Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Btrc | Mouse | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BTRC mRNA | CTD | PMID:22079256 | Btrc | Mouse | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of BTRC mRNA | CTD | PMID:22206623 | Btrc | Mouse | 17beta-estradiol | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [Estradiol co-treated with ESR1 protein] promotes the reaction [ESR1 protein binds to BTRC protein] and Estradiol inhibits the reaction [ESR1 protein promotes the reaction [BTRC protein binds to CTNNB1 protein]] | CTD | PMID:26990689 | Btrc | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of BTRC mRNA | CTD | PMID:22298810 | Btrc | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BTRC mRNA | CTD | PMID:33387578 | Btrc | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of BTRC mRNA | CTD | PMID:25975270 | Btrc | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of BTRC mRNA | CTD | PMID:21570461 | Btrc | Mouse | 2-hydroxypropanoic acid | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of BTRC mRNA | CTD | PMID:30851411 | Btrc | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BTRC mRNA | CTD | PMID:28628672 | Btrc | Mouse | 4,4'-sulfonyldiphenol | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BTRC mRNA | CTD | PMID:28628672 | Btrc | Mouse | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of BTRC gene | CTD | PMID:31683443 | Btrc | Mouse | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of BTRC exon | CTD | PMID:33297965 | Btrc | Mouse | 5-aza-2'-deoxycytidine | decreases expression | EXP | | 6480464 | Decitabine results in decreased expression of BTRC mRNA | CTD | PMID:27915011 | Btrc | Mouse | acrolein | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BTRC mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BTRC mRNA | CTD | PMID:32699268 | Btrc | Mouse | actinomycin D | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA] and Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA] | CTD | PMID:35561756 | Btrc | Mouse | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of BTRC mRNA | CTD | PMID:19770486 | Btrc | Mouse | aflatoxin B1 | increases methylation | ISO | BTRC (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of BTRC intron | CTD | PMID:30157460 | Btrc | Mouse | alpha-pinene | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BTRC mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of BTRC mRNA | CTD | PMID:32699268 | Btrc | Mouse | benzo[a]pyrene | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of BTRC mRNA | CTD | PMID:26238291 | Btrc | Mouse | benzo[a]pyrene | affects methylation | ISO | BTRC (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of BTRC promoter | CTD | PMID:27901495 | Btrc | Mouse | bisphenol A | affects expression | ISO | Btrc (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of BTRC mRNA | CTD | PMID:25181051 | Btrc | Mouse | bisphenol A | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of BTRC gene | CTD | PMID:31601247 | Btrc | Mouse | bisphenol A | increases methylation | ISO | BTRC (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of BTRC gene | CTD | PMID:31601247 | Btrc | Mouse | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of BTRC mRNA | CTD | PMID:20061341 | Btrc | Mouse | cadmium dichloride | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of BTRC mRNA | CTD | PMID:38568856 | Btrc | Mouse | carbamazepine | affects expression | ISO | BTRC (Homo sapiens) | 6480464 | Carbamazepine affects the expression of BTRC mRNA | CTD | PMID:25979313 | Btrc | Mouse | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Btrc | Mouse | chloroquine | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA] more ... | CTD | PMID:35561756 | Btrc | Mouse | daunorubicin | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | BTRC protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] more ... | CTD | PMID:34963561 | Btrc | Mouse | daunorubicin | increases expression | ISO | BTRC (Homo sapiens) | 6480464 | Daunorubicin results in increased expression of BTRC mRNA and Daunorubicin results in increased expression of BTRC protein | CTD | PMID:34963561 | Btrc | Mouse | dexamethasone | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BTRC mRNA | CTD | PMID:28628672 | Btrc | Mouse | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of BTRC mRNA | CTD | PMID:17361019 | Btrc | Mouse | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of BTRC mRNA | CTD | PMID:30319688 | Btrc | Mouse | fulvestrant | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of BTRC gene | CTD | PMID:31601247 | Btrc | Mouse | gentamycin | increases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of BTRC mRNA | CTD | PMID:33387578 | Btrc | Mouse | hydroquinone | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC protein] more ... | CTD | PMID:35561756 | Btrc | Mouse | indometacin | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of BTRC mRNA | CTD | PMID:28628672 | Btrc | Mouse | lead(0) | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Lead results in decreased expression of BTRC mRNA | CTD | PMID:19921347 | Btrc | Mouse | methotrexate | increases expression | ISO | BTRC (Homo sapiens) | 6480464 | Methotrexate results in increased expression of BTRC mRNA | CTD | PMID:24449571 | Btrc | Mouse | methoxychlor | affects methylation | ISO | Btrc (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of BTRC gene | CTD | PMID:35440735 | Btrc | Mouse | methylmercury chloride | decreases expression | EXP | | 6480464 | methylmercuric chloride results in decreased expression of BTRC mRNA | CTD | PMID:20061341 | Btrc | Mouse | methylmercury chloride | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of BTRC mRNA | CTD | PMID:28001369 | Btrc | Mouse | o-anisidine | increases expression | ISO | BTRC (Homo sapiens) | 6480464 | 2-anisidine results in increased expression of BTRC mRNA | CTD | PMID:28089782 | Btrc | Mouse | oxaliplatin | multiple interactions | ISO | Btrc (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of BTRC mRNA | CTD | PMID:25729387 | Btrc | Mouse | oxaliplatin | decreases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | oxaliplatin results in decreased expression of BTRC mRNA | CTD | PMID:25729387 | Btrc | Mouse | ozone | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of BTRC mRNA more ... | CTD | PMID:32699268 | Btrc | Mouse | paraquat | increases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Paraquat results in increased expression of BTRC mRNA | CTD | PMID:32680482 | Btrc | Mouse | potassium chromate | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of BTRC mRNA | CTD | PMID:22079256 | Btrc | Mouse | potassium chromate | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BTRC mRNA | CTD | PMID:22079256 | Btrc | Mouse | progesterone | increases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Progesterone results in increased expression of BTRC mRNA | CTD | PMID:17170212 | Btrc | Mouse | quinacrine | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in decreased expression of BTRC protein] more ... | CTD | PMID:28867437 | Btrc | Mouse | quinacrine | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Quinacrine results in decreased expression of BTRC protein | CTD | PMID:28867437 | Btrc | Mouse | rac-lactic acid | decreases expression | ISO | BTRC (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of BTRC mRNA | CTD | PMID:30851411 | Btrc | Mouse | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of BTRC mRNA | CTD | PMID:23186747 | Btrc | Mouse | sodium arsenite | increases expression | ISO | BTRC (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of BTRC mRNA | CTD | PMID:38568856 | Btrc | Mouse | tetrachloromethane | decreases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of BTRC mRNA | CTD | PMID:31150632 | Btrc | Mouse | thioacetamide | decreases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of BTRC mRNA | CTD | PMID:34492290 | Btrc | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of BTRC gene | CTD | PMID:35295148 | Btrc | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of BTRC enhancer | CTD | PMID:35295148 | Btrc | Mouse | topotecan | decreases expression | ISO | Btrc (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of BTRC mRNA | CTD | PMID:25729387 | Btrc | Mouse | topotecan | multiple interactions | ISO | Btrc (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of BTRC mRNA | CTD | PMID:25729387 | Btrc | Mouse | trichostatin A | affects expression | ISO | BTRC (Homo sapiens) | 6480464 | trichostatin A affects the expression of BTRC mRNA | CTD | PMID:28542535 | Btrc | Mouse | triphenyl phosphate | affects expression | ISO | BTRC (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of BTRC mRNA | CTD | PMID:37042841 | Btrc | Mouse | valproic acid | affects expression | ISO | BTRC (Homo sapiens) | 6480464 | Valproic Acid affects the expression of BTRC mRNA | CTD | PMID:25979313 | Btrc | Mouse | venetoclax | multiple interactions | ISO | BTRC (Homo sapiens) | 6480464 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC protein] more ... | CTD | PMID:35561756 | | 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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Hedgehog signaling update. | Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909. |
| 2. | Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. | Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30. |
| 3. | The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. | Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16. |
| 4. | Wnt signalling and its impact on development and cancer. | Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98. |
| 5. | Expanding role of ubiquitination in NF-kappaB signaling. | Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7. |
| 6. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 7. | MGD IEA | MGD IEA |
| 8. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 9. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 10. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:9859996 | PMID:9990852 | PMID:9990853 | PMID:10072378 | PMID:10097128 | PMID:10228155 | PMID:10349636 | PMID:10564661 | PMID:10790373 | PMID:10922068 | PMID:11042159 | PMID:11076861 |
| PMID:11217851 | PMID:11735228 | PMID:11850407 | PMID:12151397 | PMID:12477932 | PMID:12520002 | PMID:12702649 | PMID:12791266 | PMID:12843402 | PMID:14610273 | PMID:14681479 | PMID:15340078 |
| PMID:15721142 | PMID:15747579 | PMID:15767683 | PMID:15782199 | PMID:15855639 | PMID:16141072 | PMID:16141073 | PMID:16371461 | PMID:16611981 | PMID:16919269 | PMID:17387146 | PMID:17462724 |
| PMID:17636028 | PMID:17967808 | PMID:18281465 | PMID:18287559 | PMID:18354483 | PMID:18363964 | PMID:18782782 | PMID:18799693 | PMID:18929646 | PMID:18991257 | PMID:19047045 | PMID:19103752 |
| PMID:19150432 | PMID:19196987 | PMID:19515997 | PMID:19521566 | PMID:19576224 | PMID:19705444 | PMID:19795382 | PMID:19933270 | PMID:20194439 | PMID:20359476 | PMID:20531388 | PMID:20625400 |
| PMID:20797629 | PMID:21068446 | PMID:21070969 | PMID:21187057 | PMID:21245377 | PMID:21267068 | PMID:21606193 | PMID:21677750 | PMID:21807946 | PMID:21873635 | PMID:21911472 | PMID:22037600 |
| PMID:22964642 | PMID:23453598 | PMID:24194600 | PMID:24469832 | PMID:24952961 | PMID:25849460 | PMID:26009993 | PMID:26022109 | PMID:26056141 | PMID:26240281 | PMID:26418746 | PMID:26903623 |
| PMID:26942574 | PMID:27476970 | PMID:27626380 | PMID:28049764 | PMID:28808228 | PMID:28982686 | PMID:29038250 | PMID:29103939 | PMID:29593216 | PMID:30031111 | PMID:30391586 | PMID:30619291 |
| PMID:30988430 | PMID:31040226 | PMID:32188758 | PMID:32558204 | PMID:33020978 | PMID:33976226 | PMID:34424219 | PMID:34731635 | PMID:35674451 | PMID:36252997 | PMID:36417873 | PMID:36438474 |
| PMID:36928426 | PMID:37287397 | PMID:37584358 | PMID:38184999 | PMID:38280229 | PMID:38355793 |
Genomics
Comparative Map Data
| Btrc (Mus musculus - house mouse) |
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| BTRC (Homo sapiens - human) |
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| Btrc (Rattus norvegicus - Norway rat) |
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| Btrc (Chinchilla lanigera - long-tailed chinchilla) |
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| BTRC (Pan paniscus - bonobo/pygmy chimpanzee) |
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| BTRC (Canis lupus familiaris - dog) |
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| Btrc (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| BTRC (Sus scrofa - pig) |
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| BTRC (Chlorocebus sabaeus - green monkey) |
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| Btrc (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Btrc
4544 total Variants 
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