Muc1 (mucin 1, transmembrane) - Rat Genome Database

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Gene: Muc1 (mucin 1, transmembrane) Mus musculus
Analyze
Symbol: Muc1
Name: mucin 1, transmembrane
RGD ID: 10927
MGI Page MGI
Description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of DNA-templated transcription. Located in apical plasma membrane and cell surface. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD227; EM; EMA; episialin; Muc-1; mucin-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,136,363 - 89,140,688 (+)NCBIGRCm39mm39
GRCm39 Ensembl389,136,364 - 89,140,688 (+)Ensembl
GRCm38389,229,056 - 89,233,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,229,057 - 89,233,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,032,974 - 89,037,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,314,979 - 89,319,296 (+)NCBImm8
Celera389,262,943 - 89,267,242 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult respiratory distress syndrome  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 2  (ISO)
bacterial conjunctivitis  (IMP)
biliary tract benign neoplasm  (ISO)
bird fancier's lung  (ISO)
blepharitis  (IMP)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
common bile duct neoplasm  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Diabetes Complications  (ISO)
dry eye syndrome  (ISO)
dyschromatosis symmetrica hereditaria  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO)
heart disease  (ISO)
Hematologic Neoplasms  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunodeficiency 42  (ISO)
interstitial lung disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
malignant mesothelioma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
measles  (ISO)
Mesothelioma  (ISO)
MHC class II deficiency  (ISO)
mucinous adenocarcinoma  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Peritoneal Neoplasms  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
pulmonary sarcoidosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
severe congenital neutropenia 5  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
urinary bladder cancer  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
boric acids  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
calcitriol  (ISO)
ceric oxide  (ISO)
chitin  (ISO)
chloroquine  (ISO)
chlorothalonil  (EXP)
choline  (EXP)
cisplatin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enilconazole  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
hydralazine  (ISO)
indole-3-methanol  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
mifepristone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (EXP,ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vandetanib  (ISO)
vinclozolin  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease. Al-Salmi QA, etal., Chest. 2005 Jan;127(1):403-7.
2. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
3. Circulating levels of KL-6 in acute respiratory distress syndrome sepsis or traumatic brain injury in critically ill children. Briassoulis G, etal., Pediatr Pulmonol. 2006 Aug;41(8):790-5.
4. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Chang HJ, etal., Pathol Int. 2004 Aug;54(8):576-84.
5. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. Chhieng DC, etal., Cancer. 2003 Dec 25;99(6):365-71.
6. MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer. Cozzi PJ, etal., Clin Exp Metastasis. 2005;22(7):565-73. Epub 2006 Feb 11.
7. Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. de Paiva Haddad LB, etal., J Gastrointest Surg. 2010 Apr;14(4):719-28. Epub 2010 Jan 27.
8. Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. Dogru M, etal., Clin Exp Allergy. 2006 Dec;36(12):1556-65.
9. Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail. Dorai T, etal., J Urol. 2011 Dec;186(6):2448-54. doi: 10.1016/j.juro.2011.08.010. Epub 2011 Oct 21.
10. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Fanca-Berthon P, etal., Pediatr Res. 2009 Jul;66(1):47-52. doi: 10.1203/PDR.0b013e3181a2047e.
11. Proteomic analysis of human bile from malignant biliary stenosis induced by pancreatic cancer. Farina A, etal., J Proteome Res. 2009 Jan;8(1):159-69.
12. Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients. Fujita K, etal., Br J Cancer. 1999 Apr;80(1-2):301-8.
13. Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model. Ghosh SK, etal., Int J Cancer. 2013 Apr 15;132(8):1860-7. doi: 10.1002/ijc.27872. Epub 2012 Oct 25.
14. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Gipson IK, etal., Cornea. 2011 Dec;30(12):1346-52. doi: 10.1097/ICO.0b013e31820d852a.
15. KL-6 as a serologic indicator of Pneumocystis carinii pneumonia in immunocompromised hosts. Hamada H, etal., Intern Med. 1998 Mar;37(3):307-10.
16. Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. Hant FN, etal., J Rheumatol. 2009 Apr;36(4):773-80. Epub 2009 Mar 13.
17. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Ho SB, etal., Cancer Res. 1993 Feb 1;53(3):641-51.
18. Serum KL-6 levels in pediatric patients: reference values for children and levels in pneumonia, asthma, and measles patients. Imai T, etal., Pediatr Pulmonol. 2002 Feb;33(2):135-41.
19. MUC1 and estrogen receptor alpha gene polymorphisms in dry eye patients. Imbert Y, etal., Exp Eye Res. 2009 Mar;88(3):334-8. doi: 10.1016/j.exer.2008.05.019. Epub 2008 Jun 20.
20. Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis. Ishikawa N, etal., Respiration. 2011 Apr 7.
21. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Jan YY, etal., Ann Surg. 2004 Jul;240(1):89-94.
22. Study of Clara cell 16, KL-6, and surfactant protein-D in serum as disease markers in pulmonary sarcoidosis. Janssen R, etal., Chest. 2003 Dec;124(6):2119-25.
23. Analysis of KL-6 and SP-D as disease markers in bird fancier's lung. Janssen R, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Mar;22(1):51-7.
24. Bacterial conjunctivitis in Muc1 null mice. Kardon R, etal., Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1328-35.
25. Elevation of serum Krebs von den Lunge-6 levels in patients with tubulointerstitial nephritis and uveitis syndrome. Kase S, etal., Am J Kidney Dis. 2006 Dec;48(6):935-41.
26. MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis. Kashiwagi H, etal., Oncol Rep. 2001 May-Jun;8(3):485-9.
27. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. Kaufman HL, etal., J Transl Med. 2007 Nov 26;5:60.
28. Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder. Kawamoto T, etal., Clin Exp Metastasis. 2004;21(4):353-62.
29. Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1. Kawaoka T, etal., Oncol Rep. 2008 Jul;20(1):155-63.
30. Serum KL-6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis. Kawasaki Y, etal., J Med Virol. 2009 Dec;81(12):2104-8.
31. Cord blood KL-6, a specific lung injury marker, correlates with the subsequent development and severity of atypical bronchopulmonary dysplasia. Kim DH, etal., Neonatology. 2008;93(4):223-9. Epub 2007 Nov 16.
32. Role of KL-6 in evaluating the disease severity of rheumatoid lung disease: comparison with HRCT. Kinoshita F, etal., Respir Med. 2004 Nov;98(11):1131-7.
33. Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing. Kirby A, etal., Nat Genet. 2013 Mar;45(3):299-303. doi: 10.1038/ng.2543. Epub 2013 Feb 10.
34. Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: their relationship to prognosis. Kitamura H, etal., Jpn J Cancer Res. 1996 Jun;87(6):631-40.
35. Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line. Kohlgraf KG, etal., Cancer Res. 2003 Aug 15;63(16):5011-20.
36. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Kondo H, etal., Anticancer Res. 2008 Jan-Feb;28(1B):379-87.
37. Circulating KL-6, a biomarker of lung injury, in obstructive sleep apnoea. Lederer DJ, etal., Eur Respir J. 2009 Apr;33(4):793-6.
38. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Lepisto AJ, etal., Cancer Ther. 2008;6(B):955-964.
39. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
40. MGDs mouse GO annotations MGD data from the GO Consortium
41. MGD IEA MGD IEA
42. Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. Mukherjee P, etal., J Immunol. 2009 Jan 1;182(1):216-24.
43. Novel biomarkers of arterial and venous ischemia in microvascular flaps. Nguyen GK, etal., PLoS One. 2013 Aug 14;8(8):e71628. doi: 10.1371/journal.pone.0071628.
44. KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn. Ogihara T, etal., J Pediatr. 2000 Aug;137(2):280-2.
45. Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis. Ohshimo S, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(1):47-53.
46. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact. Park SY, etal., Oncol Rep. 2009 Sep;22(3):649-57.
49. Mouse MP Annotation Import Pipeline RGD automated import pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D. Samukawa T, etal., BMC Pulm Med. 2012 Sep 11;12:55. doi: 10.1186/1471-2466-12-55.
53. Pattern of mucin gene expression in normal and neoplastic lung tissues. Seregni E, etal., Anticancer Res. 1996 Jul-Aug;16(4B):2209-13.
54. MUC1 Is a Useful Molecular Marker for Malignant Intraductal Papillary Mucinous Neoplasms in Pancreatic Juice Obtained From Endoscopic Retrograde Pancreatography. Shimamoto T, etal., Pancreas. 2010 Mar 30.
55. MUC1 mucin as a tumour marker in bladder cancer. Simms MS, etal., BJU Int. 1999 Aug;84(3):350-2.
56. A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. Sirica AE, etal., Hepatology. 2008 Apr;47(4):1178-90.
57. Elevation of serum KL-6 levels in patients with hematological malignancies associated with cytomegalovirus or Pneumocystis carinii pneumonia. Tanaka M, etal., Hematology. 2002 Apr;7(2):105-8.
58. KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. Tang W, etal., World J Gastroenterol. 2005 Sep 21;11(35):5450-4.
59. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
60. MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. Tinder TL, etal., J Immunol. 2008 Sep 1;181(5):3116-25.
61. Pattern changes of mucin gene expression with pneumococcal otitis media. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
62. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Tsutsumida H, etal., Clin Cancer Res. 2006 May 15;12(10):2976-87.
63. Serum level of KL-6 as a marker of interstitial lung disease in patients with juvenile systemic sclerosis. Vesely R, etal., J Rheumatol. 2004 Apr;31(4):795-800.
64. Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours. von Mensdorff-Pouilly S, etal., Eur J Cancer. 1996 Jul;32A(8):1325-31.
65. Serum KL-6 as a marker for bronchiolitis obliterans syndrome after lung transplantation. Walter JN, etal., Transplantation. 2006 Sep 15;82(5):709-11.
66. Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma. Xu H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2000-4.
67. Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors. Yamasaki H, etal., Int J Oncol. 2004 Jan;24(1):107-13.
68. Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study. Yamato T, etal., J Pathol. 1999 May;188(1):30-7.
69. MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13. Ye Q, etal., Lab Invest. 2011 May;91(5):778-87. doi: 10.1038/labinvest.2011.12. Epub 2011 Feb 21.
70. MUC1 deficiency promotes nasal epithelial barrier dysfunction in subjects with allergic rhinitis. Zhou LB, etal., J Allergy Clin Immunol. 2019 Dec;144(6):1716-1719.e5. doi: 10.1016/j.jaci.2019.07.042. Epub 2019 Aug 16.
Additional References at PubMed
PMID:1425334   PMID:1569123   PMID:1601886   PMID:1714452   PMID:1958179   PMID:7491952   PMID:7626896   PMID:7628404   PMID:7657131   PMID:7691839   PMID:7753840   PMID:7883868  
PMID:8530414   PMID:8597643   PMID:8747930   PMID:8833262   PMID:8910427   PMID:9421796   PMID:9693136   PMID:9819365   PMID:9935162   PMID:10674981   PMID:10922068   PMID:10975866  
PMID:11095599   PMID:11208732   PMID:11278868   PMID:11359807   PMID:11859096   PMID:11984004   PMID:12147624   PMID:12377938   PMID:12477932   PMID:12529261   PMID:12618757   PMID:14703511  
PMID:14737104   PMID:14999776   PMID:15020226   PMID:15075252   PMID:15226261   PMID:15265901   PMID:15572671   PMID:15734845   PMID:15809042   PMID:15897873   PMID:16141072   PMID:16472605  
PMID:16500918   PMID:16547220   PMID:16602821   PMID:16611688   PMID:16618389   PMID:16831603   PMID:17267606   PMID:17276340   PMID:17524503   PMID:17563382   PMID:17638868   PMID:17641781  
PMID:17804764   PMID:17919495   PMID:18035521   PMID:18079492   PMID:18198997   PMID:18452912   PMID:18558092   PMID:18560595   PMID:18719000   PMID:18772165   PMID:18801836   PMID:19018774  
PMID:19022256   PMID:19166413   PMID:19351842   PMID:19403103   PMID:19487660   PMID:19684334   PMID:19711367   PMID:19841240   PMID:19914171   PMID:20003423   PMID:20043902   PMID:20081068  
PMID:20084048   PMID:20375631   PMID:20377894   PMID:20430889   PMID:20448050   PMID:20484415   PMID:20533404   PMID:20685850   PMID:20869363   PMID:21098570   PMID:21109593   PMID:21266405  
PMID:21267068   PMID:21281624   PMID:21307095   PMID:21533058   PMID:21558393   PMID:21593350   PMID:21677750   PMID:21816184   PMID:21873635   PMID:21888903   PMID:21909240   PMID:21947380  
PMID:21965615   PMID:22021035   PMID:22202458   PMID:22250084   PMID:22266848   PMID:22298528   PMID:22434868   PMID:22529374   PMID:22539679   PMID:22643830   PMID:22766025   PMID:22869720  
PMID:22912777   PMID:22967998   PMID:23006330   PMID:23071096   PMID:23149663   PMID:23175628   PMID:23177622   PMID:23261777   PMID:23370147   PMID:23431054   PMID:23471965   PMID:23684747  
PMID:23759257   PMID:23823474   PMID:23852729   PMID:23873692   PMID:24045940   PMID:24153432   PMID:24163148   PMID:24164893   PMID:24449844   PMID:24499815   PMID:24561267   PMID:24810688  
PMID:24909139   PMID:24924635   PMID:24929016   PMID:24971735   PMID:25063451   PMID:25078979   PMID:25387004   PMID:25523391   PMID:25563498   PMID:25659581   PMID:25715395   PMID:25739861  
PMID:25925251   PMID:26033091   PMID:26057579   PMID:26079943   PMID:26184908   PMID:26450967   PMID:26494792   PMID:26657766   PMID:26739894   PMID:26771085   PMID:26804176   PMID:26938663  
PMID:26973247   PMID:27585590   PMID:27736991   PMID:27740873   PMID:28002412   PMID:28049832   PMID:28071719   PMID:28116088   PMID:28301257   PMID:28327617   PMID:28366875   PMID:28369354  
PMID:28424251   PMID:28472347   PMID:28605238   PMID:28893946   PMID:28916165   PMID:29058721   PMID:29330353   PMID:29463648   PMID:30111221   PMID:30126902   PMID:30135482   PMID:30429216  
PMID:30452456   PMID:30487608   PMID:30590051   PMID:30853440   PMID:31160421   PMID:31201281   PMID:31240265   PMID:31323030   PMID:31337812   PMID:31412250   PMID:31604927   PMID:31776260  
PMID:31882545   PMID:32017380   PMID:32059775   PMID:32245295   PMID:32247267   PMID:32401676   PMID:32460029   PMID:32793510   PMID:32857951   PMID:33153107   PMID:33737325   PMID:34066999  
PMID:34070449   PMID:34151589   PMID:34292881   PMID:34520253   PMID:34694686   PMID:34852453   PMID:34975747   PMID:34984523   PMID:35383354   PMID:35461328   PMID:35706909  


Genomics

Comparative Map Data
Muc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,136,363 - 89,140,688 (+)NCBIGRCm39mm39
GRCm39 Ensembl389,136,364 - 89,140,688 (+)Ensembl
GRCm38389,229,056 - 89,233,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,229,057 - 89,233,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,032,974 - 89,037,291 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,314,979 - 89,319,296 (+)NCBImm8
Celera389,262,943 - 89,267,242 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.02NCBI
MUC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,185,824 - 155,192,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1155,185,824 - 155,192,916 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,158,300 - 155,162,706 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,424,924 - 153,429,324 (-)NCBINCBI36hg18NCBI36
Build 341151,971,671 - 151,975,732NCBI
Celera1128,229,565 - 128,235,983 (-)NCBI
Cytogenetic Map1q22NCBI
HuRef1126,521,570 - 126,525,810 (-)NCBIHuRef
CHM1_11156,554,155 - 156,558,213 (-)NCBICHM1_1
T2T-CHM13v2.01154,325,440 - 154,331,478 (-)NCBI
Muc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,635,559 - 174,640,738 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2174,635,995 - 174,640,733 (+)Ensembl
Rnor_6.02188,543,137 - 188,547,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,543,137 - 188,547,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,957,206 - 207,962,396 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,399,482 - 181,403,640 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,352,002 - 181,353,687 (+)NCBI
Celera2168,578,421 - 168,583,038 (+)NCBICelera
RH 3.4 Map21155.0RGD
Cytogenetic Map2q34NCBI
Muc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555451,657,728 - 1,662,112 (-)NCBIChiLan1.0ChiLan1.0
MUC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11134,141,969 - 134,146,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,141,969 - 134,145,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01130,533,508 - 130,537,866 (-)NCBIMhudiblu_PPA_v0panPan3
MUC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,338,939 - 42,344,690 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,340,375 - 42,344,690 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,831,252 - 41,835,267 (+)NCBI
ROS_Cfam_1.0742,208,174 - 42,213,894 (+)NCBI
ROS_Cfam_1.0 Ensembl742,209,579 - 42,213,894 (+)Ensembl
UMICH_Zoey_3.1741,989,397 - 41,993,712 (+)NCBI
UNSW_CanFamBas_1.0742,043,322 - 42,047,575 (+)NCBI
UU_Cfam_GSD_1.0742,326,882 - 42,331,197 (+)NCBI
Muc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,661,448 - 25,667,022 (-)NCBI
SpeTri2.0NW_0049365804,691,870 - 4,694,092 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1494,626,317 - 94,631,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,409,143 - 103,413,841 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,641,701 - 8,646,739 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl208,642,842 - 8,646,962 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660387,970,061 - 7,974,280 (+)NCBIVero_WHO_p1.0
Muc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248852,339,281 - 2,343,351 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Mit49  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,232,660 - 89,232,787UniSTSGRCm38
MGSCv37389,036,582 - 89,036,709UniSTSGRCm37
Celera389,266,551 - 89,266,660UniSTS
Cytogenetic Map3F1UniSTS
cM Map341.0UniSTS
Whitehead Genetic330.6UniSTS
D3Dcr14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,232,671 - 89,232,778UniSTSGRCm38
MGSCv37389,036,593 - 89,036,700UniSTSGRCm37
Celera389,266,562 - 89,266,651UniSTS
Cytogenetic Map3F1UniSTS
cM Map3 UniSTS
Muc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,230,714 - 89,231,793UniSTSGRCm38
MGSCv37389,034,636 - 89,035,715UniSTSGRCm37
Celera389,264,605 - 89,265,684UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
cM Map344.8UniSTS
Muc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,231,966 - 89,233,312UniSTSGRCm38
MGSCv37389,035,888 - 89,037,234UniSTSGRCm37
Celera389,265,857 - 89,267,185UniSTS
Cytogenetic Map3F1UniSTS
cM Map344.8UniSTS
Muc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38389,232,063 - 89,233,284UniSTSGRCm38
MGSCv37389,035,985 - 89,037,206UniSTSGRCm37
Celera389,265,954 - 89,267,157UniSTS
Cytogenetic Map3F1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38717045489140094Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir125b-1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21308711
Mir125b-1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20729973
Mir125b-2mmu-miR-125b-5pOncomiRDBexternal_infoNANA21308711
Mir125b-2mmu-miR-125b-5pOncomiRDBexternal_infoNANA20729973

Predicted Target Of
Summary Value
Count of predictions:603
Count of miRNA genes:349
Interacting mature miRNAs:410
Transcripts:ENSMUST00000041142, ENSMUST00000139206, ENSMUST00000146844
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000041142   ⟹   ENSMUSP00000041963
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,136,364 - 89,140,688 (+)Ensembl
GRCm38.p6 Ensembl389,229,057 - 89,233,381 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139206
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,138,778 - 89,140,504 (+)Ensembl
GRCm38.p6 Ensembl389,231,471 - 89,233,197 (+)Ensembl
RefSeq Acc Id: ENSMUST00000146844
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl389,138,546 - 89,139,389 (+)Ensembl
GRCm38.p6 Ensembl389,231,239 - 89,232,082 (+)Ensembl
RefSeq Acc Id: NM_013605   ⟹   NP_038633
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39389,136,363 - 89,140,688 (+)NCBI
GRCm38389,229,056 - 89,233,381 (+)NCBI
MGSCv37389,032,974 - 89,037,291 (+)RGD
Celera389,262,947 - 89,267,254 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038633   ⟸   NM_013605
- Peptide Label: precursor
- UniProtKB: Q02496 (UniProtKB/Swiss-Prot),   A0A0R4J0H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000041963   ⟸   ENSMUST00000041142
Protein Domains
SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02496-F1-model_v2 AlphaFold Q02496 1-630 view protein structure

Promoters
RGD ID:6834134
Promoter ID:MM_KWN:34931
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung
Transcripts:OTTMUST00000048120
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36389,032,241 - 89,033,067 (+)MPROMDB
RGD ID:6834135
Promoter ID:MM_KWN:34932
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000048121,   OTTMUST00000048122
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36389,034,484 - 89,034,984 (+)MPROMDB
RGD ID:6881218
Promoter ID:EPDNEW_M4060
Type:multiple initiation site
Name:Muc1_1
Description:Mus musculus mucin 1, transmembrane , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38389,229,059 - 89,229,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97231 AgrOrtholog
Ensembl Genes ENSMUSG00000042784 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000041963 ENTREZGENE
  ENSMUSP00000041963.4 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041142 ENTREZGENE
  ENSMUST00000041142.4 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.600 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17829 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97231 ENTREZGENE
NCBI Gene 17829 ENTREZGENE
Pfam SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Muc1 PhenoGen
PROSITE SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0H1 ENTREZGENE, UniProtKB/TrEMBL
  MUC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99K60_MOUSE UniProtKB/TrEMBL