Epn2 (epsin 2) - Rat Genome Database

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Gene: Epn2 (epsin 2) Rattus norvegicus
Analyze
Symbol: Epn2
Name: epsin 2
RGD ID: 619773
Description: Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in regulation of endocytosis. Part of clathrin coat of endocytic vesicle. Is active in postsynaptic endocytic zone. Orthologous to human EPN2 (epsin 2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EH domain binding protein epsin 2; EPS-15-interacting protein 2; epsin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,697,238 - 46,759,128 (-)NCBIGRCr8
mRatBN7.21046,197,785 - 46,259,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,197,785 - 46,259,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,901,225 - 50,963,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,391,750 - 50,453,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,895,176 - 45,957,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,795,496 - 47,857,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,795,524 - 47,857,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,567,990 - 47,630,470 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,677,508 - 47,739,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,692,479 - 47,719,900 (-)NCBI
Celera1045,449,426 - 45,511,171 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Ratautistic disorder  ISOEPN2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Epn2Ratcommon variable immunodeficiency 2  ISOEPN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency more ...ClinVarPMID:28492532
Epn2RatJoubert syndrome 1  ISOEPN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial aplasia of the vermisClinVarPMID:28492532
Epn2RatMeckel Syndrome 9  ISOEPN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Meckel syndrome and type 9ClinVarPMID:21493627
Epn2RatPotocki-Lupski syndrome  ISOEPN2 (Homo sapiens)8554872ClinVar Annotator: match by term: Potocki-Lupski syndromeClinVarPMID:28837307

1 to 20 of 85 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of EPN2 mRNA]CTDPMID:31150632
Epn2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOEPN2 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EPN2 mRNACTDPMID:22079256
Epn2Rat1,2-dimethylhydrazine increases expressionISOEpn2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of EPN2 mRNACTDPMID:22206623
Epn2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of EPN2 mRNACTDPMID:30723492
Epn2Rat17beta-estradiol increases expressionISOEpn2 (Mus musculus)6480464Estradiol results in increased expression of EPN2 mRNACTDPMID:39298647
Epn2Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOEPN2 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of EPN2 mRNACTDPMID:29581250
Epn2Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Epn2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOEpn2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of EPN2 mRNACTDPMID:18691609
Epn2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOEpn2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of EPN2 mRNACTDPMID:21570461 and PMID:26377647
Epn2Rat2-ethoxyethanol increases expressionEXP 64804642-ethoxyethanol results in increased expression of EPN2 mRNACTDPMID:19643169
Epn2Rat2-hydroxypropanoic acid decreases expressionISOEPN2 (Homo sapiens)6480464Lactic Acid results in decreased expression of EPN2 mRNACTDPMID:30851411
Epn2Rat2-methoxyethanol increases expressionEXP 6480464methyl cellosolve results in increased expression of EPN2 mRNACTDPMID:19643169
Epn2Rat2-methylcholine affects expressionISOEPN2 (Homo sapiens)6480464beta-methylcholine affects the expression of EPN2 mRNACTDPMID:21179406
Epn2Rat4,4'-sulfonyldiphenol affects expressionISOEpn2 (Mus musculus)6480464bisphenol S affects the expression of EPN2 mRNACTDPMID:39298647
Epn2Rat4,4'-sulfonyldiphenol affects methylationISOEpn2 (Mus musculus)6480464bisphenol S affects the methylation of EPN2 geneCTDPMID:31683443
Epn2Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of EPN2 mRNACTDPMID:36041667
Epn2Rat4,4'-sulfonyldiphenol multiple interactionsISOEPN2 (Homo sapiens)6480464[bisphenol S co-treated with Fulvestrant] results in decreased methylation of EPN2 geneCTDPMID:31601247
Epn2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of EPN2 mRNACTDPMID:24780913
Epn2Rataflatoxin B1 increases expressionISOEpn2 (Mus musculus)6480464Aflatoxin B1 results in increased expression of EPN2 mRNACTDPMID:19770486
Epn2RatAflatoxin B2 alpha increases methylationISOEPN2 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of EPN2 intronCTDPMID:30157460

1 to 20 of 85 rows

Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Ratembryonic organ development acts_upstream_of_or_withinISOEpn2 (Mus musculus)1624291MGI:1333763 PMID:19666558RGDPMID:19666558
Epn2Ratendocytosis involved_inIEAUniProtKB-KW:KW-02541600115GO_REF:0000043UniProtGO_REF:0000043
Epn2Ratendocytosis involved_inIBACGD:CAL0000186455 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratin utero embryonic development acts_upstream_of_or_withinISOEpn2 (Mus musculus)1624291MGI:1333763 PMID:19666558RGDPMID:19666558
Epn2Ratnegative regulation of sprouting angiogenesis involved_inISOEPN2 (Homo sapiens)1624291 PMID:28717225RGDPMID:28717225
Epn2Ratnegative regulation of sprouting angiogenesis involved_inIEAUniProtKB:O95208 and ensembl:ENSP000003205431600115GO_REF:0000107EnsemblGO_REF:0000107
Epn2Ratnegative regulation of vascular endothelial growth factor receptor signaling pathway involved_inISOEPN2 (Homo sapiens)1624291 PMID:28717225RGDPMID:28717225
Epn2Ratnegative regulation of vascular endothelial growth factor receptor signaling pathway involved_inIEAUniProtKB:O95208 and ensembl:ENSP000003205431600115GO_REF:0000107EnsemblGO_REF:0000107
Epn2RatNotch signaling pathway acts_upstream_of_or_withinISOEpn2 (Mus musculus)1624291MGI:1333763 PMID:19666558RGDPMID:19666558
Epn2Ratpositive regulation of Notch signaling pathway involved_inISOEPN2 (Homo sapiens)1624291 PMID:28717225RGDPMID:28717225
Epn2Ratpositive regulation of Notch signaling pathway involved_inIEAUniProtKB:O95208 and ensembl:ENSP000003205431600115GO_REF:0000107EnsemblGO_REF:0000107
Epn2Ratregulation of endocytosis  IDA 708327 RGD 
1 to 12 of 12 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Ratclathrin coat of endocytic vesicle  IDA 708327 RGD 
Epn2Ratclathrin vesicle coat part_ofIBAPANTHER:PTN000263675 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Epn2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Epn2Ratendosome is_active_inIBAFB:FBgn0261279 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratplasma membrane is_active_inIBAFB:FBgn0028582 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratpostsynaptic endocytic zone is_active_inIDA 405650252PMID:35072626SynGO 
Epn2Ratpostsynaptic endocytic zone is_active_inIMP 405650252PMID:35072626SynGO 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Ratclathrin binding enablesIBAPANTHER:PTN000263675 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Epn2Ratphospholipid binding enablesIBAPANTHER:PTN000263675 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Epn2Ratprotein binding enablesISOEPN2 (Homo sapiens)1624291UniProtKB:Q96PV0 more ...RGDPMID:18199683 and PMID:37207277
Epn2Ratprotein binding enablesISOEPN2 (Homo sapiens) and UniProtKB:O95208-21624291UniProtKB:O15344 more ...RGDPMID:32296183

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Epn2Ratendocytosis pathway  IEA 6907045 KEGGrno:04144

#
Reference Title
Reference Citation
1. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
PMID:11919637   PMID:12477932   PMID:12750376   PMID:16903783   PMID:19666558   PMID:22942912   PMID:25468996   PMID:28717225  



Epn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81046,697,238 - 46,759,128 (-)NCBIGRCr8
mRatBN7.21046,197,785 - 46,259,673 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,197,785 - 46,259,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,901,225 - 50,963,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01050,391,750 - 50,453,612 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01045,895,176 - 45,957,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01047,795,496 - 47,857,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,795,524 - 47,857,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,567,990 - 47,630,470 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,677,508 - 47,739,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,692,479 - 47,719,900 (-)NCBI
Celera1045,449,426 - 45,511,171 (-)NCBICelera
Cytogenetic Map10q22NCBI
EPN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,237,366 - 19,336,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1719,215,615 - 19,336,715 (+)EnsemblGRCh38hg38GRCh38
GRCh371719,140,679 - 19,240,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,081,283 - 19,180,621 (+)NCBINCBI36Build 36hg18NCBI36
Build 341719,081,302 - 19,180,620NCBI
Celera1716,598,294 - 16,653,109 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1718,520,401 - 18,619,785 (+)NCBIHuRef
CHM1_11719,149,312 - 19,248,777 (+)NCBICHM1_1
T2T-CHM13v2.01719,185,353 - 19,284,762 (+)NCBIT2T-CHM13v2.0
Epn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,406,709 - 61,470,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,408,075 - 61,470,513 (-)EnsemblGRCm39 Ensembl
GRCm381161,515,883 - 61,579,717 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,517,249 - 61,579,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv371161,330,751 - 61,393,153 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,947,228 - 62,009,626 (-)NCBIMGSCv36mm8
MGSCv361161,333,444 - 61,395,846 (-)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Epn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467419,289 - 506,092 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955467419,342 - 505,909 (-)NCBIChiLan1.0ChiLan1.0
EPN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21954,247,862 - 54,344,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11759,060,262 - 59,157,329 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,777,430 - 31,874,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,942,381 - 37,038,509 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,942,381 - 37,038,509 (-)Ensemblpanpan1.1panPan2
EPN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,871,157 - 40,951,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,872,006 - 40,919,416 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,013,217 - 41,097,323 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,979,692 - 41,063,821 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,978,782 - 41,063,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,948,008 - 41,032,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,894,780 - 40,978,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,086,888 - 41,170,974 (-)NCBIUU_Cfam_GSD_1.0
Epn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,082,613 - 60,169,915 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936881419,682 - 504,650 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936881417,348 - 504,650 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,171,920 - 60,234,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,171,916 - 60,249,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EPN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,820,896 - 17,919,374 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,864,423 - 17,920,426 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660592,931,751 - 3,030,618 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248495,577,679 - 5,633,008 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248495,520,279 - 5,632,152 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Epn2
176 total Variants

Predicted Target Of
Summary Value
Count of predictions:1124
Count of miRNA genes:326
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000003493, ENSRNOT00000043052
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 66 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 66 rows
BE113852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,255,302 - 46,255,480 (+)MAPPERmRatBN7.2
Rnor_6.01047,853,011 - 47,853,188NCBIRnor6.0
Rnor_5.01047,642,561 - 47,642,738UniSTSRnor5.0
Rnor_5.01047,626,150 - 47,626,327UniSTSRnor5.0
RGSC_v3.41047,734,873 - 47,735,050UniSTSRGSC3.4
Celera1045,506,830 - 45,507,007UniSTS
RH 3.4 Map10529.57UniSTS
Cytogenetic Map10q23UniSTS
RH139797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,199,264 - 46,199,466 (+)MAPPERmRatBN7.2
Rnor_6.01047,796,976 - 47,797,177NCBIRnor6.0
Rnor_5.01047,569,470 - 47,569,671UniSTSRnor5.0
RGSC_v3.41047,678,199 - 47,678,400UniSTSRGSC3.4
Celera1045,450,906 - 45,451,107UniSTS
RH 3.4 Map10531.28UniSTS
Cytogenetic Map10q23UniSTS
RH141144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,197,894 - 46,198,112 (+)MAPPERmRatBN7.2
Rnor_6.01047,795,606 - 47,795,823NCBIRnor6.0
Rnor_5.01047,568,100 - 47,568,317UniSTSRnor5.0
RGSC_v3.41047,676,829 - 47,677,046UniSTSRGSC3.4
Celera1045,449,536 - 45,449,753UniSTS
Cytogenetic Map10q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 30 of 56 rows
RefSeq Transcripts NM_001033914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001305628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039086751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 56 rows

Ensembl Acc Id: ENSRNOT00000085703   ⟹   ENSRNOP00000074461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,197,785 - 46,259,642 (-)Ensembl
Rnor_6.0 Ensembl1047,796,285 - 47,857,326 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087102   ⟹   ENSRNOP00000070453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,197,905 - 46,259,640 (-)Ensembl
Rnor_6.0 Ensembl1047,795,524 - 47,825,252 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091963   ⟹   ENSRNOP00000073697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,199,077 - 46,259,640 (-)Ensembl
Rnor_6.0 Ensembl1047,796,285 - 47,857,326 (-)Ensembl
RefSeq Acc Id: NM_001033914   ⟹   NP_001029086
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,092 (-)NCBI
mRatBN7.21046,197,785 - 46,259,642 (-)NCBI
Rnor_6.01047,795,496 - 47,857,350 (-)NCBI
Rnor_5.01047,567,990 - 47,630,470 (-)NCBI
RGSC_v3.41047,677,508 - 47,739,193 (-)RGD
Celera1045,449,426 - 45,511,171 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001305628   ⟹   NP_001292557
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,092 (-)NCBI
mRatBN7.21046,197,785 - 46,259,642 (-)NCBI
Rnor_6.01047,795,496 - 47,857,350 (-)NCBI
Celera1045,449,426 - 45,511,171 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021852   ⟹   NP_068624
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,726,959 (-)NCBI
mRatBN7.21046,197,785 - 46,227,507 (-)NCBI
Rnor_6.01047,795,496 - 47,825,217 (-)NCBI
Rnor_5.01047,567,990 - 47,630,470 (-)NCBI
RGSC_v3.41047,677,508 - 47,739,193 (-)RGD
Celera1045,449,426 - 45,479,114 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246521   ⟹   XP_006246583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,125 (-)NCBI
mRatBN7.21046,197,785 - 46,259,673 (-)NCBI
Rnor_6.01047,795,496 - 47,857,373 (-)NCBI
Rnor_5.01047,567,990 - 47,630,470 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597506   ⟹   XP_017452995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,116 (-)NCBI
mRatBN7.21046,197,785 - 46,259,669 (-)NCBI
Rnor_6.01047,795,496 - 47,857,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597507   ⟹   XP_017452996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,116 (-)NCBI
mRatBN7.21046,197,785 - 46,259,669 (-)NCBI
Rnor_6.01047,795,496 - 47,857,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597508   ⟹   XP_017452997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,096 (-)NCBI
mRatBN7.21046,197,785 - 46,259,656 (-)NCBI
Rnor_6.01047,795,496 - 47,857,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597510   ⟹   XP_017452999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,855 (-)NCBI
mRatBN7.21046,197,785 - 46,259,424 (-)NCBI
Rnor_6.01047,795,496 - 47,857,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597511   ⟹   XP_017453000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,113 (-)NCBI
mRatBN7.21046,197,785 - 46,259,663 (-)NCBI
Rnor_6.01047,795,496 - 47,857,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086740   ⟹   XP_038942668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,075 (-)NCBI
mRatBN7.21046,197,785 - 46,258,748 (-)NCBI
RefSeq Acc Id: XM_039086741   ⟹   XP_038942669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,097 (-)NCBI
mRatBN7.21046,197,785 - 46,259,656 (-)NCBI
RefSeq Acc Id: XM_039086742   ⟹   XP_038942670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,075 (-)NCBI
mRatBN7.21046,197,785 - 46,258,748 (-)NCBI
RefSeq Acc Id: XM_039086743   ⟹   XP_038942671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,096 (-)NCBI
mRatBN7.21046,197,785 - 46,259,656 (-)NCBI
RefSeq Acc Id: XM_039086744   ⟹   XP_038942672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,855 (-)NCBI
mRatBN7.21046,197,785 - 46,259,424 (-)NCBI
RefSeq Acc Id: XM_039086745   ⟹   XP_038942673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,075 (-)NCBI
mRatBN7.21046,197,785 - 46,258,748 (-)NCBI
RefSeq Acc Id: XM_039086746   ⟹   XP_038942674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,112 (-)NCBI
mRatBN7.21046,197,785 - 46,259,663 (-)NCBI
RefSeq Acc Id: XM_039086747   ⟹   XP_038942675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,128 (-)NCBI
mRatBN7.21046,197,785 - 46,259,672 (-)NCBI
RefSeq Acc Id: XM_039086748   ⟹   XP_038942676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,125 (-)NCBI
mRatBN7.21046,197,785 - 46,259,672 (-)NCBI
RefSeq Acc Id: XM_039086749   ⟹   XP_038942677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,125 (-)NCBI
mRatBN7.21046,197,785 - 46,259,668 (-)NCBI
RefSeq Acc Id: XM_039086751   ⟹   XP_038942679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,082 (-)NCBI
mRatBN7.21046,197,785 - 46,259,652 (-)NCBI
RefSeq Acc Id: XM_063269764   ⟹   XP_063125834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,855 (-)NCBI
RefSeq Acc Id: XM_063269765   ⟹   XP_063125835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,075 (-)NCBI
RefSeq Acc Id: XM_063269766   ⟹   XP_063125836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,855 (-)NCBI
RefSeq Acc Id: XM_063269767   ⟹   XP_063125837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,115 (-)NCBI
RefSeq Acc Id: XM_063269768   ⟹   XP_063125838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,115 (-)NCBI
RefSeq Acc Id: XM_063269769   ⟹   XP_063125839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,075 (-)NCBI
RefSeq Acc Id: XM_063269770   ⟹   XP_063125840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,124 (-)NCBI
RefSeq Acc Id: XM_063269771   ⟹   XP_063125841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,749,504 (-)NCBI
RefSeq Acc Id: XM_063269772   ⟹   XP_063125842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,095 (-)NCBI
RefSeq Acc Id: XM_063269773   ⟹   XP_063125843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,849 (-)NCBI
RefSeq Acc Id: XM_063269774   ⟹   XP_063125844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,849 (-)NCBI
RefSeq Acc Id: XM_063269775   ⟹   XP_063125845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,112 (-)NCBI
RefSeq Acc Id: XM_063269776   ⟹   XP_063125846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,095 (-)NCBI
RefSeq Acc Id: XM_063269777   ⟹   XP_063125847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,849 (-)NCBI
RefSeq Acc Id: XM_063269778   ⟹   XP_063125848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,849 (-)NCBI
RefSeq Acc Id: XM_063269779   ⟹   XP_063125849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,116 (-)NCBI
RefSeq Acc Id: XM_063269780   ⟹   XP_063125850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,093 (-)NCBI
RefSeq Acc Id: XM_063269781   ⟹   XP_063125851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,111 (-)NCBI
RefSeq Acc Id: XM_063269782   ⟹   XP_063125852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,759,093 (-)NCBI
RefSeq Acc Id: XM_063269783   ⟹   XP_063125853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81046,697,238 - 46,758,844 (-)NCBI
1 to 30 of 47 rows
Protein RefSeqs NP_001029086 (Get FASTA)   NCBI Sequence Viewer  
  NP_001292557 (Get FASTA)   NCBI Sequence Viewer  
  NP_068624 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246583 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452995 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452996 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452997 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452999 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453000 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942668 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942669 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942670 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942671 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942672 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942673 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942674 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942675 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942676 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942677 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942679 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125834 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125835 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125836 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125837 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125838 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125839 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125840 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125841 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125842 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125843 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 47 rows
1 to 5 of 43 rows
1 to 5 of 43 rows
RefSeq Acc Id: NP_001029086   ⟸   NM_001033914
- Peptide Label: isoform b
- UniProtKB: Q505I9 (UniProtKB/TrEMBL),   A6HF84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_068624   ⟸   NM_021852
- Peptide Label: isoform a
- UniProtKB: A6HF84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246583   ⟸   XM_006246521
- Peptide Label: isoform X1
- UniProtKB: A6HF84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292557   ⟸   NM_001305628
- Peptide Label: isoform b
- UniProtKB: Q505I9 (UniProtKB/TrEMBL),   A6HF84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453000   ⟸   XM_017597511
- Peptide Label: isoform X1
- UniProtKB: A6HF84 (UniProtKB/TrEMBL)
- Sequence:
ENTH   UIM

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Z3-F1-model_v2 AlphaFold Q9Z1Z3 1-583 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697262
Promoter ID:EPDNEW_R7787
Type:initiation region
Name:Epn2_1
Description:epsin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01047,857,336 - 47,857,396EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BIND 144373
  144374
BioCyc Gene G2FUF-24794 BioCyc
Ensembl Genes ENSRNOG00000060550 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085703 ENTREZGENE
  ENSRNOT00000091963 ENTREZGENE
  ENSRNOT00000155858 ENTREZGENE
Gene3D-CATH 1.25.40.90 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7318094 IMAGE-MGC_LOAD
InterPro ENTH UniProtKB/Swiss-Prot
  ENTH_VHS UniProtKB/Swiss-Prot
  UIM_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:105438 IMAGE-MGC_LOAD
NCBI Gene 60443 ENTREZGENE
PANTHER EPSIN/ENT-RELATED UniProtKB/Swiss-Prot
  PTHR12276:SF50 UniProtKB/Swiss-Prot
Pfam ENTH UniProtKB/Swiss-Prot
PhenoGen Epn2 PhenoGen
PROSITE ENTH UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060550 RatGTEx
SMART ENTH UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48464 UniProtKB/Swiss-Prot
UniProt A0A0G2JXY9_RAT UniProtKB/TrEMBL
  A6HF84 ENTREZGENE, UniProtKB/TrEMBL
  EPN2_RAT UniProtKB/Swiss-Prot
  F1LQ45 ENTREZGENE, UniProtKB/TrEMBL
  Q505I9 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1Z3 ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Epn2  epsin 2    EH domain binding protein epsin 2  Name updated 1299863 APPROVED
2002-08-07 Epn2  EH domain binding protein epsin 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization localized clathrin-coated vesicle fraction, enriched in the peri-Golgi region and at the cell periphery 708327
gene_domains contains an ENTH (epsin NH(2) terminal homology ) domain, multiple DPW motifs and three NPF motifs 708327
gene_expression abundant in brain 708327
gene_physical_interaction interacts with clathrin 708327