Ctsl (cathepsin L) - Rat Genome Database

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Gene: Ctsl (cathepsin L) Mus musculus
Analyze
Symbol: Ctsl
Name: cathepsin L
RGD ID: 10424
MGI Page MGI
Description: Exhibits cysteine-type carboxypeptidase activity; endopeptidase activity; and histone binding activity. Involved in several processes, including collagen catabolic process; hair follicle development; and protein catabolic process. Localizes to several cellular components, including external side of plasma membrane; lysosome; and nucleolus. Predicted to colocalize with apical part of cell and secretory granule. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and hemolymphoid system. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (cathepsin V).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1190035F06Rik; Cat L; cathepsin L1; CatL; Ctsl1; fs; furless; major excreted protein; ME; MEP; nackt; nkt; p39 cysteine proteinase; procathepsin L
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm17885  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,509,704 - 64,518,586 (-)NCBIGRCm39mm39
GRCm39 Ensembl1364,507,151 - 64,518,704 (-)Ensembl
GRCm381364,361,890 - 64,370,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,464,522 - 64,471,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361364,377,945 - 64,385,037 (-)NCBImm8
Celera1366,025,830 - 66,032,878 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminobutyric acid  (ISO)
2-methoxyethanol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
asperphenamate  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beryllium sulfate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bromobenzene  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (EXP)
carbon nanotube  (EXP)
carmustine  (ISO)
CCCP  (EXP)
chloroform  (ISO)
chloroquine  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
fenamidone  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
fumonisin B1  (EXP)
genistein  (EXP)
glucose  (ISO)
glyphosate  (ISO)
imiquimod  (EXP)
indoles  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
okadaic acid  (EXP)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirimiphos-methyl  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP)
ranitidine  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP)
teicoplanin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
tioguanine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD8-positive, alpha beta T cell morphology  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal coat appearance  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair cycle catagen phase  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair growth  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heartbeat  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal lymph node cortex morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neuron apoptosis  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal R wave  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal T cell differentiation  (IEA)
abnormal T wave  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus lobule morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal thyroid hormone level  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
absent vibrissae  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
amyloidosis  (IAGP)
aortic valve regurgitation  (IAGP)
atrioventricular block  (IAGP)
cachexia  (IAGP)
cardiac interstitial fibrosis  (IAGP)
corneal opacity  (IAGP)
decreased alpha-beta T cell number  (IEA)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased testis weight  (IAGP)
decreased thyroxine level  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased vertical activity  (IAGP)
delayed hair appearance  (IAGP)
dental pulp necrosis  (IAGP)
dermatitis  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated lymph node medullary sinus  (IAGP)
dilated piliary canal  (IAGP)
enlarged heart  (IAGP)
enlarged heart left atrium  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged thymus cortex  (IAGP)
epidermal hyperplasia  (IAGP)
excessive scratching  (IAGP)
focal dorsal hair loss  (IAGP)
folliculitis  (IAGP)
gliosis  (IAGP)
granulomatous inflammation  (IAGP)
greasy coat  (IAGP)
hair follicle outer root sheath hyperplasia  (IAGP)
heart left ventricle hypertrophy  (IAGP)
hyperglycemia  (IAGP)
hypergranulosis  (IAGP)
hyperkeratosis  (IAGP)
increased alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased heart rate  (IAGP)
increased heart weight  (IAGP)
increased inflammatory response  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased regulatory T cell number  (IAGP)
insulitis  (IAGP)
liver inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
lymph node inflammation  (IAGP)
mitral valve regurgitation  (IAGP)
neuron degeneration  (IAGP)
orthokeratosis  (IAGP)
periodontal ligament necrosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
Purkinje cell degeneration  (IAGP)
rough coat  (IAGP)
salivary gland inflammation  (IAGP)
scaly skin  (IAGP)
shiny skin  (IAGP)
short hair  (IAGP)
short vibrissae  (IAGP)
skin lesions  (IAGP)
sparse hair  (IAGP)
sparse vibrissae  (IAGP)
thick dermal layer  (IAGP)
thick epidermis  (IAGP)
thick skin  (IAGP)
thymus atrophy  (IAGP)
tremors  (IAGP)
underdeveloped hair follicles  (IAGP)
References

References - curated
1. Aricha R, etal., FASEB J. 2006 Feb;20(2):374-6. Epub 2005 Dec 19.
2. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
3. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
4. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11.
5. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21.
6. Hsing LC, etal., J Autoimmun. 2009 Aug 5.
7. Huang X, etal., Diabetes. 2003 Sep;52(9):2411-8.
8. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
9. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
10. Judge AR, etal., Am J Physiol Cell Physiol. 2007 Jan;292(1):C372-82. Epub 2006 Aug 23.
11. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Lecker SH, etal., FASEB J. 2004 Jan;18(1):39-51.
13. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
14. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
15. Mareninova OA, etal., J Clin Invest. 2009 Nov;119(11):3340-55. doi: 10.1172/JCI38674. Epub 2009 Oct 1.
16. Meng W, etal., J Musculoskelet Neuronal Interact. 2001 Dec;2(2):171-6.
17. MGD and Homologene mouse data transfer
18. MGD data from the GO Consortium
19. MGD IEA
20. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
21. O'Neal P, etal., J Cell Biochem. 2009 Nov 1;108(4):963-73.
22. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Provenzano PP, etal., Matrix Biol. 2005 Jan;23(8):543-55. Epub 2004 Dec 1.
25. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
26. Reiser J, etal., J Biol Chem 2004 Aug 13;279(33):34827-32. Epub 2004 Jun 14.
27. RGD automated import pipeline
28. RGD automated import pipeline for gene-chemical interactions
29. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92.
30. Sodha NR, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H428-34. Epub 2008 Dec 12.
31. Sol-Church K, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):23-9.
32. Sol-Church K, etal., Biochim Biophys Acta 2000 Apr 25;1491(1-3):289-94.
33. Sriraman V and Richards JS, Endocrinology 2004 Feb;145(2):582-91. Epub 2003 Oct 16.
34. Stypmann J, etal., Proc Natl Acad Sci U S A 2002 Apr 30;99(9):6234-9. Epub 2002 Apr 23.
35. Sukhova GK, etal., J Clin Invest. 1998 Aug 1;102(3):576-83.
36. Tang Q, etal., J Mol Med. 2009 Mar;87(3):249-60. Epub 2008 Dec 19.
Additional References at PubMed
PMID:1482371   PMID:1751032   PMID:2034277   PMID:2275556   PMID:2826441   PMID:2835398   PMID:3533924   PMID:3689328   PMID:3755373   PMID:5563943   PMID:7774911   PMID:8043949  
PMID:8419312   PMID:8554545   PMID:9096102   PMID:9310336   PMID:9507200   PMID:9545226   PMID:10199917   PMID:10349636   PMID:10395917   PMID:10516062   PMID:10600178   PMID:10633857  
PMID:10716919   PMID:10748235   PMID:10922068   PMID:11022031   PMID:11023992   PMID:11042159   PMID:11076861   PMID:11119260   PMID:11398968   PMID:11483509   PMID:11829493   PMID:11830565  
PMID:11884425   PMID:11929604   PMID:11978977   PMID:11986312   PMID:12000732   PMID:12014504   PMID:12021314   PMID:12048238   PMID:12163394   PMID:12186844   PMID:12368909   PMID:12417635  
PMID:12466121   PMID:12477932   PMID:12533435   PMID:12676526   PMID:12775715   PMID:12782676   PMID:12815617   PMID:12867662   PMID:12869695   PMID:12904583   PMID:14681235   PMID:14681479  
PMID:15099520   PMID:15154914   PMID:15308097   PMID:15489334   PMID:15582152   PMID:15665831   PMID:15679121   PMID:15782199   PMID:15831716   PMID:15860733   PMID:15905545   PMID:15905550  
PMID:16079282   PMID:16140986   PMID:16141072   PMID:16141073   PMID:16170054   PMID:16184198   PMID:16314482   PMID:16393949   PMID:16481467   PMID:16508006   PMID:16602821   PMID:16621972  
PMID:16636100   PMID:16705169   PMID:16731916   PMID:16895486   PMID:16939398   PMID:17068745   PMID:17222401   PMID:17404153   PMID:17500053   PMID:17519890   PMID:17622569   PMID:17643114  
PMID:17671649   PMID:17697143   PMID:17765022   PMID:17942402   PMID:18292516   PMID:18362148   PMID:18410501   PMID:18450756   PMID:18469859   PMID:18591414   PMID:18776147   PMID:18829740  
PMID:18849346   PMID:18957203   PMID:19028686   PMID:19589362   PMID:19801522   PMID:19837164   PMID:19900452   PMID:20017393   PMID:20023699   PMID:20075068   PMID:20080943   PMID:20304958  
PMID:20338168   PMID:20428172   PMID:20487527   PMID:20495178   PMID:20497254   PMID:20536383   PMID:20541250   PMID:20562862   PMID:20877570   PMID:21147810   PMID:21251246   PMID:21292981  
PMID:21434350   PMID:21538579   PMID:21750527   PMID:21868704   PMID:21873635   PMID:21911934   PMID:21956111   PMID:21972973   PMID:22126332   PMID:22245096   PMID:22451661   PMID:22668694  
PMID:22916010   PMID:23233448   PMID:23236527   PMID:23315080   PMID:23468951   PMID:23516607   PMID:23585893   PMID:23600672   PMID:23608608   PMID:23811845   PMID:23912553   PMID:24145449  
PMID:24154525   PMID:24164898   PMID:24319737   PMID:24388751   PMID:24902901   PMID:25063677   PMID:25144390   PMID:25222295   PMID:25283994   PMID:25514977   PMID:25927437   PMID:25957406  
PMID:26075905   PMID:26170293   PMID:26343333   PMID:26639231   PMID:26682926   PMID:27143361   PMID:27477282   PMID:27575559   PMID:27586811   PMID:27626662   PMID:27716790   PMID:27997605  
PMID:28071719   PMID:28087651   PMID:28332696   PMID:28759565   PMID:28827407   PMID:28835281   PMID:29154036   PMID:29386126   PMID:29909986   PMID:30824970   PMID:30931961   PMID:31010818  
PMID:31096818   PMID:31771567   PMID:31932607   PMID:32325033   PMID:32707827   PMID:33758261  


Genomics

Comparative Map Data
Ctsl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,509,704 - 64,518,586 (-)NCBIGRCm39mm39
GRCm39 Ensembl1364,507,151 - 64,518,704 (-)Ensembl
GRCm381364,361,890 - 64,370,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,464,522 - 64,471,614 (-)NCBIGRCm37mm9NCBIm37
MGSCv361364,377,945 - 64,385,037 (-)NCBImm8
Celera1366,025,830 - 66,032,878 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
CTSL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl987,724,051 - 87,731,469 (+)EnsemblGRCh38hg38GRCh38
GRCh38987,726,119 - 87,731,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37990,341,034 - 90,346,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36989,530,794 - 89,536,204 (+)NCBINCBI36hg18NCBI36
Build 34987,570,533 - 87,575,862NCBI
Celera960,911,195 - 60,916,605 (+)NCBI
Cytogenetic Map9q21.33NCBI
HuRef960,165,416 - 60,170,826 (+)NCBIHuRef
CHM1_1990,488,740 - 90,494,151 (+)NCBICHM1_1
Ctsl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.217764,370 - 770,533 (+)NCBI
Rnor_6.0 Ensembl171,872,848 - 1,879,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0171,873,105 - 1,879,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0171,861,403 - 1,867,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,288,013 - 6,294,174 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,288,015 - 6,294,173 (+)NCBI
Celera171,745,833 - 1,751,993 (-)NCBICelera
RH 3.4 Map1716.0RGD
Cytogenetic Map17p14NCBI
CTSL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1986,903,001 - 86,908,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,903,006 - 86,908,303 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0958,851,899 - 58,857,170 (+)NCBIMhudiblu_PPA_v0panPan3
CTSL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,215,774 - 72,219,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,978,019 - 72,981,188 (-)NCBI
ROS_Cfam_1.0172,520,707 - 72,523,876 (-)NCBI
UMICH_Zoey_3.1172,331,483 - 72,334,652 (-)NCBI
UNSW_CanFamBas_1.0172,097,122 - 72,100,291 (-)NCBI
UU_Cfam_GSD_1.0172,802,852 - 72,806,021 (-)NCBI
Ctsl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947118,687,401 - 118,693,831 (-)NCBI
SpeTri2.0NW_0049366803,047,355 - 3,050,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,668,264 - 27,674,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,668,523 - 27,674,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,907,421 - 31,913,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11298,347,770 - 98,353,426 (+)NCBI
ChlSab1.1 Ensembl1298,347,800 - 98,353,467 (+)Ensembl
Vero_WHO_p1.0NW_02366603886,669,582 - 86,675,194 (+)NCBI

Position Markers
Ctsl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381364,364,077 - 64,365,302UniSTSGRCm38
MGSCv371364,465,385 - 64,466,610UniSTSGRCm37
Celera1366,026,692 - 66,027,919UniSTS
Cytogenetic Map13B3UniSTS
cM Map1330.0UniSTS
MGI:6430  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381364,369,188 - 64,370,170UniSTSGRCm38
MGSCv371364,470,496 - 64,471,478UniSTSGRCm37
Celera1366,031,760 - 66,032,742UniSTS
Cytogenetic Map13B3UniSTS
cM Map1330.0UniSTS
MGI:6402  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381364,363,870 - 64,363,972UniSTSGRCm38
MGSCv371364,465,178 - 64,465,280UniSTSGRCm37
Celera1366,026,485 - 66,026,587UniSTS
Cytogenetic Map13B3UniSTS
cM Map1330.0UniSTS
Ctsl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381364,366,581 - 64,366,990UniSTSGRCm38
MGSCv371364,467,889 - 64,468,298UniSTSGRCm37
Celera1366,029,178 - 66,029,587UniSTS
Cytogenetic Map13B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13390000075900000Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20293442112761890Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132043134272237070Mouse
10755517Chol15_mcholesterol 15 (mouse)133081599164815991Mouse
10755533Chol18_mcholesterol 18 (mouse)133081599164815991Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133097563464975634Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133119126065191260Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133476790768768045Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133587692596102654Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133594749469947604Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133594749469947604Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133599078469990868Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133857254572572704Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133948143673481584Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133948143673481584Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133948143673481584Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134044044074440440Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134134122875341344Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4505696683596627Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134505696683596627Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134770000073000000Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5017034784170495Mouse
1300916Mobe2_mmodifier of obesity 2 (mouse)Not determined135017034784170495Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135017034784170495Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135046870984468908Mouse
14746975Manh74_mmandible shape 74 (mouse)135232915086329150Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135367266487672778Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135523686189237021Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55572541112294569Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55572541112294569Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55572541112294569Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55572541112294569Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135632264376823195Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356322643105285678Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135648143696102654Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135898448192984619Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136410270298102826Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136410270298102826Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:196
Interacting mature miRNAs:204
Transcripts:ENSMUST00000021933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF121837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV023994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ076620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y18465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000021933   ⟹   ENSMUSP00000021933
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,363,214 - 64,370,306 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220617
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,368,872 - 64,370,306 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220737   ⟹   ENSMUSP00000152551
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,366,999 - 64,370,753 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222462   ⟹   ENSMUSP00000152497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,366,479 - 64,370,306 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222517   ⟹   ENSMUSP00000152169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,359,337 - 64,370,890 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222971   ⟹   ENSMUSP00000152819
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,365,092 - 64,367,055 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223494   ⟹   ENSMUSP00000152357
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1364,366,874 - 64,370,306 (-)Ensembl
RefSeq Acc Id: NM_009984   ⟹   NP_034114
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391364,509,704 - 64,518,334 (-)NCBI
GRCm381364,361,890 - 64,370,520 (-)NCBI
MGSCv371364,464,522 - 64,471,614 (-)RGD
Celera1366,025,830 - 66,032,878 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517080   ⟹   XP_006517143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391364,511,610 - 64,518,586 (-)NCBI
GRCm381364,363,796 - 64,370,772 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_034114 (Get FASTA)   NCBI Sequence Viewer  
  XP_006517143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37445 (Get FASTA)   NCBI Sequence Viewer  
  AAA39984 (Get FASTA)   NCBI Sequence Viewer  
  AAD32136 (Get FASTA)   NCBI Sequence Viewer  
  AAD32137 (Get FASTA)   NCBI Sequence Viewer  
  AAD32138 (Get FASTA)   NCBI Sequence Viewer  
  AAH68163 (Get FASTA)   NCBI Sequence Viewer  
  BAB21945 (Get FASTA)   NCBI Sequence Viewer  
  BAB27719 (Get FASTA)   NCBI Sequence Viewer  
  BAC33761 (Get FASTA)   NCBI Sequence Viewer  
  BAE22939 (Get FASTA)   NCBI Sequence Viewer  
  BAE26206 (Get FASTA)   NCBI Sequence Viewer  
  BAE27712 (Get FASTA)   NCBI Sequence Viewer  
  BAE29572 (Get FASTA)   NCBI Sequence Viewer  
  BAE30172 (Get FASTA)   NCBI Sequence Viewer  
  BAE31701 (Get FASTA)   NCBI Sequence Viewer  
  BAE31977 (Get FASTA)   NCBI Sequence Viewer  
  BAE35143 (Get FASTA)   NCBI Sequence Viewer  
  BAE35627 (Get FASTA)   NCBI Sequence Viewer  
  BAE36450 (Get FASTA)   NCBI Sequence Viewer  
  BAE38161 (Get FASTA)   NCBI Sequence Viewer  
  BAE41141 (Get FASTA)   NCBI Sequence Viewer  
  BAE41323 (Get FASTA)   NCBI Sequence Viewer  
  CAA27980 (Get FASTA)   NCBI Sequence Viewer  
  CAA29470 (Get FASTA)   NCBI Sequence Viewer  
  CAA77183 (Get FASTA)   NCBI Sequence Viewer  
  EDL16242 (Get FASTA)   NCBI Sequence Viewer  
  P06797 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034114   ⟸   NM_009984
- Peptide Label: preproprotein
- UniProtKB: P06797 (UniProtKB/Swiss-Prot),   Q543M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517143   ⟸   XM_006517080
- Peptide Label: isoform X1
- UniProtKB: P06797 (UniProtKB/Swiss-Prot),   Q543M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000152357   ⟸   ENSMUST00000223494
RefSeq Acc Id: ENSMUSP00000152819   ⟸   ENSMUST00000222971
RefSeq Acc Id: ENSMUSP00000152497   ⟸   ENSMUST00000222462
RefSeq Acc Id: ENSMUSP00000152169   ⟸   ENSMUST00000222517
RefSeq Acc Id: ENSMUSP00000021933   ⟸   ENSMUST00000021933
RefSeq Acc Id: ENSMUSP00000152551   ⟸   ENSMUST00000220737
Protein Domains
Inhibitor_I29   Pept_C1

Promoters
RGD ID:8680650
Promoter ID:EPDNEW_M18355
Type:initiation region
Name:Ctsl_1
Description:Mus musculus cathepsin L , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381364,370,306 - 64,370,366EPDNEW
RGD ID:6847029
Promoter ID:MM_ACW:13632
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   MEF_B6
Transcripts:CTSL.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361364,465,131 - 64,465,631 (-)MPROMDB
RGD ID:6823791
Promoter ID:MM_KWN:14476
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009984
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361364,471,466 - 64,471,966 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88564 AgrOrtholog
Ensembl Genes ENSMUSG00000021477 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021933 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000152169 UniProtKB/Swiss-Prot
  ENSMUSP00000152357 UniProtKB/TrEMBL
  ENSMUSP00000152497 UniProtKB/TrEMBL
  ENSMUSP00000152551 UniProtKB/TrEMBL
  ENSMUSP00000152819 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021933 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000220737 UniProtKB/TrEMBL
  ENSMUST00000222462 UniProtKB/TrEMBL
  ENSMUST00000222517 UniProtKB/Swiss-Prot
  ENSMUST00000222971 UniProtKB/TrEMBL
  ENSMUST00000223494 UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13039 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88564 ENTREZGENE
NCBI Gene 13039 ENTREZGENE
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTSL1 RGD
PhenoGen Ctsl PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VJC1_MOUSE UniProtKB/TrEMBL
  A0A1Y7VNM3_MOUSE UniProtKB/TrEMBL
  A0A1Y7VNQ4_MOUSE UniProtKB/TrEMBL
  A0A1Y7VP49_MOUSE UniProtKB/TrEMBL
  CATL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TNC8_MOUSE UniProtKB/TrEMBL
  Q3TT75_MOUSE UniProtKB/TrEMBL
  Q3TVJ1_MOUSE UniProtKB/TrEMBL
  Q3U5U9_MOUSE UniProtKB/TrEMBL
  Q3UHZ4_MOUSE UniProtKB/TrEMBL
  Q3UWH6_MOUSE UniProtKB/TrEMBL
  Q543M3 ENTREZGENE, UniProtKB/TrEMBL
  Q6LAF5_MOUSE UniProtKB/TrEMBL
  Q9D0C0_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q91UZ0 UniProtKB/Swiss-Prot