Itk (IL2 inducible T cell kinase) - Rat Genome Database

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Gene: Itk (IL2 inducible T cell kinase) Mus musculus
Analyze
Symbol: Itk
Name: IL2 inducible T cell kinase
RGD ID: 1323170
MGI Page MGI
Description: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; gamma-delta T cell activation; and positive regulation of cytokine production. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Emt; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; kinase EMT; kinase TLK; T-cell-specific kinase; Tcs; Tcsk; Ts; Tsk; tyrosine-protein kinase ITK/TSK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,215,975 - 46,280,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,215,977 - 46,280,342 (-)EnsemblGRCm39 Ensembl
GRCm381146,325,148 - 46,389,515 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,325,150 - 46,389,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,138,652 - 46,203,017 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,168,576 - 46,232,923 (-)NCBIMGSCv36mm8
Celera1150,911,124 - 50,975,428 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IDA)
cytoplasm  (IEA)
cytosol  (ISO,TAS)
nucleus  (IDA)
plasma membrane  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IEA)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell death  (IAGP)
abnormal cell proliferation  (IEA)
abnormal cytokine secretion  (IAGP)
abnormal gamma-delta T cell morphology  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal NK T cell morphology  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal response to infection  (IAGP)
abnormal spleen morphology  (IEA)
abnormal T cell activation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymus cell ratio  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IEA)
decreased CD8-positive, alpha-beta memory T cell number  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased double-positive T cell number  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-5 secretion  (IAGP)
decreased NK T cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
enlarged spleen  (IEA)
increased B cell number  (IAGP)
increased CD8-positive, alpha-beta memory T cell proliferation  (IEA)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased double-negative T cell number  (IAGP)
increased double-positive T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased germinal center B cell number  (IAGP)
increased IgE level  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased mature gamma-delta T cell number  (IAGP)
increased memory T cell number  (IAGP)
increased startle reflex  (IEA)
increased susceptibility to parasitic infection  (IAGP)
increased T cell apoptosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1280821   PMID:2357970   PMID:7522330   PMID:7524075   PMID:7829087   PMID:8421704   PMID:8476425   PMID:8777721   PMID:8893810   PMID:8943565   PMID:8985255   PMID:9070927  
PMID:9177770   PMID:9311799   PMID:9396778   PMID:9584150   PMID:10213685   PMID:10349636   PMID:10549622   PMID:10556826   PMID:10562318   PMID:10570288   PMID:11015440   PMID:11042159  
PMID:11076861   PMID:11114734   PMID:11702066   PMID:11859102   PMID:12055226   PMID:12193707   PMID:12477932   PMID:12682224   PMID:12734350   PMID:12798690   PMID:12810687   PMID:12842872  
PMID:13678593   PMID:14993283   PMID:15123627   PMID:15345221   PMID:15661896   PMID:15662016   PMID:15761153   PMID:15778496   PMID:15814667   PMID:16042784   PMID:16141072   PMID:16141073  
PMID:16237085   PMID:16424186   PMID:16547221   PMID:16602821   PMID:16630934   PMID:16631752   PMID:16860759   PMID:16860760   PMID:16880398   PMID:17412921   PMID:17425330   PMID:17579028  
PMID:17724684   PMID:18025201   PMID:18031697   PMID:18292523   PMID:18320328   PMID:18322190   PMID:18342008   PMID:18424706   PMID:18453573   PMID:18523250   PMID:18941202   PMID:19009524  
PMID:19416854   PMID:19443662   PMID:19449311   PMID:19597499   PMID:19682494   PMID:19701889   PMID:19818650   PMID:19917685   PMID:19955438   PMID:20108770   PMID:20126642   PMID:20237289  
PMID:20305788   PMID:20457812   PMID:20483745   PMID:20596543   PMID:20670954   PMID:20826165   PMID:20974963   PMID:21036902   PMID:21138328   PMID:21212279   PMID:21280324   PMID:21497118  
PMID:21677750   PMID:21873635   PMID:21971040   PMID:22289921   PMID:22403441   PMID:22967998   PMID:22988097   PMID:23011795   PMID:23028816   PMID:23219468   PMID:23378428   PMID:23562159  
PMID:23768572   PMID:23793062   PMID:23851691   PMID:23982207   PMID:24270545   PMID:24462896   PMID:24534190   PMID:24610010   PMID:24620029   PMID:24928994   PMID:25063868   PMID:25097034  
PMID:25105474   PMID:25250764   PMID:25271622   PMID:25492967   PMID:25548254   PMID:25568116   PMID:25989458   PMID:26466958   PMID:26581914   PMID:26628680   PMID:26936133   PMID:28213500  
PMID:28406139   PMID:28516764   PMID:28635957   PMID:29129599   PMID:30770814   PMID:31505252   PMID:31591574   PMID:31663508   PMID:31757864   PMID:32034085   PMID:32038633   PMID:32493815  
PMID:33324410   PMID:33931484   PMID:34309585   PMID:34452995   PMID:34566971   PMID:35210549   PMID:37175808  


Genomics

Comparative Map Data
Itk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,215,975 - 46,280,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,215,977 - 46,280,342 (-)EnsemblGRCm39 Ensembl
GRCm381146,325,148 - 46,389,515 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,325,150 - 46,389,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,138,652 - 46,203,017 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,168,576 - 46,232,923 (-)NCBIMGSCv36mm8
Celera1150,911,124 - 50,975,428 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.75NCBI
ITK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,180,840 - 157,255,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,142,933 - 157,255,185 (+)EnsemblGRCh38hg38GRCh38
GRCh375156,607,851 - 156,682,195 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,540,485 - 156,614,687 (+)NCBINCBI36Build 36hg18NCBI36
Build 345156,540,484 - 156,614,687NCBI
Celera5152,634,440 - 152,708,658 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,695,940 - 151,769,767 (+)NCBIHuRef
CHM1_15156,040,619 - 156,114,765 (+)NCBICHM1_1
T2T-CHM13v2.05157,699,782 - 157,774,113 (+)NCBIT2T-CHM13v2.0
Itk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,254,667 - 31,316,004 (-)NCBIGRCr8
mRatBN7.21030,753,344 - 30,814,685 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,753,344 - 30,814,685 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,480,495 - 35,541,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,018,954 - 4,080,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,455,134 - 30,516,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,431,820 - 31,493,413 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,431,809 - 31,493,419 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,248,181 - 31,308,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,455,982 - 31,518,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,457,025 - 31,519,124 (-)NCBI
Celera1030,205,244 - 30,266,599 (-)NCBICelera
Cytogenetic Map10q21NCBI
Itk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,387,589 - 11,448,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,387,595 - 11,447,896 (+)NCBIChiLan1.0ChiLan1.0
ITK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,364,876 - 152,450,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,504,423 - 150,590,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,582,125 - 152,656,211 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15159,204,016 - 159,277,689 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,204,016 - 159,277,689 (+)Ensemblpanpan1.1panPan2
ITK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1452,902,886 - 52,966,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl452,902,871 - 52,966,542 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,795,128 - 52,858,373 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,339,439 - 53,402,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl453,340,020 - 53,402,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1453,165,818 - 53,229,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,272,737 - 53,336,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,789,682 - 53,852,963 (-)NCBIUU_Cfam_GSD_1.0
Itk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,441,822 - 107,503,029 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365155,891,828 - 5,952,458 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365155,891,873 - 5,952,400 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1666,010,772 - 66,082,185 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11666,010,766 - 66,082,263 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,884,821 - 71,940,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,575,113 - 59,650,166 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,575,179 - 59,650,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,980,495 - 18,055,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473332,127,388 - 32,198,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473332,125,005 - 32,198,901 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itk
2525 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1961
Count of miRNA genes:598
Interacting mature miRNAs:736
Transcripts:ENSMUST00000020664, ENSMUST00000101306, ENSMUST00000109237, ENSMUST00000155991
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001281965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001281966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001281967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001281968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB018562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB843988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY589043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L00619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L05631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000020664   ⟹   ENSMUSP00000020664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,215,977 - 46,280,342 (-)Ensembl
GRCm38.p6 Ensembl1146,325,150 - 46,389,515 (-)Ensembl
RefSeq Acc Id: ENSMUST00000101306   ⟹   ENSMUSP00000098864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,235,305 - 46,280,284 (-)Ensembl
GRCm38.p6 Ensembl1146,344,478 - 46,389,457 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109237   ⟹   ENSMUSP00000104860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,215,977 - 46,280,320 (-)Ensembl
GRCm38.p6 Ensembl1146,325,150 - 46,389,493 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155991
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1146,253,930 - 46,280,288 (-)Ensembl
GRCm38.p6 Ensembl1146,363,103 - 46,389,461 (-)Ensembl
RefSeq Acc Id: NM_001281965   ⟹   NP_001268894
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,215,975 - 46,280,342 (-)NCBI
GRCm381146,325,148 - 46,389,515 (-)NCBI
Celera1150,911,122 - 50,975,428 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001281966   ⟹   NP_001268895
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,215,975 - 46,280,342 (-)NCBI
GRCm381146,325,148 - 46,389,515 (-)NCBI
Celera1150,911,122 - 50,975,428 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001281967   ⟹   NP_001268896
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,235,305 - 46,280,342 (-)NCBI
GRCm381146,344,478 - 46,389,515 (-)NCBI
Celera1150,911,122 - 50,975,428 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001281968   ⟹   NP_001268897
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,215,975 - 46,280,342 (-)NCBI
GRCm381146,325,148 - 46,389,515 (-)NCBI
Celera1150,911,122 - 50,975,428 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010583   ⟹   NP_034713
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391146,215,975 - 46,280,342 (-)NCBI
GRCm381146,325,148 - 46,389,515 (-)NCBI
MGSCv371146,138,652 - 46,203,017 (-)RGD
Celera1150,911,122 - 50,975,428 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034713   ⟸   NM_010583
- Peptide Label: isoform 2
- UniProtKB: Q3U5G1 (UniProtKB/TrEMBL),   Q5STT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001268897   ⟸   NM_001281968
- Peptide Label: isoform 5
- UniProtKB: A1A560 (UniProtKB/TrEMBL),   Q3U5G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001268895   ⟸   NM_001281966
- Peptide Label: isoform 3
- UniProtKB: Q3U5G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001268894   ⟸   NM_001281965
- Peptide Label: isoform 1
- UniProtKB: Q03526 (UniProtKB/Swiss-Prot),   Q3U5G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001268896   ⟸   NM_001281967
- Peptide Label: isoform 4
- UniProtKB: Q5STT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020664   ⟸   ENSMUST00000020664
RefSeq Acc Id: ENSMUSP00000098864   ⟸   ENSMUST00000101306
RefSeq Acc Id: ENSMUSP00000104860   ⟸   ENSMUST00000109237
Protein Domains
PH   Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03526-F1-model_v2 AlphaFold Q03526 1-625 view protein structure

Promoters
RGD ID:6821126
Promoter ID:MM_KWN:7097
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_010583,   OTTMUST00000012227,   OTTMUST00000061071,   UC007IOI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361146,202,711 - 46,203,211 (-)MPROMDB
RGD ID:8674402
Promoter ID:EPDNEW_M15232
Type:initiation region
Name:Itk_1
Description:Mus musculus IL2 inducible T cell kinase , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381146,389,484 - 46,389,544EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96621 AgrOrtholog
Ensembl Genes ENSMUSG00000020395 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020664 ENTREZGENE
  ENSMUST00000020664.13 UniProtKB/TrEMBL
  ENSMUST00000101306 ENTREZGENE
  ENSMUST00000101306.4 UniProtKB/TrEMBL
  ENSMUST00000109237 ENTREZGENE
  ENSMUST00000109237.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Grb2-like UniProtKB/TrEMBL
  ITK_PTKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITK_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16428 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96621 ENTREZGENE
NCBI Gene 16428 ENTREZGENE
PANTHER PROTEIN ENHANCER OF SEVENLESS 2B UniProtKB/TrEMBL
  SRC-LIKE-ADAPTER UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE ITK/TSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itk PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1A560 ENTREZGENE, UniProtKB/TrEMBL
  ITK_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U5G1 ENTREZGENE, UniProtKB/TrEMBL
  Q5STT7 ENTREZGENE, UniProtKB/TrEMBL
  Q5STT8 ENTREZGENE, UniProtKB/TrEMBL
  Q76N02_MOUSE UniProtKB/TrEMBL
  Q8CAW3_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Itk  IL2 inducible T cell kinase  Itk  IL2-inducible T-cell kinase  Symbol and/or name change 5135510 APPROVED