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Gene: Nod2 (nucleotide-binding oligomerization domain containing 2) Mus musculus
Symbol: Nod2
Name: nucleotide-binding oligomerization domain containing 2
Description: ENCODES a protein that exhibits muramyl dipeptide binding; actin binding (ortholog); CARD domain binding (ortholog); INVOLVED IN activation of immune response; cellular response to peptidoglycan; defense response to Gram-positive bacterium; PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; tuberculosis pathway; ASSOCIATED WITH abnormal autophagy; abnormal cytokine level; abnormal cytokine secretion; ASSOCIATED WITH asthma; atherosclerosis; bacterial infectious disease; FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; benzo[a]pyrene; buta-1,3-diene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ACUG; BLAU; Card15; caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15; CD; F830032C23Rik; IBD1; Nlrc2; nucleotide-binding oligomerization domain-containing protein 2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBImm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8 C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nod2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314946
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.