Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | lymphoproliferative syndrome 1 | | ISO | ITK (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | lymphoproliferative syndrome 1 | | ISO | ITK (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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# | Reference Title | Reference Citation |
1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
3. | MGD IEA | MGD IEA |
4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
5. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
6. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
7. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
8. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
9. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
10. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
PMID:1280821 | PMID:2357970 | PMID:7522330 | PMID:7524075 | PMID:7829087 | PMID:8421704 | PMID:8476425 | PMID:8777721 | PMID:8893810 | PMID:8943565 | PMID:8985255 | PMID:9070927 |
PMID:9177770 | PMID:9311799 | PMID:9396778 | PMID:9584150 | PMID:10213685 | PMID:10349636 | PMID:10549622 | PMID:10556826 | PMID:10562318 | PMID:10570288 | PMID:11015440 | PMID:11042159 |
PMID:11076861 | PMID:11114734 | PMID:11702066 | PMID:11859102 | PMID:12055226 | PMID:12193707 | PMID:12477932 | PMID:12682224 | PMID:12734350 | PMID:12798690 | PMID:12810687 | PMID:12842872 |
PMID:13678593 | PMID:14993283 | PMID:15123627 | PMID:15345221 | PMID:15661896 | PMID:15662016 | PMID:15761153 | PMID:15778496 | PMID:15814667 | PMID:16042784 | PMID:16141072 | PMID:16141073 |
PMID:16237085 | PMID:16424186 | PMID:16547221 | PMID:16602821 | PMID:16630934 | PMID:16631752 | PMID:16860759 | PMID:16860760 | PMID:16880398 | PMID:17412921 | PMID:17425330 | PMID:17579028 |
PMID:17724684 | PMID:18025201 | PMID:18031697 | PMID:18292523 | PMID:18320328 | PMID:18322190 | PMID:18342008 | PMID:18424706 | PMID:18453573 | PMID:18523250 | PMID:18941202 | PMID:19009524 |
PMID:19416854 | PMID:19443662 | PMID:19449311 | PMID:19597499 | PMID:19682494 | PMID:19701889 | PMID:19818650 | PMID:19917685 | PMID:19955438 | PMID:20108770 | PMID:20126642 | PMID:20237289 |
PMID:20305788 | PMID:20457812 | PMID:20483745 | PMID:20596543 | PMID:20670954 | PMID:20826165 | PMID:20974963 | PMID:21036902 | PMID:21138328 | PMID:21212279 | PMID:21280324 | PMID:21497118 |
PMID:21677750 | PMID:21873635 | PMID:21971040 | PMID:22289921 | PMID:22403441 | PMID:22967998 | PMID:22988097 | PMID:23011795 | PMID:23028816 | PMID:23219468 | PMID:23378428 | PMID:23562159 |
PMID:23768572 | PMID:23793062 | PMID:23851691 | PMID:23982207 | PMID:24270545 | PMID:24462896 | PMID:24534190 | PMID:24610010 | PMID:24620029 | PMID:24928994 | PMID:25063868 | PMID:25097034 |
PMID:25105474 | PMID:25250764 | PMID:25271622 | PMID:25492967 | PMID:25548254 | PMID:25568116 | PMID:25989458 | PMID:26466958 | PMID:26581914 | PMID:26628680 | PMID:26936133 | PMID:28213500 |
PMID:28406139 | PMID:28516764 | PMID:28635957 | PMID:29129599 | PMID:30770814 | PMID:31505252 | PMID:31591574 | PMID:31663508 | PMID:31757864 | PMID:32034085 | PMID:32038633 | PMID:32493815 |
PMID:33324410 | PMID:33931484 | PMID:34309585 | PMID:34452995 | PMID:34566971 | PMID:35210549 | PMID:37175808 |
Itk (Mus musculus - house mouse) |
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ITK (Homo sapiens - human) |
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Itk (Rattus norvegicus - Norway rat) |
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Itk (Chinchilla lanigera - long-tailed chinchilla) |
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ITK (Pan paniscus - bonobo/pygmy chimpanzee) |
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ITK (Canis lupus familiaris - dog) |
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Itk (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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ITK (Sus scrofa - pig) |
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ITK (Chlorocebus sabaeus - green monkey) |
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Itk (Heterocephalus glaber - naked mole-rat) |
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Variants in Itk
2525 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RefSeq Transcripts | NM_001281965 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_001281966 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NM_001281967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NM_001281968 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
NM_010583 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AB018562 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AK020772 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK037554 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK079693 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK083380 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK138113 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK153613 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AK153692 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
AL662806 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BB843988 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC028478 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC128374 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC128375 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BY589043 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH466575 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D14042 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L00619 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L05631 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L10628 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSMUST00000020664 ⟹ ENSMUSP00000020664 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000101306 ⟹ ENSMUSP00000098864 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000109237 ⟹ ENSMUSP00000104860 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSMUST00000155991 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001281965 ⟹ NP_001268894 | ||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_001281966 ⟹ NP_001268895 | ||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_001281967 ⟹ NP_001268896 | ||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_001281968 ⟹ NP_001268897 | ||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_010583 ⟹ NP_034713 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_001268894 | (Get FASTA) | NCBI Sequence Viewer |
NP_001268895 | (Get FASTA) | NCBI Sequence Viewer | |
NP_001268896 | (Get FASTA) | NCBI Sequence Viewer | |
NP_001268897 | (Get FASTA) | NCBI Sequence Viewer | |
NP_034713 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA39337 | (Get FASTA) | NCBI Sequence Viewer |
AAA40518 | (Get FASTA) | NCBI Sequence Viewer | |
AAI28375 | (Get FASTA) | NCBI Sequence Viewer | |
AAI28376 | (Get FASTA) | NCBI Sequence Viewer | |
BAA03129 | (Get FASTA) | NCBI Sequence Viewer | |
BAA33864 | (Get FASTA) | NCBI Sequence Viewer | |
BAC29830 | (Get FASTA) | NCBI Sequence Viewer | |
BAE32118 | (Get FASTA) | NCBI Sequence Viewer | |
EDL33821 | (Get FASTA) | NCBI Sequence Viewer | |
EDL33822 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSMUSP00000020664 | ||
ENSMUSP00000020664.7 | |||
ENSMUSP00000098864 | |||
ENSMUSP00000098864.4 | |||
ENSMUSP00000104860 | |||
ENSMUSP00000104860.3 | |||
GenBank Protein | Q03526 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_034713 ⟸ NM_010583 |
- Peptide Label: | isoform 2 |
- UniProtKB: | Q3U5G1 (UniProtKB/TrEMBL), Q5STT8 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001268897 ⟸ NM_001281968 |
- Peptide Label: | isoform 5 |
- UniProtKB: | A1A560 (UniProtKB/TrEMBL), Q3U5G1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001268895 ⟸ NM_001281966 |
- Peptide Label: | isoform 3 |
- UniProtKB: | Q3U5G1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001268894 ⟸ NM_001281965 |
- Peptide Label: | isoform 1 |
- UniProtKB: | Q03526 (UniProtKB/Swiss-Prot), Q3U5G1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001268896 ⟸ NM_001281967 |
- Peptide Label: | isoform 4 |
- UniProtKB: | Q5STT7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSMUSP00000020664 ⟸ ENSMUST00000020664 |
RefSeq Acc Id: | ENSMUSP00000098864 ⟸ ENSMUST00000101306 |
RefSeq Acc Id: | ENSMUSP00000104860 ⟸ ENSMUST00000109237 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q03526-F1-model_v2 | AlphaFold | Q03526 | 1-625 | view protein structure |
RGD ID: | 6821126 | ||||||||
Promoter ID: | MM_KWN:7097 | ||||||||
Type: | Non-CpG | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | MPROMDB | ||||||||
Tissues & Cell Lines: | Spleen | ||||||||
Transcripts: | NM_010583, OTTMUST00000012227, OTTMUST00000061071, UC007IOI.1 | ||||||||
Position: |
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RGD ID: | 8674402 | ||||||||
Promoter ID: | EPDNEW_M15232 | ||||||||
Type: | initiation region | ||||||||
Name: | Itk_1 | ||||||||
Description: | Mus musculus IL2 inducible T cell kinase , transcript variant4, mRNA. | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | MGI:96621 | AgrOrtholog |
Ensembl Genes | ENSMUSG00000020395 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSMUST00000020664 | ENTREZGENE |
ENSMUST00000020664.13 | UniProtKB/TrEMBL | |
ENSMUST00000101306 | ENTREZGENE | |
ENSMUST00000101306.4 | UniProtKB/TrEMBL | |
ENSMUST00000109237 | ENTREZGENE | |
ENSMUST00000109237.9 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 2.30.29.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
3.30.505.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3 Domains | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Transferase(Phosphotransferase) domain 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | Grb2-like | UniProtKB/TrEMBL |
ITK_PTKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ITK_SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Kinase-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Prot_kinase_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Ser-Thr/Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH2_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_kinase_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Znf_Btk_motif | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | mmu:16428 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGD | MGI:96621 | ENTREZGENE |
NCBI Gene | 16428 | ENTREZGENE |
PANTHER | PROTEIN ENHANCER OF SEVENLESS 2B | UniProtKB/TrEMBL |
SRC-LIKE-ADAPTER | UniProtKB/TrEMBL | |
TYROSINE-PROTEIN KINASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TYROSINE-PROTEIN KINASE ITK/TSK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | BTK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PF00169 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pkinase_Tyr | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Itk | PhenoGen |
PRINTS | SH2DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TECBTKDOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TYRKINASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | PH_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
ZF_BTK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | BTK | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SH2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00233 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TyrKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | PH domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF50044 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF55550 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF56112 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A1A560 | ENTREZGENE, UniProtKB/TrEMBL |
ITK_MOUSE | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q3U5G1 | ENTREZGENE, UniProtKB/TrEMBL | |
Q5STT7 | ENTREZGENE, UniProtKB/TrEMBL | |
Q5STT8 | ENTREZGENE, UniProtKB/TrEMBL | |
Q76N02_MOUSE | UniProtKB/TrEMBL | |
Q8CAW3_MOUSE | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2012-02-07 | Itk | IL2 inducible T cell kinase | Itk | IL2-inducible T-cell kinase | Symbol and/or name change | 5135510 | APPROVED |