Nod2 (nucleotide-binding oligomerization domain containing 2) - Rat Genome Database

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Gene: Nod2 (nucleotide-binding oligomerization domain containing 2) Mus musculus
Analyze
Symbol: Nod2
Name: nucleotide-binding oligomerization domain containing 2
RGD ID: 1314946
MGI Page MGI
Description: Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACUG; BLAU; Card; Card15; caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15; CD; F830032C23Rik; IBD1; Nl; Nlrc2; nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)EnsemblGRCm39 Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBIMGSCv36mm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
asthma  (IDA,ISO)
atherosclerosis  (IMP)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (IMP)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
Chediak-Higashi syndrome  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IMP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (IMP)
Experimental Colitis  (ISO)
familial Mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
Granuloma  (IMP)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (IAGP,ISO)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (IMP)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (IMP)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (IMP)
PFAPA Syndrome  (ISO)
Pneumococcal Meningitis  (IEP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (IMP)
systemic lupus erythematosus  (ISO)
transient cerebral ischemia  (IEP)
ulcerative colitis  (ISO)
uveitis  (IMP)
YAO SYNDROME  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (IMP)
biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IMP)
cellular response to lipopolysaccharide  (ISO)
cellular response to muramyl dipeptide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to peptidoglycan  (IMP,ISO)
defense response  (TAS)
defense response to bacterium  (IBA,ISO)
defense response to Gram-positive bacterium  (IGI,IMP)
detection of bacterium  (ISO)
detection of biotic stimulus  (TAS)
detection of muramyl dipeptide  (ISO)
ERK1 and ERK2 cascade  (IDA)
establishment of localization in cell  (IMP)
I-kappaB kinase/NF-kappaB signaling  (IDA)
immune system process  (IEA)
inflammatory response  (TAS)
innate immune response  (ISO)
innate immune response in mucosa  (IMP)
intracellular signal transduction  (ISO)
JNK cascade  (IDA)
maintenance of gastrointestinal epithelium  (ISO)
MAPK cascade  (IMP)
negative regulation of inflammatory response to antigenic stimulus  (IMP)
negative regulation of interleukin-12 production  (IDA,IMP)
negative regulation of interleukin-18 production  (IMP)
negative regulation of interleukin-2 production  (IMP)
negative regulation of macrophage apoptotic process  (IDA)
negative regulation of macrophage cytokine production  (IDA,IMP)
negative regulation of NF-kappaB transcription factor activity  (IMP)
negative regulation of T cell mediated immunity  (IMP)
negative regulation of toll-like receptor 2 signaling pathway  (IMP)
negative regulation of tumor necrosis factor production  (IMP)
negative regulation of type II interferon production  (IMP)
NIK/NF-kappaB signaling  (IMP)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IMP,ISO)
pattern recognition receptor signaling pathway  (ISO)
peptidyl-tyrosine phosphorylation  (IMP)
phagocytosis  (IMP)
positive regulation of antibacterial peptide biosynthetic process  (IDA)
positive regulation of B cell activation  (ISO)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (IMP)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IDA,ISO)
positive regulation of innate immune response  (IDA,IMP)
positive regulation of interleukin-1 beta production  (IDA,ISO)
positive regulation of interleukin-10 production  (IMP)
positive regulation of interleukin-12 production  (IDA,IMP)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-6 production  (IC,IDA,IGI,IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,ISO)
positive regulation of macrophage cytokine production  (IDA,IGI,IMP)
positive regulation of MAP kinase activity  (IDA)
positive regulation of MAPK cascade  (IMP)
positive regulation of monocyte chemotactic protein-1 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of NIK/NF-kappaB signaling  (IMP,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IMP)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of oxidoreductase activity  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of phosphatidylinositol 3-kinase activity  (IMP)
positive regulation of prostaglandin-E synthase activity  (IDA)
positive regulation of prostaglandin-endoperoxide synthase activity  (IDA)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein ubiquitination  (IDA)
positive regulation of stress-activated MAPK cascade  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IDA,IGI,IMP,ISO)
positive regulation of type 2 immune response  (ISO)
positive regulation of xenophagy  (IMP)
regulation of apoptotic process  (IEA)
regulation of inflammatory response  (IMP)
regulation of neutrophil chemotaxis  (IMP)
response to exogenous dsRNA  (IMP)
response to lipopolysaccharide  (IMP)
response to muramyl dipeptide  (IBA,IDA,IMP,ISO)
response to nutrient  (ISO)
response to peptidoglycan  (IDA,IMP)
signal transduction  (TAS)
stress-activated MAPK cascade  (IDA)
toll-like receptor 2 signaling pathway  (IMP)
xenophagy  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal behavior  (IEA)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node morphology  (IEA)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal pancreas morphology  (IEA)
abnormal Peyer's patch morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal testis morphology  (IEA)
abnormal tumor necrosis factor level  (IAGP)
decreased anxiety-related response  (IEA)
decreased IgG level  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased thigmotaxis  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
enlarged lymph nodes  (IEA)
enlarged Peyer's patches  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-2 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased double-negative T cell number  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased Peyer's patch number  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans. Austin CM, etal., J Infect Dis. 2008 Jun 15;197(12):1713-6.
2. Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-¿B, MMP-9 and up-regulated claudin-5 expression. Bai X, etal., Neurochem Res. 2014 Aug;39(8):1405-15. doi: 10.1007/s11064-014-1326-y. Epub 2014 May 20.
3. NOD2/CARD15 gene mutations in patients with familial Mediterranean fever. Berkun Y, etal., Semin Arthritis Rheum. 2012 Aug;42(1):84-8. doi: 10.1016/j.semarthrit.2011.12.002. Epub 2012 Jan 12.
4. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. Berrington WR, etal., J Infect Dis. 2010 May 1;201(9):1422-35.
5. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Biswas A, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44. Epub 2010 Aug 2.
6. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. De Jager PL, etal., Genes Immun. 2006 Jun;7(4):327-34. Epub 2006 Apr 27.
7. Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. Duan W, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1284-93.e10. Epub 2010 Nov 4.
8. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. Dutra MS, etal., J Infect Dis. 2013 Jan 1;207(1):152-63. doi: 10.1093/infdis/jis640. Epub 2012 Oct 24.
9. Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. Enevold C, etal., Mult Scler. 2010 Aug;16(8):942-9. doi: 10.1177/1352458510373264. Epub 2010 Jul 1.
10. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Fernandez EM, etal., Gut. 2011 Aug;60(8):1050-9. Epub 2011 Apr 6.
11. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2.
12. Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats. Fujisawa M, etal., J Vet Med Sci. 2006 Jul;68(7):701-8.
13. Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case-control study. Galluzzo S, etal., Hum Immunol. 2011 Aug;72(8):636-40. Epub 2011 Apr 29.
14. Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
15. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
16. Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine. Hagiwara S, etal., Surg Today. 2010;40(2):137-45. Epub 2010 Jan 28.
17. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Hildebrandt GC, etal., Biol Blood Marrow Transplant. 2008 Jan;14(1):67-74.
18. Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients. Hnatyszyn A, etal., Exp Mol Pathol. 2010 Jun;88(3):388-93. Epub 2010 Mar 15.
19. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Holler E, etal., Blood. 2004 Aug 1;104(3):889-94. Epub 2004 Apr 15.
20. [The expression of NOD1 and NOD2 and the regulation of glucocorticoids on them in allergic rhinitis]. Hu S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Apr;27(8):393-6.
21. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Hugot JP, etal., Nature. 2001 May 31;411(6837):599-603.
22. Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations. Kabesch M, etal., J Allergy Clin Immunol. 2003 Apr;111(4):813-7.
23. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
24. Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia. Kapetanovic R, etal., Microbes Infect. 2010 Sep;12(10):759-67. Epub 2010 May 21.
25. Low prevalence of NOD2 SNPs in Behcet's disease suggests protective association in Caucasians. Kappen JH, etal., Rheumatology (Oxford). 2009 Nov;48(11):1375-7. doi: 10.1093/rheumatology/kep292. Epub 2009 Sep 11.
26. Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Kim YG, etal., Cell Host Microbe. 2011 Jun 16;9(6):496-507.
27. A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population. Kinose D, etal., Respirology. 2011 Sep 22. doi: 10.1111/j.1440-1843.2011.02069.x.
28. Prevalence of the NOD2 3020insC mutation in aggregations of breast and lung cancer. Lener MR, etal., Breast Cancer Res Treat. 2006 Jan;95(2):141-5.
29. Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Li H, etal., Eur J Pharmacol. 2010 Dec 15;649(1-3):92-9. Epub 2010 Sep 20.
30. Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis. Liu X, etal., BMC Infect Dis. 2014 Dec 2;14(1):648.
31. The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs. Lubinski J, etal., Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63.
32. Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians. Mahurkar S, etal., J Gastroenterol Hepatol. 2011 Apr;26(4):694-9. doi: 10.1111/j.1440-1746.2010.06533.x.
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. CARD15 mutations in Blau syndrome. Miceli-Richard C, etal., Nat Genet. 2001 Sep;29(1):19-20.
36. Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis. Okafuji I, etal., Arthritis Rheum. 2009 Jan;60(1):242-50. doi: 10.1002/art.24134.
37. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23.
40. Significance of mannose-binding lectin deficiency and nucleotide-binding oligomerization domain 2 polymorphisms in Staphylococcus aureus bloodstream infections: a case-control study. Osthoff M, etal., PLoS One. 2013 Sep 27;8(9):e76218. doi: 10.1371/journal.pone.0076218. eCollection 2013.
41. NOD2 polymorphisms in clinical phenotypes of common variable immunodeficiency disorders. Packwood K, etal., Clin Exp Immunol. 2010 Sep;161(3):536-41. doi: 10.1111/j.1365-2249.2010.04216.x.
42. Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-kappaB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture. Peng Z, etal., Int Immunopharmacol. 2012 Aug;13(4):440-5. doi: 10.1016/j.intimp.2012.04.006. Epub 2012 May 7.
43. Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance. Petnicki-Ocwieja T, etal., PLoS One. 2011 Feb 28;6(2):e17414.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Expression of NOD2 in a rat model of acute pancreatitis. Qian M, etal., Pancreas. 2010 Oct;39(7):1034-40.
47. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
48. Mouse MP Annotation Import Pipeline RGD automated import pipeline
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Richardson WM, etal., Gastroenterology. 2010 Sep;139(3):904-17, 917.e1-6. doi: 10.1053/j.gastro.2010.05.038. Epub 2010 May 24.
52. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Rivas MA, etal., Nat Genet. 2011 Oct 9. doi: 10.1038/ng.952.
53. NOD2-associated pediatric granulomatous arthritis, an expanding phenotype: study of an international registry and a national cohort in Spain. Rose CD, etal., Arthritis Rheum. 2009 Jun;60(6):1797-803. doi: 10.1002/art.24533.
54. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
55. Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Rosenzweig HL, etal., Inflamm Res. 2011 Jul;60(7):705-14. Epub 2011 Mar 20.
56. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Rosenzweig HL, etal., Invest Ophthalmol Vis Sci. 2011 Jun 9;52(7):4106-12. Print 2011 Jun.
57. CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis. Sato H, etal., Eur Respir J. 2010 Feb;35(2):324-30. Epub 2009 Aug 13.
58. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10.
59. [Study on protective mechanism of kushenin injection on colonic mucosa of experimental colitis rats]. Tang Q, etal., Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1814-7.
60. Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children. Tekin D, etal., Pediatr Crit Care Med. 2011 Mar 31.
61. Common Crohn's disease-predisposing variants of the CARD15/NOD2 gene are not associated with Behçet's disease in Turkey. Uyar FA, etal., Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S50-2.
62. A new CARD15 mutation in Blau syndrome. van Duist MM, etal., Eur J Hum Genet. 2005 Jun;13(6):742-7.
63. Single nucleotide polymorphisms in pathogen recognition receptor genes are associated with susceptibility to meningococcal meningitis in a pediatric cohort. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
64. Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults. Weidinger S, etal., Clin Exp Allergy. 2005 Jul;35(7):866-72.
65. [Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during early phase of acute intra-abdominal infection]. Xiao YT, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Sep;25(9):527-32. doi: 10.3760/cma.j.issn.2095-4352.2013.09.005.
66. A new category of autoinflammatory disease associated with NOD2 gene mutations. Yao Q, etal., Arthritis Res Ther. 2011;13(5):R148. doi: 10.1186/ar3462. Epub 2011 Sep 14.
67. Down-Regulated NOD2 by Immunosuppressants in Peripheral Blood Cells in Patients with SLE Reduces the Muramyl Dipeptide-Induced IL-10 Production. Yu SL, etal., PLoS One. 2011;6(8):e23855. Epub 2011 Aug 19.
68. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Yuan H, etal., Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5059-68. doi: 10.1073/pnas.1320862110. Epub 2013 Dec 9.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12527755   PMID:12676561   PMID:12835899   PMID:14560001   PMID:15220916   PMID:15489334   PMID:15585867  
PMID:15620648   PMID:15692051   PMID:15692052   PMID:15845503   PMID:15967716   PMID:16034140   PMID:16141072   PMID:16141073   PMID:16203728   PMID:16265673   PMID:16322770   PMID:16407890  
PMID:16492792   PMID:16585574   PMID:16949315   PMID:17056547   PMID:17187069   PMID:17277144   PMID:17356065   PMID:17397264   PMID:17403772   PMID:17433728   PMID:17562858   PMID:17565376  
PMID:17652449   PMID:17705131   PMID:17709422   PMID:17915219   PMID:17947236   PMID:17965022   PMID:18060048   PMID:18157816   PMID:18167348   PMID:18188453   PMID:18217947   PMID:18227809  
PMID:18261938   PMID:18299458   PMID:18322214   PMID:18329614   PMID:18385071   PMID:18495787   PMID:18511561   PMID:18574154   PMID:18648508   PMID:18714036   PMID:18768892   PMID:18803303  
PMID:18855982   PMID:18981137   PMID:18987631   PMID:19006696   PMID:19017983   PMID:19075245   PMID:19098321   PMID:19129483   PMID:19139201   PMID:19218085   PMID:19299732   PMID:19407112  
PMID:19473975   PMID:19541630   PMID:19581406   PMID:19604345   PMID:19608614   PMID:19620349   PMID:19620350   PMID:19652017   PMID:19701189   PMID:19728064   PMID:19737867   PMID:19759286  
PMID:19805227   PMID:19830732   PMID:19837677   PMID:19881508   PMID:19890047   PMID:19898471   PMID:20008287   PMID:20081863   PMID:20083500   PMID:20091781   PMID:20124104   PMID:20226841  
PMID:20308305   PMID:20348425   PMID:20360399   PMID:20404081   PMID:20479237   PMID:20534456   PMID:20679445   PMID:20696824   PMID:20884650   PMID:20949035   PMID:21088051   PMID:21097508  
PMID:21108472   PMID:21123652   PMID:21156799   PMID:21199260   PMID:21236705   PMID:21245149   PMID:21267068   PMID:21307291   PMID:21335489   PMID:21411292   PMID:21411735   PMID:21421666  
PMID:21561248   PMID:21565531   PMID:21622562   PMID:21665963   PMID:21683629   PMID:21715553   PMID:21762661   PMID:21841308   PMID:21841315   PMID:21849681   PMID:21856952   PMID:21868489  
PMID:21873635   PMID:21903945   PMID:22002196   PMID:22002608   PMID:22031762   PMID:22033934   PMID:22156592   PMID:22186610   PMID:22203860   PMID:22228081   PMID:22272321   PMID:22294690  
PMID:22323544   PMID:22395788   PMID:22491249   PMID:22520462   PMID:22590599   PMID:22607974   PMID:22615249   PMID:22684551   PMID:22750073   PMID:22808176   PMID:22848538   PMID:22851749  
PMID:22905357   PMID:22911706   PMID:22951952   PMID:23019338   PMID:23064150   PMID:23109427   PMID:23123061   PMID:23148704   PMID:23197261   PMID:23209417   PMID:23213202   PMID:23219392  
PMID:23259058   PMID:23281400   PMID:23334413   PMID:23396949   PMID:23525089   PMID:23526993   PMID:23594678   PMID:23630357   PMID:23675299   PMID:23684310   PMID:23712977   PMID:23818043  
PMID:23856489   PMID:23892723   PMID:23954160   PMID:23958879   PMID:23962873   PMID:23991106   PMID:24062413   PMID:24082103   PMID:24092752   PMID:24100018   PMID:24107312   PMID:24163408  
PMID:24211871   PMID:24298015   PMID:24324812   PMID:24356239   PMID:24366254   PMID:24384785   PMID:24453255   PMID:24560660   PMID:24586160   PMID:24591373   PMID:24620022   PMID:24625812  
PMID:24670424   PMID:24695226   PMID:24706750   PMID:24722226   PMID:24766550   PMID:24872587   PMID:24882705   PMID:24927559   PMID:25042478   PMID:25084278   PMID:25088769   PMID:25114103  
PMID:25125146   PMID:25141224   PMID:25204845   PMID:25218901   PMID:25254654   PMID:25255917   PMID:25423082   PMID:25429073   PMID:25499802   PMID:25578733   PMID:25607110   PMID:25643148  
PMID:25666722   PMID:25717000   PMID:25751305   PMID:25817335   PMID:25825396   PMID:25888259   PMID:25892960   PMID:26153766   PMID:26159289   PMID:26237551   PMID:26255090   PMID:26444420  
PMID:26546009   PMID:26673231   PMID:26744177   PMID:26754352   PMID:26874029   PMID:26939856   PMID:26989200   PMID:27007849   PMID:27064448   PMID:27080105   PMID:27206769   PMID:27225947  
PMID:27265209   PMID:27312104   PMID:27325889   PMID:27377650   PMID:27605548   PMID:27624090   PMID:27670879   PMID:27694635   PMID:27799160   PMID:27830463   PMID:27848951   PMID:27879260  
PMID:28004792   PMID:28087670   PMID:28105518   PMID:28330897   PMID:28373658   PMID:28410990   PMID:28434881   PMID:28442553   PMID:28450277   PMID:28520587   PMID:28576260   PMID:28580440  
PMID:28592385   PMID:28647345   PMID:28652394   PMID:28658623   PMID:28693414   PMID:28752081   PMID:28778866   PMID:28834747   PMID:28912259   PMID:29234083   PMID:29445379   PMID:29560100  
PMID:29734365   PMID:29980664   PMID:30012848   PMID:30026309   PMID:30041769   PMID:30150283   PMID:30157869   PMID:30221681   PMID:30250234   PMID:30405132   PMID:30559449   PMID:30651577  
PMID:30774010   PMID:30793522   PMID:30902986   PMID:31019287   PMID:31113864   PMID:31237655   PMID:31352002   PMID:31474163   PMID:31478196   PMID:31480799   PMID:31509436   PMID:31652348  
PMID:31760144   PMID:31784737   PMID:31919280   PMID:32101030   PMID:32167239   PMID:32209432   PMID:32289499   PMID:32350141   PMID:32353008   PMID:32473019   PMID:32487756   PMID:32516028  
PMID:32588196   PMID:32610078   PMID:32625209   PMID:32778560   PMID:32986710   PMID:33106495   PMID:33239685   PMID:33412104   PMID:33413510   PMID:33431850   PMID:33444291   PMID:33555306  
PMID:33670592   PMID:34186435   PMID:34613696   PMID:34748820   PMID:35418999   PMID:35420957   PMID:36002575   PMID:36189261  


Genomics

Comparative Map Data
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)EnsemblGRCm39 Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBIMGSCv36mm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381650,693,606 - 50,733,075 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1650,693,588 - 50,733,077 (+)EnsemblGRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36Build 36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
T2T-CHM13v2.01656,491,240 - 56,530,709 (+)NCBIT2T-CHM13v2.0
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,379,720 - 18,422,817 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1920,062,002 - 20,096,735 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01925,256,605 - 25,291,343 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01928,214,380 - 28,249,133 (-)NCBIRnor_WKY
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,182,339 - 65,212,649 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBIUU_Cfam_GSD_1.0
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364753,713,362 - 3,745,982 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247575,958,486 - 6,000,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1734
Count of miRNA genes:403
Interacting mature miRNAs:466
Transcripts:ENSMUST00000054324, ENSMUST00000109634, ENSMUST00000118370, ENSMUST00000124091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88079340489740987Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF520774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY160220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY160221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01040580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ289012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ289013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000054324   ⟹   ENSMUSP00000050538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109634   ⟹   ENSMUSP00000105262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,377,969 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,651,341 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118370   ⟹   ENSMUSP00000113773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,374,012 - 89,392,328 (+)Ensembl
GRCm38.p6 Ensembl888,647,384 - 88,665,700 (+)Ensembl
RefSeq Acc Id: NM_145857   ⟹   NP_665856
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,975 - 89,415,102 (+)NCBI
GRCm38888,647,347 - 88,688,474 (+)NCBI
MGSCv37891,171,246 - 91,212,373 (+)RGD
Celera892,927,621 - 92,968,882 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531028   ⟹   XP_006531091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,378,275 - 89,415,103 (+)NCBI
GRCm38888,651,647 - 88,688,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006531029   ⟹   XP_006531092
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,411,111 (+)NCBI
GRCm38888,647,315 - 88,684,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011248390   ⟹   XP_011246692
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,415,103 (+)NCBI
GRCm38888,647,315 - 88,688,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154050   ⟹   XP_036009943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,415,095 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154051   ⟹   XP_036009944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,397,122 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_665856 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531091 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531092 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246692 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009943 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH44774 (Get FASTA)   NCBI Sequence Viewer  
  AAM76073 (Get FASTA)   NCBI Sequence Viewer  
  AAN52477 (Get FASTA)   NCBI Sequence Viewer  
  AAN52478 (Get FASTA)   NCBI Sequence Viewer  
  AAN52480 (Get FASTA)   NCBI Sequence Viewer  
  AAN52481 (Get FASTA)   NCBI Sequence Viewer  
  AAN52482 (Get FASTA)   NCBI Sequence Viewer  
  AAN52483 (Get FASTA)   NCBI Sequence Viewer  
  AAN52484 (Get FASTA)   NCBI Sequence Viewer  
  AAN52934 (Get FASTA)   NCBI Sequence Viewer  
  AAN52935 (Get FASTA)   NCBI Sequence Viewer  
  AAN52936 (Get FASTA)   NCBI Sequence Viewer  
  AAN52937 (Get FASTA)   NCBI Sequence Viewer  
  AAN52939 (Get FASTA)   NCBI Sequence Viewer  
  AAN57787 (Get FASTA)   NCBI Sequence Viewer  
  AAN57788 (Get FASTA)   NCBI Sequence Viewer  
  AAN57789 (Get FASTA)   NCBI Sequence Viewer  
  AAN57790 (Get FASTA)   NCBI Sequence Viewer  
  AAN57791 (Get FASTA)   NCBI Sequence Viewer  
  AAN57792 (Get FASTA)   NCBI Sequence Viewer  
  AAN57793 (Get FASTA)   NCBI Sequence Viewer  
  AAN59991 (Get FASTA)   NCBI Sequence Viewer  
  AAN59992 (Get FASTA)   NCBI Sequence Viewer  
  AAN59993 (Get FASTA)   NCBI Sequence Viewer  
  AAN59994 (Get FASTA)   NCBI Sequence Viewer  
  AAN59995 (Get FASTA)   NCBI Sequence Viewer  
  AAN60733 (Get FASTA)   NCBI Sequence Viewer  
  AAN60734 (Get FASTA)   NCBI Sequence Viewer  
  AAN60735 (Get FASTA)   NCBI Sequence Viewer  
  AAN60736 (Get FASTA)   NCBI Sequence Viewer  
  AAN60737 (Get FASTA)   NCBI Sequence Viewer  
  AAN62467 (Get FASTA)   NCBI Sequence Viewer  
  AAN62468 (Get FASTA)   NCBI Sequence Viewer  
  AAN62469 (Get FASTA)   NCBI Sequence Viewer  
  AAN62470 (Get FASTA)   NCBI Sequence Viewer  
  AAN62471 (Get FASTA)   NCBI Sequence Viewer  
  AAN62472 (Get FASTA)   NCBI Sequence Viewer  
  AAN63034 (Get FASTA)   NCBI Sequence Viewer  
  AAN63035 (Get FASTA)   NCBI Sequence Viewer  
  AAN63036 (Get FASTA)   NCBI Sequence Viewer  
  AAN63037 (Get FASTA)   NCBI Sequence Viewer  
  AAN63038 (Get FASTA)   NCBI Sequence Viewer  
  AAN63039 (Get FASTA)   NCBI Sequence Viewer  
  AAN63040 (Get FASTA)   NCBI Sequence Viewer  
  AAN63041 (Get FASTA)   NCBI Sequence Viewer  
  AAN78329 (Get FASTA)   NCBI Sequence Viewer  
  AAN78330 (Get FASTA)   NCBI Sequence Viewer  
  AAN84594 (Get FASTA)   NCBI Sequence Viewer  
  ABC25455 (Get FASTA)   NCBI Sequence Viewer  
  ABC25456 (Get FASTA)   NCBI Sequence Viewer  
  BAE43397 (Get FASTA)   NCBI Sequence Viewer  
  BAE43401 (Get FASTA)   NCBI Sequence Viewer  
  EDL11059 (Get FASTA)   NCBI Sequence Viewer  
  Q8K3Z0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_665856   ⟸   NM_145857
- UniProtKB: Q80SY9 (UniProtKB/TrEMBL),   Q80SY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531092   ⟸   XM_006531029
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006531091   ⟸   XM_006531028
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011246692   ⟸   XM_011248390
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000113773   ⟸   ENSMUST00000118370
RefSeq Acc Id: ENSMUSP00000050538   ⟸   ENSMUST00000054324
RefSeq Acc Id: ENSMUSP00000105262   ⟸   ENSMUST00000109634
RefSeq Acc Id: XP_036009943   ⟸   XM_036154050
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036009944   ⟸   XM_036154051
- Peptide Label: isoform X4
- UniProtKB: Q3V2V8 (UniProtKB/TrEMBL)
Protein Domains
CARD   NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3Z0-F1-model_v2 AlphaFold Q8K3Z0 1-1020 view protein structure

Promoters
RGD ID:8667827
Promoter ID:EPDNEW_M11945
Type:multiple initiation site
Name:Nod2_1
Description:Mus musculus nucleotide-binding oligomerization domain containing2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38888,647,375 - 88,647,435EPDNEW
RGD ID:6843551
Promoter ID:MM_KWN:55216
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000118370,   OTTMUST00000074063,   UC009MRQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,170,901 - 91,171,401 (+)MPROMDB
RGD ID:6843555
Promoter ID:MM_KWN:55217
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000074062
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,174,531 - 91,175,031 (+)MPROMDB
RGD ID:6842914
Promoter ID:MM_KWN:55218
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC009MRS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,176,101 - 91,176,802 (+)MPROMDB
RGD ID:6848331
Promoter ID:MM_ACW:48386
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NOD2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,207,386 - 91,207,886 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2429397 AgrOrtholog
Ensembl Genes ENSMUSG00000055994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000050538 UniProtKB/Swiss-Prot
  ENSMUSP00000105262 UniProtKB/Swiss-Prot
  ENSMUSP00000113773 ENTREZGENE
  ENSMUSP00000113773.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000054324 UniProtKB/Swiss-Prot
  ENSMUST00000109634 UniProtKB/Swiss-Prot
  ENSMUST00000118370 ENTREZGENE
  ENSMUST00000118370.8 UniProtKB/TrEMBL
  ENSMUST00000124091 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNase_TatD-rel_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:257632 UniProtKB/TrEMBL
MGD MGI:2429397 ENTREZGENE
NCBI Gene 257632 ENTREZGENE
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CARD15 RGD
PhenoGen Nod2 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TATD_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NOD2_MOUSE UniProtKB/Swiss-Prot
  Q2PZA2_MOUSE UniProtKB/TrEMBL
  Q2PZA3_MOUSE UniProtKB/TrEMBL
  Q3V2V4_MOUSE UniProtKB/TrEMBL
  Q3V2V8 ENTREZGENE, UniProtKB/TrEMBL
  Q80SS7_MOUSE UniProtKB/TrEMBL
  Q80SV8_MOUSE UniProtKB/TrEMBL
  Q80SY7_MOUSE UniProtKB/TrEMBL
  Q80SY8 ENTREZGENE
  Q80SY9 ENTREZGENE, UniProtKB/TrEMBL
  Q80UH1_MOUSE UniProtKB/TrEMBL
  Q80UH3_MOUSE UniProtKB/TrEMBL
  Q80UH4_MOUSE UniProtKB/TrEMBL
  Q8K3Z0 ENTREZGENE