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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1614930
Species: Mus musculus
RGD Object: Gene
Symbol: Mavs
Name: mitochondrial antiviral signaling protein
Acc ID: CHEBI:5801
Term: hydroxychloroquine
Definition: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Chemical ID: MESH:D006886
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mavsincreases expressionEXP 6480464CTDHydroxychloroquine results in increased expression of MAVS mRNAPMID:25321315
Mavsincreases expressionISOMAVS (Homo sapiens)6480464CTDHydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS proteinPMID:25321315
Mavsmultiple interactionsISOMAVS (Homo sapiens)6480464CTDphenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]PMID:25321315
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