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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloroquine
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Accession:CHEBI:3638 term browser browse the term
Definition:An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Synonyms:exact_synonym: N(4)-(7-chloroquinolin-4-yl)-N(1),N(1)-diethylpentane-1,4-diamine
 related_synonym: Aralen;   Artrichin;   Bemaphate;   Capquin;   Chlorochin;   Formula=C18H26ClN3;   InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);   InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N;   N(4)-(7-chloro-4-quinolinyl)-N(1),N(1)-diethyl-1,4-pentanediamine;   Nivaquine B;   Resoquine;   Reumachlor;   SMILES=CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12;   Sanoquin;   chloroquinum;   cloroquina
 xref: Beilstein:482809;   CAS:54-05-7;   DrugBank:DB00608;   Drug_Central:607;   Gmelin:781126;   HMDB:HMDB0014746;   KEGG:C07625;   KEGG:D02366;   LINCS:LSM-1901
 xref_mesh: MESH:D002738
 xref: PDBeChem:CLQ;   PMID:11198399;   PMID:17594118;   PMID:18052874;   PMID:19426658;   PMID:23288916;   PMID:23580861;   PMID:23635029;   PMID:23644906;   PMID:23706562;   PMID:23852712;   PMID:23891850;   PMID:25285162;   Patent:DE683692;   Patent:US2233970;   Reaxys:482809;   Wikipedia:Chloroquine
 cyclic_relationship: is_conjugate_base_of CHEBI:149484


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chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A decreases expression
multiple interactions		 ISO
EXP		 Chloroquine results in decreased expression of ABCB1 mRNA; Chloroquine results in decreased expression of ABCB1 protein
[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein; Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1A mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1A mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]
Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1 mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein		 CTD PMID:25987058 PMID:27692344 PMID:30482226 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases expression ISO Chloroquine results in decreased expression of ABCC1 mRNA; Chloroquine results in decreased expression of ABCC1 protein CTD PMID:27692344 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 decreases expression ISO Chloroquine results in decreased expression of ABCC2 mRNA; Chloroquine results in decreased expression of ABCC2 protein CTD PMID:27692344 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) decreases expression ISO Chloroquine results in decreased expression of ABCG2 mRNA; Chloroquine results in decreased expression of ABCG2 protein CTD PMID:27692344 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase multiple interactions ISO Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein] CTD PMID:33070465 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Chloroquine inhibits the reaction [Particulate Matter results in increased expression of ACSL4 protein] CTD PMID:36700298 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]] CTD PMID:35104487 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation		 ISO Chloroquine affects the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of AKT1 protein]
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]
Chloroquine results in decreased phosphorylation of AKT1 protein		 CTD PMID:24990399 PMID:27180204 PMID:32060308 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions ISO Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr 7:44,498,648...44,504,845
Ensembl chr 7:44,498,415...44,504,845 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO Chloroquine results in decreased expression of ALDH1B1 mRNA CTD PMID:19393257 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604 		JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 9:21,746,806...21,748,643
Ensembl chr 9:21,746,806...21,748,643 		JBrowse link
G Apod apolipoprotein D affects localization ISO Chloroquine affects the localization of APOD protein CTD PMID:28182653 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626 		JBrowse link
G Apoe apolipoprotein E affects localization ISO Chloroquine affects the localization of APOE protein CTD PMID:8616629 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein affects expression
increases expression
affects localization
multiple interactions		 ISO Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein
Chloroquine results in increased expression of APP protein
Chloroquine affects the localization of APP protein
Chloroquine affects the localization of and affects the cleavage of APP protein		 CTD PMID:7715800 PMID:8616629 PMID:8787835 PMID:9690670 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 multiple interactions EXP Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr14:26,640,943...26,692,567
Ensembl chr14:26,640,945...26,693,189 		JBrowse link
G Aqp2 aquaporin 2 decreases degradation
decreases expression
multiple interactions		 EXP
ISO		 Chloroquine results in decreased degradation of AQP2 protein
Chloroquine results in decreased expression of AQP2 protein
Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]		 CTD PMID:21734099 PMID:22791344 NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428 		JBrowse link
G Aqp5 aquaporin 5 multiple interactions EXP Chloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein] CTD PMID:15536076 NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710 		JBrowse link
G Ar androgen receptor multiple interactions ISO Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] CTD PMID:30280407 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arcn1 archain 1 affects localization ISO Chloroquine affects the localization of ARCN1 protein CTD PMID:29940786 NCBI chr 9:44,653,440...44,679,105
Ensembl chr 9:44,652,861...44,679,142 		JBrowse link
G Ass1 argininosuccinate synthetase 1 decreases expression ISO Chloroquine results in decreased expression of ASS1 mRNA CTD PMID:19393257 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Chloroquine promotes the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29870746 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of ATG5 protein]
Chloroquine results in increased expression of ATG5 protein
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of ATG5 protein]		 CTD PMID:28184909 PMID:29870746 PMID:30338810 NCBI chr10:44,144,325...44,240,295
Ensembl chr10:44,144,354...44,240,287 		JBrowse link
G Atm ataxia telangiectasia mutated increases phosphorylation ISO Chloroquine results in increased phosphorylation of ATM protein CTD PMID:18089834 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions
increases expression		 ISO Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]
Chloroquine results in increased expression of ATP1A1 protein		 CTD PMID:10506578 PMID:26750564 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]; Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Bax BCL2-associated X protein multiple interactions EXP
ISO		 BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]
Chloroquine affects the folding of and results in increased activity of BAX protein; Chloroquine inhibits the reaction [formosanin C results in increased expression of BAX protein]; Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]		 CTD PMID:11589424 PMID:23151917 PMID:27180204 PMID:28713934 PMID:33684387 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression EXP Chloroquine results in increased expression of BBC3 mRNA CTD PMID:31310755 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Chloroquine inhibits the reaction [formosanin C results in decreased expression of BCL2 protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]		 CTD PMID:27180204 PMID:28713934 PMID:35104487 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
increases expression		 EXP BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine results in increased expression of BCL2L1 mRNA		 CTD PMID:11589424 PMID:31310755 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
decreases expression		 ISO
EXP		 Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cannabidiol results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein]
Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 mRNA]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BECN1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]
Chloroquine results in decreased expression of BECN1 mRNA; Chloroquine results in decreased expression of BECN1 protein		 CTD PMID:25987058 PMID:27692344 PMID:28184909 PMID:29870746 PMID:31862506 More... NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions EXP
ISO		 Chloroquine promotes the reaction [sunitinib results in decreased expression of BIRC5 protein]
Chloroquine promotes the reaction [Immunologic Factors results in decreased expression of BIRC5 protein]		 CTD PMID:24751611 PMID:27823620 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression
multiple interactions		 ISO Chloroquine results in increased expression of BNIP3 protein
vistusertib inhibits the reaction [Chloroquine results in increased expression of BNIP3 protein]		 CTD PMID:26853465 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Btrc beta-transducin repeat containing protein multiple interactions ISO Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC protein] CTD PMID:35561756 NCBI chr19:45,352,119...45,521,782
Ensembl chr19:45,352,173...45,518,452 		JBrowse link
G Calr calreticulin multiple interactions
increases expression		 EXP
ISO		 [Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]
Chloroquine results in increased expression of CALR mRNA
[CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein; [Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Chloroquine results in increased expression of and affects the localization of CALR protein; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; Doxorubicin promotes the reaction [Chloroquine affects the localization of CALR protein]		 CTD PMID:30482226 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Chloroquine promotes the reaction [cadmium acetate results in increased expression of CASP12 protein] CTD PMID:29870746 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity		 EXP
ISO		 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Chloroquine results in increased expression of CASP3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with vandetanib] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cannabidiol results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]		 CTD PMID:11589424 PMID:23151917 PMID:23799852 PMID:24751611 PMID:25078063 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions		 ISO
EXP		 Chloroquine results in increased cleavage of CASP8 protein
Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein]
Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]		 CTD PMID:27692344 PMID:28906492 PMID:29111403 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO [Chloroquine co-treated with vandetanib] results in increased activity of CASP9 protein; Chloroquine inhibits the reaction [Cannabidiol results in increased cleavage of CASP9 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 PMID:23799852 PMID:28184909 PMID:28906492 PMID:32060308 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR protein] CTD PMID:32956540 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression		 ISO
EXP		 Chloroquine results in decreased activity of CAT protein
Chloroquine promotes the reaction [Sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA]
Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]
Chloroquine results in decreased expression of CAT protein		 CTD PMID:15526909 PMID:17076682 PMID:23607047 PMID:24751611 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL1 protein] CTD PMID:22341560 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases secretion
multiple interactions		 ISO
EXP		 Chloroquine results in decreased secretion of CCL11 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL11 protein]		 CTD PMID:22341560 PMID:29772762 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
decreases secretion		 ISO
EXP		 Chloroquine results in increased expression of CCL2 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein]
Chloroquine results in decreased secretion of CCL2 protein
Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of MCP1 protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]		 CTD PMID:15139008 PMID:22341560 PMID:29772762 PMID:35561756 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr 8:4,375,207...4,410,020
Ensembl chr 8:4,375,210...4,410,020 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL9 protein] CTD PMID:22341560 NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
multiple interactions		 ISO Chloroquine results in increased expression of CCN1 mRNA
Chloroquine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]		 CTD PMID:19393257 PMID:34405320 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736 		JBrowse link
G Cd274 CD274 antigen decreases expression ISO Chloroquine results in decreased expression of CD274 protein CTD PMID:27692344 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Cd34 CD34 antigen multiple interactions EXP Chloroquine promotes the reaction [sunitinib results in decreased expression of CD34 protein] CTD PMID:24751611 NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein] CTD PMID:30053495 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein] CTD PMID:30053495 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases activity
multiple interactions
increases expression		 ISO Chloroquine results in increased activity of CDKN1A
[Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]
Chloroquine results in increased expression of CDKN1A protein		 CTD PMID:12243503 PMID:18089834 PMID:22927544 PMID:30025493 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions EXP Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]] CTD PMID:36792013 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions		 EXP
ISO		 Chloroquine results in increased expression of CEBPB protein alternative form
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]		 CTD PMID:30482226 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase decreases expression ISO Chloroquine results in decreased expression of CHUK protein CTD PMID:26116531 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A multiple interactions ISO Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr16:48,814,524...48,840,079
Ensembl chr16:48,814,548...48,840,072 		JBrowse link
G Cldn1 claudin 1 increases expression ISO Chloroquine results in increased expression of CLDN1 mRNA CTD PMID:25752684 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Cldn2 claudin 2 multiple interactions ISO Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein] CTD PMID:29597147 NCBI chr  X:138,701,552...138,712,135
Ensembl chr  X:138,701,577...138,712,135 		JBrowse link
G Clu clusterin affects localization ISO Chloroquine affects the localization of CLU protein CTD PMID:8616629 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase decreases expression ISO Chloroquine results in decreased expression of COQ6 mRNA CTD PMID:19393257 NCBI chr12:84,408,530...84,420,570
Ensembl chr12:84,408,431...84,420,570 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions EXP Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cs citrate synthase multiple interactions EXP Chloroquine affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA] CTD PMID:30053495 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctrl chymotrypsin-like decreases expression ISO Chloroquine results in decreased expression of CTRB1 mRNA CTD PMID:19393257 NCBI chr 8:106,658,626...106,660,494
Ensembl chr 8:106,658,635...106,660,494 		JBrowse link
G Ctsa cathepsin A multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein CTD PMID:30821613 NCBI chr 2:164,674,792...164,682,952
Ensembl chr 2:164,674,793...164,682,952 		JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
decreases activity		 ISO
EXP		 Chloroquine results in increased expression of CTSB protein
Chloroquine promotes the reaction [Arsenic results in increased activity of CTSB protein]
Chloroquine results in decreased activity of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]		 CTD PMID:2759144 PMID:23151917 PMID:30338810 PMID:30821613 PMID:36117518 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Ctsd cathepsin D affects localization
multiple interactions
increases expression		 ISO Chloroquine affects the localization of CTSD protein
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein
Chloroquine results in increased expression of CTSD protein		 CTD PMID:2759144 PMID:7715800 PMID:30821613 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsk cathepsin K multiple interactions EXP Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK protein] CTD PMID:35843418 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673 		JBrowse link
G Ctsl cathepsin L increases expression ISO Chloroquine results in increased expression of CTSL protein CTD PMID:2759144 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Chloroquine inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases expression		 ISO
EXP		 [Chloroquine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of CXCL8]		 CTD PMID:15139008 PMID:22595112 PMID:25915936 PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL9 protein] CTD PMID:22341560 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Chloroquine results in decreased expression of CYP11A1 mRNA CTD PMID:19393257 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Chloroquine results in decreased expression of CYP17A1 mRNA CTD PMID:19393257 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine] CTD PMID:7946932 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 affects metabolic processing
multiple interactions
increases metabolic processing		 ISO CYP2C8 polymorphism affects the metabolism of Chloroquine; CYP2C8 protein affects the metabolism of Chloroquine
[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]		 CTD PMID:12756207 PMID:12920490 PMID:12967198 PMID:17286541 PMID:19560616 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing
decreases activity
multiple interactions		 ISO CYP2D6 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine		 CTD PMID:12756207 PMID:12920490 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 multiple interactions ISO Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form] CTD PMID:28275691 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO
EXP		 Chloroquine promotes the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein]
Chloroquine results in increased expression of DDIT3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; [Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]		 CTD PMID:27658547 PMID:29870746 PMID:30482226 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Ddx3x DEAD box helicase 3, X-linked multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein] CTD PMID:30821613 NCBI chr  X:13,147,261...13,160,222
Ensembl chr  X:13,147,209...13,160,291 		JBrowse link
G Eea1 early endosome antigen 1 affects localization ISO Chloroquine affects the localization of EEA1 protein CTD PMID:29940786 NCBI chr10:95,776,525...95,881,380
Ensembl chr10:95,776,512...95,881,380 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]
Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]		 CTD PMID:20332299 PMID:22689575 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]
Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
Chloroquine results in decreased expression of EGFR protein		 CTD PMID:20056314 PMID:20332299 PMID:22457794 PMID:22689575 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein] CTD PMID:30821613 NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702 		JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein] CTD PMID:30821613 NCBI chr 5:134,648,726...134,668,263
Ensembl chr 5:134,648,575...134,668,344 		JBrowse link
G Eno2 enolase 2, gamma neuronal multiple interactions ISO Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein] CTD PMID:26676567 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression
multiple interactions		 ISO Chloroquine results in decreased expression of ERBB2 protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]		 CTD PMID:20056314 PMID:20332299 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Chloroquine results in decreased expression of ERBB3 protein CTD PMID:20332299 NCBI chr10:128,403,392...128,425,504
Ensembl chr10:128,403,392...128,425,521 		JBrowse link
G Ergic3 ERGIC and golgi 3 multiple interactions ISO ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] CTD PMID:27588471 NCBI chr 2:155,849,948...155,860,199
Ensembl chr 2:155,849,965...155,860,199 		JBrowse link
G Eva1a eva-1 homolog A, regulator of programmed cell death multiple interactions ISO Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in increased degradation of EVA1A protein] CTD PMID:36078115 NCBI chr 6:82,018,058...82,070,079
Ensembl chr 6:82,018,024...82,070,080 		JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Chloroquine results in decreased expression of FADS2 mRNA CTD PMID:19393257 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Fasl Fas ligand multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FASL protein] CTD PMID:22341560 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fbxo32 F-box protein 32 affects expression ISO Chloroquine affects the expression of FBXO32 mRNA CTD PMID:19296457 NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]] CTD PMID:31332898 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fmn1 formin 1 decreases expression ISO Chloroquine results in decreased expression of FMN1 mRNA CTD PMID:19393257 NCBI chr 2:113,158,029...113,547,113
Ensembl chr 2:113,158,081...113,547,112 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 protein] CTD PMID:31900833 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression		 ISO Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]
Chloroquine results in increased expression of FTH1 mRNA		 CTD PMID:30551460 PMID:32937103 PMID:37951334 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein] CTD PMID:37951334 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions ISO Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein] CTD PMID:32001317 PMID:37156403 NCBI chr  X:17,386,206...17,438,600
Ensembl chr  X:17,422,803...17,438,564 		JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 increases expression ISO Chloroquine results in increased expression of GABARAPL2 protein CTD PMID:36482696 NCBI chr 8:112,667,335...112,679,547
Ensembl chr 8:112,667,335...112,680,244 		JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 multiple interactions ISO GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr11:3,933,636...3,949,328
Ensembl chr11:3,933,636...3,949,326 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO
EXP		 Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein]
Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]		 CTD PMID:8824497 PMID:22150760 PMID:28713934 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression ISO Chloroquine results in decreased expression of GJB2 mRNA CTD PMID:19393257 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO
EXP		 [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein
Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]]		 CTD PMID:30025493 PMID:36792013 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions ISO Chloroquine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] CTD PMID:22925809 NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765 		JBrowse link
G Glul glutamate-ammonia ligase decreases expression ISO Chloroquine results in decreased expression of GLUL protein CTD PMID:36482696 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Golga2 golgin A2 affects localization ISO Chloroquine affects the localization of GOLGA2 protein CTD PMID:29940786 NCBI chr 2:32,178,299...32,197,925
Ensembl chr 2:32,177,396...32,197,933 		JBrowse link
G Gpnmb glycoprotein (transmembrane) nmb increases expression ISO Chloroquine results in increased expression of GPNMB mRNA CTD PMID:19393257 NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863 		JBrowse link
G Gpr182 G protein-coupled receptor 182 decreases expression ISO Chloroquine results in decreased expression of GPR182 mRNA CTD PMID:19393257 NCBI chr10:127,585,471...127,587,667
Ensembl chr10:127,583,145...127,587,601 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO		 Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]; Chloroquine promotes the reaction [Acetaminophen results in increased activity of GPT protein]
[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein		 CTD PMID:26498332 PMID:33271250 PMID:36482696 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions		 EXP
ISO		 Chloroquine results in decreased expression of GPX4 mRNA
Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of GPX4 protein]
Chloroquine inhibits the reaction [Cisplatin results in decreased expression of GPX4 protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]		 CTD PMID:23607047 PMID:34302894 PMID:36700298 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions ISO Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B] CTD PMID:26327526 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein] CTD PMID:34920032 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257 		JBrowse link
G Gsr glutathione reductase decreases activity
decreases expression
multiple interactions		 EXP Chloroquine results in decreased activity of GSR protein
Chloroquine results in decreased expression of GSR mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GSR mRNA]		 CTD PMID:23607047 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hbb-bh1 hemoglobin Z, beta-like embryonic chain decreases expression ISO Chloroquine results in decreased expression of HBG1 mRNA CTD PMID:19393257 NCBI chr 7:103,490,845...103,492,369
Ensembl chr 7:103,490,844...103,492,371 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions ISO Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]] CTD PMID:35104487 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit decreases expression ISO Chloroquine results in decreased expression of HIF1A protein CTD PMID:32060308 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein] CTD PMID:30821613 NCBI chr 6:82,702,004...82,751,437
Ensembl chr 6:82,702,006...82,751,435 		JBrowse link
G Hmbs hydroxymethylbilane synthase increases response to substance ISO HMBS mutant form results in increased susceptibility to Chloroquine CTD PMID:8772850 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G Hspa1b heat shock protein 1B multiple interactions ISO Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein] CTD PMID:17046822 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions ISO Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29870746 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa8 heat shock protein 8 multiple interactions ISO
EXP		 [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form
Chloroquine inhibits the reaction [Thymol inhibits the reaction [Ethanol results in decreased expression of HSPA8 protein]]		 CTD PMID:30821613 PMID:36535314 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:24145604 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]] CTD PMID:28134560 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 [Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IFNG protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]		 CTD PMID:22341560 PMID:29594315 PMID:30482226 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 multiple interactions ISO [Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein CTD PMID:36822301 NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta decreases expression ISO Chloroquine results in decreased expression of IKBKB protein CTD PMID:26116531 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma decreases expression ISO Chloroquine results in decreased expression of IKBKG protein CTD PMID:26116531 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL10 protein] CTD PMID:22341560 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL13 protein] CTD PMID:22341560 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL17A protein] CTD PMID:22341560 PMID:36002070 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL18 protein] CTD PMID:34920032 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions		 ISO
EXP		 Chloroquine results in increased expression of IL1A
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1A protein]		 CTD PMID:15139008 PMID:22341560 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
multiple interactions		 ISO
EXP		 Chloroquine results in increased expression of IL1B
Chloroquine results in decreased expression of IL1B mRNA
Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL1B protein]		 CTD PMID:15139008 PMID:21051542 PMID:22341560 PMID:26498332 PMID:29594315 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 ISO
EXP		 Chloroquine results in decreased expression of IL2 mRNA; Chloroquine results in decreased expression of IL2 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein]
[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA		 CTD PMID:7554381 PMID:22341560 PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il3 interleukin 3 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
decreases secretion
increases expression		 ISO
EXP		 Chloroquine results in decreased expression of IL6 protein
Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]]
Chloroquine results in decreased secretion of IL6 protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]]
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]
Chloroquine results in increased expression of IL6		 CTD PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]] CTD PMID:22341560 PMID:25780039 PMID:28134560 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Itgam integrin alpha M multiple interactions ISO [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with Chloroquine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; Chloroquine inhibits the reaction [Tretinoin affects the localization of ITGAM protein] CTD PMID:29743969 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO chloroquine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium RGD PMID:30755242 RGD:149735343 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Lamb1 laminin B1 multiple interactions EXP Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr12:31,315,230...31,379,643
Ensembl chr12:31,315,233...31,379,643 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein] CTD PMID:30821613 NCBI chr  X:37,488,524...37,545,337
Ensembl chr  X:37,490,234...37,545,331 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 increases response to substance ISO LAT2 protein results in increased susceptibility to Chloroquine CTD PMID:32587277 NCBI chr 5:134,628,957...134,648,637
Ensembl chr 5:134,628,876...134,643,879 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Chloroquine results in increased expression of LCN2 mRNA CTD PMID:19393257 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]] CTD PMID:30950489 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lep leptin multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor increases expression EXP Chloroquine results in increased expression of LEPR protein CTD PMID:31199479 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Ltb lymphotoxin B increases expression ISO Chloroquine results in increased expression of LTB CTD PMID:15139008 NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296 		JBrowse link
G M6pr mannose-6-phosphate receptor, cation dependent affects expression
affects localization		 ISO Chloroquine affects the expression of M6PR mRNA
Chloroquine affects the localization of M6PR protein		 CTD PMID:15712280 PMID:29940786 NCBI chr 6:122,285,679...122,294,639
Ensembl chr 6:122,285,679...122,294,639 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression
multiple interactions		 ISO
EXP		 Chloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified form
Chloroquine inhibits the reaction [doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of MAP1LC3A protein]
Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3A protein]
Chloroquine inhibits the reaction [hydroquinone results in increased degradation of MAP1LC3A protein]		 CTD PMID:30280407 PMID:30871063 PMID:35137919 PMID:35302183 PMID:35843418 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
decreases degradation
increases lipidation
multiple interactions
affects localization
increases cleavage		 ISO
EXP		 Chloroquine results in increased expression of MAP1LC3B mRNA; Chloroquine results in increased expression of MAP1LC3B protein; Chloroquine results in increased expression of MAP1LC3B protein modified form
Chloroquine results in decreased degradation of MAP1LC3B protein modified form
Chloroquine results in increased lipidation of MAP1LC3B protein
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [trichostatin A results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]
Chloroquine affects the localization of MAP1LC3B protein
Chloroquine results in increased cleavage of MAP1LC3B protein
[Ethanol co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased lipidation of MAP1LC3B protein]; MJN110 affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
[4-nitrochalcone co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; [Chloroquine co-treated with Oxygen deficiency] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [dorsomorphin results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [cordycepin results in increased expression of MAP1LC3B mRNA]; Chloroquine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Chloroquine promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline affects the localization of MAP1LC3B protein]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [ABBV-744 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [ABBV-744 results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Ethanol results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [fosbretabulin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [palmitoyl glycerol results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sepantronium results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sodium arsenite results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein; Chloroquine results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Paraquat inhibits the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]		 CTD PMID:17643062 PMID:23880069 PMID:24095927 PMID:24145604 PMID:24161432 More... NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein] CTD PMID:26676567 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]
Chloroquine results in decreased phosphorylation of MAPK1 protein
[Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK1 protein; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK1 protein]
Chloroquine results in increased phosphorylation of MAPK1 protein		 CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 PMID:32060308 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO Chloroquine inhibits the reaction [hydroquinone results in increased phosphorylation of MAPK14 protein] CTD PMID:35302183 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO
EXP		 Chloroquine results in increased phosphorylation of MAPK3 protein
Chloroquine results in decreased phosphorylation of MAPK3 protein
[Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK3 protein; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK3 protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]		 CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 PMID:32060308 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO		 Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]		 CTD PMID:22341560 PMID:28134560 PMID:31648047 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapt microtubule-associated protein tau affects expression
multiple interactions		 ISO Chloroquine affects the expression of MAPT mRNA; Chloroquine affects the expression of MAPT protein
Chloroquine inhibits the reaction [Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein]
Chloroquine affects the localization of and affects the degradation of MAPT protein		 CTD PMID:9690670 PMID:33124469 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA CTD PMID:27692344 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir224 microRNA 224 ISO inhibits the reaction [Amiodarone decreased expression of miR224 in a human hepatoma cell line] RGD PMID:23913306 RGD:18182923 NCBI chr  X:71,304,637...71,304,718
Ensembl chr  X:71,304,637...71,304,718 		JBrowse link
G Mir669n microRNA 669n multiple interactions EXP [Lipopolysaccharides co-treated with Chloroquine] results in decreased expression of MIR669N mRNA CTD PMID:26807181 NCBI chr 3:115,773,551...115,773,604
Ensembl chr 3:115,773,551...115,773,604 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO
EXP		 [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein
[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]		 CTD PMID:30025493 PMID:30482226 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression		 EXP
ISO		 Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
Chloroquine results in increased expression of MMP13 mRNA; Chloroquine results in increased expression of MMP13 protein
Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]		 CTD PMID:23331101 PMID:24273604 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO Chloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 protein
Chloroquine inhibits the reaction [cordycepin results in decreased activity of MMP2 protein]; Chloroquine inhibits the reaction [cordycepin results in decreased expression of MMP2 mRNA]; Sirolimus inhibits the reaction [Chloroquine results in decreased expression of MMP2 protein]		 CTD PMID:24273604 PMID:34278709 PMID:36299321 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
increases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Oxygen deficiency inhibits the reaction [Chloroquine results in decreased expression of MMP9 mRNA]
Chloroquine results in decreased expression of MMP9 mRNA; Chloroquine results in decreased expression of MMP9 protein
Chloroquine results in increased expression of MMP9 mRNA		 CTD PMID:24145604 PMID:24273604 PMID:30551460 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 multiple interactions ISO Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MTERF3 protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of MTERF3 protein] CTD PMID:35904214 NCBI chr13:67,053,520...67,081,148
Ensembl chr13:67,055,032...67,081,152 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases expression
decreases phosphorylation		 ISO
EXP		 Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]
Chloroquine results in increased expression of MTOR protein
Chloroquine results in decreased phosphorylation of MTOR protein		 CTD PMID:25884947 PMID:27180204 PMID:31310755 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions
increases expression		 ISO
EXP		 [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Chloroquine] results in increased expression of MTTP protein
Chloroquine results in increased expression of MTTP protein		 CTD PMID:34516972 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Muc1 mucin 1, transmembrane multiple interactions ISO Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein] CTD PMID:22457794 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 mRNA] CTD PMID:22341560 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Myom2 myomesin 2 increases expression ISO Chloroquine results in increased expression of MYOM2 mRNA CTD PMID:19393257 NCBI chr 8:15,107,653...15,183,410
Ensembl chr 8:15,107,653...15,183,541 		JBrowse link
G Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing multiple interactions ISO Chloroquine affects the reaction [NACC1 affects the susceptibility to Cisplatin] CTD PMID:21743489 NCBI chr 8:85,397,106...85,414,528
Ensembl chr 8:85,397,108...85,414,531 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 increases expression
multiple interactions		 ISO Chloroquine results in increased expression of NCOA4 mRNA; Chloroquine results in increased expression of NCOA4 protein
Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]; Chloroquine inhibits the reaction [Particulate Matter results in increased expression of NCOA4 protein]		 CTD PMID:30551460 PMID:32937103 PMID:36482696 PMID:36700298 PMID:37951334 NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812 		JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 multiple interactions ISO Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of NDRG1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased expression of NDRG1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the susceptibility to [fosbretabulin co-treated with Chloroquine] CTD PMID:28906492 NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression
multiple interactions		 ISO
EXP		 Chloroquine results in decreased expression of NFKB1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein]		 CTD PMID:22341560 PMID:26116531 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO
EXP		 [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; Chloroquine inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]		 CTD PMID:24085292 PMID:28134560 PMID:30821613 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Chloroquine promotes the reaction [sunitinib results in increased expression of NOS2 protein] CTD PMID:24751611 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Notch1 notch 1 multiple interactions ISO [Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein CTD PMID:29917191 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Nppc natriuretic peptide type C decreases expression ISO Chloroquine results in decreased expression of NPPC mRNA CTD PMID:19393257 NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 multiple interactions ISO Chloroquine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP Chloroquine results in decreased expression of NR0B2 mRNA CTD PMID:24189133 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Chloroquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015 		JBrowse link
G Ocln occludin increases expression ISO Chloroquine results in increased expression of OCLN mRNA CTD PMID:25752684 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Optn optineurin multiple interactions EXP Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein] CTD PMID:25884947 NCBI chr 2:5,023,902...5,069,210
Ensembl chr 2:5,025,453...5,068,862 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression ISO Chloroquine results in decreased expression of OSGIN1 mRNA CTD PMID:19393257 NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO
EXP		 Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein]
Chloroquine results in increased cleavage of PARP1 protein
[Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased activity of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]		 CTD PMID:27658547 PMID:28906492 PMID:29111403 PMID:30025493 PMID:30338810 More... NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Chloroquine inhibits the reaction [Imiquimod results in increased expression of PCNA protein] CTD PMID:36002070 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PINK1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]] CTD PMID:33271250 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plin3 perilipin 3 multiple interactions EXP Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA]; Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 protein] CTD PMID:20628022 NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of PMAIP1 protein] CTD PMID:35561756 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform multiple interactions ISO Chloroquine inhibits the reaction [hydroquinone results in increased expression of PPP2CA protein] CTD PMID:35302183 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO Chloroquine analog binds to and results in decreased activity of PPT1 protein; Chloroquine binds to and results in decreased activity of PPT1 protein CTD PMID:30442709 NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968 		JBrowse link
G Prkd2 protein kinase D2 multiple interactions ISO Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein] CTD PMID:37951334 NCBI chr 7:16,576,827...16,604,386
Ensembl chr 7:16,576,827...16,604,389 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP
ISO		 Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PRKN protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]		 CTD PMID:33271250 PMID:35104487 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Prlr prolactin receptor decreases expression ISO Chloroquine results in decreased expression of PRLR mRNA CTD PMID:19393257 NCBI chr15:10,177,324...10,349,276
Ensembl chr15:10,177,324...10,349,266 		JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Chloroquine results in increased expression of PTEN mRNA CTD PMID:31310755 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Chloroquine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:24145604 PMID:36700298 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO Chloroquine results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases expression
increases activity		 ISO
EXP		 [Chloroquine co-treated with Cannabidiol] results in decreased phosphorylation of RELA protein; Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased activity of RELA protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of RELA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of RELA protein]
Chloroquine results in decreased expression of RELA protein		 CTD PMID:15139008 PMID:24990399 PMID:26116531 PMID:28134560 PMID:32060308 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rheb Ras homolog enriched in brain multiple interactions ISO Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein] CTD PMID:22689575 NCBI chr 5:25,007,821...25,047,359
Ensembl chr 5:25,007,821...25,047,622 		JBrowse link
G Rhob ras homolog family member B increases expression ISO Chloroquine results in increased expression of RHOB protein CTD PMID:36482696 NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 multiple interactions
increases expression
decreases phosphorylation		 ISO
EXP		 Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]
Chloroquine results in increased expression of RPS6KB1 protein modified form
Chloroquine results in decreased phosphorylation of RPS6KB1 protein		 CTD PMID:22689575 PMID:25884947 PMID:31310755 NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions		 ISO
EXP		 Chloroquine results in decreased expression of SCARB1 mRNA
[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]		 CTD PMID:19393257 PMID:20404351 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158 		JBrowse link
G Sccpdh saccharopine dehydrogenase (putative) decreases expression ISO Chloroquine results in decreased expression of SCCPDH mRNA CTD PMID:19393257 NCBI chr 1:179,495,796...179,514,754
Ensembl chr 1:179,495,775...179,514,754 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO Chloroquine results in decreased expression of SCD1 mRNA CTD PMID:19393257 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Senp6 SUMO/sentrin specific peptidase 6 multiple interactions EXP [Lipopolysaccharides co-treated with Chloroquine] results in increased expression of SENP6 protein CTD PMID:26807181 NCBI chr 9:79,973,862...80,052,064
Ensembl chr 9:79,974,185...80,052,235 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N affects localization ISO Chloroquine affects the localization of SERPINA3 protein CTD PMID:8616629 NCBI chr12:104,372,967...104,380,588
Ensembl chr12:104,372,988...104,380,588 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein] CTD PMID:30341573 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sirt3 sirtuin 3 increases stability
multiple interactions		 ISO Chloroquine results in increased stability of SIRT3 mRNA
Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 mRNA]; Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 protein]		 CTD PMID:35302183 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc12a1 solute carrier family 12, member 1 decreases expression ISO Chloroquine results in decreased expression of SLC12A1 protein CTD PMID:22791344 NCBI chr 2:124,994,430...125,071,922
Ensembl chr 2:124,994,425...125,071,922 		JBrowse link
G Slc14a2 solute carrier family 14 (urea transporter), member 2 multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr18:78,189,359...78,640,165
Ensembl chr18:78,189,363...78,640,157 		JBrowse link
G Slc19a3 solute carrier family 19, member 3 multiple interactions ISO Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] CTD PMID:26528626 NCBI chr 1:82,990,242...83,016,541
Ensembl chr 1:82,990,244...83,016,169 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 affects localization
multiple interactions		 ISO Chloroquine affects the localization of SLC2A4 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein; gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]		 CTD PMID:27160165 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions EXP
ISO		 Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SLC7A11 protein]
Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of SLC7A11 protein]		 CTD PMID:34302894 PMID:36700298 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1a5 multiple interactions ISO Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 6:142,179,953...142,268,707
Ensembl chr 6:142,179,953...142,268,707 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA] CTD PMID:30053495 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
decreases expression		 EXP Quercetin inhibits the reaction [Chloroquine results in decreased expression of SOD1 mRNA] CTD PMID:23607047 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sort1 sortilin 1 decreases expression
multiple interactions		 EXP Chloroquine results in decreased expression of SORT1 protein
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]		 CTD PMID:25805502 PMID:30950489 NCBI chr 3:108,191,272...108,268,835
Ensembl chr 3:108,191,398...108,268,827 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein] CTD PMID:35561756 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO
EXP		 [Chloroquine co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein; Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[venetoclax co-treated with WEHI-539] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ABBV-744 results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [decabromobiphenyl ether results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [fosbretabulin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [hydroquinone results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [SC-66 compound results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [sepantronium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [lead acetate results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]]
[bisphenol A co-treated with Chloroquine] results in increased expression of SQSTM1 protein; Chloroquine affects the reaction [SQSTM1 protein affects the susceptibility to methylmercuric chloride]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Sunitinib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]		 CTD PMID:21858812 PMID:22927544 PMID:23651616 PMID:24262987 PMID:24751611 More... NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Ssb small RNA binding exonuclease protection factor La multiple interactions ISO Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein] CTD PMID:25915936 NCBI chr 2:69,691,963...69,702,185
Ensembl chr 2:69,691,906...69,702,190 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Chloroquine results in decreased expression of STAR mRNA CTD PMID:19393257 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Stc2 stanniocalcin 2 decreases expression ISO Chloroquine results in decreased expression of STC2 mRNA CTD PMID:19393257 NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074 		JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression ISO Chloroquine results in decreased expression of STRAP mRNA CTD PMID:19393257 NCBI chr 6:137,712,080...137,728,928
Ensembl chr 6:137,712,076...137,728,930 		JBrowse link
G Syp synaptophysin multiple interactions ISO Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP] CTD PMID:26327526 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tardbp TAR DNA binding protein multiple interactions
increases expression		 ISO
EXP		 Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
Chloroquine results in increased expression of TARDBP protein		 CTD PMID:25884947 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 protein] CTD PMID:31900833 NCBI chr 3:133,169,438...133,250,882
Ensembl chr 3:133,169,440...133,250,900 		JBrowse link
G Tgoln1 trans-golgi network protein affects localization ISO Chloroquine affects the localization of TGOLN2 protein CTD PMID:29940786 NCBI chr 6:72,585,403...72,593,983
Ensembl chr 6:72,585,415...72,593,983 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:46,691,298...46,707,600
Ensembl chr18:46,690,358...46,707,600 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
decreases expression		 EXP
ISO		 Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein]
Chloroquine results in decreased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]		 CTD PMID:22341560 PMID:30551460 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP2 protein] CTD PMID:22341560 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Chloroquine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tlr7 toll-like receptor 7 decreases activity ISO Chloroquine results in decreased activity of TLR7 protein CTD PMID:27385120 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tlr8 toll-like receptor 8 decreases activity ISO Chloroquine results in decreased activity of TLR8 protein CTD PMID:27385120 NCBI chr  X:166,024,119...166,047,325
Ensembl chr  X:166,025,692...166,047,325 		JBrowse link
G Tlr9 toll-like receptor 9 decreases expression
multiple interactions
increases expression
decreases activity		 ISO
EXP		 Chloroquine results in decreased expression of TLR9 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein]
Chloroquine inhibits the reaction [CpG ODN 2006 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [CpG ODN 2395 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TLR9 mRNA]; Oxygen deficiency inhibits the reaction [Chloroquine results in increased expression of TLR9 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine results in decreased activity of TLR9 protein		 CTD PMID:21398612 PMID:22595112 PMID:24273604 PMID:24990399 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression ISO Chloroquine results in decreased expression of TM7SF2 mRNA CTD PMID:19393257 NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
increases expression		 ISO
EXP		 Chloroquine results in decreased expression of TNF protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
[Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [hydroquinone results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]
Chloroquine results in decreased secretion of TNF protein
Chloroquine results in increased expression of TNF
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]		 CTD PMID:8244452 PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b increases expression ISO Chloroquine results in increased expression of TNFRSF10A protein CTD PMID:27692344 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator multiple interactions EXP Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A protein] CTD PMID:35843418 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1B protein] CTD PMID:22341560 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions EXP Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein] CTD PMID:30209975 NCBI chr 8:127,657,414...127,672,671
Ensembl chr 8:127,657,417...127,672,594 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions		 ISO
EXP		 Chloroquine results in increased expression of TRIB3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]		 CTD PMID:30482226 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trim63 tripartite motif-containing 63 affects expression ISO Chloroquine affects the expression of TRIM63 mRNA CTD PMID:19296457 NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940 		JBrowse link
G Trp53 transformation related protein 53 increases activity
multiple interactions		 ISO
EXP		 Chloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 protein
Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]		 CTD PMID:11589424 PMID:12082016 PMID:18089834 PMID:22927544 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:32956540 NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428 		JBrowse link
G Ubc ubiquitin C increases expression ISO Chloroquine results in increased expression of UBC mRNA CTD PMID:19296457 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266 		JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of USP2 mRNA
Chloroquine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of USP2 mRNA]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Chloroquine results in increased expression of USP2 mRNA]		 CTD PMID:28134560 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924 		JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of USP25 mRNA; Chloroquine results in increased expression of USP25 protein
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Chloroquine] results in increased expression of USP25 protein; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP25 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]		 CTD PMID:28134560 NCBI chr16:76,810,573...76,913,671
Ensembl chr16:76,810,594...76,913,668 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of USP28 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP28 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP28 mRNA]		 CTD PMID:28134560 NCBI chr 9:48,896,577...48,953,817
Ensembl chr 9:48,896,675...48,953,817 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 increases expression
multiple interactions		 EXP Chloroquine results in increased expression of USP7 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP7 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP7 mRNA]		 CTD PMID:28134560 NCBI chr16:8,506,586...8,574,931
Ensembl chr16:8,507,459...8,610,172 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 multiple interactions ISO [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein] CTD PMID:35022897 NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217 		JBrowse link
G Vcp valosin containing protein multiple interactions ISO
EXP		 Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]		 CTD PMID:25884947 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507 		JBrowse link
G Vsnl1 visinin-like 1 decreases expression ISO Chloroquine results in decreased expression of VSNL1 mRNA CTD PMID:19393257 NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614 		JBrowse link
G Xcl1 chemokine (C motif) ligand 1 multiple interactions EXP Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of XCL1 protein] CTD PMID:22341560 NCBI chr 1:164,759,216...164,763,094
Ensembl chr 1:164,759,213...164,763,096 		JBrowse link
G Xpo1 exportin 1 multiple interactions ISO Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein] CTD PMID:33070465 NCBI chr11:23,205,768...23,248,250
Ensembl chr11:23,206,055...23,248,249 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta multiple interactions ISO Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein] CTD PMID:33070465 NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638 		JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO Chloroquine inhibits the reaction [hydroquinone results in decreased expression of ZFP36 protein] CTD PMID:35302183 NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678 		JBrowse link
hydroxychloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, liver/bone/kidney affects expression
multiple interactions		 ISO Hydroxychloroquine affects the expression of ALPL mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]		 CTD PMID:28975700 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Bax BCL2-associated X protein increases activity
multiple interactions		 ISO Hydroxychloroquine results in increased activity of BAX protein
bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein]		 CTD PMID:12813466 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein] CTD PMID:36843289 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Hydroxychloroquine results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein] CTD PMID:12813466 PMID:16734620 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Hydroxychloroquine results in increased expression of CCL2 mRNA CTD PMID:15139008 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cd14 CD14 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd19 CD19 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061 		JBrowse link
G Cd27 CD27 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973 		JBrowse link
G Cd38 CD38 antigen multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717 		JBrowse link
G Cd3d CD3 antigen, delta polypeptide multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637 		JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Hydroxychloroquine results in decreased expression of CD40LG protein CTD PMID:28793932 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Hydroxychloroquine results in decreased expression of CFLAR mRNA; Hydroxychloroquine results in decreased expression of CFLAR protein CTD PMID:16734620 NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043 		JBrowse link
G Cldn1 claudin 1 increases expression ISO Hydroxychloroquine results in increased expression of CLDN1 mRNA CTD PMID:25752684 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Ctsb cathepsin B multiple interactions
affects localization		 ISO
EXP		 bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein] CTD PMID:12813466 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA CTD PMID:28863153 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Hydroxychloroquine results in increased expression of CXCL10 mRNA CTD PMID:25321315 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Hydroxychloroquine results in increased expression of CXCL8 mRNA CTD PMID:15139008 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA CTD PMID:28863153 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity		 ISO Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]
Hydroxychloroquine results in decreased activity of CYP2D6 protein		 CTD PMID:10848718 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase multiple interactions
affects expression		 ISO Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]
Hydroxychloroquine affects the expression of DHCR7 mRNA		 CTD PMID:28975700 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 increases expression ISO Hydroxychloroquine results in increased expression of ERN1 protein CTD PMID:25321315 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein] CTD PMID:16734620 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase affects expression
multiple interactions		 ISO Hydroxychloroquine affects the expression of HMGCR mRNA
Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]		 CTD PMID:28975700 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression EXP
ISO		 Hydroxychloroquine results in increased expression of IFIH1 mRNA CTD PMID:25321315 NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO
EXP		 Hydroxychloroquine results in increased expression of IFIT3 mRNA CTD PMID:25321315 NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast increases expression ISO
EXP		 Hydroxychloroquine results in increased expression of IFNB1 mRNA CTD PMID:25321315 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein CTD PMID:31082466 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il10ra interleukin 10 receptor, alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447 		JBrowse link
G Il12b interleukin 12b increases expression EXP Hydroxychloroquine results in increased expression of IL12B mRNA CTD PMID:25321315 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]		 CTD PMID:16393772 PMID:32314717 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 increases expression EXP Hydroxychloroquine results in increased expression of IL23A mRNA CTD PMID:25321315 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 [Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; [Hydroxychloroquine co-treated with ODN2006] results in increased secretion of IL6 protein; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hydroxychloroquine results in increased expression of IL6 mRNA		 CTD PMID:9002011 PMID:25321315 PMID:31082466 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf3 interferon regulatory factor 3 increases expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Hydroxychloroquine results in increased expression of IRF3 mRNA
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of IRF3 protein]		 CTD PMID:25321315 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Hydroxychloroquine results in increased expression of IRF7 mRNA CTD PMID:25321315 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Itk IL2 inducible T cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr11:46,215,975...46,280,342
Ensembl chr11:46,215,977...46,280,342 		JBrowse link
G Jchain immunoglobulin joining chain multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr 5:88,667,663...88,675,667
Ensembl chr 5:88,667,668...88,675,750 		JBrowse link
G Jun jun proto-oncogene increases phosphorylation
multiple interactions		 ISO Hydroxychloroquine results in increased phosphorylation of JUN protein
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of JUN protein]		 CTD PMID:25321315 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO [Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Lck lymphocyte protein tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434 		JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression
multiple interactions		 EXP
ISO		 Hydroxychloroquine results in increased expression of MAVS mRNA
Hydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS protein
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]		 CTD PMID:25321315 NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO Sirolimus inhibits the reaction [Hydroxychloroquine results in decreased expression of MMP2 protein]
Hydroxychloroquine results in decreased expression of MMP2 mRNA; Hydroxychloroquine results in decreased expression of MMP2 protein		 CTD PMID:34278709 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr19:11,227,043...11,243,513
Ensembl chr19:11,227,039...11,243,605 		JBrowse link
G Mvp major vault protein increases expression EXP Hydroxychloroquine results in increased expression of MVP mRNA CTD PMID:25321315 NCBI chr 7:126,586,036...126,613,729
Ensembl chr 7:126,586,032...126,613,793 		JBrowse link
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 affects expression ISO Hydroxychloroquine affects the expression of NFATC1 protein CTD PMID:28793932 NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286 		JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 affects localization ISO Hydroxychloroquine affects the localization of NFATC2 protein CTD PMID:28793932 NCBI chr 2:168,318,330...168,443,900
Ensembl chr 2:168,318,330...168,443,577 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases degradation
multiple interactions		 ISO Hydroxychloroquine results in increased degradation of NFKBIA protein
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased degradation of NFKBIA protein]		 CTD PMID:25321315 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:16393772 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Ocln occludin increases expression ISO Hydroxychloroquine results in increased expression of OCLN mRNA CTD PMID:25752684 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein] CTD PMID:36843289 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO Hydroxychloroquine binds to and results in decreased activity of PPT1 protein CTD PMID:30442709 NCBI chr 4:122,729,879...122,752,968
Ensembl chr 4:122,730,035...122,752,968 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases expression ISO Hydroxychloroquine results in increased expression of RELA protein CTD PMID:25321315 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rigi RNA sensor RIG-I increases expression EXP Hydroxychloroquine results in increased expression of RIGI mRNA CTD PMID:25321315 NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO
EXP		 Hydroxychloroquine results in increased expression of RSAD2 mRNA CTD PMID:25321315 NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451 		JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions ISO Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein] CTD PMID:30341573 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr 1:171,458,506...171,480,522
Ensembl chr 1:171,459,971...171,480,603 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression		 ISO
EXP		 Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]
Hydroxychloroquine results in increased expression of SQSTM1 protein
[Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein		 CTD PMID:29426000 PMID:32773031 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tlr7 toll-like receptor 7 decreases expression ISO Hydroxychloroquine results in decreased expression of TLR7 protein CTD PMID:22513098 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tlr9 toll-like receptor 9 decreases expression
multiple interactions		 ISO
EXP		 Hydroxychloroquine results in decreased expression of TLR9 protein
Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]		 CTD PMID:22513098 PMID:32314717 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Hydroxychloroquine results in increased expression of TNF mRNA		 CTD PMID:9002011 PMID:25321315 PMID:28863153 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr16:11,131,131...11,137,938
Ensembl chr16:11,131,676...11,137,938 		JBrowse link
G Traf3 TNF receptor-associated factor 3 increases expression ISO
EXP		 Hydroxychloroquine results in increased expression of TRAF3 mRNA CTD PMID:25321315 NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587 		JBrowse link
G Traf6 TNF receptor-associated factor 6 increases expression EXP Hydroxychloroquine results in increased expression of TRAF6 mRNA CTD PMID:25321315 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trim21 tripartite motif-containing 21 increases expression EXP Hydroxychloroquine results in increased expression of TRIM21 mRNA CTD PMID:25321315 NCBI chr 7:102,207,127...102,214,689
Ensembl chr 7:102,207,128...102,214,693 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]] CTD PMID:29426000 NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199 		JBrowse link
G Uxt ubiquitously expressed prefoldin like chaperone increases expression EXP Hydroxychloroquine results in increased expression of UXT mRNA CTD PMID:25321315 NCBI chr  X:20,818,162...20,828,259
Ensembl chr  X:20,807,961...20,828,256 		JBrowse link
G Vcl vinculin multiple interactions ISO Hydroxychloroquine inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of VCL protein] CTD PMID:28975700 NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        inhibitor 20017
          autophagy inhibitor 845
            chloroquine 317
              (R)-chloroquine 0
              (S)-chloroquine 0
              chloroquine sulfate 0
              hydroxychloroquine 74
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        aromatic amine 15716
                                          aminoquinoline 1716
                                            chloroquine 317
                                              (R)-chloroquine 0
                                              (S)-chloroquine 0
                                              chloroquine sulfate 0
                                              hydroxychloroquine 74
paths to the root