Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) - Rat Genome Database

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Gene: Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) Mus musculus
Analyze
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
RGD ID: 1621551
MGI Page MGI
Description: Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of apoptotic process; and positive regulation of establishment of protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; immune system; limb; and liver. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N; Noxa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,591,675 - 66,598,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,591,604 - 66,598,636 (+)EnsemblGRCm39 Ensembl
GRCm381866,458,604 - 66,465,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,458,533 - 66,465,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371866,618,258 - 66,625,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,583,973 - 66,590,927 (+)NCBIMGSCv36mm8
Celera1867,745,077 - 67,752,031 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-O-methylguanine  (ISO)
9,10-phenanthroquinone  (ISO)
ABT-737  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Aurin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
benzyl bromide  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP)
carboplatin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloromethylisothiazolinone  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
dihydroartemisinin  (ISO)
dimethyl sulfate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
Dodecyl gallate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (ISO)
flubendazole  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glutaraldehyde  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexaconazole  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
motexafin gadolinium  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
pevonedistat  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
promethazine  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
ruthenium atom  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selinexor  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
torcetrapib  (ISO)
triacsin C  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
venetoclax  (ISO)
versicolorin A  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hypoxia  (ISO)
defense response to virus  (ISO)
DNA damage response  (IMP)
fibroblast apoptotic process  (IMP)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IMP,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IDA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IMP)
negative regulation of fibroblast proliferation  (IMP)
negative regulation of mitochondrial membrane potential  (IDA)
positive regulation of apoptotic process  (ISO)
positive regulation of cysteine-type endopeptidase activity  (IDA,ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (IMP,ISO)
positive regulation of establishment of protein localization to mitochondrion  (IMP)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast apoptotic process  (IMP)
positive regulation of glucose metabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of release of cytochrome c from mitochondria  (ISO)
proteasomal protein catabolic process  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of apoptotic process  (RCA)
regulation of mitochondrial membrane permeability  (ISO)
release of cytochrome c from mitochondria  (IDA,IMP)
response to dsRNA  (ISO)
response to UV  (IMP)
response to X-ray  (IMP)
T cell homeostasis  (IMP)

Cellular Component
Bcl-2 family protein complex  (ISO)
cytosol  (ISO)
mitochondrion  (HDA,IBA,IDA,ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
2. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. Onoue S, etal., FEBS J. 2008 Nov;275(22):5542-51.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10807576   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12819136   PMID:12952892   PMID:14500851   PMID:14651853   PMID:14699081  
PMID:15081359   PMID:15694340   PMID:15703398   PMID:15721256   PMID:15750633   PMID:16059910   PMID:16118324   PMID:16141072   PMID:16141073   PMID:16407291   PMID:16697956   PMID:16822983  
PMID:16832056   PMID:16928686   PMID:17024184   PMID:17167080   PMID:17283183   PMID:17307841   PMID:17389404   PMID:17476283   PMID:17518541   PMID:17576813   PMID:17618288   PMID:17634411  
PMID:17893884   PMID:18032672   PMID:18192275   PMID:18246078   PMID:18259198   PMID:18287039   PMID:18287559   PMID:18411339   PMID:18589438   PMID:18974090   PMID:19144853   PMID:19148184  
PMID:19152337   PMID:19237507   PMID:19285955   PMID:19334288   PMID:19959756   PMID:20195489   PMID:20498273   PMID:20620942   PMID:20627101   PMID:20664053   PMID:20798045   PMID:20829369  
PMID:21040902   PMID:21148109   PMID:21163929   PMID:21267068   PMID:21491542   PMID:21660046   PMID:21677750   PMID:21689638   PMID:21690328   PMID:21727192   PMID:21742363   PMID:21873635  
PMID:21945433   PMID:22144184   PMID:22185759   PMID:22212482   PMID:22343714   PMID:22380599   PMID:22402282   PMID:22538851   PMID:22573037   PMID:22960223   PMID:23000175   PMID:23068609  
PMID:23277490   PMID:23589895   PMID:23593480   PMID:23665218   PMID:23678004   PMID:23733106   PMID:23770082   PMID:23922240   PMID:23975731   PMID:24013501   PMID:25081090   PMID:25124553  
PMID:25299781   PMID:25698446   PMID:25733019   PMID:26045049   PMID:26181197   PMID:26222436   PMID:26334721   PMID:26344567   PMID:26437021   PMID:26497683   PMID:26742432   PMID:26866517  
PMID:27064265   PMID:27479816   PMID:27510977   PMID:27792866   PMID:27862899   PMID:28049824   PMID:28079889   PMID:28594399   PMID:28777373   PMID:29931031   PMID:30154103   PMID:30333037  
PMID:30348983   PMID:30858352   PMID:31178404   PMID:31580946   PMID:31749402   PMID:32312973   PMID:32451402   PMID:33086063   PMID:33253203   PMID:33323382   PMID:33334825   PMID:33586242  
PMID:34242585   PMID:35139355   PMID:35361962   PMID:36656901   PMID:36856110   PMID:37612280   PMID:37926300   PMID:38131461   PMID:38226173   PMID:38359835   PMID:38489392  


Genomics

Comparative Map Data
Pmaip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,591,675 - 66,598,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,591,604 - 66,598,636 (+)EnsemblGRCm39 Ensembl
GRCm381866,458,604 - 66,465,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,458,533 - 66,465,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371866,618,258 - 66,625,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,583,973 - 66,590,927 (+)NCBIMGSCv36mm8
Celera1867,745,077 - 67,752,031 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.52NCBI
PMAIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,899,996 - 59,904,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,899,996 - 59,904,305 (+)EnsemblGRCh38hg38GRCh38
GRCh371857,567,228 - 57,571,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,718,172 - 55,722,518 (+)NCBINCBI36Build 36hg18NCBI36
Build 341855,718,216 - 55,722,517NCBI
Celera1854,285,254 - 54,289,600 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,276,682 - 54,281,028 (+)NCBIHuRef
CHM1_11857,562,830 - 57,567,176 (+)NCBICHM1_1
T2T-CHM13v2.01860,102,671 - 60,106,980 (+)NCBIT2T-CHM13v2.0
Pmaip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Celera1858,105,912 - 58,109,899 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Pmaip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540244,005,517 - 44,010,722 (+)NCBIChiLan1.0ChiLan1.0
LOC100979315
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21777,437,419 - 77,441,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,130,031 - 63,134,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,286,590 - 53,290,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,611,098 - 56,615,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1856,611,098 - 56,615,449 (+)Ensemblpanpan1.1panPan2
PMAIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,469,793 - 16,472,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,469,793 - 16,472,910 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,446,017 - 17,449,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,340,520 - 16,344,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,340,520 - 16,344,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,376,897 - 16,380,246 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,303,869 - 16,307,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,558,934 - 16,562,268 (-)NCBIUU_Cfam_GSD_1.0
Pmaip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494429,746,960 - 29,747,884 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364974,985,995 - 4,986,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMAIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,182,887 - 161,188,164 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11161,184,458 - 161,188,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,853,630 - 178,857,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PMAIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11819,861,182 - 19,865,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,862,743 - 19,865,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660605,737,434 - 5,741,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmaip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pmaip1
319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:626
Count of miRNA genes:413
Interacting mature miRNAs:482
Transcripts:ENSMUST00000025399
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse

Markers in Region
Pmaip1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381866,464,176 - 66,465,060UniSTSGRCm38
MGSCv371866,623,830 - 66,624,714UniSTSGRCm37
Celera1867,750,649 - 67,751,533UniSTS
Cytogenetic Map18E1UniSTS
cM Map18 UniSTS
UniSTS:237827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381866,465,086 - 66,465,325UniSTSGRCm38
MGSCv371866,624,740 - 66,624,979UniSTSGRCm37
Celera1867,751,559 - 67,751,798UniSTS
Cytogenetic Map18E1UniSTS
Pmaip1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381866,464,659 - 66,465,459UniSTSGRCm38
Celera1867,751,132 - 67,751,932UniSTS
Cytogenetic Map18E1UniSTS
Pmaip1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381866,464,401 - 66,464,745UniSTSGRCm38
MGSCv371866,624,055 - 66,624,399UniSTSGRCm37
Celera1867,750,874 - 67,751,218UniSTS
Cytogenetic Map18E1UniSTS
cM Map18 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025399   ⟹   ENSMUSP00000025399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1866,591,604 - 66,598,631 (+)Ensembl
GRCm38.p6 Ensembl1866,458,533 - 66,465,560 (+)Ensembl
Ensembl Acc Id: ENSMUST00000236933   ⟹   ENSMUSP00000158157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1866,591,664 - 66,597,151 (+)Ensembl
GRCm38.p6 Ensembl1866,458,593 - 66,464,080 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237161   ⟹   ENSMUSP00000158228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1866,591,646 - 66,598,636 (+)Ensembl
GRCm38.p6 Ensembl1866,458,575 - 66,465,565 (+)Ensembl
RefSeq Acc Id: NM_021451   ⟹   NP_067426
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391866,591,675 - 66,598,629 (+)NCBI
GRCm381866,458,604 - 66,465,558 (+)ENTREZGENE
MGSCv371866,618,258 - 66,625,212 (+)RGD
Celera1867,745,077 - 67,752,031 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_067426   ⟸   NM_021451
- UniProtKB: Q9JM54 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000158228   ⟸   ENSMUST00000237161
Ensembl Acc Id: ENSMUSP00000158157   ⟸   ENSMUST00000236933
Ensembl Acc Id: ENSMUSP00000025399   ⟸   ENSMUST00000025399

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM54-F1-model_v2 AlphaFold Q9JM54 1-103 view protein structure

Promoters
RGD ID:13678052
Promoter ID:EPDNEW_M23175
Type:single initiation site
Name:Pmaip1_1
Description:Mus musculus phorbol-12-myristate-13-acetate-induced protein1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381866,458,595 - 66,458,655EPDNEW
RGD ID:6829465
Promoter ID:MM_KWN:25533
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000025399
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361866,617,251 - 66,618,362 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930146 AgrOrtholog
Ensembl Genes ENSMUSG00000024521 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025399 ENTREZGENE
  ENSMUST00000025399.9 UniProtKB/Swiss-Prot
  ENSMUST00000236933.2 UniProtKB/TrEMBL
  ENSMUST00000237161.2 UniProtKB/TrEMBL
InterPro Noxa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58801 UniProtKB/Swiss-Prot
MGD MGI:1930146 ENTREZGENE
NCBI Gene 58801 ENTREZGENE
PANTHER PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMAIP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pmaip1 PhenoGen
UniProt A0A494BAM9_MOUSE UniProtKB/TrEMBL
  A0A494BAU0_MOUSE UniProtKB/TrEMBL
  APR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE