD PMID:25086211 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd74 CD74 molecule decreases expression ISO ferric oxide analog results in decreased expression of CD74 mRNA CTD PMID:25086211 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cd83 CD83 molecule increases expression ISO ferric oxide analog results in increased expression of CD83 mRNA CTD PMID:24525745 PMID:25086211 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP ferric oxide analog results in increased expression of CDKN1A protein CTD PMID:22995439 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein CTD PMID:24847785 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO ferric oxide analog results in decreased expression of CDKN2A mRNA CTD PMID:24525745 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cep83 centrosomal protein 83 decreases expression ISO ferric oxide analog results in decreased expression of CEP83 mRNA CTD PMID:24525745 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
JBrowse link
G Clec5a C-type lectin domain containing 5A decreases expression ISO ferric oxide analog results in decreased expression of CLEC5A mRNA CTD PMID:25086211 NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO ferric oxide analog results in increased expression of CLK4 mRNA CTD PMID:25086211 NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO ferric oxide analog results in decreased expression of COX6A2 mRNA CTD PMID:25086211 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
JBrowse link
G Csnk1e casein kinase 1, epsilon increases expression ISO ferric oxide analog results in increased expression of CSNK1E mRNA CTD PMID:25086211 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO ferric oxide analog results in decreased expression of CX3CR1 mRNA CTD PMID:25086211 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO ferric oxide analog results in increased expression of CXCR4 mRNA CTD PMID:25086211 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15211619 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of DDIT3 mRNA; ferric oxide analog results in increased expression of DDIT3 protein
ferric oxide analog results in decreased expression of DDIT3 mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO ferric oxide analog results in decreased expression of DDIT4 mRNA CTD PMID:24525745 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dgkg diacylglycerol kinase, gamma decreases expression ISO ferric oxide analog results in decreased expression of DGKG mRNA CTD PMID:25086211 NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO ferric oxide analog results in decreased expression of DUSP1 mRNA CTD PMID:25086211 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression ISO ferric oxide analog results in increased expression of DUSP4 mRNA CTD PMID:25086211 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO ferric oxide analog results in decreased expression of EEF1A1 mRNA CTD PMID:25086211 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO ferric oxide analog results in increased phosphorylation of EGFR protein CTD PMID:24068039 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 decreases expression ISO ferric oxide analog results in decreased expression of EGR1 mRNA CTD PMID:25086211 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression ISO ferric oxide analog results in increased expression of EGR2 mRNA CTD PMID:24525745 PMID:25086211 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO ferric oxide analog results in decreased expression of EIF2AK2 mRNA CTD PMID:25086211 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eno2 enolase 2 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of ENO2 mRNA
ferric oxide analog results in decreased expression of ENO2 mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Epn2 epsin 2 increases expression ISO ferric oxide analog results in increased expression of EPN2 mRNA CTD PMID:25086211 NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO ferric oxide analog results in increased expression of and results in increased phosphorylation of ERN1 protein CTD PMID:25086211 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fam214a family with sequence similarity 214, member A increases expression ISO ferric oxide analog results in increased expression of FAM214A mRNA CTD PMID:25086211 NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression ISO ferric oxide analog results in increased expression of FBLIM1 mRNA CTD PMID:25086211 NCBI chr 5:153,883,946...153,915,524
Ensembl chr 5:153,883,960...153,913,757
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of FOS mRNA
ferric oxide analog results in increased expression of FOS mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fus FUS RNA binding protein decreases expression ISO ferric oxide analog results in decreased expression of FUS mRNA CTD PMID:25086211 NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO ferric oxide analog results in decreased expression of FYB mRNA CTD PMID:25086211 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases phosphorylation EXP ferric oxide analog results in increased phosphorylation of GADD45A protein CTD PMID:22995439 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO ferric oxide analog results in increased expression of GADD45B mRNA CTD PMID:25086211 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO ferric oxide analog results in increased expression of GJA1 mRNA CTD PMID:25086211 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO ferric oxide analog results in increased expression of GPR183 mRNA CTD PMID:24525745 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G Gpr84 G protein-coupled receptor 84 decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of GPR84 mRNA
ferric oxide analog results in increased expression of GPR84 mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 7:134,443,904...134,446,173
Ensembl chr 7:134,443,936...134,446,178
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Benzo(a)pyrene co-treated with ferric oxide] results in increased activity of GSR protein CTD PMID:11033230 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein] CTD PMID:27270449 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO ferric oxide analog results in decreased expression of H2BC9 mRNA CTD PMID:24525745 PMID:25086211 NCBI chr17:42,470,593...42,478,605 JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO ferric oxide analog results in decreased expression of H3C1 mRNA CTD PMID:25086211 NCBI chr17:41,367,824...41,368,902 JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO ferric oxide analog results in increased expression of HBEGF mRNA CTD PMID:25086211 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Heatr3 HEAT repeat containing 3 decreases expression ISO ferric oxide analog results in decreased expression of HEATR3 mRNA CTD PMID:25086211 NCBI chr19:18,892,477...18,930,502
Ensembl chr19:18,893,144...18,930,509
JBrowse link
G Hebp1 heme binding protein 1 increases expression ISO ferric oxide analog results in increased expression of HEBP1 mRNA CTD PMID:25086211 NCBI chr 4:167,974,318...168,003,859
Ensembl chr 4:167,974,319...168,003,854
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO ferric oxide analog results in increased expression of HILPDA mRNA CTD PMID:25086211 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hist1h2ail1 histone cluster 1 H2a family member I like 1 decreases expression ISO ferric oxide analog results in decreased expression of H3C6 mRNA CTD PMID:25086211 NCBI chr17:41,568,666...41,569,076
Ensembl chr17:41,568,471...41,569,109
JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D decreases expression ISO ferric oxide analog results in decreased expression of H2BC14 mRNA CTD PMID:25086211 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hist1h2bl histone cluster 1 H2B family member l decreases expression ISO ferric oxide analog results in decreased expression of H2BC7 mRNA CTD PMID:24525745 PMID:25086211 NCBI chr17:42,708,646...42,709,435 JBrowse link
G Hist2h2be histone cluster 2 H2B family member E decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of H2BC11 mRNA
ferric oxide analog results in increased expression of H2BC21 mRNA
CTD PMID:25086211 NCBI chr 2:183,780,449...183,783,030 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ferric oxide analog results in increased expression of HMOX1 mRNA CTD PMID:24525745 PMID:25086211 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 increases expression ISO ferric oxide analog results in increased expression of HSD3B7 mRNA CTD PMID:25086211 NCBI chr 1:182,411,836...182,415,447
Ensembl chr 1:182,412,151...182,415,442
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA1A mRNA CTD PMID:20540983
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA8 mRNA CTD PMID:20540983 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression ISO ferric oxide results in decreased expression of HSPD1 protein CTD PMID:28077287 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hyal1 hyaluronidase 1 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of HYAL1 mRNA
ferric oxide analog results in decreased expression of HYAL1 mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO ferric oxide results in increased expression of ICAM1 protein CTD PMID:21439359 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Icam2 intercellular adhesion molecule 2 decreases expression ISO ferric oxide analog results in decreased expression of ICAM2 mRNA CTD PMID:25086211 NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO ferric oxide analog results in increased expression of ID1 mRNA CTD PMID:24525745 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO ferric oxide analog results in increased expression of ID3 mRNA CTD PMID:24525745 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO ferric oxide analog results in decreased expression of IL10RA mRNA CTD PMID:25086211 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO ferric oxide analog results in increased secretion of IL1B protein
ferric oxide results in increased secretion of IL1B protein
CTD PMID:24525745 PMID:24885771 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL2 protein CTD PMID:20540983 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein; ferric oxide inhibits the reaction [Ovalbumin results in increased expression of IL4 protein] CTD PMID:20540983 PMID:23147377 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL5 protein CTD PMID:20540983 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL6 protein
ferric oxide results in increased secretion of IL6 protein
ferric oxide analog results in increased secretion of IL6 protein
CTD PMID:20540983 PMID:24525745 PMID:24885771 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO ferric oxide analog results in decreased expression of IRF7 mRNA CTD PMID:25086211 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP ferric oxide analog results in increased phosphorylation of JUN protein CTD PMID:22995439 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression ISO ferric oxide analog results in decreased expression of KLF2 mRNA CTD PMID:25086211 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klf4 Kruppel like factor 4 decreases expression ISO ferric oxide analog results in decreased expression of KLF4 mRNA CTD PMID:25086211 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein CTD PMID:24847785 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression ISO ferric oxide analog results in increased expression of LAMP2 protein CTD PMID:25086211 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 decreases expression ISO ferric oxide analog results in decreased expression of LILRB4B mRNA CTD PMID:24525745 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Lima1 LIM domain and actin binding 1 increases expression ISO ferric oxide analog results in increased expression of LIMA1 mRNA CTD PMID:25086211 NCBI chr 7:130,901,717...131,001,573
Ensembl chr 7:130,901,717...131,001,473
JBrowse link
G Lims2 LIM zinc finger domain containing 2 increases expression ISO ferric oxide analog results in increased expression of LIMS2 mRNA CTD PMID:25086211 NCBI chr18:23,553,813...23,592,137
Ensembl chr18:23,553,937...23,592,137
JBrowse link
G Lst1 leukocyte specific transcript 1 decreases expression ISO ferric oxide analog results in decreased expression of LST1 mRNA CTD PMID:24525745 NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO ferric oxide analog results in decreased expression of LYZ2 mRNA CTD PMID:25086211 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mafb MAF bZIP transcription factor B increases expression ISO ferric oxide analog results in increased expression of MAFB mRNA CTD PMID:24525745 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO ferric oxide analog results in increased expression of MAP1LC3A protein CTD PMID:25086211 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO ferric oxide analog results in increased expression of MAP1LC3B protein CTD PMID:24068039 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
ferric oxide analog results in increased phosphorylation of MAPK1 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein
CTD PMID:24068039 PMID:24847785 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
ferric oxide analog results in increased phosphorylation of MAPK3 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK3 protein
CTD PMID:24068039 PMID:24847785 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mat2a methionine adenosyltransferase 2A decreases expression
increases expression
ISO ferric oxide analog results in decreased expression of MAT2A mRNA
ferric oxide analog results in increased expression of MAT2A mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression ISO ferric oxide analog results in decreased expression of MEF2C mRNA CTD PMID:25086211 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA CTD PMID:20540983 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp19 matrix metallopeptidase 19 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP19 mRNA CTD PMID:20540983 NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP2 mRNA CTD PMID:20540983 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp23 matrix metallopeptidase 23 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP23 mRNA CTD PMID:20540983 NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO ferric oxide results in increased expression of MMP7 protein CTD PMID:24885771 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Msmb microseminoprotein, beta affects expression ISO ferric oxide affects the expression of MSMB mRNA CTD PMID:28077287 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
JBrowse link
G Naa80 N(alpha)-acetyltransferase 80, NatH catalytic subunit increases expression ISO ferric oxide analog results in increased expression of NAA80 mRNA CTD PMID:25086211 NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563
JBrowse link
G Nckap5l NCK-associated protein 5-like decreases expression ISO ferric oxide analog results in decreased expression of NCKAP5L mRNA CTD PMID:24525745 NCBI chr 7:130,553,683...130,591,886
Ensembl chr 7:130,555,368...130,591,857
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO ferric oxide analog results in increased expression of NDRG1 mRNA CTD PMID:25086211 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO ferric oxide analog results in increased expression of NEDD9 mRNA CTD PMID:24525745 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO ferric oxide results in increased expression of NOX4 protein CTD PMID:28077287 PMID:28993115 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npm3 nucleophosmin/nucleoplasmin, 3 decreases expression ISO ferric oxide analog results in decreased expression of NPM3 mRNA CTD PMID:25086211 NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO ferric oxide analog results in decreased expression of NRP1 mRNA CTD PMID:25086211 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Nt5c2 5'-nucleotidase, cytosolic II increases expression ISO ferric oxide analog results in increased expression of NT5C2 mRNA CTD PMID:24525745 NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO ferric oxide analog results in decreased expression of NUPR1 mRNA CTD PMID:24525745 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 decreases expression ISO ferric oxide analog results in decreased expression of OAS2 mRNA CTD PMID:25086211 NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO ferric oxide analog results in decreased expression of OASL1 mRNA CTD PMID:25086211 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO ferric oxide analog results in increased cleavage of PARP1 protein
ferric oxide results in decreased expression of and results in increased cleavage of PARP1 protein
ferric oxide results in increased cleavage of PARP1 protein
CTD PMID:26991130 PMID:27270449 PMID:28993115 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pate4 prostate and testis expressed 4 affects expression ISO ferric oxide affects the expression of PATE4 mRNA CTD PMID:28077287 NCBI chr 8:33,988,812...33,991,552
Ensembl chr 8:33,988,812...33,991,552
JBrowse link
G Pcdh7 protocadherin 7 decreases expression ISO ferric oxide analog results in decreased expression of PCDH7 mRNA CTD PMID:25086211 NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO ferric oxide analog results in increased expression of PER2 mRNA CTD PMID:25086211 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO ferric oxide analog results in decreased expression of PES1 mRNA CTD PMID:25086211 NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO ferric oxide analog results in increased expression of PHLDA1 mRNA CTD PMID:25086211 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 increases expression ISO ferric oxide analog results in increased expression of PLEKHF1 mRNA CTD PMID:25086211 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO ferric oxide analog results in increased expression of PLK2 mRNA CTD PMID:25086211 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO ferric oxide analog results in increased expression of PLK3 mRNA CTD PMID:25086211 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plpbp pyridoxal phosphate binding protein increases expression ISO ferric oxide analog results in increased expression of PLPBP mRNA CTD PMID:25086211 NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO ferric oxide analog results in decreased expression of PPP1R15A mRNA CTD PMID:24525745 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prf1 perforin 1 decreases expression ISO ferric oxide analog results in decreased expression of PRF1 mRNA CTD PMID:24525745 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Prmt6 protein arginine methyltransferase 6 decreases expression ISO ferric oxide analog results in decreased expression of PRMT6 mRNA CTD PMID:25086211 NCBI chr 2:197,927,750...197,932,980
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prr18 proline rich 18 increases expression ISO ferric oxide analog results in increased expression of PRR18 mRNA CTD PMID:25086211 NCBI chr 1:52,400,215...52,404,492
Ensembl chr 1:52,400,215...52,404,309
JBrowse link
G Prr33 proline rich 33 decreases expression ISO ferric oxide analog results in decreased expression of PRR33 mRNA CTD PMID:25086211 NCBI chr 1:197,644,903...197,650,774
Ensembl chr 1:197,644,902...197,650,714
JBrowse link
G Rab15 RAB15, member RAS oncogene family increases expression ISO ferric oxide analog results in increased expression of RAB15 mRNA CTD PMID:25086211 NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942
JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO ferric oxide analog results in decreased expression of RAD50 mRNA CTD PMID:24525745 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rbak RB-associated KRAB zinc finger increases expression ISO ferric oxide analog results in increased expression of RBAK mRNA CTD PMID:24525745 NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934
JBrowse link
G Rcan1 regulator of calcineurin 1 increases expression ISO ferric oxide analog results in increased expression of RCAN1 mRNA CTD PMID:25086211 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Rcbtb2 RCC1 and BTB domain containing protein 2 increases expression ISO ferric oxide analog results in increased expression of RCBTB2 mRNA CTD PMID:24525745 NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750
JBrowse link
G Rilpl1 Rab interacting lysosomal protein-like 1 decreases expression ISO ferric oxide analog results in decreased expression of RILPL1 mRNA CTD PMID:24525745 NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein CTD PMID:24847785 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP [ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK3 protein CTD PMID:24847785 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-EB1 mRNA CTD PMID:20540983 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-T23 mRNA CTD PMID:20540983 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Rusc2 RUN and SH3 domain containing 2 increases expression ISO ferric oxide analog results in increased expression of RUSC2 mRNA CTD PMID:25086211 NCBI chr 5:57,628,397...57,675,524
Ensembl chr 5:57,629,904...57,675,524
JBrowse link
G Samd9 sterile alpha motif domain containing 9 decreases expression ISO ferric oxide analog results in decreased expression of SAMD9L mRNA CTD PMID:25086211 NCBI chr 4:31,164,639...31,184,325
Ensembl chr 4:31,164,510...31,184,322
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO ferric oxide analog results in decreased expression of SERPINB1A mRNA CTD PMID:24525745 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Skil SKI-like proto-oncogene increases expression ISO ferric oxide analog results in increased expression of SKIL mRNA CTD PMID:24525745 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Slamf8 SLAM family member 8 increases expression ISO ferric oxide analog results in increased expression of SLAMF8 mRNA CTD PMID:24525745 NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression ISO ferric oxide analog results in increased expression of SLC11A1 mRNA CTD PMID:25086211 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Slc46a3 solute carrier family 46, member 3 decreases expression ISO ferric oxide analog results in decreased expression of SLC46A3 mRNA CTD PMID:25086211 NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA CTD PMID:20540983 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO ferric oxide analog results in increased expression of SOD1 protein CTD PMID:24068039 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO ferric oxide analog results in increased expression of SOD2 protein; ferric oxide results in increased expression of SOD2 protein CTD PMID:24068039 PMID:25086211 PMID:26991130 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spata24 spermatogenesis associated 24 decreases expression ISO ferric oxide analog results in decreased expression of SPATA24 mRNA CTD PMID:24525745 NCBI chr18:27,249,047...27,257,129
Ensembl chr18:27,248,609...27,257,124
JBrowse link
G Tatdn2 TatD DNase domain containing 2 decreases expression ISO ferric oxide analog results in decreased expression of TATDN2 mRNA CTD PMID:24525745 NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897
JBrowse link
G Tbc1d2 TBC1 domain family, member 2 increases expression
decreases expression
ISO ferric oxide analog results in increased expression of TBC1D2 mRNA
ferric oxide analog results in decreased expression of TBC1D2 mRNA
CTD PMID:24525745 PMID:25086211 NCBI chr 5:60,884,114...60,931,717
Ensembl chr 5:60,884,124...60,931,352
JBrowse link
G Tbxas1 thromboxane A synthase 1 increases expression ISO ferric oxide analog results in increased expression of TBXAS1 mRNA CTD PMID:24525745 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tf transferrin increases expression EXP ferric oxide results in increased expression of TF mRNA CTD PMID:16428268 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor decreases expression ISO ferric oxide analog results in decreased expression of TFRC mRNA CTD PMID:25086211 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO ferric oxide analog results in increased expression of TGFBI mRNA CTD PMID:24525745 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO ferric oxide analog results in increased expression of TGM2 mRNA CTD PMID:25086211 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TIMP1 mRNA CTD PMID:20540983 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO ferric oxide results in increased expression of TIMP2 protein CTD PMID:24885771 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO ferric oxide analog results in increased expression of TLR2 mRNA CTD PMID:24525745 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tmem176a transmembrane protein 176A decreases expression ISO ferric oxide analog results in decreased expression of TMEM176A mRNA CTD PMID:25086211 NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TNF protein
ferric oxide results in increased secretion of TNF protein
ferric oxide analog results in increased secretion of TNF protein
CTD PMID:20540983 PMID:24068039 PMID:24525745 PMID:24885771 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression ISO ferric oxide results in increased expression of TNNI3 protein CTD PMID:28993115 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
EXP ferric oxide analog results in increased phosphorylation of TP53 protein
[ferric oxide analog co-treated with Acrolein] results in increased expression of TP53 protein
CTD PMID:22995439 PMID:24847785 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO ferric oxide analog results in increased expression of TRP53INP1 mRNA CTD PMID:25086211 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tpr translocated promoter region, nuclear basket protein decreases expression ISO ferric oxide analog results in decreased expression of TPR mRNA CTD PMID:24525745 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO ferric oxide analog results in decreased expression of TRIB3 mRNA CTD PMID:24525745 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Ttpal alpha tocopherol transfer protein like decreases expression ISO ferric oxide analog results in decreased expression of TTPAL mRNA CTD PMID:25086211 NCBI chr 3:152,278,246...152,296,550
Ensembl chr 3:152,278,303...152,296,513
JBrowse link
G Tubb2b tubulin, beta 2B class IIb increases expression ISO ferric oxide analog results in increased expression of TUBB2B mRNA CTD PMID:24525745 NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO ferric oxide analog results in increased expression of WDFY3 mRNA CTD PMID:24525745 NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482
JBrowse link
G Yipf7 Yip1 domain family, member 7 increases expression ISO ferric oxide analog results in increased expression of YIPF7 mRNA CTD PMID:25086211 NCBI chr14:38,571,045...38,599,070
Ensembl chr14:38,571,066...38,599,055
JBrowse link
G Zbtb2 zinc finger and BTB domain containing 2 decreases expression ISO ferric oxide analog results in decreased expression of ZBTB2 mRNA CTD PMID:24525745 NCBI chr 1:40,827,457...40,846,733
Ensembl chr 1:40,827,457...40,846,594
JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression ISO ferric oxide analog results in increased expression of ZC3H13 mRNA CTD PMID:24525745 NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO ferric oxide analog results in increased expression of ZFP36 mRNA CTD PMID:24525745 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
ferric pyrophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tf transferrin multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein CTD PMID:16772442 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein CTD PMID:16772442 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
ferrichrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
ferricyanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP hexacyanoferrate III results in increased expression of HMOX1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [hexacyanoferrate III results in increased expression of HMOX1 protein]
CTD PMID:16439612 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Por cytochrome p450 oxidoreductase increases reduction EXP POR protein results in increased reduction of hexacyanoferrate III CTD PMID:18678259 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
multiple interactions
ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]
CTD PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026
JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions
EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA
CTD PMID:15539406 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:85,586,985...85,902,820
Ensembl chr 9:85,586,987...85,902,637
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686
JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions
ISO Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]
CTD PMID:18983524 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA
CTD PMID:15539406 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997
JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP
Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
CTD PMID:19466990 PMID:22171090 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:130,469,841...130,479,802
Ensembl chr 5:130,469,840...130,478,561
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression
ISO
EXP
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpx hemopexin multiple interactions
affects binding
ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein
CTD PMID:11076874 PMID:23355332 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227
JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:84,384,802...84,394,107
Ensembl chr10:84,384,802...84,394,107
JBrowse link
G Lep leptin multiple interactions
increases abundance
ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion
ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions
EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]
CTD PMID:15539406 NCBI chr13:85,728,076...85,731,469
Ensembl chr13:85,728,076...85,731,469
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme
CTD PMID:11213479 PMID:11878821 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:121,433,993...121,439,158
Ensembl chr 5:121,434,096...121,439,154
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:15,520,717...15,538,579
Ensembl chr 3:15,520,481...15,538,581
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:135,406,177...135,419,511
Ensembl chr 5:135,406,176...135,419,235
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:71,310,387...71,396,752
Ensembl chr18:71,311,020...71,395,709
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:127,694,219...127,706,378
Ensembl chr  X:127,694,964...127,706,378
JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:130,026,309...130,031,127
Ensembl chr 7:130,026,341...130,030,248
JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:106,746,642...106,768,182
Ensembl chr 3:106,656,742...106,768,151
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake
ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme
CTD PMID:17156779 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein
CTD PMID:11076874 PMID:23355332 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:79,185,563...79,192,719
Ensembl chr10:79,186,647...79,191,657
JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208
JBrowse link
ferrosoferric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of BAX protein CTD PMID:30098274 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of BCL2 protein CTD PMID:30098274 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP3 protein; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 mRNA; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 protein modified form CTD PMID:24935781 PMID:30098274 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP9 protein CTD PMID:30098274 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of FADD protein CTD PMID:30098274 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FAS protein CTD PMID:30098274 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FOS protein CTD PMID:30098274 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of HMOX1 protein CTD PMID:30098274 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta increases secretion EXP
ISO
Ferrosoferric Oxide analog results in increased secretion of IL1B protein
Ferrosoferric Oxide results in increased secretion of IL1B protein
CTD PMID:22939914 PMID:24885771 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion EXP
ISO
Ferrosoferric Oxide analog results in increased secretion of IL6 protein
Ferrosoferric Oxide results in increased secretion of IL6 protein
CTD PMID:22939914 PMID:24885771 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of JUN protein CTD PMID:30098274 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK1 protein CTD PMID:30098274 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK3 protein CTD PMID:30098274 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK8 protein CTD PMID:30098274 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK9 protein CTD PMID:30098274 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of NQO1 protein CTD PMID:30098274 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of PARP1 protein CTD PMID:30098274 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of PTGS2 protein CTD PMID:30098274 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rras RAS related multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of RRAS protein CTD PMID:30098274 NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357
JBrowse link
G Tnf tumor necrosis factor increases secretion EXP Ferrosoferric Oxide analog results in increased secretion of TNF protein CTD PMID:22939914 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of TP53 protein CTD PMID:30098274 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
ferrous oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein] CTD PMID:19421372 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions ISO bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein] CTD PMID:19421372 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO ferrous oxide results in increased expression of ICAM1 protein CTD PMID:21439359 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
heme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions
decreases expression
ISO MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein] CTD PMID:21659532 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein] CTD PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026
JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions
EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA
CTD PMID:15539406 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:85,586,985...85,902,820
Ensembl chr 9:85,586,987...85,902,637
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:58,916,513...58,939,923
Ensembl chr  X:58,917,490...58,940,686
JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression
multiple interactions
EXP Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
CTD PMID:15539406 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997
JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP
Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
CTD PMID:19466990 PMID:22171090 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:130,469,841...130,479,802
Ensembl chr 5:130,469,840...130,478,561
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression
ISO
EXP
Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpx hemopexin multiple interactions
affects binding
ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein
CTD PMID:11076874 PMID:23355332 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227
JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:84,384,802...84,394,107
Ensembl chr10:84,384,802...84,394,107
JBrowse link
G Lep leptin multiple interactions
increases abundance
ISO cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [LEP gene mutant form results in increased abundance of Heme]] CTD PMID:23839791 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lyz2 lysozyme 2 increases secretion
multiple interactions
ISO Heme analog results in increased secretion of LYZ protein
SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]
CTD PMID:23355332 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions
EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]
CTD PMID:15539406 NCBI chr13:85,728,076...85,731,469
Ensembl chr13:85,728,076...85,731,469
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Mt1 metallothionein 1 multiple interactions
decreases response to substance
ISO [Heme co-treated with HPX protein] affects the activity of MT1 promoter
MT1A protein results in decreased susceptibility to Heme
CTD PMID:11213479 PMID:11878821 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein CTD PMID:23355332 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:121,433,993...121,439,158
Ensembl chr 5:121,434,096...121,439,154
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:15,520,717...15,538,579
Ensembl chr 3:15,520,481...15,538,581
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:135,406,177...135,419,511
Ensembl chr 5:135,406,176...135,419,235
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:71,310,387...71,396,752
Ensembl chr18:71,311,020...71,395,709
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:127,694,219...127,706,378
Ensembl chr  X:127,694,964...127,706,378
JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Heme analog affects the localization of RELA protein CTD PMID:23355332 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:130,026,309...130,031,127
Ensembl chr 7:130,026,341...130,030,248
JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:106,746,642...106,768,182
Ensembl chr 3:106,656,742...106,768,151
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake
ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme
CTD PMID:17156779 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein
CTD PMID:11076874 PMID:23355332 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693
JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:79,185,563...79,192,719
Ensembl chr10:79,186,647...79,191,657
JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208
JBrowse link
hemin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 decreases activity EXP Hemin results in decreased activity of ACO1 protein CTD PMID:16568477 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Aco2 aconitase 2 increases expression EXP Hemin results in increased expression of ACO2 protein CTD PMID:16568477 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases secretion EXP Hemin results in increased secretion of ADIPOQ protein CTD PMID:20016031 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] CTD PMID:18215737 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression
multiple interactions
ISO Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]
CTD PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin affects binding ISO Hemin binds to ALB protein CTD PMID:10506189 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] CTD PMID:17541025 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 increases expression ISO Hemin results in increased expression of ARL6IP5 protein CTD PMID:16430862 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions
affects localization
ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; Hemin results in decreased localization of and results in decreased activity of BACH1 protein
Hemin affects the localization of BACH1 protein
CTD PMID:18550526 PMID:33434570 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein
CTD PMID:27815112 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Hemin results in decreased expression of BCL2 protein CTD PMID:27815112 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Hemin results in increased expression of BIRC2 protein CTD PMID:14647439 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased cleavage of CASP3 protein
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]
CTD PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:19150641 PMID:27815112 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP [Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA CTD PMID:29269057 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]
CTD PMID:14647439 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases degradation ISO Hemin results in decreased degradation of CDKN1B protein CTD PMID:17283133 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA] CTD PMID:29749404 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Crh corticotropin releasing hormone increases secretion
multiple interactions
ISO Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]
CTD PMID:11232018 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]] CTD PMID:23272707 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]
CTD PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP1A2 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A2 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]] CTD PMID:22159698 PMID:26747958 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO Hemin results in increased expression of CYP2A5 mRNA; Hemin results in increased expression of CYP2A5 protein
[tin protoporphyrin IX co-treated with Hemin] affects the localization of CYP2A5 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of CYP2A5 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of CYP2A5 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in decreased expression of CYP2B1 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP2B1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP2B1 protein] CTD PMID:26747958 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] CTD PMID:11368792 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of CYP2E1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of CYP2E1 protein]
Hemin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]
CTD PMID:19325051 PMID:26747958 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of DDIT3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of DDIT3 protein]
Hemin results in increased expression of DDIT3 mRNA
CTD PMID:26747958 PMID:29749404 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA CTD PMID:32198055 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26747958 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Hemin results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]; KN 62 inhibits the reaction [Hemin results in increased expression of FOS mRNA]; staurosporine aglycone inhibits the reaction [Hemin results in increased expression of FOS mRNA] CTD PMID:10381381 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression ISO Hemin results in decreased expression of FOSL1 protein CTD PMID:20006635 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression EXP
ISO
Hemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 protein CTD PMID:15893546 PMID:16568477 PMID:17469137 PMID:29749404 PMID:31054940 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions
increases expression
ISO
EXP
[Hemin results in increased abundance of Iron] which results in increased expression of FTL mRNA
Hemin results in increased expression of FTL1 mRNA
Hemin results in increased expression of FTL mRNA; Hemin results in increased expression of FTL1 protein
CTD PMID:12393473 PMID:15893546 PMID:16568477 PMID:29749404 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of GAS1 mRNA CTD PMID:12393473 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gata1 GATA binding protein 1 increases expression
multiple interactions
ISO Hemin results in increased expression of GATA1 mRNA
catechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]
CTD PMID:21414390 PMID:23973255 PMID:28552822 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions
ISO Hemin results in decreased expression of GATA2 mRNA
hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of GATA2 mRNA]
CTD PMID:21414390 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Hemin results in increased expression of GCLC mRNA; Hemin results in increased expression of GCLC protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLC protein
CTD PMID:16631525 PMID:33434570 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO Hemin results in increased expression of GCLM mRNA; Hemin results in increased expression of GCLM protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GCLM protein
CTD PMID:33434570 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSR protein
Hemin results in increased expression of GSR mRNA; Hemin results in increased expression of GSR protein
CTD PMID:33434570 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions
ISO Hemin results in increased expression of GSTO1 mRNA
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of GSTO1 mRNA
CTD PMID:33434570 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hemin results in increased stability of and results in increased expression of GSTP1 mRNA CTD PMID:15313425 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases activity ISO Hemin results in decreased activity of GSTZ1 protein CTD PMID:1846734 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
decreases response to substance
ISO Hemin results in increased expression of HAMP mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA; [HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA; HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]; necrostatin-1 promotes the reaction [HAMP mRNA results in decreased susceptibility to Hemin]
CTD PMID:29749404 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions
increases expression
ISO [catechol co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]; catechol promotes the reaction [Hemin results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HBB mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HBB mRNA]; trichostatin A inhibits the reaction [hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 PMID:30327826 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO [Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNA
Hemin results in decreased expression of HIF1A mRNA
CTD PMID:12393473 PMID:29749404 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions
increases expression
ISO [catechol co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]; catechol promotes the reaction [Hemin results in increased expression of HMBS mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]; Decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; Hemin promotes the reaction [catechol results in increased expression of HMBS mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of HMBS mRNA] CTD PMID:21414390 PMID:23973255 PMID:24141029 PMID:28552822 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
increases activity
decreases response to substance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of HMOX1 protein; [Hemin results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA; [Hemin results in increased activity of HMOX1 protein] which results in decreased chemical synthesis of Reactive Oxygen Species; [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Genistein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; herbimycin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]
Hemin results in increased expression of HMOX1 mRNA; Hemin results in increased expression of HMOX1 protein
Hemin results in decreased expression of HMOX1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in decreased expression of HMOX1 protein; [Hemin co-treated with Fructose] results in increased expression of HMOX1 protein; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Hemin results in decreased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; Hemin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; protoporphyrin IX inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; [tin protoporphyrin IX co-treated with Hemin] results in increased expression of HMOX1 mRNA; [zinc protoporphyrin co-treated with Hemin] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Dichlororibofuranosylbenzimidazole inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Hemin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [3-hydroxyflavone results in increased expression of HMOX1 protein]; Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [kaempferol results in increased expression of HMOX1 protein]; Hemin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Hemin
CTD PMID:3343248 PMID:8764571 PMID:9337616 PMID:9722676 PMID:10349844 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases response to substance ISO HMOX2 protein results in decreased susceptibility to Hemin CTD PMID:15589375 PMID:16459095 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Hemin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA CTD PMID:12393473 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA CTD PMID:12393473 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of HSPH1 mRNA CTD PMID:12393473 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Ifng interferon gamma multiple interactions ISO IFNG protein inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA] CTD PMID:10349844 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases response to substance
ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]; Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]; Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]; HMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein] CTD PMID:18215737 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Hemin results in increased expression of IL6 mRNA
[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of IL6 mRNA
CTD PMID:29749404 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Hemin inhibits the reaction [Fructose results in increased expression of INS protein] CTD PMID:25268984 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions EXP Hemin results in decreased expression of and results in decreased activity of IREB2 protein CTD PMID:16568477 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Ivl involucrin decreases expression ISO Hemin results in decreased expression of IVL mRNA CTD PMID:20006635 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
[Hemin results in decreased abundance of Iron] which results in increased expression of JUN mRNA
Hemin results in decreased expression of JUN mRNA
Hemin promotes the reaction [Paraquat results in increased phosphorylation of JUN protein]
CTD PMID:12393473 PMID:19080378 PMID:20016031 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of LOX mRNA CTD PMID:12393473 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr 4:126,205,667...126,811,354
Ensembl chr 4:126,206,816...126,811,691
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Hemin results in increased phosphorylation of MAPK1 protein
diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK1 protein]
CTD PMID:16959797 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein] CTD PMID:18215737 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein] CTD PMID:18215737 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO diacetyldichlorofluorescein inhibits the reaction [Hemin results in increased phosphorylation of MAPK3 protein] CTD PMID:16959797 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Hemin promotes the reaction [Paraquat results in increased phosphorylation of MAPK8 protein] CTD PMID:19080378 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
Hemin results in decreased expression of MAPK9 mRNA
CTD PMID:19190261 PMID:20016031 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]; Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin promotes the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin inhibits the reaction [Lipopolysaccharides results in decreased expression of MFN1 protein]] CTD PMID:27830717 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:19111564 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mir486 microRNA 486 increases expression
multiple interactions
ISO Hemin results in increased expression of MIR486-1 mRNA
[Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of MAGI1 protein; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]
CTD PMID:32198055
G Mmp1 matrix metallopeptidase 1 increases expression ISO Hemin results in increased expression of MMP1 protein CTD PMID:19136476 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Hemin inhibits the reaction [Cyclophosphamide results in increased activity of MPO protein] CTD PMID:17979934 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA CTD PMID:12393473 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Hemin results in increased abundance of Iron] which results in increased expression of MYC mRNA CTD PMID:12393473 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression
multiple interactions
ISO Hemin results in increased expression of NFE2 mRNA
catechol promotes the reaction [Hemin results in increased expression of NFE2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of NFE2 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of NFE2 mRNA]
CTD PMID:21414390 PMID:28552822 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects localization
decreases expression
ISO
EXP
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of and affects the localization of NFE2L2 protein; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Hemin results in increased expression of and affects the localization of NFE2L2 protein; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]
NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]
CTD PMID:10473555 PMID:16959797 PMID:21464371 PMID:21525764 PMID:22859313 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Hemin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; Hemin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of NOS2 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of NOS2 protein]
CTD PMID:14563492 PMID:15316927 PMID:26747958 PMID:27815112 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA CTD PMID:17541025 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Hemin results in increased expression of NQO1 mRNA; Hemin results in increased expression of NQO1 protein
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 mRNA; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of NQO1 protein; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]
CTD PMID:21464371 PMID:31054940 PMID:33434570 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of NRF1 protein] CTD PMID:30040983 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Hemin results in decreased expression of PDE5A protein CTD PMID:16839318 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA CTD PMID:32198055 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions ISO [Hemin results in decreased abundance of Iron] which results in increased expression of PMP22 mRNA CTD PMID:12393473 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein] CTD PMID:11368792 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hemin inhibits the reaction [manganese chloride affects the expression of PPARGC1A protein] CTD PMID:30040983 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases response to substance ISO PTGER2 gene mutant form results in increased susceptibility to Hemin CTD PMID:25451967 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein] CTD PMID:32198055 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 multiple interactions ISO [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] CTD PMID:32198055 NCBI chr 2:164,207,513...164,322,157
Ensembl chr 2:164,207,513...164,244,247
JBrowse link
G Rassf5 Ras association domain family member 5 multiple interactions ISO [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA; [Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 protein; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] CTD PMID:32198055 NCBI chr13:42,637,513...42,703,024
Ensembl chr13:42,637,549...42,703,024
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
Hemin results in decreased expression of RELA mRNA
CTD PMID:19190261 PMID:20016031 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sesn2 sestrin 2 multiple interactions
increases expression
affects response to substance
ISO [SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
[Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; SESN2 protein inhibits the reaction [Hemin results in increased expression of NQO1 protein]
CTD PMID:31054940 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Hemin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:19190261 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hemin promotes the reaction [Acetaminophen results in increased expression of SOD2 protein] CTD PMID:12051994 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression EXP Hemin results in decreased expression of TFAP2C mRNA CTD PMID:20016031 NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995
JBrowse link
G Tfrc transferrin receptor decreases expression
multiple interactions
EXP
ISO
Hemin results in decreased expression of TFRC protein
Hemin results in decreased expression of TFRC mRNA; Hemin results in decreased expression of TFRC protein
[Hemin results in decreased abundance of Iron] which results in increased expression of TFRC mRNA; hydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA]; Phenol promotes the reaction [Hemin results in decreased expression of TFRC mRNA]
CTD PMID:12393473 PMID:16568477 PMID:16760464 PMID:21414390 PMID:25576684 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO [Hemin co-treated with Tretinoin] affects the localization of TGM2 protein CTD PMID:15556610 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of TNF mRNA; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Hemin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:17173083 PMID:19150641 PMID:26747958 PMID:27815112 PMID:29269057 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein] CTD PMID:17541025 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases expression
ISO zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of ZFP36 mRNA] CTD PMID:24095726 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
iron dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP ferrous chloride inhibits the reaction [Dithionite results in decreased activity of ACP5 protein] CTD PMID:6886379 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Aqp4 aquaporin 4 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 mRNA; [ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein; SB 203580 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; U 0126 inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein]; Vitamin E inhibits the reaction [[ferrous chloride results in increased abundance of Iron] which results in increased expression of AQP4 protein] CTD PMID:30914277 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ferrous chloride results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO ferrous chloride results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO ferrous chloride results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO ferrous chloride results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]; ferrous chloride inhibits the reaction [sodium arsenite results in decreased hydroxylation of HIF1A protein]; ferrous chloride inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]] CTD PMID:19263519 PMID:24188932 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO ferrous chloride results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferrous chloride results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein CTD PMID:30914277 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [ferrous chloride results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein CTD PMID:30914277 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO ferrous chloride results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO ferrous chloride results in increased expression of and affects the localization of NFE2L2 protein
ferrous chloride results in increased expression of NFE2L2 mRNA
CTD PMID:27037625 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G P4htm prolyl 4-hydroxylase, transmembrane multiple interactions ISO [Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] results in increased activity of P4HTM protein CTD PMID:19263519 NCBI chr 8:109,274,629...109,292,802
Ensembl chr 8:109,274,626...109,292,473
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO ferrous chloride results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression