iron group molecular entity - Ontology Report

ferbam results in decreased activity of HSD3B1 protein

PMID:36965607

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

Tgfb1

transforming growth factor, beta 1

decreases activity

ferbam results in decreased activity of TGFB1 protein

PMID:31652400

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

ferric ammonium citrate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aco1

aconitase 1

increases activity
decreases activity

ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein

PMID:11054110 PMID:18073202

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Aco2

aconitase 2

multiple interactions
increases activity

ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein

PMID:16625280

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

Acp5

acid phosphatase 5, tartrate resistant

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of ACP5 protein
Silybin inhibits the reaction [ferric ammonium citrate results in increased expression of ACP5 protein]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

Akt1

AKT serine/threonine kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

albumin

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Alpl

alkaline phosphatase, biomineralization associated

multiple interactions

ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein; Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

Anxa3

annexin A3

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein]

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

Arhgdia

Rho GDP dissociation inhibitor alpha

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein]

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

Becn1

beclin 1

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of BECN1 protein; [Hydrogen Peroxide co-treated with [ferric ammonium citrate results in increased abundance of Iron]] results in increased expression of BECN1 protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]

PMID:34826546

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bmp6

bone morphogenetic protein 6

multiple interactions

ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]

PMID:25633564

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

caspase 3

increases cleavage
multiple interactions

ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]

PMID:17191120 PMID:26318285 PMID:27481217

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein]
ferric ammonium citrate results in increased expression of CDKN1A protein

PMID:12807743 PMID:38483099

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn2a

cyclin-dependent kinase inhibitor 2A

increases expression

ferric ammonium citrate results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

Col1a1

collagen type I alpha 1 chain

decreases expression

ferric ammonium citrate results in decreased expression of COL1A1 mRNA

PMID:19735707

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Dnm1l

dynamin 1-like

multiple interactions
decreases phosphorylation

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]

PMID:26318285 PMID:27481217

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

Ern1

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

Erp29

endoplasmic reticulum protein 29

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein]

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

coagulation factor III, tissue factor

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]

PMID:25858758

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fth1

ferritin heavy chain 1

multiple interactions
increases expression

ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein]
ferric ammonium citrate results in increased expression of FTH1 protein

PMID:32283200 PMID:38483099

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

Ftl1

ferritin light chain 1

multiple interactions
increases expression

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL protein
ferric ammonium citrate results in increased expression of FTL1 protein
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]

PMID:12393473 PMID:19913091 PMID:38483099

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

Gapdh

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

Glb1

galactosidase, beta 1

increases expression

ferric ammonium citrate results in increased expression of GLB1 protein

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

Glo1

glyoxalase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

H2ax

H2A.X variant histone

increases expression

ferric ammonium citrate results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

Hamp

hepcidin antimicrobial peptide

multiple interactions
decreases expression

Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]

PMID:25633564

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

heme oxygenase 1

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]

PMID:12393473 PMID:16439612

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hspa1a

heat shock protein family A (Hsp70) member 1A

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

Hspa1l

heat shock protein family A (Hsp70) member 1 like

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

Hspa9

heat shock protein family A (Hsp70) member 9

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

Hspd1

heat shock protein family D (Hsp60) member 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein]

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

interleukin 1 beta

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

interleukin 6

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Ins1

insulin 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

Ins2

insulin 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

Ireb2

iron responsive element binding protein 2

decreases expression
decreases activity

ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein

PMID:11054110 PMID:17469137 PMID:18073202

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

Lcn2

lipocalin 2

multiple interactions

ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]

PMID:17350462

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

Map1lc3b

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]

PMID:34826546

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein

PMID:17191120 PMID:25858758

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk14

mitogen activated protein kinase 14

increases phosphorylation

ferric ammonium citrate results in increased phosphorylation of MAPK14 protein

PMID:17191120

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein

PMID:17191120 PMID:25858758

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mrps9

mitochondrial ribosomal protein S9

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein]

NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375

Mt2A

metallothionein 2A

multiple interactions

[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

Ncoa4

nuclear receptor coactivator 4

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein]

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

Nos2

nitric oxide synthase 2

multiple interactions

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]

PMID:9826428

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Oga

O-GlcNAcase

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein]

NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359

P4ha1

prolyl 4-hydroxylase subunit alpha 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

Parp1

poly (ADP-ribose) polymerase 1

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]

PMID:34826546

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Pdhb

pyruvate dehydrogenase E1 subunit beta

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein]

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

Pgk1

phosphoglycerate kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

Pmp22

peripheral myelin protein 22

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

Ppia

peptidylprolyl isomerase A

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein]

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Rack1

receptor for activated C kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein]

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

Runx2

RUNX family transcription factor 2

multiple interactions
decreases expression

Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of RUNX2 protein]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

Sirt1

sirtuin 1

multiple interactions
decreases expression

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]
Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein]

PMID:34826546 PMID:36087815

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

Slc11a1

solute carrier family 11 member 1

increases expression

ferric ammonium citrate results in increased expression of SLC11A1 mRNA

PMID:11054110

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

Slc11a2

solute carrier family 11 member 2

increases expression

ferric ammonium citrate results in increased expression of SLC11A2 mRNA

PMID:11054110

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

Slc40a1

solute carrier family 40 member 1

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]

PMID:19913091

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

Sod1

superoxide dismutase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sod2

superoxide dismutase 2

multiple interactions
decreases expression

Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

transferrin

multiple interactions

ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron]

PMID:11335103

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

Tfr2

transferrin receptor 2

decreases expression

ferric ammonium citrate results in decreased expression of TFR2 protein

PMID:25633564

NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591

Tfrc

transferrin receptor

decreases expression
multiple interactions

ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA

PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

tumor necrosis factor

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tp53

tumor protein p53

increases expression

ferric ammonium citrate results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tpd52l1

TPD52 like 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein]

NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109

Vdac2

voltage-dependent anion channel 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein]

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

Xbp1

X-box binding protein 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

ferric oxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aatk

apoptosis-associated tyrosine kinase

increases expression

ferric oxide analog results in increased expression of AATK mRNA

NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112

Abcg1

ATP binding cassette subfamily G member 1

increases expression

ferric oxide analog results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

Acan

aggrecan

increases expression

ferric oxide analog results in increased expression of ACAN mRNA

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

Ache

acetylcholinesterase

decreases activity

ferric oxide results in decreased activity of ACHE protein

PMID:28993115

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

Acss2

acyl-CoA synthetase short-chain family member 2

increases expression

ferric oxide analog results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

Adgre1

adhesion G protein-coupled receptor E1

increases expression

ferric oxide analog results in increased expression of ADGRE1 mRNA

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

Adm

adrenomedullin

increases expression

ferric oxide analog results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Adora2b

adenosine A2B receptor

increases expression

ferric oxide analog results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

Agtr2

angiotensin II receptor, type 2

decreases expression

ferric oxide analog results in decreased expression of AGTR2 mRNA

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

Ahnak2

AHNAK nucleoprotein 2

increases expression

ferric oxide analog results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311

Ahrr

aryl-hydrocarbon receptor repressor

increases expression

ferric oxide analog results in increased expression of AHRR mRNA

PMID:24525745 PMID:38615722

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

Aig1

androgen-induced 1

increases expression

ferric oxide analog results in increased expression of AIG1 mRNA

NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084

Akt1

AKT serine/threonine kinase 1

multiple interactions

[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

5'-aminolevulinate synthase 1

increases expression

ferric oxide analog results in increased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

Aldh1a2

aldehyde dehydrogenase 1 family, member A2

decreases expression

ferric oxide analog results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

Aldh1l2

aldehyde dehydrogenase 1 family, member L2

decreases expression

ferric oxide analog results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

Angpt1

angiopoietin 1

increases expression

ferric oxide analog results in increased expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

Angptl2

angiopoietin-like 2

decreases expression

ferric oxide analog results in decreased expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

Ankrd12

ankyrin repeat domain 12

decreases expression

ferric oxide analog results in decreased expression of ANKRD12 mRNA

NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911

Anln

anillin, actin binding protein

decreases expression
increases expression

ferric oxide analog results in decreased expression of ANLN mRNA
ferric oxide analog results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

Anxa3

annexin A3

decreases expression

ferric oxide analog results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

Aox1

aldehyde oxidase 1

increases expression

ferric oxide analog results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

Ap5b1

adaptor related protein complex 5 subunit beta 1

decreases expression

ferric oxide analog results in decreased expression of AP5B1 mRNA

NCBI chr 1:202,876,272...202,880,303
Ensembl chr 1:202,876,272...202,880,289

Arhgap24

Rho GTPase activating protein 24

increases expression

ferric oxide analog results in increased expression of ARHGAP24 mRNA

NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823

Atf3

activating transcription factor 3

increases expression

ferric oxide analog results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

Atg5

autophagy related 5

increases expression

ferric oxide analog results in increased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

Atosa

atos homolog A

increases expression

ferric oxide analog results in increased expression of ATOSA mRNA

NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549

B3galnt1

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

increases expression

ferric oxide analog results in increased expression of B3GALNT1 mRNA

NCBI chr 2:153,847,297...153,877,371
Ensembl chr 2:153,846,474...153,877,332

B3galt2

Beta-1,3-galactosyltransferase 2

decreases expression

ferric oxide analog results in decreased expression of B3GALT2 mRNA

NCBI chr13:55,389,406...55,398,419
Ensembl chr13:55,389,406...55,398,419

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression
increases phosphorylation

bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]
ferric oxide results in increased expression of BAX protein
ferric oxide results in decreased expression of BAX protein
ferric oxide analog results in increased phosphorylation of BAX protein

PMID:19421372 PMID:22995439 PMID:25086211 PMID:26991130

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

increases phosphorylation
increases expression

ferric oxide analog results in increased phosphorylation of BCL2 protein
ferric oxide results in increased expression of BCL2 mRNA
ferric oxide analog results in increased expression of BCL2 protein

PMID:22995439 PMID:25086211 PMID:33554279

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2l11

Bcl2-like 11

increases expression

ferric oxide analog results in increased expression of BCL2L11 mRNA; ferric oxide analog results in increased expression of BCL2L11 protein

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

Bdh2

3-hydroxybutyrate dehydrogenase 2

increases expression

ferric oxide analog results in increased expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

Becn1

beclin 1

decreases expression
increases expression

ferric oxide results in decreased expression of BECN1 protein
ferric oxide analog results in increased expression of BECN1 protein

PMID:24068039 PMID:25086211

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bhlhe40

basic helix-loop-helix family, member e40

increases expression

ferric oxide analog results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

Bmp2

bone morphogenetic protein 2

increases expression

ferric oxide analog results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

C1s

complement C1s

increases expression

ferric oxide analog results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

Canx

calnexin

decreases expression

ferric oxide results in decreased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

Car5b

carbonic anhydrase 5B

increases expression

ferric oxide analog results in increased expression of CAR5B mRNA

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837

caspase 3

multiple interactions
affects activity
increases expression
increases cleavage

bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]
ferric oxide affects the activity of CASP3 protein
ferric oxide results in increased expression of CASP3 protein modified form
ferric oxide results in increased cleavage of CASP3 protein

PMID:19421372 PMID:26991130 PMID:33554279

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp9

caspase 9

increases activity

ferric oxide results in increased activity of CASP9 protein

PMID:33554279

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Castor1

cytosolic arginine sensor for mTORC1 subunit 1

increases expression

ferric oxide analog results in increased expression of CASTOR1 mRNA

NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548

Cat

catalase

decreases activity
decreases expression

ferric oxide results in decreased activity of CAT protein
ferric oxide results in decreased expression of CAT protein

PMID:19699289 PMID:26991130 PMID:28993115

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Ccdc85b

coiled-coil domain containing 85B

increases expression

ferric oxide analog results in increased expression of CCDC85B mRNA

NCBI chr 1:202,763,645...202,764,660
Ensembl chr 1:202,763,631...202,764,703

Ccl11

C-C motif chemokine ligand 11

multiple interactions
increases expression

ferric oxide results in increased expression of and results in increased secretion of CCL11 protein; RAG1 promotes the reaction [ferric oxide analog results in increased expression of CCL11 protein]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

C-C motif chemokine ligand 2

increases secretion
increases expression

ferric oxide results in increased secretion of CCL2 protein
ferric oxide analog results in increased expression of CCL2 mRNA

PMID:24885771 PMID:38615722

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl20

C-C motif chemokine ligand 20

increases expression

ferric oxide analog results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

Ccl22

C-C motif chemokine ligand 22

increases secretion

ferric oxide results in increased secretion of CCL22 protein

PMID:24885771

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

Ccl3

C-C motif chemokine ligand 3

increases secretion
multiple interactions
increases expression

ferric oxide results in increased secretion of CCL3 protein
ferric oxide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]
ferric oxide results in increased expression of CCL3 protein

PMID:24885771 PMID:35872045 PMID:36416909

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl4

C-C motif chemokine ligand 4

decreases expression
increases expression
increases secretion

ferric oxide analog results in decreased expression of CCL4 mRNA
ferric oxide results in increased expression of CCL4 protein
ferric oxide results in increased secretion of CCL4 protein

PMID:24525745 PMID:24885771 PMID:35872045

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

Ccl5

C-C motif chemokine ligand 5

increases expression

ferric oxide analog results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

Ccl7

C-C motif chemokine ligand 7

increases secretion
increases expression
multiple interactions

ferric oxide results in increased secretion of CCL7 protein
ferric oxide analog results in increased expression of CCL7 mRNA
ferric oxide results in increased expression of and results in increased secretion of CCL7 protein; RAG1 inhibits the reaction [ferric oxide analog results in increased expression of CCL7 protein]

PMID:24885771 PMID:34982504 PMID:36935073 PMID:38615722

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

Cd14

CD14 molecule

decreases expression

ferric oxide analog results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

Cd274

CD274 molecule

increases expression

ferric oxide analog results in increased expression of CD274 mRNA

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

Cd74

CD74 molecule

decreases expression

ferric oxide analog results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

Cd83

CD83 molecule

increases expression

ferric oxide analog results in increased expression of CD83 mRNA

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

Cdh1

cadherin 1

decreases expression

ferric oxide results in decreased expression of CDH1 protein
ferric oxide analog results in decreased expression of CDH1 mRNA

PMID:34982504 PMID:38615722

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cdhr1

cadherin-related family member 1

increases expression

ferric oxide analog results in increased expression of CDHR1 mRNA

NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396

Cdkn1a

cyclin-dependent kinase inhibitor 1A

increases expression

ferric oxide analog results in increased expression of CDKN1A protein

PMID:22995439

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn1b

cyclin-dependent kinase inhibitor 1B

multiple interactions

[ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

Cdkn2a

cyclin-dependent kinase inhibitor 2A

decreases expression

ferric oxide analog results in decreased expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

Cep83

centrosomal protein 83

decreases expression

ferric oxide analog results in decreased expression of CEP83 mRNA

NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574

Clec5a

C-type lectin domain containing 5A

decreases expression

ferric oxide analog results in decreased expression of CLEC5A mRNA

NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859

Clk4

CDC-like kinase 4

increases expression

ferric oxide analog results in increased expression of CLK4 mRNA

NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352

Cntn3

contactin 3

decreases expression

ferric oxide analog results in decreased expression of CNTN3 mRNA

NCBI chr 4:134,841,268...135,214,460
Ensembl chr 4:134,842,266...135,125,613

Col3a1

collagen type III alpha 1 chain

decreases expression

ferric oxide analog results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

Col6a3

collagen type VI alpha 3 chain

increases expression

ferric oxide analog results in increased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

Col8a1

collagen type VIII alpha 1 chain

decreases expression

ferric oxide analog results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

Cox6a2

cytochrome c oxidase subunit 6A2

decreases expression

ferric oxide analog results in decreased expression of COX6A2 mRNA

NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274

Crabp2

cellular retinoic acid binding protein 2

increases expression

ferric oxide analog results in increased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

Csnk1e

casein kinase 1, epsilon

increases expression

ferric oxide analog results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

Cx3cr1

C-X3-C motif chemokine receptor 1

decreases expression

ferric oxide analog results in decreased expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

Cxcl1

C-X-C motif chemokine ligand 1

increases expression

ferric oxide results in increased expression of CXCL1 protein
ferric oxide analog results in increased expression of CXCL1 mRNA

PMID:35872045 PMID:38615722

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

Cxcl10

C-X-C motif chemokine ligand 10

increases expression

ferric oxide analog results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cxcl3

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

ferric oxide results in increased expression of and results in increased secretion of CXCL1 protein
ferric oxide results in increased expression of CXCL1 protein

PMID:34982504 PMID:35872045

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

Cxcr4

C-X-C motif chemokine receptor 4

increases expression

ferric oxide analog results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; ferric oxide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
ferric oxide analog results in increased expression of CYP1A1 mRNA

PMID:15211619 PMID:38615722

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

ferric oxide analog results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

Ddit3

DNA-damage inducible transcript 3

increases expression
decreases expression

ferric oxide analog results in increased expression of DDIT3 mRNA; ferric oxide analog results in increased expression of DDIT3 protein
ferric oxide analog results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Ddit4

DNA-damage-inducible transcript 4

decreases expression

ferric oxide analog results in decreased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

Dgkg

diacylglycerol kinase, gamma

decreases expression

ferric oxide analog results in decreased expression of DGKG mRNA

NCBI chr11:78,384,212...78,579,158
Ensembl chr11:78,384,458...78,577,212

Dock3

dedicator of cyto-kinesis 3

increases expression

ferric oxide analog results in increased expression of DOCK3 mRNA

NCBI chr 8:107,552,462...107,903,527
Ensembl chr 8:107,552,463...107,903,514

Dusp1

dual specificity phosphatase 1

decreases expression

ferric oxide analog results in decreased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

Dusp4

dual specificity phosphatase 4

increases expression

ferric oxide analog results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

Eef1a1

eukaryotic translation elongation factor 1 alpha 1

decreases expression

ferric oxide analog results in decreased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

Egfr

epidermal growth factor receptor

increases phosphorylation

ferric oxide analog results in increased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

Egr1

early growth response 1

decreases expression

ferric oxide analog results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

Egr2

early growth response 2

increases expression

ferric oxide analog results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

decreases expression

ferric oxide analog results in decreased expression of EIF2AK2 mRNA

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

Eno2

enolase 2

increases expression
decreases expression

ferric oxide analog results in increased expression of ENO2 mRNA
ferric oxide analog results in decreased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Epn2

epsin 2

increases expression

ferric oxide analog results in increased expression of EPN2 mRNA

NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642

Ern1

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ferric oxide analog results in increased expression of and results in increased phosphorylation of ERN1 protein

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

Esm1

endothelial cell-specific molecule 1

increases expression

ferric oxide analog results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

Fblim1

filamin binding LIM protein 1

increases expression

ferric oxide analog results in increased expression of FBLIM1 mRNA

NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757

Filip1

filamin A interacting protein 1

increases expression

ferric oxide analog results in increased expression of FILIP1 mRNA

NCBI chr 8:80,761,283...80,956,556
Ensembl chr 8:80,764,604...80,922,549

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

ferric oxide analog results in decreased expression of FOS mRNA
ferric oxide analog results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fosb

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

ferric oxide analog results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

Fosl1

FOS like 1, AP-1 transcription factor subunit

increases expression

ferric oxide analog results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

Fus

Fus RNA binding protein

decreases expression

ferric oxide analog results in decreased expression of FUS mRNA

NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414

Fyb1

FYN binding protein 1

decreases expression

ferric oxide analog results in decreased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

Gadd45a

growth arrest and DNA-damage-inducible, alpha

increases phosphorylation

ferric oxide analog results in increased phosphorylation of GADD45A protein

PMID:22995439

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

Gadd45b

growth arrest and DNA-damage-inducible, beta

increases expression

ferric oxide analog results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

Gbp2

guanylate binding protein 2

increases expression

ferric oxide analog results in increased expression of GBP2 mRNA

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

Gja1

gap junction protein, alpha 1

increases expression

ferric oxide analog results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Gpnmb

glycoprotein nmb

increases expression

ferric oxide analog results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

Gpr183

G protein-coupled receptor 183

increases expression

ferric oxide analog results in increased expression of GPR183 mRNA

NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559

Gpr84

G protein-coupled receptor 84

decreases expression
increases expression

ferric oxide analog results in decreased expression of GPR84 mRNA
ferric oxide analog results in increased expression of GPR84 mRNA

NCBI chr 7:134,443,904...134,446,173
Ensembl chr 7:134,443,936...134,446,178

Gsr

glutathione-disulfide reductase

multiple interactions

[Benzo(a)pyrene co-treated with ferric oxide] results in increased activity of GSR protein

PMID:11033230

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Gsta1

glutathione S-transferase alpha 1

increases expression

ferric oxide analog results in increased expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

Gstp1

glutathione S-transferase pi 1

increases expression

ferric oxide analog results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

H2ax

H2A.X variant histone

multiple interactions
increases expression

Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein]

PMID:27270449

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

H2bc8

H2B clustered histone 8

decreases expression

ferric oxide analog results in decreased expression of H2BC7 mRNA

NCBI chr17:42,708,658...42,709,408

H2bc9

H2B clustered histone 9

decreases expression

ferric oxide analog results in decreased expression of H2BC9 mRNA

NCBI chr17:42,470,593...42,478,590

H3c1

H3 clustered histone 1

decreases expression

ferric oxide analog results in decreased expression of H3C1 mRNA

NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

Hbegf

heparin-binding EGF-like growth factor

increases expression

ferric oxide analog results in increased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

Heatr3

HEAT repeat containing 3

decreases expression

ferric oxide analog results in decreased expression of HEATR3 mRNA

NCBI chr19:18,892,477...18,930,502
Ensembl chr19:18,893,144...18,930,509

Hebp1

heme binding protein 1

increases expression

ferric oxide analog results in increased expression of HEBP1 mRNA

NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854

Hilpda

hypoxia inducible lipid droplet-associated

increases expression

ferric oxide analog results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

Hist1h2ail1

histone cluster 1 H2a family member I like 1

decreases expression

ferric oxide analog results in decreased expression of H3C6 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109

Hist1h4b

histone cluster 1 H4 family member B

decreases expression

ferric oxide analog results in decreased expression of HIST1H4B mRNA

NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370

Hist2h2be

histone cluster 2 H2B family member E

decreases expression
increases expression

ferric oxide analog results in decreased expression of H2BC11 mRNA
ferric oxide analog results in increased expression of H2BC21 mRNA

NCBI chr 2:183,780,583...183,783,030

heme oxygenase 1

increases expression

ferric oxide analog results in increased expression of HMOX1 mRNA

PMID:24525745 PMID:25086211 PMID:38615722

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hsd11b1

hydroxysteroid 11-beta dehydrogenase 1

increases expression

ferric oxide analog results in increased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

increases expression

ferric oxide analog results in increased expression of HSD3B7 mRNA

NCBI chr 1:182,412,216...182,415,447
Ensembl chr 1:182,412,151...182,415,442

Hspa1a

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

Hspa8

heat shock protein family A (Hsp70) member 8

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

Hspd1

heat shock protein family D (Hsp60) member 1

decreases expression

ferric oxide results in decreased expression of HSPD1 protein

PMID:28077287

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

Hyal1

hyaluronidase 1

increases expression
decreases expression

ferric oxide analog results in increased expression of HYAL1 mRNA
ferric oxide analog results in decreased expression of HYAL1 mRNA

NCBI chr 8:108,250,668...108,254,519
Ensembl chr 8:108,250,667...108,260,210

Icam1

intercellular adhesion molecule 1

increases expression

ferric oxide results in increased expression of ICAM1 protein

PMID:21439359

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Icam2

intercellular adhesion molecule 2

decreases expression

ferric oxide analog results in decreased expression of ICAM2 mRNA

NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293

Id1

inhibitor of DNA binding 1

increases expression

ferric oxide analog results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

Id3

inhibitor of DNA binding 3

increases expression

ferric oxide analog results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

Il10ra

interleukin 10 receptor subunit alpha

decreases expression

ferric oxide analog results in decreased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

Il12b

interleukin 12B

multiple interactions

ferric oxide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]

PMID:36416909

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

Il13

interleukin 13

multiple interactions
increases expression

RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL13 protein]

PMID:36935073

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

Il17a

interleukin 17A

multiple interactions

ferric oxide results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

interleukin 1 beta

increases secretion

ferric oxide analog results in increased secretion of IL1B protein
ferric oxide results in increased secretion of IL1B protein

PMID:24525745 PMID:24885771

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1rl2

interleukin 1 receptor-like 2

increases expression

ferric oxide analog results in increased expression of IL1RL2 mRNA

NCBI chr 9:42,591,658...42,639,351
Ensembl chr 9:42,591,934...42,636,667

Il2

interleukin 2

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Il33

interleukin 33

multiple interactions

ferric oxide results in increased expression of and results in increased secretion of IL33 protein

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

Il4

interleukin 4

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL4 protein; ferric oxide inhibits the reaction [Ovalbumin results in increased expression of IL4 protein]

PMID:20540983 PMID:23147377

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

Il4i1

interleukin 4 induced 1

decreases expression

ferric oxide analog results in decreased expression of IL4I1 mRNA

NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562

Il5

interleukin 5

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL5 protein; ferric oxide results in increased expression of and results in increased secretion of IL5 protein

PMID:20540983 PMID:34982504

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

interleukin 6

multiple interactions
increases expression
increases secretion

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of IL6 protein; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL6 protein]
ferric oxide results in increased secretion of IL6 protein
ferric oxide analog results in increased secretion of IL6 protein

PMID:20540983 PMID:24525745 PMID:24885771 PMID:36935073

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Irf7

interferon regulatory factor 7

decreases expression

ferric oxide analog results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

ferric oxide analog results in increased phosphorylation of JUN protein

PMID:22995439

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Klf2

KLF transcription factor 2

decreases expression

ferric oxide analog results in decreased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

Klf4

KLF transcription factor 4

decreases expression

ferric oxide analog results in decreased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

Klhl31

kelch-like family member 31

increases expression

ferric oxide analog results in increased expression of KLHL31 mRNA

NCBI chr 8:78,515,514...78,538,873
Ensembl chr 8:78,515,514...78,538,873

Lama3

laminin subunit alpha 3

increases expression

ferric oxide analog results in increased expression of LAMA3 mRNA

NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353

Lamp1

lysosomal-associated membrane protein 1

multiple interactions

[ferric oxide analog co-treated with Acrolein] results in decreased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

Lamp2

lysosomal-associated membrane protein 2

increases expression

ferric oxide analog results in increased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

Lgals3

galectin 3

increases expression

ferric oxide analog results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

Lilrb4

leukocyte immunoglobulin like receptor B4

decreases expression

ferric oxide analog results in decreased expression of LILRB4B mRNA

NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660

Lima1

LIM domain and actin binding 1

increases expression

ferric oxide analog results in increased expression of LIMA1 mRNA

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

Lims2

LIM zinc finger domain containing 2

increases expression

ferric oxide analog results in increased expression of LIMS2 mRNA

NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137

LOC120095805

U6 spliceosomal RNA

decreases expression

ferric oxide analog results in decreased expression of RNU6 mRNA

NCBI chr11:16,655,090...16,655,196
Ensembl chr11:16,655,090...16,655,196

Loxl4

lysyl oxidase-like 4

increases expression

ferric oxide analog results in increased expression of LOXL4 mRNA

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

Lst1

leukocyte specific transcript 1

decreases expression

ferric oxide analog results in decreased expression of LST1 mRNA

NCBI chr20:3,634,680...3,639,731
Ensembl chr20:3,634,749...3,637,997

Ly6a

lymphocyte antigen 6 family member A

decreases expression

ferric oxide analog results in decreased expression of LY6A mRNA

NCBI chr 7:107,177,191...107,189,436
Ensembl chr 7:107,183,469...107,189,981

Lypd6

Ly6/Plaur domain containing 6

decreases expression

ferric oxide analog results in decreased expression of LYPD6 mRNA

NCBI chr 3:34,487,425...34,632,887
Ensembl chr 3:34,496,485...34,630,308

Lyz2

lysozyme 2

decreases expression

ferric oxide analog results in decreased expression of LYZ2 mRNA

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

Mafb

MAF bZIP transcription factor B

increases expression

ferric oxide analog results in increased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

Map1lc3a

microtubule-associated protein 1 light chain 3 alpha

increases expression

ferric oxide analog results in increased expression of MAP1LC3A protein

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

Map1lc3b

microtubule-associated protein 1 light chain 3 beta

increases expression

ferric oxide analog results in increased expression of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ferric oxide analog results in increased phosphorylation of MAPK1 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK1 protein

PMID:24068039 PMID:24847785

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

ferric oxide analog results in increased phosphorylation of MAPK3 protein
[ferric oxide analog co-treated with Acrolein] results in increased phosphorylation of MAPK3 protein

PMID:24068039 PMID:24847785

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mat2a

methionine adenosyltransferase 2A

decreases expression
increases expression

ferric oxide analog results in decreased expression of MAT2A mRNA
ferric oxide analog results in increased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

Mef2c

myocyte enhancer factor 2C

decreases expression

ferric oxide analog results in decreased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

Megf6

multiple EGF-like-domains 6

decreases expression

ferric oxide analog results in decreased expression of MEGF6 mRNA

NCBI chr 5:164,738,272...164,839,142
Ensembl chr 5:164,738,352...164,839,139

Mgst1

microsomal glutathione S-transferase 1

increases expression

ferric oxide analog results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

Mmp12

matrix metallopeptidase 12

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

Mmp19

matrix metallopeptidase 19

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP19 mRNA

NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555

Mmp2

matrix metallopeptidase 2

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mmp23

matrix metallopeptidase 23

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP23 mRNA

NCBI chr 5:166,239,643...166,242,734
Ensembl chr 5:166,239,644...166,242,433

Mmp7

matrix metallopeptidase 7

increases expression

ferric oxide results in increased expression of MMP7 protein

PMID:24885771

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

Mmp9

matrix metallopeptidase 9

increases expression

ferric oxide analog results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Mnda

myeloid cell nuclear differentiation antigen

increases expression

ferric oxide analog results in increased expression of MNDA mRNA

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

Msmb

microseminoprotein, beta

affects expression

ferric oxide affects the expression of MSMB mRNA

PMID:28077287

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

Mt2A

metallothionein 2A

increases expression

ferric oxide analog results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

Myd88

MYD88, innate immune signal transduction adaptor

multiple interactions
increases expression

oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of MYD88 protein]
ferric oxide analog results in increased expression of MYD88 mRNA; ferric oxide analog results in increased expression of MYD88 protein; ferric oxide results in increased expression of MYD88 mRNA; ferric oxide results in increased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

N4bp3

Nedd4 binding protein 3

decreases expression

ferric oxide analog results in decreased expression of N4BP3 mRNA

NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001

Naa80

N(alpha)-acetyltransferase 80, NatH catalytic subunit

increases expression

ferric oxide analog results in increased expression of NAA80 mRNA

NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563

Nckap5l

NCK-associated protein 5-like

decreases expression

ferric oxide analog results in decreased expression of NCKAP5L mRNA

NCBI chr 7:130,553,683...130,591,886
Ensembl chr 7:130,555,368...130,591,857

Ndrg1

N-myc downstream regulated 1

increases expression

ferric oxide analog results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

Nedd9

neural precursor cell expressed, developmentally down-regulated 9

increases expression

ferric oxide analog results in increased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

Nfatc2

nuclear factor of activated T-cells 2

increases expression

ferric oxide analog results in increased expression of NFATC2 mRNA

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

Nfkb1

nuclear factor kappa B subunit 1

increases expression

ferric oxide results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nox4

NADPH oxidase 4

increases expression

ferric oxide results in increased expression of NOX4 protein

PMID:28077287 PMID:28993115

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

Npm3

nucleophosmin/nucleoplasmin, 3

decreases expression

ferric oxide analog results in decreased expression of NPM3 mRNA

NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591

Nqo1

NAD(P)H quinone dehydrogenase 1

increases expression

ferric oxide analog results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Nrp1

neuropilin 1

decreases expression

ferric oxide analog results in decreased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

Nsg1

neuronal vesicle trafficking associated 1

increases expression

ferric oxide analog results in increased expression of NSG1 mRNA

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

Nt5c2

5'-nucleotidase, cytosolic II

increases expression

ferric oxide analog results in increased expression of NT5C2 mRNA

NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913

Nupr1

nuclear protein 1, transcriptional regulator

decreases expression

ferric oxide analog results in decreased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

Oas2

2'-5' oligoadenylate synthetase 2

decreases expression

ferric oxide analog results in decreased expression of OAS2 mRNA

NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371

Oasl

2'-5'-oligoadenylate synthetase-like

decreases expression

ferric oxide analog results in decreased expression of OASL1 mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

Osgin1

oxidative stress induced growth inhibitor 1

increases expression

ferric oxide analog results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

Pamr1

peptidase domain containing associated with muscle regeneration 1

increases expression

ferric oxide analog results in increased expression of PAMR1 mRNA

NCBI chr 3:88,889,061...88,988,615
Ensembl chr 3:88,889,046...88,988,606

Pappa

pappalysin

increases expression

ferric oxide analog results in increased expression of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

Parp1

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ferric oxide analog results in increased cleavage of PARP1 protein
ferric oxide results in decreased expression of and results in increased cleavage of PARP1 protein
ferric oxide results in increased cleavage of PARP1 protein

PMID:26991130 PMID:27270449 PMID:28993115

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Pate4

prostate and testis expressed 4

affects expression

ferric oxide affects the expression of PATE4 mRNA

PMID:28077287

NCBI chr 8:33,988,812...33,991,552
Ensembl chr 8:33,988,812...33,991,552
Ensembl chr 8:33,988,812...33,991,552

Pcdh7

protocadherin 7

decreases expression

ferric oxide analog results in decreased expression of PCDH7 mRNA

NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051

Pcsk5

proprotein convertase subtilisin/kexin type 5

decreases expression

ferric oxide analog results in decreased expression of PCSK5 mRNA

NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600

Pde2a

phosphodiesterase 2A

decreases expression

ferric oxide analog results in decreased expression of PDE2A mRNA

NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434

Per2

period circadian regulator 2

increases expression

ferric oxide analog results in increased expression of PER2 mRNA

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

Pes1

pescadillo ribosomal biogenesis factor 1

decreases expression

ferric oxide analog results in decreased expression of PES1 mRNA

NCBI chr14:78,850,754...78,867,134
Ensembl chr14:78,850,709...78,867,134

Phlda1

pleckstrin homology-like domain, family A, member 1

increases expression

ferric oxide analog results in increased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

Pla2g7

phospholipase A2 group VII

increases expression

ferric oxide analog results in increased expression of PLA2G7 mRNA

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

Plekhf1

pleckstrin homology and FYVE domain containing 1

increases expression

ferric oxide analog results in increased expression of PLEKHF1 mRNA

NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820

Plk2

polo-like kinase 2

increases expression

ferric oxide analog results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

Plk3

polo-like kinase 3

increases expression

ferric oxide analog results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

Plpbp

pyridoxal phosphate binding protein

increases expression

ferric oxide analog results in increased expression of PLPBP mRNA

NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886

Plppr4

phospholipid phosphatase related 4

decreases expression

ferric oxide analog results in decreased expression of PLPPR4 mRNA

NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302

Ppm1e

protein phosphatase, Mg2+/Mn2+ dependent, 1E

increases expression

ferric oxide analog results in increased expression of PPM1E mRNA

NCBI chr10:72,051,643...72,187,439
Ensembl chr10:72,055,208...72,187,282

Ppp1r15a

protein phosphatase 1, regulatory subunit 15A

decreases expression

ferric oxide analog results in decreased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

Prf1

perforin 1

decreases expression

ferric oxide analog results in decreased expression of PRF1 mRNA

NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701

Prmt6

protein arginine methyltransferase 6

decreases expression

ferric oxide analog results in decreased expression of PRMT6 mRNA

NCBI chr 2:197,927,750...197,932,760
Ensembl chr 2:197,927,220...197,933,648

Prr18

proline rich 18

increases expression

ferric oxide analog results in increased expression of PRR18 mRNA

NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:52,400,215...52,404,309

Prr33

proline rich 33

decreases expression

ferric oxide analog results in decreased expression of PRR33 mRNA

NCBI chr 1:197,644,903...197,650,774
Ensembl chr 1:197,644,902...197,650,714

Ptgr1

prostaglandin reductase 1

increases expression

ferric oxide analog results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

Ptgs1

prostaglandin-endoperoxide synthase 1

increases expression

ferric oxide analog results in increased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

Rab15

RAB15, member RAS oncogene family

increases expression

ferric oxide analog results in increased expression of RAB15 mRNA

NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942

Rad50

RAD50 double strand break repair protein

decreases expression

ferric oxide analog results in decreased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

Rag1

recombination activating 1

multiple interactions

RAG1 inhibits the reaction [ferric oxide analog results in increased expression of CCL7 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of CCL11 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL13 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of IL6 protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of TNF protein]

PMID:36935073

NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291

Rbak

RB-associated KRAB zinc finger

increases expression

ferric oxide analog results in increased expression of RBAK mRNA

NCBI chr12:11,375,314...11,388,937
Ensembl chr12:11,375,318...11,388,934

Rcan1

regulator of calcineurin 1

increases expression

ferric oxide analog results in increased expression of RCAN1 mRNA

NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045

Rcbtb2

RCC1 and BTB domain containing protein 2

increases expression

ferric oxide analog results in increased expression of RCBTB2 mRNA

NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750

Rgs16

regulator of G-protein signaling 16

increases expression

ferric oxide analog results in increased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

Rilpl1

Rab interacting lysosomal protein-like 1

decreases expression

ferric oxide analog results in decreased expression of RILPL1 mRNA

NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938

Ripk1

receptor interacting serine/threonine kinase 1

multiple interactions

[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

Ripk3

receptor-interacting serine-threonine kinase 3

multiple interactions

[ferric oxide analog co-treated with Acrolein] results in increased expression of RIPK3 protein

NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121

RT1-A2

RT1 class Ia, locus A2

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-T23 mRNA

NCBI chr20:4,870,939...4,910,183

RT1-Db1

RT1 class II, locus Db1

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-EB1 mRNA

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

Rusc2

RUN and SH3 domain containing 2

increases expression

ferric oxide analog results in increased expression of RUSC2 mRNA

NCBI chr 5:57,628,397...57,675,524
Ensembl chr 5:57,629,904...57,675,524

Samd9l

sterile alpha motif domain containing 9 like

decreases expression

ferric oxide analog results in decreased expression of SAMD9L mRNA

NCBI chr 4:31,362,054...31,376,412
Ensembl chr 4:31,361,669...31,376,415

Scara5

scavenger receptor class A, member 5

increases expression

ferric oxide analog results in increased expression of SCARA5 mRNA

NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373

Sema3a

semaphorin 3A

increases expression

ferric oxide analog results in increased expression of SEMA3A mRNA

NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432

Sema3d

semaphorin 3D

decreases expression

ferric oxide analog results in decreased expression of SEMA3D mRNA

NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930

Serpinb1a

serpin family B member 1A

decreases expression

ferric oxide analog results in decreased expression of SERPINB1A mRNA

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

Skil

SKI-like proto-oncogene

increases expression

ferric oxide analog results in increased expression of SKIL mRNA

NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080

Slamf8

SLAM family member 8

increases expression

ferric oxide analog results in increased expression of SLAMF8 mRNA

NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211

Slc11a1

solute carrier family 11 member 1

increases expression

ferric oxide analog results in increased expression of SLC11A1 mRNA

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

Slc30a3

solute carrier family 30 member 3

increases expression

ferric oxide analog results in increased expression of SLC30A3 mRNA

NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720

Slc46a3

solute carrier family 46, member 3

decreases expression

ferric oxide analog results in decreased expression of SLC46A3 mRNA

NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092

Slc7a5

solute carrier family 7 member 5

decreases expression

ferric oxide analog results in decreased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

Slco2a1

solute carrier organic anion transporter family, member 2a1

increases expression

ferric oxide analog results in increased expression of SLCO2A1 mRNA

NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546

Slpi

secretory leukocyte peptidase inhibitor

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

Sod1

superoxide dismutase 1

increases expression

ferric oxide analog results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sod2

superoxide dismutase 2

increases expression

ferric oxide analog results in increased expression of SOD2 protein; ferric oxide results in increased expression of SOD2 protein

PMID:24068039 PMID:25086211 PMID:26991130

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Spata24

spermatogenesis associated 24

decreases expression

ferric oxide analog results in decreased expression of SPATA24 mRNA

NCBI chr18:27,249,047...27,257,129
Ensembl chr18:27,248,609...27,257,124

Spock2

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

increases expression

ferric oxide analog results in increased expression of SPOCK2 mRNA

NCBI chr20:28,037,334...28,064,272
Ensembl chr20:28,033,475...28,064,272

Spta1

spectrin, alpha, erythrocytic 1

increases expression

ferric oxide analog results in increased expression of SPTA1 mRNA

NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371

Srxn1

sulfiredoxin 1

increases expression

ferric oxide analog results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

Stmn2

stathmin 2

increases expression

ferric oxide analog results in increased expression of STMN2 mRNA

NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011

Synpo2

synaptopodin 2

increases expression

ferric oxide analog results in increased expression of SYNPO2 mRNA

NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267

Tatdn2

TatD DNase domain containing 2

decreases expression

ferric oxide analog results in decreased expression of TATDN2 mRNA

NCBI chr 4:146,845,156...146,865,708
Ensembl chr 4:146,845,156...146,860,897

Tbc1d2

TBC1 domain family, member 2

increases expression
decreases expression

ferric oxide analog results in increased expression of TBC1D2 mRNA
ferric oxide analog results in decreased expression of TBC1D2 mRNA

NCBI chr 5:60,884,114...60,931,717
Ensembl chr 5:60,884,124...60,931,352

Tbxas1

thromboxane A synthase 1

increases expression

ferric oxide analog results in increased expression of TBXAS1 mRNA

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

transferrin

increases expression

ferric oxide results in increased expression of TF mRNA

PMID:16428268

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

Tfrc

transferrin receptor

decreases expression

ferric oxide analog results in decreased expression of TFRC mRNA

PMID:25086211 PMID:38615722

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

Tgfa

transforming growth factor alpha

increases expression

ferric oxide analog results in increased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

Tgfbi

transforming growth factor, beta induced

increases expression

ferric oxide analog results in increased expression of TGFBI mRNA

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

Tgm2

transglutaminase 2

increases expression

ferric oxide analog results in increased expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

Thbs2

thrombospondin 2

decreases expression

ferric oxide analog results in decreased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

Timp1

TIMP metallopeptidase inhibitor 1

multiple interactions

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

Timp2

TIMP metallopeptidase inhibitor 2

increases expression

ferric oxide results in increased expression of TIMP2 protein

PMID:24885771

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

Tlr2

toll-like receptor 2

increases expression
multiple interactions

ferric oxide analog results in increased expression of TLR2 mRNA; ferric oxide analog results in increased expression of TLR2 protein; ferric oxide results in increased expression of TLR2 mRNA; ferric oxide results in increased expression of TLR2 protein
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TLR2 protein]

PMID:24525745 PMID:34982504 PMID:36935073

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

Tlr4

toll-like receptor 4

multiple interactions
increases expression

oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TLR4 protein]
ferric oxide analog results in increased expression of TLR4 mRNA; ferric oxide analog results in increased expression of TLR4 protein; ferric oxide results in increased expression of TLR4 mRNA; ferric oxide results in increased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

Tlr5

toll-like receptor 5

increases expression

ferric oxide analog results in increased expression of TLR5 mRNA

NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738

Tmem176a

transmembrane protein 176A

decreases expression

ferric oxide analog results in decreased expression of TMEM176A mRNA

NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620

tumor necrosis factor

multiple interactions
increases expression
increases secretion

[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of TNF protein; ferric oxide results in increased expression of and results in increased secretion of TNF protein; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [ferric oxide results in increased expression of TNF protein]; RAG1 promotes the reaction [ferric oxide analog results in increased expression of TNF protein]
ferric oxide analog results in increased expression of TNF mRNA; ferric oxide analog results in increased expression of TNF protein; ferric oxide results in increased expression of TNF mRNA
ferric oxide results in increased secretion of TNF protein
ferric oxide analog results in increased secretion of TNF protein

PMID:20540983 PMID:24068039 PMID:24525745 PMID:24885771 PMID:34982504 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnni3

troponin I3, cardiac type

increases expression

ferric oxide results in increased expression of TNNI3 protein

PMID:28993115

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

Tox3

TOX high mobility group box family member 3

decreases expression

ferric oxide analog results in decreased expression of TOX3 mRNA

NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148

Tp53

tumor protein p53

increases phosphorylation
multiple interactions

ferric oxide analog results in increased phosphorylation of TP53 protein
[ferric oxide analog co-treated with Acrolein] results in increased expression of TP53 protein

PMID:22995439 PMID:24847785

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tp53inp1

tumor protein p53 inducible nuclear protein 1

increases expression

ferric oxide analog results in increased expression of TRP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

Tpr

translocated promoter region, nuclear basket protein

decreases expression

ferric oxide analog results in decreased expression of TPR mRNA

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

Traf6

TNF receptor associated factor 6

increases expression

ferric oxide analog results in increased expression of TRAF6 mRNA; ferric oxide analog results in increased expression of TRAF6 protein; ferric oxide results in increased expression of TRAF6 mRNA; ferric oxide results in increased expression of TRAF6 protein

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

Trib3

tribbles pseudokinase 3

decreases expression

ferric oxide analog results in decreased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

Tslp

thymic stromal lymphopoietin

multiple interactions

ferric oxide results in increased expression of and results in increased secretion of TSLP protein

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

Ttpal

alpha tocopherol transfer protein like

decreases expression

ferric oxide analog results in decreased expression of TTPAL mRNA

NCBI chr 3:152,278,246...152,296,550
Ensembl chr 3:152,278,303...152,296,513

Tubb2b

tubulin, beta 2B class IIb

increases expression

ferric oxide analog results in increased expression of TUBB2B mRNA

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

Uchl1

ubiquitin C-terminal hydrolase L1

increases expression

ferric oxide analog results in increased expression of UCHL1 mRNA

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

Wdfy3

WD repeat and FYVE domain containing 3

increases expression

ferric oxide analog results in increased expression of WDFY3 mRNA

NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482

Yipf7

Yip1 domain family, member 7

increases expression

ferric oxide analog results in increased expression of YIPF7 mRNA

NCBI chr14:38,571,045...38,599,070
Ensembl chr14:38,571,066...38,599,055

Zbtb2

zinc finger and BTB domain containing 2

decreases expression

ferric oxide analog results in decreased expression of ZBTB2 mRNA

NCBI chr 1:40,827,457...40,846,733
Ensembl chr 1:40,827,457...40,846,594

Zc3h13

zinc finger CCCH type containing 13

increases expression

ferric oxide analog results in increased expression of ZC3H13 mRNA

NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802

Zfp36

zinc finger protein 36

increases expression

ferric oxide analog results in increased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

ferric pyrophosphate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

transferrin

multiple interactions

[ferric pyrophosphate co-treated with Iodine] results in increased expression of TF protein

PMID:16772442

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

Tfrc

transferrin receptor

multiple interactions

[ferric pyrophosphate co-treated with Iodine] results in increased expression of TFRC protein

PMID:16772442

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

ferrichrome

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Mmp2

matrix metallopeptidase 2

multiple interactions
decreases activity

Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]

PMID:10086886

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

ferricyanide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

heme oxygenase 1

increases expression
multiple interactions

hexacyanoferrate III results in increased expression of HMOX1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [hexacyanoferrate III results in increased expression of HMOX1 protein]

PMID:16439612

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Por

cytochrome p450 oxidoreductase

increases reduction

POR protein results in increased reduction of hexacyanoferrate III

PMID:18678259

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

ferrocene

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cat

catalase

multiple interactions

[ferrocene results in increased abundance of Iron] which results in decreased expression of CAT protein

PMID:20100038

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Gpt

glutamic--pyruvic transaminase

multiple interactions

[ferrocene results in increased abundance of Iron] which results in increased expression of GPT protein

PMID:20100038

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

ferroheme b

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abcb6

ATP binding cassette subfamily B member 6

increases expression

Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein

PMID:17006453

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

Adra1a

adrenoceptor alpha 1A

increases expression

Heme metabolite results in increased expression of ADRA1A mRNA

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

5'-aminolevulinate synthase 1

decreases expression
multiple interactions

Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]

PMID:21659532

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

Alas2

5'-aminolevulinate synthase 2

decreases expression

Heme metabolite results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

albumin

affects binding
multiple interactions

Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]

PMID:16336266

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Ambp

alpha-1-microglobulin/bikunin precursor

increases expression

Heme results in increased expression of AMBP mRNA

PMID:22096585

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

App

amyloid beta precursor protein

affects binding
multiple interactions

APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]

PMID:25211009

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

Arhgap31

Rho GTPase activating protein 31

decreases expression

Heme metabolite results in decreased expression of ARHGAP31 mRNA

NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564

Asb1

ankyrin repeat and SOCS box-containing 1

increases expression

Heme metabolite results in increased expression of ASB1 mRNA

NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376

Asxl2

ASXL transcriptional regulator 2

decreases expression

Heme metabolite results in decreased expression of ASXL2 mRNA

NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477

Atp7b

ATPase copper transporting beta

multiple interactions

ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme]

PMID:19888908

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

Bcar3

BCAR3 adaptor protein, NSP family member

increases expression

Heme metabolite results in increased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

Blvra

biliverdin reductase A

increases expression

Heme metabolite results in increased expression of BLVRA mRNA

NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033

Bok

BCL2 family apoptosis regulator BOK

decreases expression

Heme metabolite results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

Camk2b

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Heme metabolite results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

Camk2g

calcium/calmodulin-dependent protein kinase II gamma

decreases expression

Heme metabolite results in decreased expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

Car1

carbonic anhydrase 1

multiple interactions
increases expression

[Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

C-C motif chemokine ligand 2

increases expression

Heme metabolite results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl3

C-C motif chemokine ligand 3

increases secretion

Heme analog results in increased secretion of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl9

C-C motif chemokine ligand 9

increases expression

Heme metabolite results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

Ccs

copper chaperone for superoxide dismutase

multiple interactions

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]

PMID:19039664

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

Cd2

Cd2 molecule

increases expression

Heme metabolite results in increased expression of CD2 mRNA

NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026

Cel

carboxyl ester lipase

decreases expression
multiple interactions

Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

Clca1

chloride channel accessory 1

decreases expression

Heme results in decreased expression of CLCA1 mRNA

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

Cnot9

CCR4-NOT transcription complex subunit 9

increases expression

Heme metabolite results in increased expression of CNOT9 mRNA

NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100

Cops5

COP9 signalosome subunit 5

increases expression

Heme metabolite results in increased expression of COPS5 mRNA

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

Cpox

coproporphyrinogen oxidase

increases chemical synthesis

CPOX protein results in increased chemical synthesis of Heme

PMID:11248690

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

Csf2

colony stimulating factor 2

decreases expression

Heme metabolite results in decreased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

Cxcl2

C-X-C motif chemokine ligand 2

increases expression

Heme metabolite results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

Cyb5a

cytochrome b5 type A

multiple interactions

[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine]

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

Dgcr8

DGCR8 microprocessor complex subunit

affects binding

DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme

PMID:21454614

NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242

Dnajc7

DnaJ heat shock protein family (Hsp40) member C7

decreases expression

Heme results in decreased expression of DNAJC7 mRNA

NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575

Dner

delta/notch-like EGF repeat containing

decreases expression

Heme metabolite results in decreased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

Dusp14

dual specificity phosphatase 14

increases expression

Heme metabolite results in increased expression of DUSP14 mRNA

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

Dusp2

dual specificity phosphatase 2

decreases expression

Heme metabolite results in decreased expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

Eif2s3

eukaryotic translation initiation factor 2 subunit gamma

decreases expression

Heme metabolite results in decreased expression of EIF2S3X mRNA

NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686

Eno2

enolase 2

increases expression

Heme metabolite results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Ereg

epiregulin

increases expression

Heme metabolite results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

Esrra

estrogen related receptor, alpha

decreases expression

Heme metabolite results in decreased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

F10

coagulation factor X

increases expression

Heme metabolite results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

coagulation factor III, tissue factor

increases expression
multiple interactions

Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

PMID:18983524

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fabp2

fatty acid binding protein 2

multiple interactions
increases expression

[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

Fabp3

fatty acid binding protein 3

increases expression

Heme metabolite results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Heme metabolite results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fxyd4

FXYD domain-containing ion transport regulator 4

decreases expression

Heme results in decreased expression of FXYD4 mRNA

NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637

Gfod1

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

Heme metabolite results in decreased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

Gipc1

GIPC PDZ domain containing family, member 1

increases expression

Heme metabolite results in increased expression of GIPC1 mRNA

NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997

Gpr176

G protein-coupled receptor 176

increases expression

Heme metabolite results in increased expression of GPR176 mRNA

NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226

Gprc5a

G protein-coupled receptor, class C, group 5, member A

increases expression

Heme metabolite results in increased expression of GPRC5A mRNA

NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260

Gpt

glutamic--pyruvic transaminase

increases expression

Heme metabolite results in increased expression of GPT mRNA

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gucy1a1

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

PMID:19466990

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

Gucy1b1

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]

PMID:19466990 PMID:22171090

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

Hectd3

HECT domain E3 ubiquitin protein ligase 3

decreases expression

Heme metabolite results in decreased expression of HECTD3 mRNA

NCBI chr 5:130,469,840...130,479,802
Ensembl chr 5:130,469,840...130,478,561

Hk3

hexokinase 3

increases expression

Heme metabolite results in increased expression of HK3 mRNA

NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863

heme oxygenase 1

multiple interactions
increases degradation
increases metabolic processing
decreases expression
decreases abundance
increases expression

[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased metabolism of Heme
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]

PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hpx

hemopexin

multiple interactions
affects binding

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]

PMID:11213479 PMID:19039664

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

Ifng

interferon gamma

multiple interactions

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Il1a

interleukin 1 alpha

increases expression

Heme metabolite results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

multiple interactions
increases secretion

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein

PMID:11076874 PMID:23355332

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1rl1

interleukin 1 receptor-like 1

decreases expression

Heme metabolite results in decreased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

Il20

interleukin 20

increases expression

Heme metabolite results in increased expression of IL20 mRNA

NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625

interleukin 6

increases expression
multiple interactions

Heme results in increased expression of IL6 mRNA; Heme results in increased expression of IL6 protein
LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Il7r

interleukin 7 receptor

increases expression

Heme metabolite results in increased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

Irf3

interferon regulatory factor 3

decreases expression

Heme metabolite results in decreased expression of IRF3 mRNA

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

Irf4

interferon regulatory factor 4

increases expression

Heme metabolite results in increased expression of IRF4 mRNA

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

Itln1

intelectin 1

decreases expression

Heme results in decreased expression of ITLN1 mRNA

NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227

Krt20

keratin 20

increases expression

Heme results in increased expression of KRT20 mRNA

NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107

Ly96

lymphocyte antigen 96

affects binding
multiple interactions

Heme binds to LY96 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]; LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]; LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

Lyz2

lysozyme 2

multiple interactions
increases secretion

SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Heme results in increased phosphorylation of MAPK1 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Heme results in increased phosphorylation of MAPK3 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

Heme results in increased phosphorylation of MAPK8 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mpo

myeloperoxidase

multiple interactions

Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:17292349

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Mptx1

mucosal pentraxin 1

decreases expression
multiple interactions

Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]

NCBI chr13:85,727,989...85,731,523
Ensembl chr13:85,728,076...85,731,469

Mre11

MRE11 homolog, double strand break repair nuclease

decreases expression

Heme metabolite results in decreased expression of MRE11A mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

Mt1

metallothionein 1

decreases response to substance
multiple interactions

MT1A protein results in decreased susceptibility to Heme
[Heme co-treated with HPX protein] affects the activity of MT1 promoter

PMID:11213479 PMID:11878821

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

Mtf1

metal-regulatory transcription factor 1

multiple interactions

[Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]

PMID:11213479

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

Mtmr10

myotubularin related protein 10

increases expression

Heme metabolite results in increased expression of MTMR10 mRNA

NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849

Myd88

MYD88, innate immune signal transduction adaptor

multiple interactions

ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

Nfe2l2

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]

PMID:10874044

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

Nfkb1

nuclear factor kappa B subunit 1

affects localization

Heme analog affects the localization of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions
decreases localization

Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein
LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Ngb

neuroglobin

affects binding

Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein

PMID:16684569

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

Nos2

nitric oxide synthase 2

multiple interactions

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Pars2

prolyl-tRNA synthetase 2, mitochondrial

decreases expression

Heme metabolite results in decreased expression of PARS2 mRNA

NCBI chr 5:121,433,993...121,439,158
Ensembl chr 5:121,434,096...121,439,154

Pcsk2

proprotein convertase subtilisin/kexin type 2

increases expression

Heme metabolite results in increased expression of PCSK2 mRNA

NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127

Pdgfb

platelet derived growth factor subunit B

decreases expression

Heme metabolite results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

Pgap2

post-GPI attachment to proteins 2

decreases expression

Heme metabolite results in decreased expression of PGAP2 mRNA

NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114

Phlda1

pleckstrin homology-like domain, family A, member 1

decreases expression

Heme metabolite results in decreased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

Pja2

praja ring finger ubiquitin ligase 2

decreases expression

Heme metabolite results in decreased expression of PJA2 mRNA

NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783

Plekhm1

pleckstrin homology and RUN domain containing M1

increases expression

Heme metabolite results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412

Plekho1

pleckstrin homology domain containing O1

increases expression

Heme metabolite results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

Plk2

polo-like kinase 2

increases expression

Heme metabolite results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

Plxna2

plexin A2

increases expression

Heme metabolite results in increased expression of PLXNA2 mRNA

NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979

Pomt1

protein-O-mannosyltransferase 1

decreases expression

Heme metabolite results in decreased expression of POMT1 mRNA

NCBI chr 3:15,520,717...15,538,579
Ensembl chr 3:15,520,481...15,538,581

Por

cytochrome p450 oxidoreductase

multiple interactions

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

Ppie

peptidylprolyl isomerase E

increases expression

Heme metabolite results in increased expression of PPIE mRNA

NCBI chr 5:135,406,172...135,419,332
Ensembl chr 5:135,406,176...135,419,235

Pstpip2

proline-serine-threonine phosphatase-interacting protein 2

increases expression

Heme metabolite results in increased expression of PSTPIP2 mRNA

NCBI chr18:71,310,387...71,396,752
Ensembl chr18:71,311,020...71,395,709

Rab33a

RAB33A, member RAS oncogene family

increases expression

Heme metabolite results in increased expression of RAB33A mRNA

NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378

Rab3a

RAB3A, member RAS oncogene family

decreases expression

Heme metabolite results in decreased expression of RAB3A mRNA

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

Rbm39

RNA binding motif protein 39

increases expression

Heme metabolite results in increased expression of RBM39 mRNA

NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213

Rbx1

ring-box 1

increases expression

Heme metabolite results in increased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

Rela

RELA proto-oncogene, NF-kB subunit

affects localization
increases localization
multiple interactions

Heme analog affects the localization of RELA protein
Heme results in increased localization of RELA protein
LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Rhebl1

RHEB like 1

increases expression

Heme metabolite results in increased expression of RHEBL1 mRNA

NCBI chr 7:130,026,255...130,031,127
Ensembl chr 7:130,026,341...130,030,248

Rpap1

RNA polymerase II associated protein 1

decreases expression

Heme metabolite results in decreased expression of RPAP1 mRNA

NCBI chr 3:106,746,642...106,768,182
Ensembl chr 3:106,656,742...106,768,151

Rps6ka2

ribosomal protein S6 kinase A2

increases expression

Heme metabolite results in increased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

RT1-A2

RT1 class Ia, locus A2

increases expression

Heme metabolite results in increased expression of H2-T23 mRNA

NCBI chr20:4,870,939...4,910,183

RT1-Bb

RT1 class II, locus Bb

decreases expression

Heme metabolite results in decreased expression of H2-AB1 mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

RT1-CE16

RT1 class I, locus CE16

decreases expression

Heme metabolite results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

Setdb1

SET domain bifurcated histone lysine methyltransferase 1

decreases expression

Heme metabolite results in decreased expression of SETDB1 mRNA

NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506

Slamf7

SLAM family member 7

increases expression

Heme metabolite results in increased expression of SLAMF7 mRNA

NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105

Slc46a1

solute carrier family 46 member 1

multiple interactions
increases uptake

SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme

PMID:17156779

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

Smarcb1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

decreases expression

Heme metabolite results in decreased expression of SMARCB1 mRNA

NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620

Smc4

structural maintenance of chromosomes 4

decreases expression

Heme metabolite results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

Srp9

signal recognition particle 9

increases expression

Heme metabolite results in increased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

Stard4

StAR-related lipid transfer domain containing 4

increases expression

Heme metabolite results in increased expression of STARD4 mRNA

NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024

Taf7

TATA-box binding protein associated factor 7

increases expression

Heme metabolite results in increased expression of TAF7 mRNA

NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134

Tdo2

tryptophan 2,3-dioxygenase

multiple interactions

Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]

PMID:10413312

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

Tlr4

toll-like receptor 4

multiple interactions
affects binding

ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]
Heme binds to TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

tumor necrosis factor

multiple interactions
increases expression
increases secretion

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]
Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein
Heme analog results in increased secretion of TNF protein

PMID:11076874 PMID:23355332 PMID:36115635

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf13b

TNF superfamily member 13b

decreases expression

Heme metabolite results in decreased expression of TNFSF13B mRNA

NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693

Tollip

toll interacting protein

increases expression

Heme metabolite results in increased expression of TOLLIP mRNA

NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625

Tuba4a

tubulin, alpha 4A

increases expression

Heme metabolite results in increased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

Ube2l3

ubiquitin-conjugating enzyme E2L 3

increases expression

Heme metabolite results in increased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

Ube2r2

ubiquitin-conjugating enzyme E2R 2

decreases expression

Heme metabolite results in decreased expression of UBE2R2 mRNA

NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513

Wfikkn2

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

decreases expression

Heme metabolite results in decreased expression of WFIKKN2 mRNA

NCBI chr10:79,185,563...79,191,657
Ensembl chr10:79,186,647...79,191,657

Yeats2

YEATS domain containing 2

decreases expression

Heme metabolite results in decreased expression of YEATS2 mRNA

NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208

ferrosoferric oxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BCL2 associated X, apoptosis regulator

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

caspase 3

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP3 protein; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 mRNA; [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased expression of CASP3 protein modified form

PMID:24935781 PMID:30098274

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp9

caspase 9

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Fadd

Fas associated via death domain

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of FADD protein

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

Fas

Fas cell surface death receptor

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

heme oxygenase 1

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

interleukin 1 beta

increases secretion

Ferrosoferric Oxide analog results in increased secretion of IL1B protein
Ferrosoferric Oxide results in increased secretion of IL1B protein

PMID:22939914 PMID:24885771

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

interleukin 6

increases secretion

Ferrosoferric Oxide analog results in increased secretion of IL6 protein
Ferrosoferric Oxide results in increased secretion of IL6 protein

PMID:22939914 PMID:24885771

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

mitogen activated protein kinase 1

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mapk9

mitogen-activated protein kinase 9

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

Nqo1

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Parp1

poly (ADP-ribose) polymerase 1

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in decreased expression of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

Rras

RAS related

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of RRAS protein

NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357

tumor necrosis factor

increases secretion

Ferrosoferric Oxide analog results in increased secretion of TNF protein

PMID:22939914

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tp53

tumor protein p53

multiple interactions

[Ferrosoferric Oxide binds to titanium dioxide] which results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

ferrous oxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BCL2 associated X, apoptosis regulator

multiple interactions

bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of BAX protein]

PMID:19421372

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

caspase 3

multiple interactions

bromotetrandrine promotes the reaction [[ferric oxide co-treated with ferrous oxide co-treated with Daunorubicin] results in increased expression of CASP3 protein]

PMID:19421372

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Icam1

intercellular adhesion molecule 1

increases expression

ferrous oxide results in increased expression of ICAM1 protein

PMID:21439359

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

heme b

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abcb6

ATP binding cassette subfamily B member 6

increases expression

Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein

PMID:17006453

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

Adra1a

adrenoceptor alpha 1A

increases expression

Heme metabolite results in increased expression of ADRA1A mRNA

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

5'-aminolevulinate synthase 1

multiple interactions
decreases expression

MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]

PMID:21659532

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

Alas2

5'-aminolevulinate synthase 2

decreases expression

Heme metabolite results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

albumin

multiple interactions
affects binding

abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]

PMID:16336266

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Ambp

alpha-1-microglobulin/bikunin precursor

increases expression

Heme results in increased expression of AMBP mRNA

PMID:22096585

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

App

amyloid beta precursor protein

affects binding
multiple interactions

PMID:25211009

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

Arhgap31

Rho GTPase activating protein 31

decreases expression

Heme metabolite results in decreased expression of ARHGAP31 mRNA

NCBI chr11:62,038,635...62,151,564
Ensembl chr11:62,038,635...62,151,564

Asb1

ankyrin repeat and SOCS box-containing 1

increases expression

Heme metabolite results in increased expression of ASB1 mRNA

NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376

Asxl2

ASXL transcriptional regulator 2

decreases expression

Heme metabolite results in decreased expression of ASXL2 mRNA

NCBI chr 6:26,425,017...26,514,899
Ensembl chr 6:26,425,954...26,507,477

Atp7b

ATPase copper transporting beta

multiple interactions

ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme]

PMID:19888908

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

Bcar3

BCAR3 adaptor protein, NSP family member

increases expression

Heme metabolite results in increased expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

Blvra

biliverdin reductase A

increases expression

Heme metabolite results in increased expression of BLVRA mRNA

NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033

Bok

BCL2 family apoptosis regulator BOK

decreases expression

Heme metabolite results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

Camk2b

calcium/calmodulin-dependent protein kinase II beta

decreases expression

Heme metabolite results in decreased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

Camk2g

calcium/calmodulin-dependent protein kinase II gamma

decreases expression

Heme metabolite results in decreased expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

Car1

carbonic anhydrase 1

multiple interactions
increases expression

[Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

C-C motif chemokine ligand 2

increases expression

Heme metabolite results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl3

C-C motif chemokine ligand 3

increases secretion

Heme analog results in increased secretion of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl9

C-C motif chemokine ligand 9

increases expression

Heme metabolite results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

Ccs

copper chaperone for superoxide dismutase

multiple interactions

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]

PMID:19039664

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

Cd2

Cd2 molecule

increases expression

Heme metabolite results in increased expression of CD2 mRNA

NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026

Cel

carboxyl ester lipase

decreases expression
multiple interactions

Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

Clca1

chloride channel accessory 1

decreases expression

Heme results in decreased expression of CLCA1 mRNA

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

Cnot9

CCR4-NOT transcription complex subunit 9

increases expression

Heme metabolite results in increased expression of CNOT9 mRNA

NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100

Cops5

COP9 signalosome subunit 5

increases expression

Heme metabolite results in increased expression of COPS5 mRNA

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

Cpox

coproporphyrinogen oxidase

increases chemical synthesis

CPOX protein results in increased chemical synthesis of Heme

PMID:11248690

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

Csf2

colony stimulating factor 2

decreases expression

Heme metabolite results in decreased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

Cxcl2

C-X-C motif chemokine ligand 2

increases expression

Heme metabolite results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

Cyb5a

cytochrome b5 type A

multiple interactions

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

Dgcr8

DGCR8 microprocessor complex subunit

affects binding

DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme

PMID:21454614

NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242

Dnajc7

DnaJ heat shock protein family (Hsp40) member C7

decreases expression

Heme results in decreased expression of DNAJC7 mRNA

NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575

Dner

delta/notch-like EGF repeat containing

decreases expression

Heme metabolite results in decreased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

Dusp14

dual specificity phosphatase 14

increases expression

Heme metabolite results in increased expression of DUSP14 mRNA

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

Dusp2

dual specificity phosphatase 2

decreases expression

Heme metabolite results in decreased expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

Eif2s3

eukaryotic translation initiation factor 2 subunit gamma

decreases expression

Heme metabolite results in decreased expression of EIF2S3X mRNA

NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686

Eno2

enolase 2

increases expression

Heme metabolite results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Ereg

epiregulin

increases expression

Heme metabolite results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

Esrra

estrogen related receptor, alpha

decreases expression

Heme metabolite results in decreased expression of ESRRA mRNA

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

F10

coagulation factor X

increases expression

Heme metabolite results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

coagulation factor III, tissue factor

multiple interactions
increases expression

Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

PMID:18983524

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fabp2

fatty acid binding protein 2

increases expression
multiple interactions

Heme results in increased expression of FABP2 mRNA
[Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

Fabp3

fatty acid binding protein 3

increases expression

Heme metabolite results in increased expression of FABP3 mRNA

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

Heme metabolite results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fxyd4

FXYD domain-containing ion transport regulator 4

decreases expression

Heme results in decreased expression of FXYD4 mRNA

NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637

Gfod1

Gfo/Idh/MocA-like oxidoreductase domain containing 1

decreases expression

Heme metabolite results in decreased expression of GFOD1 mRNA

NCBI chr17:21,400,142...21,504,972
Ensembl chr17:21,399,479...21,499,938

Gipc1

GIPC PDZ domain containing family, member 1

increases expression

Heme metabolite results in increased expression of GIPC1 mRNA

NCBI chr19:24,474,291...24,487,083
Ensembl chr19:24,453,123...24,486,997

Gpr176

G protein-coupled receptor 176

increases expression

Heme metabolite results in increased expression of GPR176 mRNA

NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226

Gprc5a

G protein-coupled receptor, class C, group 5, member A

increases expression

Heme metabolite results in increased expression of GPRC5A mRNA

NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260

Gpt

glutamic--pyruvic transaminase

increases expression

Heme metabolite results in increased expression of GPT mRNA

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gucy1a1

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

PMID:19466990

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

Gucy1b1

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

PMID:19466990 PMID:22171090

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

Hectd3

HECT domain E3 ubiquitin protein ligase 3

decreases expression

Heme metabolite results in decreased expression of HECTD3 mRNA

NCBI chr 5:130,469,840...130,479,802
Ensembl chr 5:130,469,840...130,478,561

Hk3

hexokinase 3

increases expression

Heme metabolite results in increased expression of HK3 mRNA

NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863

heme oxygenase 1

decreases expression
multiple interactions
increases degradation
decreases abundance
increases metabolic processing
increases expression

Heme results in decreased expression of HMOX1 mRNA
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
HMOX1 protein results in increased degradation of Heme
HMOX1 protein results in decreased abundance of Heme
HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein

PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hpx

hemopexin

multiple interactions
affects binding

[Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]

PMID:11213479 PMID:19039664

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

Ifng

interferon gamma

multiple interactions

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Il1a

interleukin 1 alpha

increases expression

Heme metabolite results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

interleukin 1 beta

multiple interactions
increases secretion

PMID:11076874 PMID:23355332

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1rl1

interleukin 1 receptor-like 1

decreases expression

Heme metabolite results in decreased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

Il20

interleukin 20

increases expression

Heme metabolite results in increased expression of IL20 mRNA

NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625

interleukin 6

increases expression
multiple interactions

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Il7r

interleukin 7 receptor

increases expression

Heme metabolite results in increased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

Irf3

interferon regulatory factor 3

decreases expression

Heme metabolite results in decreased expression of IRF3 mRNA

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

Irf4

interferon regulatory factor 4

increases expression

Heme metabolite results in increased expression of IRF4 mRNA

NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070

Itln1

intelectin 1

decreases expression

Heme results in decreased expression of ITLN1 mRNA

NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227

Krt20

keratin 20

increases expression

Heme results in increased expression of KRT20 mRNA

NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107

Ly96

lymphocyte antigen 96

affects binding
multiple interactions

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

Lyz2

lysozyme 2

increases secretion
multiple interactions

Heme analog results in increased secretion of LYZ protein
SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein]

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Heme results in increased phosphorylation of MAPK3 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapk8

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

Mpo

myeloperoxidase

multiple interactions

Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:17292349

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Mptx1

mucosal pentraxin 1

decreases expression
multiple interactions

Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]

NCBI chr13:85,727,989...85,731,523
Ensembl chr13:85,728,076...85,731,469

Mre11

MRE11 homolog, double strand break repair nuclease

decreases expression

Heme metabolite results in decreased expression of MRE11A mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

Mt1

metallothionein 1

decreases response to substance
multiple interactions

MT1A protein results in decreased susceptibility to Heme
[Heme co-treated with HPX protein] affects the activity of MT1 promoter

PMID:11213479 PMID:11878821

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

Mtf1

metal-regulatory transcription factor 1

multiple interactions

PMID:11213479

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

Mtmr10

myotubularin related protein 10

increases expression

Heme metabolite results in increased expression of MTMR10 mRNA

NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849

Myd88

MYD88, innate immune signal transduction adaptor

multiple interactions

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

Nfe2l2

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]

PMID:10874044

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

Nfkb1

nuclear factor kappa B subunit 1

affects localization

Heme analog affects the localization of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions
decreases localization

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Ngb

neuroglobin

affects binding

Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein

PMID:16684569

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

Nos2

nitric oxide synthase 2

multiple interactions

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Pars2

prolyl-tRNA synthetase 2, mitochondrial

decreases expression

Heme metabolite results in decreased expression of PARS2 mRNA

NCBI chr 5:121,433,993...121,439,158
Ensembl chr 5:121,434,096...121,439,154

Pcsk2

proprotein convertase subtilisin/kexin type 2

increases expression

Heme metabolite results in increased expression of PCSK2 mRNA

NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127

Pdgfb

platelet derived growth factor subunit B

decreases expression

Heme metabolite results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

Pgap2

post-GPI attachment to proteins 2

decreases expression

Heme metabolite results in decreased expression of PGAP2 mRNA

NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114

Phlda1

pleckstrin homology-like domain, family A, member 1

decreases expression

Heme metabolite results in decreased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

Pja2

praja ring finger ubiquitin ligase 2

decreases expression

Heme metabolite results in decreased expression of PJA2 mRNA

NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783

Plekhm1

pleckstrin homology and RUN domain containing M1

increases expression

Heme metabolite results in increased expression of PLEKHM1 mRNA

NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412

Plekho1

pleckstrin homology domain containing O1

increases expression

Heme metabolite results in increased expression of PLEKHO1 mRNA

NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785

Plk2

polo-like kinase 2

increases expression

Heme metabolite results in increased expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

Plxna2

plexin A2

increases expression

Heme metabolite results in increased expression of PLXNA2 mRNA

NCBI chr13:106,163,103...106,358,979
Ensembl chr13:106,163,103...106,358,979

Pomt1

protein-O-mannosyltransferase 1

decreases expression

Heme metabolite results in decreased expression of POMT1 mRNA

NCBI chr 3:15,520,717...15,538,579
Ensembl chr 3:15,520,481...15,538,581

Por

cytochrome p450 oxidoreductase

multiple interactions

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

Ppie

peptidylprolyl isomerase E

increases expression

Heme metabolite results in increased expression of PPIE mRNA

NCBI chr 5:135,406,172...135,419,332
Ensembl chr 5:135,406,176...135,419,235

Pstpip2

proline-serine-threonine phosphatase-interacting protein 2

increases expression

Heme metabolite results in increased expression of PSTPIP2 mRNA

NCBI chr18:71,310,387...71,396,752
Ensembl chr18:71,311,020...71,395,709

Rab33a

RAB33A, member RAS oncogene family

increases expression

Heme metabolite results in increased expression of RAB33A mRNA

NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378

Rab3a

RAB3A, member RAS oncogene family

decreases expression

Heme metabolite results in decreased expression of RAB3A mRNA

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

Rbm39

RNA binding motif protein 39

increases expression

Heme metabolite results in increased expression of RBM39 mRNA

NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213

Rbx1

ring-box 1

increases expression

Heme metabolite results in increased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

Rela

RELA proto-oncogene, NF-kB subunit

affects localization
multiple interactions
increases localization

Heme analog affects the localization of RELA protein
LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Rhebl1

RHEB like 1

increases expression

Heme metabolite results in increased expression of RHEBL1 mRNA

NCBI chr 7:130,026,255...130,031,127
Ensembl chr 7:130,026,341...130,030,248

Rpap1

RNA polymerase II associated protein 1

decreases expression

Heme metabolite results in decreased expression of RPAP1 mRNA

NCBI chr 3:106,746,642...106,768,182
Ensembl chr 3:106,656,742...106,768,151

Rps6ka2

ribosomal protein S6 kinase A2

increases expression

Heme metabolite results in increased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

RT1-A2

RT1 class Ia, locus A2

increases expression

Heme metabolite results in increased expression of H2-T23 mRNA

NCBI chr20:4,870,939...4,910,183

RT1-Bb

RT1 class II, locus Bb

decreases expression

Heme metabolite results in decreased expression of H2-AB1 mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

RT1-CE16

RT1 class I, locus CE16

decreases expression

Heme metabolite results in decreased expression of H2-Q1 mRNA

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

Setdb1

SET domain bifurcated histone lysine methyltransferase 1

decreases expression

Heme metabolite results in decreased expression of SETDB1 mRNA

NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506

Slamf7

SLAM family member 7

increases expression

Heme metabolite results in increased expression of SLAMF7 mRNA

NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105

Slc46a1

solute carrier family 46 member 1

multiple interactions
increases uptake

SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme

PMID:17156779

NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848

Smarcb1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

decreases expression

Heme metabolite results in decreased expression of SMARCB1 mRNA

NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620

Smc4

structural maintenance of chromosomes 4

decreases expression

Heme metabolite results in decreased expression of SMC4 mRNA

NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571

Srp9

signal recognition particle 9

increases expression

Heme metabolite results in increased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

Stard4

StAR-related lipid transfer domain containing 4

increases expression

Heme metabolite results in increased expression of STARD4 mRNA

NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024

Taf7

TATA-box binding protein associated factor 7

increases expression

Heme metabolite results in increased expression of TAF7 mRNA

NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134

Tdo2

tryptophan 2,3-dioxygenase

multiple interactions

Heme promotes the reaction [pyridine results in increased activity of TDO2 protein]

PMID:10413312

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

Tlr4

toll-like receptor 4

affects binding
multiple interactions

Heme binds to TLR4 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

tumor necrosis factor

multiple interactions
increases expression
increases secretion

Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]
Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein
Heme analog results in increased secretion of TNF protein

PMID:11076874 PMID:23355332 PMID:36115635

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfsf13b

TNF superfamily member 13b

decreases expression

Heme metabolite results in decreased expression of TNFSF13B mRNA

NCBI chr16:79,462,406...79,492,888
Ensembl chr16:79,462,402...79,492,693

Tollip

toll interacting protein

increases expression

Heme metabolite results in increased expression of TOLLIP mRNA

NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625

Tuba4a

tubulin, alpha 4A

increases expression

Heme metabolite results in increased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

Ube2l3

ubiquitin-conjugating enzyme E2L 3

increases expression

Heme metabolite results in increased expression of UBE2L3 mRNA

NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862

Ube2r2

ubiquitin-conjugating enzyme E2R 2

decreases expression

Heme metabolite results in decreased expression of UBE2R2 mRNA

NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513

Wfikkn2

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

decreases expression

Heme metabolite results in decreased expression of WFIKKN2 mRNA

NCBI chr10:79,185,563...79,191,657
Ensembl chr10:79,186,647...79,191,657

Yeats2

YEATS domain containing 2

decreases expression

Heme metabolite results in decreased expression of YEATS2 mRNA

NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208

hemin

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aco1

aconitase 1

decreases activity

Hemin results in decreased activity of ACO1 protein

PMID:16568477

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Aco2

aconitase 2

increases expression

Hemin results in increased expression of ACO2 protein

PMID:16568477

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

Adipoq

adiponectin, C1Q and collagen domain containing

increases secretion

Hemin results in increased secretion of ADIPOQ protein

PMID:20016031

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

Akt1

AKT serine/threonine kinase 1

multiple interactions

Hemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]

PMID:18215737

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

5'-aminolevulinate synthase 1

increases degradation

Hemin results in increased degradation of ALAS1 protein

PMID:17761694

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

Alas2

5'-aminolevulinate synthase 2

increases expression
multiple interactions

Hemin results in increased expression of ALAS2 mRNA
[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]; catechol promotes the reaction [Hemin results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; Hemin promotes the reaction [catechol results in increased expression of ALAS2 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of ALAS2 mRNA]

PMID:23973255 PMID:24141029 PMID:28552822

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

albumin

affects binding

Hemin binds to ALB protein

PMID:10506189

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Aldh2

aldehyde dehydrogenase 2 family member

multiple interactions

Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]

PMID:17541025

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

Arl6ip5

ADP-ribosylation factor like GTPase 6 interacting protein 5

increases expression

Hemin results in increased expression of ARL6IP5 protein

PMID:16430862

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

Bach1

BTB domain and CNC homolog 1

multiple interactions
increases expression
affects localization

[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein]; Hemin results in decreased localization of and results in decreased activity of BACH1 protein
Hemin results in increased expression of BACH1 mRNA; Hemin results in increased expression of BACH1 protein
Hemin affects the localization of BACH1 protein

PMID:18550526 PMID:31518892 PMID:33434570 PMID:36096218

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

Hemin promotes the reaction [Cisplatin results in increased expression of BAX protein]
Hemin inhibits the reaction [lead acetate results in increased expression of BAX protein]
Hemin results in increased expression of BAX protein

PMID:27815112 PMID:29797346

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

decreases expression
multiple interactions

Hemin results in decreased expression of BCL2 protein
Hemin inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]

PMID:27815112 PMID:29797346

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Birc2

baculoviral IAP repeat-containing 2

increases expression

Hemin results in increased expression of BIRC2 protein

PMID:14647439

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

caspase 3

multiple interactions
increases cleavage

[[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with Hemin] results in increased cleavage of CASP3 protein; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased cleavage of CASP3 protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Hemin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[SESN2 protein affects the susceptibility to Hemin] which results in decreased expression of CASP3 protein modified form
Hemin results in increased cleavage of CASP3 protein
Hemin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]

PMID:17173083 PMID:18845130 PMID:19150641 PMID:19520142 PMID:26747958 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Cat

catalase

multiple interactions

Hemin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Hemin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

PMID:19150641 PMID:27815112 PMID:35691465

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

C-C motif chemokine ligand 2

multiple interactions

Hemin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]

PMID:35691465

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Cdh1

cadherin 1

multiple interactions

[Hemin co-treated with indole-3-carbinol co-treated with 1,2-Dimethylhydrazine] affects the expression of CDH1 mRNA

PMID:29269057

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cdkn1a

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Hemin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of CDKN1A protein]; SB 203580 inhibits the reaction [Hemin results in increased expression of CDKN1A protein]

PMID:14647439

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn1b

cyclin-dependent kinase inhibitor 1B

decreases degradation

Hemin results in decreased degradation of CDKN1B protein

PMID:17283133

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

Cebpa

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

HAMP mRNA promotes the reaction [Hemin results in increased expression of CEBPA mRNA]

PMID:29749404

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

Chd4

chromodomain helicase DNA binding protein 4

multiple interactions

[Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein

PMID:27231347

NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541

Comt

catechol-O-methyltransferase

multiple interactions

COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]; COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]

PMID:24141029

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

Crh

corticotropin releasing hormone

increases secretion
multiple interactions

Hemin results in increased secretion of CRH protein
mesoporphyrin IX analog inhibits the reaction [Hemin results in increased secretion of CRH protein]

PMID:11232018

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

Cybb

cytochrome b-245 beta chain

multiple interactions

Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]]

PMID:23272707

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Hemin inhibits the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [Mercuric Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin inhibits the reaction [sodium arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]; Hemin promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in decreased expression of CYP1A1 protein]; Hemin inhibits the reaction [arsenite inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]]

PMID:20188822 PMID:20837117 PMID:22120038 PMID:22159698 PMID:26747958

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

PMID:22159698 PMID:26747958

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

Cyp2b1

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

PMID:26747958

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]

PMID:11368792

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions