Tnfrsf11a (tumor necrosis factor receptor superfamily, member 11a, NFKB activator) - Rat Genome Database

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Gene: Tnfrsf11a (tumor necrosis factor receptor superfamily, member 11a, NFKB activator) Mus musculus
Symbol: Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
RGD ID: 1321640
Description: Enables tumor necrosis factor receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including lymph node development; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface and membrane raft. Is expressed in bladder; hemolymphoid system; hindlimb long bone; and mandible. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ly109; mRANK; ODFR; OFE; osteoclast differentiation factor receptor; R; Rank; receptor activator of NF-kappaB; receptor activator of NF-KB; TRAN; TRANCE-R; tumor necrosis factor receptor superfamily member 11A
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391105,708,443 - 105,777,172 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1105,708,443 - 105,775,709 (+)EnsemblGRCm39 Ensembl
GRCm381105,780,673 - 105,849,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1105,780,718 - 105,847,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv371107,677,300 - 107,744,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361107,608,270 - 107,672,989 (+)NCBIMGSCv36mm8
Celera1108,658,349 - 108,696,865 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azadirachtin A  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroquine  (EXP)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
ellagic acid  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
folic acid  (EXP)
furosemide  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
indole-3-methanol  (ISO)
isoflurane  (ISO)
kaempferol  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
mangiferin  (EXP)
methotrexate  (ISO)
modafinil  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-nitrosodiethylamine  (ISO)
naringin  (EXP)
nitrates  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentobarbital  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium fluoride  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body temperature homeostasis  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal bone structure  (IAGP)
abnormal circadian temperature homeostasis  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal nasal mucosa morphology  (IAGP)
abnormal negative T cell selection  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal Peyer's patch epithelium morphology  (IAGP)
abnormal Peyer's patch follicle morphology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal Peyer's patch T cell area morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal thymus epithelium morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent incisors  (IAGP)
absent lymph nodes  (IAGP)
anemia  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone trabecular spacing  (IAGP)
decreased compact bone thickness  (IAGP)
decreased IgA level  (IAGP)
decreased mature B cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased plasma cell number  (IAGP)
decreased prostaglandin level  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased tumor necrosis factor (ligand) superfamily member 11 level  (IAGP)
domed cranium  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of tooth eruption  (IAGP)
impaired febrile response  (IAGP)
increased bone mineral density  (IAGP)
increased bone trabecula number  (IAGP)
increased bone volume  (IAGP)
increased diameter of long bones  (IAGP)
increased femoral compact bone area  (IAGP)
increased granulocyte number  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased neutrophil cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
kyphosis  (IAGP)
lactation failure  (IAGP)
osteopetrosis  (IAGP)
osteosclerosis  (IAGP)
premature death  (IAGP)
short limbs  (IAGP)
short snout  (IAGP)
small Peyer's patches  (IAGP)
spleen hyperplasia  (IAGP)
tooth impaction  (IAGP)

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. Chen G, etal., Cancer. 2006 Jul 15;107(2):289-98.
3. Imbalance of RANK, RANKL and OPG expression during tibial fracture repair in diabetic rats. de Amorim FP, etal., J Mol Histol. 2008 Aug;39(4):401-8. Epub 2008 Jul 1.
4. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
5. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Hughes AE, etal., Nat Genet. 2000 Jan;24(1):45-8.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. NF-kappa B genes have a major role in inflammatory breast cancer. Lerebours F, etal., BMC Cancer. 2008 Feb 4;8:41.
8. Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease. Liu W, etal., Exp Mol Pathol. 2008 Jun;84(3):213-7. Epub 2008 Mar 7.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Siddiqui IA, etal., Pharm Res. 2008 Mar 4;.
17. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:9367155   PMID:9878548   PMID:10097072   PMID:10349636   PMID:10500098   PMID:10677500   PMID:11042159   PMID:11051546   PMID:11076861   PMID:11239407   PMID:11406619   PMID:11592959  
PMID:11805147   PMID:12096833   PMID:12185073   PMID:12244151   PMID:12477932   PMID:12637570   PMID:12798068   PMID:12938156   PMID:14500659   PMID:14607948   PMID:14734743   PMID:14969390  
PMID:14981127   PMID:15102471   PMID:15232218   PMID:15340228   PMID:15355564   PMID:15485878   PMID:15489334   PMID:15522223   PMID:15530848   PMID:15561968   PMID:15564564   PMID:15642143  
PMID:15647836   PMID:15678102   PMID:15757905   PMID:16083856   PMID:16141072   PMID:16141073   PMID:16147974   PMID:16234979   PMID:16251181   PMID:16260781   PMID:16373338   PMID:16602821  
PMID:16614077   PMID:16680826   PMID:17003115   PMID:17145767   PMID:17467668   PMID:17502664   PMID:17544369   PMID:17878071   PMID:18287559   PMID:18382763   PMID:18543257   PMID:18606706  
PMID:18632421   PMID:18759249   PMID:18799149   PMID:18929692   PMID:18958885   PMID:19016581   PMID:19258703   PMID:19414759   PMID:19478440   PMID:19715671   PMID:19770515   PMID:19782692  
PMID:19828638   PMID:19845770   PMID:19940926   PMID:20036645   PMID:20118276   PMID:20142327   PMID:20200955   PMID:20558734   PMID:20633538   PMID:20679512   PMID:20691668   PMID:20814988  
PMID:20870724   PMID:20881962   PMID:21029677   PMID:21059944   PMID:21084708   PMID:21153864   PMID:21267068   PMID:21325354   PMID:21326202   PMID:21332025   PMID:21402940   PMID:21441458  
PMID:21447555   PMID:21478097   PMID:21527253   PMID:21844205   PMID:21873635   PMID:22210913   PMID:22219325   PMID:22249448   PMID:22344299   PMID:22354913   PMID:22416138   PMID:22421365  
PMID:22425250   PMID:22428553   PMID:22454522   PMID:22615494   PMID:22848465   PMID:22913338   PMID:23039992   PMID:23071670   PMID:23139818   PMID:23152561   PMID:23303310   PMID:23303667  
PMID:23396210   PMID:23462470   PMID:23478294   PMID:23572233   PMID:23766243   PMID:23821519   PMID:23825189   PMID:23954298   PMID:24847069   PMID:24859969   PMID:25461255   PMID:25462844  
PMID:25554597   PMID:25615839   PMID:25727991   PMID:25751305   PMID:25864714   PMID:26052897   PMID:26061636   PMID:26093292   PMID:26095608   PMID:26195726   PMID:26276390   PMID:26429739  
PMID:26546523   PMID:26601902   PMID:26659571   PMID:26680207   PMID:26825123   PMID:26921732   PMID:27064449   PMID:27241552   PMID:27273006   PMID:27401343   PMID:27413168   PMID:27480274  
PMID:27492475   PMID:27563728   PMID:27621061   PMID:27973593   PMID:28158928   PMID:28294321   PMID:28336912   PMID:28535663   PMID:28574598   PMID:28627025   PMID:28634284   PMID:28709801  
PMID:29118048   PMID:29186688   PMID:29377122   PMID:29382610   PMID:29477253   PMID:29512766   PMID:29798841   PMID:29844572   PMID:29858011   PMID:29867988   PMID:30036881   PMID:30046112  
PMID:30201786   PMID:30478447   PMID:30510839   PMID:30538245   PMID:30633834   PMID:30737385   PMID:30918005   PMID:30971820   PMID:31074883   PMID:31081236   PMID:31146918   PMID:31173390  
PMID:31201093   PMID:31289211   PMID:31360740   PMID:31470364   PMID:31480885   PMID:31552487   PMID:32315212   PMID:32454449   PMID:32839611   PMID:32917889   PMID:33303745   PMID:33361811  
PMID:33385614   PMID:33724536   PMID:34223915   PMID:34358968   PMID:34661337   PMID:35031565   PMID:35881544   PMID:36194667   PMID:36379210   PMID:37030499   PMID:37130522   PMID:37704707  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391105,708,443 - 105,777,172 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1105,708,443 - 105,775,709 (+)EnsemblGRCm39 Ensembl
GRCm381105,780,673 - 105,849,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1105,780,718 - 105,847,981 (+)EnsemblGRCm38mm10GRCm38
MGSCv371107,677,300 - 107,744,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361107,608,270 - 107,672,989 (+)NCBIMGSCv36mm8
Celera1108,658,349 - 108,696,865 (+)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map149.7NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381862,325,310 - 62,391,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1862,325,287 - 62,391,288 (+)EnsemblGRCh38hg38GRCh38
GRCh371859,992,543 - 60,058,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,143,528 - 58,204,484 (+)NCBINCBI36Build 36hg18NCBI36
Build 341858,143,527 - 58,204,482NCBI
Celera1856,711,789 - 56,772,745 (+)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1856,726,294 - 56,766,005 (+)NCBIHuRef
CHM1_11859,988,087 - 60,050,490 (+)NCBICHM1_1
T2T-CHM13v2.01862,528,176 - 62,594,158 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81322,442,930 - 22,501,257 (+)NCBIGRCr8
mRatBN7.21321,928,370 - 21,986,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1321,928,408 - 21,986,695 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1322,247,466 - 22,306,553 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01323,532,261 - 23,591,345 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01322,216,155 - 22,275,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01325,778,306 - 25,835,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1325,778,317 - 25,835,957 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01330,966,261 - 30,997,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41311,958,002 - 12,014,371 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1321,798,588 - 21,856,355 (+)NCBICelera
Cytogenetic Map13p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540246,264,164 - 46,296,368 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540246,242,329 - 46,298,157 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21779,846,412 - 79,912,279 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11865,539,023 - 65,604,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01855,695,394 - 55,761,307 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11859,032,727 - 59,075,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1859,034,770 - 59,075,044 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1114,504,595 - 14,555,956 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,503,033 - 14,556,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,469,086 - 15,523,233 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0114,362,189 - 14,416,396 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,362,936 - 14,416,396 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1114,398,162 - 14,452,574 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,331,546 - 14,385,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,578,257 - 14,632,411 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494427,705,806 - 27,756,172 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364972,945,010 - 2,995,207 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364972,944,841 - 2,986,113 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1159,128,038 - 159,187,481 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11159,128,039 - 159,187,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,590,571 - 176,650,002 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11817,385,251 - 17,446,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660608,239,048 - 8,304,073 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247928,029,364 - 8,084,424 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247928,029,383 - 8,087,824 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tnfrsf11a
1831 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:846
Count of miRNA genes:517
Interacting mature miRNAs:584
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196618386130618557Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
13452398Leusq5_mleucocytosis susceptibility QTL 5 (mouse)198474785126386517Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
12879492Ecgnq1_meccrine gland number QTL 1 (mouse)1103278062120535225Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381105,844,900 - 105,845,027UniSTSGRCm38
MGSCv371107,741,477 - 107,741,604UniSTSGRCm37
Celera1108,693,811 - 108,693,938UniSTS
Cytogenetic Map1E2.1UniSTS



RefSeq Acc Id: ENSMUST00000027559   ⟹   ENSMUSP00000027559
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1105,708,443 - 105,775,709 (+)Ensembl
GRCm38.p6 Ensembl1105,780,718 - 105,847,981 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187658
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1105,747,595 - 105,753,126 (+)Ensembl
GRCm38.p6 Ensembl1105,819,870 - 105,825,401 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187812
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1105,708,475 - 105,742,128 (+)Ensembl
GRCm38.p6 Ensembl1105,780,750 - 105,814,403 (+)Ensembl
RefSeq Acc Id: NM_009399   ⟹   NP_033425
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391105,708,443 - 105,775,707 (+)NCBI
GRCm381105,780,723 - 105,847,981 (+)ENTREZGENE
MGSCv371107,677,300 - 107,744,558 (+)RGD
Celera1108,658,349 - 108,696,865 (+)RGD
RefSeq Acc Id: XM_006529381   ⟹   XP_006529444
Mouse AssemblyChrPosition (strand)Source
GRCm391105,708,471 - 105,777,172 (+)NCBI
GRCm381105,780,673 - 105,849,444 (+)NCBI
Protein Sequences
Protein RefSeqs NP_033425 (Get FASTA)   NCBI Sequence Viewer  
  XP_006529444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB86810 (Get FASTA)   NCBI Sequence Viewer  
  AAH19185 (Get FASTA)   NCBI Sequence Viewer  
  CAX21651 (Get FASTA)   NCBI Sequence Viewer  
  EDL39871 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000027559
GenBank Protein O35305 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033425   ⟸   NM_009399
- Peptide Label: precursor
- UniProtKB: Q8VCT7 (UniProtKB/Swiss-Prot),   O35305 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006529444   ⟸   XM_006529381
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000027559   ⟸   ENSMUST00000027559

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35305-F1-model_v2 AlphaFold O35305 1-625 view protein structure

RGD ID:6874650
Promoter ID:EPDNEW_M770
Type:initiation region
Description:Mus musculus tumor necrosis factor receptor superfamily, member11a, NFKB activator , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381105,780,718 - 105,780,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1314891 AgrOrtholog
Ensembl Genes ENSMUSG00000026321 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027559 ENTREZGENE
  ENSMUST00000027559.9 UniProtKB/Swiss-Prot
Gene3D-CATH Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot
InterPro RANK_CRD_2 UniProtKB/Swiss-Prot
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot
  TNFR_11 UniProtKB/Swiss-Prot
  TNFR_11A UniProtKB/Swiss-Prot
  TNFRSF11A_N UniProtKB/Swiss-Prot
KEGG Report mmu:21934 UniProtKB/Swiss-Prot
Pfam RANK_CRD_2 UniProtKB/Swiss-Prot
  TNFR_c6 UniProtKB/Swiss-Prot
PhenoGen Tnfrsf11a PhenoGen
  TNFACTORR11A UniProtKB/Swiss-Prot
  TNFR_NGFR_2 UniProtKB/Swiss-Prot
SMART TNFR UniProtKB/Swiss-Prot
Superfamily-SCOP TNF receptor-like UniProtKB/Swiss-Prot
  TNR11_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8VCT7 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 Tnfrsf11a  tumor necrosis factor receptor superfamily, member 11a, NFKB activator    tumor necrosis factor receptor superfamily, member 11a  Symbol and/or name change 5135510 APPROVED