Nod2 (nucleotide-binding oligomerization domain containing 2) - Rat Genome Database

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Gene: Nod2 (nucleotide-binding oligomerization domain containing 2) Mus musculus
Analyze
Symbol: Nod2
Name: nucleotide-binding oligomerization domain containing 2
RGD ID: 1314946
MGI Page MGI
Description: Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2); PARTICIPATES IN NOD-like receptor signaling pathway; nuclear factor kappa B signaling pathway; tuberculosis pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; benzo[a]pyrene; buta-1,3-diene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ACUG; BLAU; Card; Card15; caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15; CD; F830032C23Rik; IBD1; Nl; Nlrc2; nucleotide-binding oligomerization domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBImm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
Acute Lung Injury  (ISO)
allergic rhinitis  (ISO)
asthma  (IDA,ISO)
atherosclerosis  (IMP)
autoimmune disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (IMP)
bacterial pneumonia  (IMP)
Behcet's disease  (ISO)
Blau syndrome  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IMP,ISO)
Colonic Neoplasms  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
dermatitis  (ISO)
Experimental Arthritis  (IMP)
Experimental Colitis  (ISO)
familial Mediterranean fever  (ISO)
gastritis  (ISO)
gastrointestinal carcinoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (ISO)
Granuloma  (IMP)
hidradenitis suppurativa  (ISO)
inflammatory bowel disease  (ISO)
inflammatory bowel disease 1  (IEA,ISO,ISS)
intestinal disease  (ISO)
larynx cancer  (ISO)
Legionnaires' disease  (IMP)
leprosy  (ISO)
lung cancer  (ISO)
Lyme disease  (IMP)
meningococcal meningitis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
Ocular Toxoplasmosis  (ISO)
ovarian cancer  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (IMP)
PFAPA Syndrome  (ISO)
Pneumococcal Meningitis  (IEP)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyoderma gangrenosum  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Splenomegaly  (ISO)
Staphylococcal Pneumonia  (IMP)
systemic lupus erythematosus  (ISO)
transient cerebral ischemia  (IEP)
ulcerative colitis  (ISO)
uveitis  (IMP)
YAO SYNDROME  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of immune response  (IMP)
cellular response to lipopolysaccharide  (ISO)
cellular response to muramyl dipeptide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to peptidoglycan  (IMP,ISO)
defense response  (TAS)
defense response to bacterium  (IBA,ISO)
defense response to Gram-positive bacterium  (IGI,IMP)
detection of bacterium  (ISO)
detection of biotic stimulus  (TAS)
detection of muramyl dipeptide  (ISO)
immune system process  (IEA)
inflammatory response  (TAS)
innate immune response  (ISO)
innate immune response in mucosa  (IMP)
intracellular signal transduction  (IBA,ISO)
maintenance of gastrointestinal epithelium  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (IMP)
negative regulation of interferon-gamma production  (IMP)
negative regulation of interleukin-12 production  (IDA,IMP)
negative regulation of interleukin-18 production  (IMP)
negative regulation of interleukin-2 production  (IMP)
negative regulation of macrophage apoptotic process  (IDA)
negative regulation of NF-kappaB transcription factor activity  (IMP)
negative regulation of T cell mediated immunity  (IMP)
negative regulation of toll-like receptor 2 signaling pathway  (IMP)
negative regulation of tumor necrosis factor production  (IMP)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IMP,ISO)
pattern recognition receptor signaling pathway  (ISO)
positive regulation of antibacterial peptide biosynthetic process  (IDA)
positive regulation of B cell activation  (ISO)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (IMP)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP)
positive regulation of humoral immune response mediated by circulating immunoglobulin  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IDA,ISO)
positive regulation of innate immune response  (IDA,IMP)
positive regulation of interleukin-1 beta production  (IDA,ISO)
positive regulation of interleukin-10 production  (IMP)
positive regulation of interleukin-12 production  (IDA,IMP)
positive regulation of interleukin-17 production  (ISO)
positive regulation of interleukin-6 production  (IDA,IGI,IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (IDA,ISO)
positive regulation of MAP kinase activity  (IDA)
positive regulation of MAPK cascade  (IMP)
positive regulation of monocyte chemotactic protein-1 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO)
positive regulation of NIK/NF-kappaB signaling  (IMP,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IMP)
positive regulation of Notch signaling pathway  (IDA)
positive regulation of oxidoreductase activity  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phagocytosis  (IMP)
positive regulation of phosphatidylinositol 3-kinase activity  (IMP)
positive regulation of prostaglandin-E synthase activity  (IDA)
positive regulation of prostaglandin-endoperoxide synthase activity  (IDA)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein ubiquitination  (IDA)
positive regulation of stress-activated MAPK cascade  (IDA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IDA,IGI,IMP,ISO)
positive regulation of type 2 immune response  (ISO)
positive regulation of xenophagy  (IMP)
regulation of apoptotic process  (IEA)
regulation of inflammatory response  (IMP)
regulation of neutrophil chemotaxis  (IMP)
response to exogenous dsRNA  (IMP)
response to lipopolysaccharide  (IMP)
response to muramyl dipeptide  (IBA,IDA,IMP,ISO)
response to nutrient  (ISO)
response to peptidoglycan  (IDA,IMP)
signal transduction  (TAS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymph node morphology  (IEA)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal pancreas morphology  (IEA)
abnormal Peyer's patch morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal testis morphology  (IEA)
abnormal tumor necrosis factor level  (IAGP)
decreased bone mineral density  (IEA)
decreased circulating cholesterol level  (IEA)
decreased IgG level  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged lymph nodes  (IEA)
enlarged Peyer's patches  (IAGP)
hyperactivity  (IEA)
impaired macrophage phagocytosis  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-2 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased double-negative T cell number  (IAGP)
increased exploration in new environment  (IEA)
increased interleukin-1 beta secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased Peyer's patch number  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IAGP)
weight loss  (IAGP)
References

References - curated
1. Austin CM, etal., J Infect Dis. 2008 Jun 15;197(12):1713-6.
2. Bai X, etal., Neurochem Res. 2014 Aug;39(8):1405-15. doi: 10.1007/s11064-014-1326-y. Epub 2014 May 20.
3. Berkun Y, etal., Semin Arthritis Rheum. 2012 Aug;42(1):84-8. doi: 10.1016/j.semarthrit.2011.12.002. Epub 2012 Jan 12.
4. Berrington WR, etal., J Infect Dis. 2010 May 1;201(9):1422-35.
5. Biswas A, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44. Epub 2010 Aug 2.
6. De Jager PL, etal., Genes Immun. 2006 Jun;7(4):327-34. Epub 2006 Apr 27.
7. Duan W, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1284-93.e10. Epub 2010 Nov 4.
8. Dutra MS, etal., J Infect Dis. 2013 Jan 1;207(1):152-63. doi: 10.1093/infdis/jis640. Epub 2012 Oct 24.
9. Enevold C, etal., Mult Scler. 2010 Aug;16(8):942-9. doi: 10.1177/1352458510373264. Epub 2010 Jul 1.
10. Fernandez EM, etal., Gut. 2011 Aug;60(8):1050-9. Epub 2011 Apr 6.
11. Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2.
12. Fujisawa M, etal., J Vet Med Sci. 2006 Jul;68(7):701-8.
13. Galluzzo S, etal., Hum Immunol. 2011 Aug;72(8):636-40. Epub 2011 Apr 29.
14. Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4.
15. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
16. Hagiwara S, etal., Surg Today. 2010;40(2):137-45. Epub 2010 Jan 28.
17. Hildebrandt GC, etal., Biol Blood Marrow Transplant. 2008 Jan;14(1):67-74.
18. Hnatyszyn A, etal., Exp Mol Pathol. 2010 Jun;88(3):388-93. Epub 2010 Mar 15.
19. Holler E, etal., Blood. 2004 Aug 1;104(3):889-94. Epub 2004 Apr 15.
20. Hu S, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Apr;27(8):393-6.
21. Hugot JP, etal., Nature. 2001 May 31;411(6837):599-603.
22. Kabesch M, etal., J Allergy Clin Immunol. 2003 Apr;111(4):813-7.
23. Kapetanovic R, etal., Microbes Infect. 2010 Sep;12(10):759-67. Epub 2010 May 21.
24. Kappen JH, etal., Rheumatology (Oxford). 2009 Nov;48(11):1375-7. doi: 10.1093/rheumatology/kep292. Epub 2009 Sep 11.
25. Kim YG, etal., Cell Host Microbe. 2011 Jun 16;9(6):496-507.
26. Kinose D, etal., Respirology. 2011 Sep 22. doi: 10.1111/j.1440-1843.2011.02069.x.
27. Lener MR, etal., Breast Cancer Res Treat. 2006 Jan;95(2):141-5.
28. Li H, etal., Eur J Pharmacol. 2010 Dec 15;649(1-3):92-9. Epub 2010 Sep 20.
29. Liu X, etal., BMC Infect Dis. 2014 Dec 2;14(1):648.
30. Lubinski J, etal., Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63.
31. Mahurkar S, etal., J Gastroenterol Hepatol. 2011 Apr;26(4):694-9. doi: 10.1111/j.1440-1746.2010.06533.x.
32. MGD data from the GO Consortium
33. MGD IEA
34. Miceli-Richard C, etal., Nat Genet. 2001 Sep;29(1):19-20.
35. Okafuji I, etal., Arthritis Rheum. 2009 Jan;60(1):242-50. doi: 10.1002/art.24134.
36. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
37. OMIM Disease Annotation Pipeline
38. Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23.
39. Osthoff M, etal., PLoS One. 2013 Sep 27;8(9):e76218. doi: 10.1371/journal.pone.0076218. eCollection 2013.
40. Packwood K, etal., Clin Exp Immunol. 2010 Sep;161(3):536-41. doi: 10.1111/j.1365-2249.2010.04216.x.
41. Peng Z, etal., Int Immunopharmacol. 2012 Aug;13(4):440-5. doi: 10.1016/j.intimp.2012.04.006. Epub 2012 May 7.
42. Petnicki-Ocwieja T, etal., PLoS One. 2011 Feb 28;6(2):e17414.
43. Pipeline to import KEGG annotations from KEGG into RGD
44. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. Qian M, etal., Pancreas. 2010 Oct;39(7):1034-40.
46. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
47. RGD automated import pipeline
48. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. RGD automated import pipeline for gene-chemical interactions
50. Richardson WM, etal., Gastroenterology. 2010 Sep;139(3):904-17, 917.e1-6. doi: 10.1053/j.gastro.2010.05.038. Epub 2010 May 24.
51. Rivas MA, etal., Nat Genet. 2011 Oct 9. doi: 10.1038/ng.952.
52. Rose CD, etal., Arthritis Rheum. 2009 Jun;60(6):1797-803. doi: 10.1002/art.24533.
53. Rosenzweig HL, etal., Arthritis Rheum. 2010 Apr;62(4):1051-9. doi: 10.1002/art.27335.
54. Rosenzweig HL, etal., Inflamm Res. 2011 Jul;60(7):705-14. Epub 2011 Mar 20.
55. Rosenzweig HL, etal., Invest Ophthalmol Vis Sci. 2011 Jun 9;52(7):4106-12. Print 2011 Jun.
56. Sato H, etal., Eur Respir J. 2010 Feb;35(2):324-30. Epub 2009 Aug 13.
57. Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10.
58. Tang Q, etal., Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1814-7.
59. Tekin D, etal., Pediatr Crit Care Med. 2011 Mar 31.
60. Uyar FA, etal., Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S50-2.
61. van Duist MM, etal., Eur J Hum Genet. 2005 Jun;13(6):742-7.
62. van Well GT, etal., PLoS One. 2013 May 14;8(5):e64252. doi: 10.1371/journal.pone.0064252. Print 2013.
63. Weidinger S, etal., Clin Exp Allergy. 2005 Jul;35(7):866-72.
64. Xiao YT, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Sep;25(9):527-32. doi: 10.3760/cma.j.issn.2095-4352.2013.09.005.
65. Yao Q, etal., Arthritis Res Ther. 2011;13(5):R148. doi: 10.1186/ar3462. Epub 2011 Sep 14.
66. Yu SL, etal., PLoS One. 2011;6(8):e23855. Epub 2011 Aug 19.
67. Yuan H, etal., Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5059-68. doi: 10.1073/pnas.1320862110. Epub 2013 Dec 9.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12527755   PMID:12676561   PMID:12835899   PMID:14560001   PMID:15220916   PMID:15489334   PMID:15585867  
PMID:15620648   PMID:15692051   PMID:15692052   PMID:15845503   PMID:15967716   PMID:16034140   PMID:16141072   PMID:16141073   PMID:16203728   PMID:16265673   PMID:16322770   PMID:16407890  
PMID:16492792   PMID:16585574   PMID:16949315   PMID:17056547   PMID:17187069   PMID:17277144   PMID:17356065   PMID:17397264   PMID:17403772   PMID:17433728   PMID:17562858   PMID:17565376  
PMID:17652449   PMID:17705131   PMID:17709422   PMID:17915219   PMID:17947236   PMID:17965022   PMID:18060048   PMID:18157816   PMID:18167348   PMID:18188453   PMID:18217947   PMID:18227809  
PMID:18261938   PMID:18299458   PMID:18322214   PMID:18329614   PMID:18385071   PMID:18495787   PMID:18511561   PMID:18574154   PMID:18648508   PMID:18714036   PMID:18768892   PMID:18803303  
PMID:18855982   PMID:18981137   PMID:18987631   PMID:19006696   PMID:19017983   PMID:19075245   PMID:19098321   PMID:19129483   PMID:19139201   PMID:19218085   PMID:19299732   PMID:19407112  
PMID:19473975   PMID:19541630   PMID:19581406   PMID:19604345   PMID:19608614   PMID:19620349   PMID:19620350   PMID:19652017   PMID:19701189   PMID:19728064   PMID:19737867   PMID:19759286  
PMID:19805227   PMID:19830732   PMID:19837677   PMID:19881508   PMID:19890047   PMID:19898471   PMID:20008287   PMID:20081863   PMID:20083500   PMID:20091781   PMID:20124104   PMID:20226841  
PMID:20308305   PMID:20348425   PMID:20360399   PMID:20404081   PMID:20479237   PMID:20534456   PMID:20679445   PMID:20696824   PMID:20884650   PMID:20949035   PMID:21088051   PMID:21097508  
PMID:21108472   PMID:21123652   PMID:21156799   PMID:21199260   PMID:21236705   PMID:21245149   PMID:21267068   PMID:21307291   PMID:21335489   PMID:21411292   PMID:21411735   PMID:21421666  
PMID:21561248   PMID:21565531   PMID:21622562   PMID:21665963   PMID:21683629   PMID:21715553   PMID:21762661   PMID:21841308   PMID:21841315   PMID:21849681   PMID:21856952   PMID:21868489  
PMID:21873635   PMID:21903945   PMID:22002196   PMID:22002608   PMID:22031762   PMID:22033934   PMID:22156592   PMID:22186610   PMID:22203860   PMID:22228081   PMID:22272321   PMID:22294690  
PMID:22323544   PMID:22395788   PMID:22491249   PMID:22520462   PMID:22590599   PMID:22607974   PMID:22615249   PMID:22684551   PMID:22750073   PMID:22808176   PMID:22848538   PMID:22851749  
PMID:22905357   PMID:22911706   PMID:22951952   PMID:23019338   PMID:23064150   PMID:23109427   PMID:23123061   PMID:23148704   PMID:23197261   PMID:23209417   PMID:23213202   PMID:23219392  
PMID:23259058   PMID:23281400   PMID:23334413   PMID:23396949   PMID:23525089   PMID:23526993   PMID:23594678   PMID:23630357   PMID:23675299   PMID:23712977   PMID:23818043   PMID:23856489  
PMID:23892723   PMID:23954160   PMID:23958879   PMID:23962873   PMID:23991106   PMID:24062413   PMID:24082103   PMID:24092752   PMID:24100018   PMID:24107312   PMID:24163408   PMID:24211871  
PMID:24298015   PMID:24324812   PMID:24356239   PMID:24366254   PMID:24384785   PMID:24453255   PMID:24560660   PMID:24586160   PMID:24591373   PMID:24620022   PMID:24625812   PMID:24670424  
PMID:24695226   PMID:24706750   PMID:24722226   PMID:24766550   PMID:24872587   PMID:24882705   PMID:24927559   PMID:25042478   PMID:25084278   PMID:25088769   PMID:25114103   PMID:25125146  
PMID:25141224   PMID:25204845   PMID:25218901   PMID:25254654   PMID:25255917   PMID:25423082   PMID:25429073   PMID:25499802   PMID:25578733   PMID:25643148   PMID:25666722   PMID:25717000  
PMID:25751305   PMID:25817335   PMID:25825396   PMID:25888259   PMID:25892960   PMID:26153766   PMID:26159289   PMID:26237551   PMID:26255090   PMID:26444420   PMID:26546009   PMID:26673231  
PMID:26744177   PMID:26754352   PMID:26874029   PMID:26939856   PMID:26989200   PMID:27007849   PMID:27064448   PMID:27080105   PMID:27206769   PMID:27225947   PMID:27265209   PMID:27312104  
PMID:27325889   PMID:27377650   PMID:27605548   PMID:27624090   PMID:27670879   PMID:27694635   PMID:27799160   PMID:27830463   PMID:27848951   PMID:27879260   PMID:28004792   PMID:28087670  
PMID:28105518   PMID:28330897   PMID:28373658   PMID:28410990   PMID:28434881   PMID:28442553   PMID:28450277   PMID:28520587   PMID:28576260   PMID:28580440   PMID:28592385   PMID:28647345  
PMID:28652394   PMID:28658623   PMID:28693414   PMID:28752081   PMID:28778866   PMID:28834747   PMID:28912259   PMID:29234083   PMID:29445379   PMID:29560100   PMID:29734365   PMID:29980664  
PMID:30012848   PMID:30026309   PMID:30041769   PMID:30150283   PMID:30157869   PMID:30221681   PMID:30250234   PMID:30405132   PMID:30559449   PMID:30651577   PMID:30774010   PMID:30793522  
PMID:30902986   PMID:31019287   PMID:31237655   PMID:31352002   PMID:31474163   PMID:31478196   PMID:31480799   PMID:31509436   PMID:31652348   PMID:31760144   PMID:31784737   PMID:31919280  
PMID:32101030   PMID:32167239   PMID:32289499   PMID:32350141   PMID:32473019   PMID:32487756   PMID:32516028   PMID:32610078   PMID:32778560   PMID:32986710   PMID:33106495   PMID:33239685  
PMID:33413510   PMID:33431850   PMID:33670592  


Genomics

Comparative Map Data
Nod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39889,373,943 - 89,415,103 (+)NCBIGRCm39mm39
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38888,647,315 - 88,688,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37891,171,246 - 91,212,373 (+)NCBIGRCm37mm9NCBIm37
MGSCv36891,537,452 - 91,578,579 (+)NCBImm8
Celera892,927,621 - 92,968,882 (+)NCBICelera
Cytogenetic Map8C3NCBI
NOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1650,693,588 - 50,734,041 (+)EnsemblGRCh38hg38GRCh38
GRCh381650,693,587 - 50,733,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371650,727,517 - 50,766,986 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361649,288,551 - 49,324,488 (+)NCBINCBI36hg18NCBI36
Build 341649,288,550 - 49,324,488NCBI
Celera1635,246,377 - 35,282,313 (+)NCBI
Cytogenetic Map16q12.1NCBI
HuRef1636,618,016 - 36,653,950 (+)NCBIHuRef
CHM1_11652,138,579 - 52,174,513 (+)NCBICHM1_1
Nod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21918,379,720 - 18,422,817 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1918,382,439 - 18,417,177 (-)Ensembl
Rnor_6.01919,342,061 - 19,389,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1919,332,594 - 19,377,492 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01930,375,065 - 30,409,527 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41919,662,337 - 19,697,341 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11919,670,606 - 19,715,845 (-)NCBI
Celera1918,269,940 - 18,304,004 (-)NCBICelera
Cytogenetic Map19p11NCBI
Nod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554338,746,004 - 8,782,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554338,746,213 - 8,780,119 (+)NCBIChiLan1.0ChiLan1.0
NOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11649,834,385 - 49,873,783 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1649,837,891 - 49,873,773 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01630,955,976 - 30,995,451 (+)NCBIMhudiblu_PPA_v0panPan3
NOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,636,850 - 64,667,232 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl264,635,519 - 64,667,232 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,209,788 - 61,240,085 (-)NCBI
ROS_Cfam_1.0265,182,339 - 65,218,538 (-)NCBI
UMICH_Zoey_3.1262,006,039 - 62,036,328 (-)NCBI
UNSW_CanFamBas_1.0263,025,931 - 63,056,292 (-)NCBI
UU_Cfam_GSD_1.0263,913,478 - 63,943,824 (-)NCBI
Nod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934955,844,066 - 55,881,006 (-)NCBI
SpeTri2.0NW_0049364753,708,069 - 3,742,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl634,130,938 - 34,177,534 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1634,132,127 - 34,167,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1536,492,158 - 36,531,766 (+)NCBI
ChlSab1.1 Ensembl536,496,414 - 36,530,499 (+)Ensembl
Vero_WHO_p1.0NW_02366604739,970,704 - 40,009,792 (-)NCBI
Nod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247575,956,873 - 6,000,052 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1734
Count of miRNA genes:403
Interacting mature miRNAs:466
Transcripts:ENSMUST00000054324, ENSMUST00000109634, ENSMUST00000118370, ENSMUST00000124091
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011248390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF520774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH012203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY160220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY160221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01040580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ289012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ289013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000054324   ⟹   ENSMUSP00000050538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109634   ⟹   ENSMUSP00000105262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,377,969 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,651,341 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118370   ⟹   ENSMUSP00000113773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,373,943 - 89,415,102 (+)Ensembl
GRCm38.p6 Ensembl888,647,315 - 88,688,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl889,374,012 - 89,392,328 (+)Ensembl
GRCm38.p6 Ensembl888,647,384 - 88,665,700 (+)Ensembl
RefSeq Acc Id: NM_145857   ⟹   NP_665856
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,975 - 89,415,102 (+)NCBI
GRCm38888,647,347 - 88,688,474 (+)NCBI
MGSCv37891,171,246 - 91,212,373 (+)RGD
Celera892,927,621 - 92,968,882 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531028   ⟹   XP_006531091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,378,275 - 89,415,103 (+)NCBI
GRCm38888,651,647 - 88,688,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006531029   ⟹   XP_006531092
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,411,111 (+)NCBI
GRCm38888,647,315 - 88,684,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011248390   ⟹   XP_011246692
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,415,103 (+)NCBI
GRCm38888,647,315 - 88,688,472 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154050   ⟹   XP_036009943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,415,095 (+)NCBI
RefSeq Acc Id: XM_036154051   ⟹   XP_036009944
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39889,373,943 - 89,397,122 (+)NCBI
Protein Sequences
Protein RefSeqs NP_665856 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531091 (Get FASTA)   NCBI Sequence Viewer  
  XP_006531092 (Get FASTA)   NCBI Sequence Viewer  
  XP_011246692 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009943 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009944 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH44774 (Get FASTA)   NCBI Sequence Viewer  
  AAM76073 (Get FASTA)   NCBI Sequence Viewer  
  AAN52477 (Get FASTA)   NCBI Sequence Viewer  
  AAN52478 (Get FASTA)   NCBI Sequence Viewer  
  AAN52480 (Get FASTA)   NCBI Sequence Viewer  
  AAN52481 (Get FASTA)   NCBI Sequence Viewer  
  AAN52482 (Get FASTA)   NCBI Sequence Viewer  
  AAN52483 (Get FASTA)   NCBI Sequence Viewer  
  AAN52484 (Get FASTA)   NCBI Sequence Viewer  
  AAN52934 (Get FASTA)   NCBI Sequence Viewer  
  AAN52935 (Get FASTA)   NCBI Sequence Viewer  
  AAN52936 (Get FASTA)   NCBI Sequence Viewer  
  AAN52937 (Get FASTA)   NCBI Sequence Viewer  
  AAN52939 (Get FASTA)   NCBI Sequence Viewer  
  AAN57787 (Get FASTA)   NCBI Sequence Viewer  
  AAN57788 (Get FASTA)   NCBI Sequence Viewer  
  AAN57789 (Get FASTA)   NCBI Sequence Viewer  
  AAN57790 (Get FASTA)   NCBI Sequence Viewer  
  AAN57791 (Get FASTA)   NCBI Sequence Viewer  
  AAN57792 (Get FASTA)   NCBI Sequence Viewer  
  AAN57793 (Get FASTA)   NCBI Sequence Viewer  
  AAN59991 (Get FASTA)   NCBI Sequence Viewer  
  AAN59992 (Get FASTA)   NCBI Sequence Viewer  
  AAN59993 (Get FASTA)   NCBI Sequence Viewer  
  AAN59994 (Get FASTA)   NCBI Sequence Viewer  
  AAN59995 (Get FASTA)   NCBI Sequence Viewer  
  AAN60733 (Get FASTA)   NCBI Sequence Viewer  
  AAN60734 (Get FASTA)   NCBI Sequence Viewer  
  AAN60735 (Get FASTA)   NCBI Sequence Viewer  
  AAN60736 (Get FASTA)   NCBI Sequence Viewer  
  AAN60737 (Get FASTA)   NCBI Sequence Viewer  
  AAN62467 (Get FASTA)   NCBI Sequence Viewer  
  AAN62468 (Get FASTA)   NCBI Sequence Viewer  
  AAN62469 (Get FASTA)   NCBI Sequence Viewer  
  AAN62470 (Get FASTA)   NCBI Sequence Viewer  
  AAN62471 (Get FASTA)   NCBI Sequence Viewer  
  AAN62472 (Get FASTA)   NCBI Sequence Viewer  
  AAN63034 (Get FASTA)   NCBI Sequence Viewer  
  AAN63035 (Get FASTA)   NCBI Sequence Viewer  
  AAN63036 (Get FASTA)   NCBI Sequence Viewer  
  AAN63037 (Get FASTA)   NCBI Sequence Viewer  
  AAN63038 (Get FASTA)   NCBI Sequence Viewer  
  AAN63039 (Get FASTA)   NCBI Sequence Viewer  
  AAN63040 (Get FASTA)   NCBI Sequence Viewer  
  AAN63041 (Get FASTA)   NCBI Sequence Viewer  
  AAN78329 (Get FASTA)   NCBI Sequence Viewer  
  AAN78330 (Get FASTA)   NCBI Sequence Viewer  
  AAN84594 (Get FASTA)   NCBI Sequence Viewer  
  ABC25455 (Get FASTA)   NCBI Sequence Viewer  
  ABC25456 (Get FASTA)   NCBI Sequence Viewer  
  BAE43397 (Get FASTA)   NCBI Sequence Viewer  
  BAE43401 (Get FASTA)   NCBI Sequence Viewer  
  EDL11059 (Get FASTA)   NCBI Sequence Viewer  
  Q8K3Z0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_665856   ⟸   NM_145857
- UniProtKB: Q80SY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531092   ⟸   XM_006531029
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006531091   ⟸   XM_006531028
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011246692   ⟸   XM_011248390
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000113773   ⟸   ENSMUST00000118370
RefSeq Acc Id: ENSMUSP00000050538   ⟸   ENSMUST00000054324
RefSeq Acc Id: ENSMUSP00000105262   ⟸   ENSMUST00000109634
RefSeq Acc Id: XP_036009943   ⟸   XM_036154050
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036009944   ⟸   XM_036154051
- Peptide Label: isoform X4
Protein Domains
CARD   NACHT

Promoters
RGD ID:8667827
Promoter ID:EPDNEW_M11945
Type:multiple initiation site
Name:Nod2_1
Description:Mus musculus nucleotide-binding oligomerization domain containing2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38888,647,375 - 88,647,435EPDNEW
RGD ID:6843551
Promoter ID:MM_KWN:55216
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000118370,   OTTMUST00000074063,   UC009MRQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,170,901 - 91,171,401 (+)MPROMDB
RGD ID:6843555
Promoter ID:MM_KWN:55217
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000074062
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,174,531 - 91,175,031 (+)MPROMDB
RGD ID:6842914
Promoter ID:MM_KWN:55218
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC009MRS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,176,101 - 91,176,802 (+)MPROMDB
RGD ID:6848331
Promoter ID:MM_ACW:48386
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NOD2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36891,207,386 - 91,207,886 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2429397 AgrOrtholog
Ensembl Genes ENSMUSG00000055994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000050538 UniProtKB/Swiss-Prot
  ENSMUSP00000105262 UniProtKB/Swiss-Prot
  ENSMUSP00000113773 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000054324 UniProtKB/Swiss-Prot
  ENSMUST00000109634 UniProtKB/Swiss-Prot
  ENSMUST00000118370 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000124091 ENTREZGENE
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNase_TatD-rel_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:257632 UniProtKB/TrEMBL
MGD MGI:2429397 ENTREZGENE
NCBI Gene 257632 ENTREZGENE
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CARD15 RGD
PhenoGen Nod2 PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TATD_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NOD2_MOUSE UniProtKB/Swiss-Prot
  Q2PZA2_MOUSE UniProtKB/TrEMBL
  Q2PZA3_MOUSE UniProtKB/TrEMBL
  Q3V2V4_MOUSE UniProtKB/TrEMBL
  Q3V2V8_MOUSE UniProtKB/TrEMBL
  Q80SS7_MOUSE UniProtKB/TrEMBL
  Q80SV8_MOUSE UniProtKB/TrEMBL
  Q80SY7_MOUSE UniProtKB/TrEMBL
  Q80SY9 ENTREZGENE, UniProtKB/TrEMBL
  Q80UH1_MOUSE UniProtKB/TrEMBL
  Q80UH3_MOUSE UniProtKB/TrEMBL
  Q80UH4_MOUSE UniProtKB/TrEMBL
  Q8K3Z0 ENTREZGENE