Tlr9 (toll-like receptor 9) - Rat Genome Database

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Gene: Tlr9 (toll-like receptor 9) Mus musculus
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Symbol: Tlr9
Name: toll-like receptor 9
RGD ID: 1549988
MGI Page MGI
Description: Predicted to enable interleukin-1 receptor binding activity; pattern recognition receptor activity; and siRNA binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of defense response; and regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in intestine and small intestine mucosa. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9); PARTICIPATES IN Toll-like receptor signaling pathway; Chagas disease pathway; malaria pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Chinchilla
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,099,797 - 106,104,075 (+)NCBIGRCm39mm39
GRCm39 Ensembl9106,099,797 - 106,104,082 (+)Ensembl
GRCm389106,222,598 - 106,226,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,222,598 - 106,226,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,124,929 - 106,129,207 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,080,699 - 106,084,977 (+)NCBImm8
Celera9105,848,890 - 105,853,167 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Achlorhydria  (ISO)
acute kidney failure  (IMP)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (IMP)
alcoholic liver cirrhosis  (ISO)
allergic bronchopulmonary aspergillosis  (IMP,ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
anogenital venereal wart  (ISO)
asthma  (IMP,ISO)
bacterial pneumonia  (IMP)
Brain Injuries  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (IMP,ISO)
chronic granulomatous disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (ISS)
Chronic Periodontitis  (ISO)
crescentic glomerulonephritis  (IMP)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Granuloma, Foreign-Body  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (IMP)
Hypergammaglobulinemia  (IMP)
IgA glomerulonephritis  (IAGP,IDA,IEP,ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
Klebsiella Infections  (IMP)
Legionnaires' disease  (IMP)
Liver Injury  (IMP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (IDA,IEP,IMP,ISO)
Malarial Anemia  (ISO)
mastitis  (ISO)
membranoproliferative glomerulonephritis  (IEP)
non-alcoholic fatty liver disease  (IEP)
non-alcoholic steatohepatitis  (IEP)
Oral Lichen Planus  (ISO)
papillomavirus infectious disease  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Pneumococcal Infections  (IMP)
Pneumococcal Meningitis  (IEP)
primary biliary cholangitis  (ISO)
proteinuria  (IMP,ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Respiratory Sounds  (ISO)
Respiratory Tract Granuloma  (IMP,ISO)
Schistosomiasis Mansoni  (ISO)
sinusitis  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (IEP,IMP,ISO)
Tracheoesophageal Fistula  (ISO)
Transplant Rejection  (ISO)
Triple Negative Breast Neoplasms  (ISO)
trypanosomiasis  (IEP)
ureteral obstruction  (IEP)
viral pneumonia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IDA)
cellular response to chloroquine  (IDA)
cellular response to lipopolysaccharide  (ISO)
cellular response to metal ion  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to virus  (IBA,IGI,ISO)
I-kappaB kinase/NF-kappaB signaling  (IBA,IDA)
I-kappaB phosphorylation  (ISO)
immune response  (IMP)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (TAS)
maintenance of gastrointestinal epithelium  (IMP)
male gonad development  (ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (IPI)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IGI)
negative regulation of interleukin-6 production  (IMP)
negative regulation of interleukin-8 production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (IDA,ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-18 production  (IDA)
positive regulation of interleukin-6 production  (IBA,IDA,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IBA,IDA,ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA)
positive regulation of toll-like receptor 9 signaling pathway  (IMP)
positive regulation of toll-like receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
positive regulation of tumor necrosis factor production  (IDA,IMP)
regulation of B cell activation  (IGI)
regulation of B cell differentiation  (ISO)
regulation of cytokine production  (IEA)
regulation of dendritic cell cytokine production  (IDA)
regulation of inflammatory response  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of toll-like receptor 9 signaling pathway  (ISO)
response to molecule of bacterial origin  (TAS)
response to virus  (IMP)
signal transduction  (IEA)
toll-like receptor 9 signaling pathway  (IEA)
toll-like receptor signaling pathway  (IBA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal NK T cell physiology  (IAGP)
abnormal plasmacytoid dendritic cell physiology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to infection  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
autoimmune response  (IAGP)
decreased autoantibody level  (IAGP)
decreased B cell proliferation  (IEA)
decreased IgM level  (IAGP)
decreased inflammatory response  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interferon-gamma secretion  (IEA)
decreased interleukin-12b secretion  (IAGP)
decreased mature B cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
increased autoantibody level  (IAGP)
increased B-1 B cell number  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased circulating interferon-alpha level  (IAGP)
increased double-negative T cell number  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG3 level  (IAGP)
increased susceptibility to Herpesvirales infection  (IAGP)
increased susceptibility to Herpesvirales infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IEA)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased urine protein level  (IAGP)
kidney inflammation  (IAGP)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:8889548   PMID:11130078   PMID:11470918   PMID:11812998   PMID:11867692   PMID:11923871   PMID:11947920   PMID:12193753   PMID:12244198   PMID:12356687   PMID:12408049   PMID:12515817  
PMID:12538732   PMID:12626528   PMID:12626561   PMID:12630564   PMID:12759192   PMID:12875990   PMID:12900525   PMID:12902324   PMID:12935356   PMID:14563635   PMID:14607920   PMID:14657211  
PMID:14716310   PMID:14734643   PMID:14762789   PMID:14976262   PMID:14978111   PMID:14993594   PMID:15128790   PMID:15197227   PMID:15210814   PMID:15272082   PMID:15345224   PMID:15356140  
PMID:15373969   PMID:15534227   PMID:15538945   PMID:15630134   PMID:15634876   PMID:15634897   PMID:15650774   PMID:15654341   PMID:15671286   PMID:15678105   PMID:15709004   PMID:15765149  
PMID:15767370   PMID:15778393   PMID:15860593   PMID:15922717   PMID:16027240   PMID:16034101   PMID:16039576   PMID:16047338   PMID:16059640   PMID:16081822   PMID:16142239   PMID:16143103  
PMID:16148144   PMID:16204620   PMID:16219804   PMID:16230478   PMID:16244651   PMID:16260486   PMID:16272281   PMID:16272328   PMID:16301648   PMID:16301743   PMID:16325814   PMID:16341217  
PMID:16365150   PMID:16413926   PMID:16415873   PMID:16421948   PMID:16440059   PMID:16458386   PMID:16461338   PMID:16492804   PMID:16554027   PMID:16554296   PMID:16585586   PMID:16602821  
PMID:16604075   PMID:16612387   PMID:16650483   PMID:16670325   PMID:16703567   PMID:16741252   PMID:16751377   PMID:16751405   PMID:16798839   PMID:16818796   PMID:16840729   PMID:16878177  
PMID:16886064   PMID:16889948   PMID:16896155   PMID:16906541   PMID:16926427   PMID:16951309   PMID:16954198   PMID:16982883   PMID:17030073   PMID:17038535   PMID:17082664   PMID:17085599  
PMID:17114418   PMID:17114424   PMID:17117477   PMID:17118979   PMID:17128265   PMID:17135446   PMID:17170125   PMID:17177977   PMID:17202381   PMID:17227820   PMID:17229689   PMID:17277148  
PMID:17325049   PMID:17331636   PMID:17339472   PMID:17339488   PMID:17353291   PMID:17360957   PMID:17371986   PMID:17389237   PMID:17404286   PMID:17404301   PMID:17404302   PMID:17417641  
PMID:17452530   PMID:17456769   PMID:17462991   PMID:17464186   PMID:17473064   PMID:17474149   PMID:17475835   PMID:17485512   PMID:17488193   PMID:17521621   PMID:17548579   PMID:17570345  
PMID:17572686   PMID:17579017   PMID:17599410   PMID:17646407   PMID:17705137   PMID:17705260   PMID:17713535   PMID:17725607   PMID:17804687   PMID:17875630   PMID:17878370   PMID:17913820  
PMID:17918201   PMID:17939949   PMID:17942529   PMID:17947693   PMID:17950005   PMID:17982056   PMID:17984204   PMID:17992263   PMID:17998391   PMID:18025183   PMID:18034422   PMID:18060042  
PMID:18086870   PMID:18097045   PMID:18097414   PMID:18166152   PMID:18178848   PMID:18183029   PMID:18194990   PMID:18203139   PMID:18239127   PMID:18250457   PMID:18250459   PMID:18256672  
PMID:18266299   PMID:18273445   PMID:18276597   PMID:18288107   PMID:18305095   PMID:18305481   PMID:18322216   PMID:18332208   PMID:18342006   PMID:18354200   PMID:18378636   PMID:18378686  
PMID:18394314   PMID:18398511   PMID:18406377   PMID:18423196   PMID:18424698   PMID:18474631   PMID:18480050   PMID:18480244   PMID:18513998   PMID:18552210   PMID:18559428   PMID:18606688  
PMID:18614760   PMID:18624303   PMID:18641311   PMID:18641342   PMID:18641352   PMID:18664530   PMID:18684928   PMID:18691914   PMID:18760996   PMID:18794294   PMID:18802047   PMID:18817866  
PMID:18820679   PMID:18835196   PMID:18931679   PMID:18941203   PMID:18950591   PMID:18974086   PMID:18981243   PMID:19009528   PMID:19019086   PMID:19047410   PMID:19050267   PMID:19050280  
PMID:19075396   PMID:19088275   PMID:19109197   PMID:19120284   PMID:19122641   PMID:19144984   PMID:19155485   PMID:19200758   PMID:19200759   PMID:19201879   PMID:19228664   PMID:19265155  
PMID:19272387   PMID:19297619   PMID:19299691   PMID:19299716   PMID:19332776   PMID:19362372   PMID:19382893   PMID:19414781   PMID:19414785   PMID:19433551   PMID:19451267   PMID:19474102  
PMID:19494293   PMID:19528537   PMID:19535142   PMID:19535645   PMID:19551900   PMID:19553540   PMID:19561095   PMID:19567203   PMID:19574451   PMID:19576795   PMID:19585512   PMID:19587007  
PMID:19587376   PMID:19587448   PMID:19596990   PMID:19648272   PMID:19657352   PMID:19687229   PMID:19720755   PMID:19758186   PMID:19767510   PMID:19786067   PMID:19797157   PMID:19834064  
PMID:19841163   PMID:19846276   PMID:19874547   PMID:19879164   PMID:19890330   PMID:19913447   PMID:19918123   PMID:19923461   PMID:19923465   PMID:19923471   PMID:19933833   PMID:19933834  
PMID:19942314   PMID:19944565   PMID:19995952   PMID:20005572   PMID:20007584   PMID:20011699   PMID:20042593   PMID:20049870   PMID:20051628   PMID:20089701   PMID:20093775   PMID:20107166  
PMID:20107183   PMID:20114022   PMID:20114028   PMID:20145605   PMID:20174568   PMID:20187710   PMID:20200270   PMID:20200276   PMID:20200279   PMID:20205276   PMID:20228254   PMID:20231379  
PMID:20231693   PMID:20308556   PMID:20347818   PMID:20393135   PMID:20400700   PMID:20424013   PMID:20427776   PMID:20431620   PMID:20432233   PMID:20442858   PMID:20451253   PMID:20451901  
PMID:20466823   PMID:20483722   PMID:20483769   PMID:20488791   PMID:20495560   PMID:20526283   PMID:20581055   PMID:20610651   PMID:20639251   PMID:20660347   PMID:20660707   PMID:20668698  
PMID:20696824   PMID:20739833   PMID:20804821   PMID:20810248   PMID:20847273   PMID:20864677   PMID:20865117   PMID:20865800   PMID:20876455   PMID:20937844   PMID:20966396   PMID:20974942  
PMID:21045126   PMID:21059889   PMID:21078886   PMID:21098227   PMID:21115691   PMID:21115693   PMID:21116636   PMID:21132311   PMID:21190299   PMID:21239460   PMID:21239713   PMID:21273385  
PMID:21278302   PMID:21282509   PMID:21287547   PMID:21300776   PMID:21311566   PMID:21368092   PMID:21376231   PMID:21402738   PMID:21435586   PMID:21439959   PMID:21458307   PMID:21474674  
PMID:21482737   PMID:21497117   PMID:21515789   PMID:21525381   PMID:21525388   PMID:21538349   PMID:21538629   PMID:21547259   PMID:21559519   PMID:21567398   PMID:21571065   PMID:21603856  
PMID:21604257   PMID:21609647   PMID:21625574   PMID:21666062   PMID:21683627   PMID:21685327   PMID:21687712   PMID:21690093   PMID:21690387   PMID:21698299   PMID:21721026   PMID:21762664  
PMID:21765404   PMID:21766476   PMID:21788345   PMID:21801870   PMID:21808234   PMID:21820332   PMID:21829705   PMID:21835795   PMID:21844387   PMID:21849499   PMID:21859955   PMID:21860217  
PMID:21873635   PMID:21911421   PMID:21940676   PMID:21947771   PMID:21960132   PMID:21982832   PMID:21987815   PMID:22031762   PMID:22036947   PMID:22039448   PMID:22078208   PMID:22078797  
PMID:22085974   PMID:22096530   PMID:22104112   PMID:22114338   PMID:22156340   PMID:22170068   PMID:22171256   PMID:22184724   PMID:22205030   PMID:22205119   PMID:22207622   PMID:22227568  
PMID:22250086   PMID:22258621   PMID:22297845   PMID:22306056   PMID:22311925   PMID:22323544   PMID:22342842   PMID:22422883   PMID:22442158   PMID:22453241   PMID:22505996   PMID:22508063  
PMID:22516959   PMID:22544937   PMID:22553782   PMID:22574220   PMID:22611152   PMID:22628437   PMID:22634614   PMID:22635254   PMID:22653776   PMID:22659029   PMID:22662179   PMID:22666391  
PMID:22677561   PMID:22693446   PMID:22706912   PMID:22718261   PMID:22719247   PMID:22745710   PMID:22777843   PMID:22777876   PMID:22795895   PMID:22816092   PMID:22821982   PMID:22822061  
PMID:22826298   PMID:22832815   PMID:22837383   PMID:22844124   PMID:22893852   PMID:22896628   PMID:22902233   PMID:22908309   PMID:22915067   PMID:22940550   PMID:22962685   PMID:22967069  
PMID:22970242   PMID:22988114   PMID:23008447   PMID:23010947   PMID:23028824   PMID:23034650   PMID:23043942   PMID:23071157   PMID:23109291   PMID:23110142   PMID:23142781   PMID:23180821  
PMID:23189191   PMID:23219390   PMID:23241879   PMID:23290966   PMID:23296704   PMID:23296706   PMID:23313320   PMID:23325805   PMID:23357786   PMID:23370539   PMID:23372731   PMID:23382217  
PMID:23439309   PMID:23479602   PMID:23497207   PMID:23584070   PMID:23585677   PMID:23600828   PMID:23630357   PMID:23650544   PMID:23673637   PMID:23686399   PMID:23752491   PMID:23778142  
PMID:23843525   PMID:23853597   PMID:23893288   PMID:23913633   PMID:23935245   PMID:23936560   PMID:23956420   PMID:23966630   PMID:23967355   PMID:23993650   PMID:24023674   PMID:24038087  
PMID:24041926   PMID:24042114   PMID:24080854   PMID:24081950   PMID:24114535   PMID:24154870   PMID:24169824   PMID:24170313   PMID:24184555   PMID:24249581   PMID:24267232   PMID:24340043  
PMID:24342772   PMID:24353176   PMID:24353186   PMID:24386404   PMID:24387292   PMID:24436372   PMID:24474776   PMID:24478078   PMID:24489947   PMID:24500834   PMID:24514026   PMID:24516163  
PMID:24528866   PMID:24534189   PMID:24595157   PMID:24598055   PMID:24610369   PMID:24634489   PMID:24637670   PMID:24651487   PMID:24711620   PMID:24719374   PMID:24719462   PMID:24721797  
PMID:24722226   PMID:24726642   PMID:24740015   PMID:24742987   PMID:24743339   PMID:24801628   PMID:24888966   PMID:24942583   PMID:24973449   PMID:25053813   PMID:25063677   PMID:25078697  
PMID:25079212   PMID:25098409   PMID:25126943   PMID:25170774   PMID:25171368   PMID:25187653   PMID:25188232   PMID:25194054   PMID:25217236   PMID:25310967   PMID:25378393   PMID:25416814  
PMID:25536171   PMID:25557539   PMID:25593326   PMID:25600358   PMID:25612611   PMID:25637383   PMID:25638261   PMID:25639361   PMID:25646267   PMID:25654671   PMID:25657250   PMID:25667264  
PMID:25673780   PMID:25681333   PMID:25681338   PMID:25686612   PMID:25735984   PMID:25751136   PMID:25769918   PMID:25871979   PMID:25880099   PMID:25885582   PMID:25907537   PMID:25911242  
PMID:25917084   PMID:25925170   PMID:25929465   PMID:25930080   PMID:25937283   PMID:25944185   PMID:25964477   PMID:25981615   PMID:26000727   PMID:26003847   PMID:26030851   PMID:26067373  
PMID:26095358   PMID:26095366   PMID:26116356   PMID:26172047   PMID:26173697   PMID:26179893   PMID:26187411   PMID:26218271   PMID:26238713   PMID:26260403   PMID:26297795   PMID:26332085  
PMID:26371124   PMID:26371257   PMID:26416273   PMID:26423149   PMID:26440518   PMID:26440613   PMID:26461521   PMID:26481685   PMID:26482993   PMID:26553076   PMID:26567289   PMID:26574043  
PMID:26578650   PMID:26595890   PMID:26607445   PMID:26641462   PMID:26649979   PMID:26680206   PMID:26680738   PMID:26682986   PMID:26719148   PMID:26748860   PMID:26751387   PMID:26796361  
PMID:26808498   PMID:26829985   PMID:26831104   PMID:26882889   PMID:26911613   PMID:26954233   PMID:26955780   PMID:26965188   PMID:27001940   PMID:27015965   PMID:27035940   PMID:27041637  
PMID:27159323   PMID:27189410   PMID:27253707   PMID:27288485   PMID:27357505   PMID:27373163   PMID:27374884   PMID:27421483   PMID:27459510   PMID:27505671   PMID:27509078   PMID:27542117  
PMID:27606421   PMID:27621416   PMID:27621476   PMID:27693915   PMID:27758771   PMID:27760315   PMID:27769998   PMID:27793594   PMID:27912060   PMID:27930350   PMID:27937044   PMID:28002730  
PMID:28099322   PMID:28102569   PMID:28111081   PMID:28186087   PMID:28278279   PMID:28300057   PMID:28319098   PMID:28329706   PMID:28346226   PMID:28360906   PMID:28378742   PMID:28400473  
PMID:28410407   PMID:28410990   PMID:28426135   PMID:28461572   PMID:28468798   PMID:28490840   PMID:28530246   PMID:28554874   PMID:28576980   PMID:28592426   PMID:28605247   PMID:28618428  
PMID:28652397   PMID:28704709   PMID:28723546   PMID:28724791   PMID:28803064   PMID:28875549   PMID:28884630   PMID:28889202   PMID:28978634   PMID:29053005   PMID:29062042   PMID:29097808  
PMID:29101363   PMID:29118245   PMID:29150239   PMID:29150564   PMID:29295842   PMID:29476183   PMID:29576482   PMID:29625894   PMID:29632021   PMID:29706455   PMID:29717061   PMID:29760192  
PMID:29760708   PMID:29880832   PMID:29889098   PMID:29896197   PMID:29898963   PMID:29914886   PMID:29934589   PMID:29943459   PMID:29945961   PMID:29961984   PMID:29963044   PMID:29972776  
PMID:29988090   PMID:29992753   PMID:29995930   PMID:29997629   PMID:30024926   PMID:30073799   PMID:30094467   PMID:30108181   PMID:30111894   PMID:30131424   PMID:30185516   PMID:30209187  
PMID:30209397   PMID:30364002   PMID:30429335   PMID:30442666   PMID:30449314   PMID:30460242   PMID:30498494   PMID:30510167   PMID:30515151   PMID:30523277   PMID:30546358   PMID:30592438  
PMID:30627652   PMID:30630901   PMID:30777286   PMID:30802247   PMID:30851061   PMID:30905257   PMID:30914379   PMID:30936294   PMID:30953770   PMID:31003004   PMID:31087643   PMID:31094704  
PMID:31160091   PMID:31170232   PMID:31209243   PMID:31270160   PMID:31293597   PMID:31380807   PMID:31401214   PMID:31408613   PMID:31462711   PMID:31534550   PMID:31619293   PMID:31619733  
PMID:31694883   PMID:31703913   PMID:31729371   PMID:31737959   PMID:31748116   PMID:31760767   PMID:31836766   PMID:31851971   PMID:31852751   PMID:31859049   PMID:31980536   PMID:32016843  
PMID:32051584   PMID:32059873   PMID:32064589   PMID:32173534   PMID:32191633   PMID:32205444   PMID:32209688   PMID:32265274   PMID:32268093   PMID:32290861   PMID:32360132   PMID:32375035  
PMID:32386967   PMID:32424365   PMID:32506732   PMID:32515732   PMID:32527277   PMID:32559406   PMID:32610078   PMID:32623292   PMID:32631940   PMID:32632165   PMID:32644192   PMID:32652081  
PMID:32661363   PMID:32700178   PMID:32738096   PMID:32840578   PMID:32841647   PMID:33093516   PMID:33127821   PMID:33140535   PMID:33140921   PMID:33148715   PMID:33154070   PMID:33446850  
PMID:33497574   PMID:33510463   PMID:33741290   PMID:34034463   PMID:34206257   PMID:34216140   PMID:34395439  


Genomics

Comparative Map Data
Tlr9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,099,797 - 106,104,075 (+)NCBIGRCm39mm39
GRCm39 Ensembl9106,099,797 - 106,104,082 (+)Ensembl
GRCm389106,222,598 - 106,226,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,222,598 - 106,226,883 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,124,929 - 106,129,207 (+)NCBIGRCm37mm9NCBIm37
MGSCv369106,080,699 - 106,084,977 (+)NCBImm8
Celera9105,848,890 - 105,853,167 (+)NCBICelera
Cytogenetic Map9F1NCBI
TLR9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl352,221,080 - 52,225,645 (-)EnsemblGRCh38hg38GRCh38
GRCh38352,221,080 - 52,225,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,255,096 - 52,259,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,230,138 - 52,235,219 (-)NCBINCBI36hg18NCBI36
Build 34352,230,137 - 52,233,247NCBI
Celera352,234,410 - 52,239,491 (-)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,317,258 - 52,322,341 (-)NCBIHuRef
CHM1_1352,207,624 - 52,212,707 (-)NCBICHM1_1
Tlr9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28106,864,680 - 106,868,796 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8106,864,680 - 106,868,796 (+)Ensembl
Rnor_6.08114,916,122 - 114,920,171 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8114,916,122 - 114,920,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,279,020 - 114,283,069 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8106,185,754 - 106,189,869 (+)NCBICelera
Cytogenetic Map8q32NCBI
Tlr9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,828,645 - 3,832,699 (-)NCBIChiLan1.0ChiLan1.0
TLR9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,529,322 - 37,547,117 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,542,340 - 37,547,114 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,529,401 - 37,539,957 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,510,887 - 37,521,504 (+)NCBI
Dog10K_Boxer_Tasha2037,523,889 - 37,528,666 (+)NCBI
ROS_Cfam_1.02037,879,856 - 37,897,682 (+)NCBI
UMICH_Zoey_3.12037,256,577 - 37,261,354 (+)NCBI
UMICH_Zoey_3.12037,243,558 - 37,254,192 (+)NCBI
UNSW_CanFamBas_1.02037,652,111 - 37,662,740 (+)NCBI
UNSW_CanFamBas_1.02037,665,125 - 37,669,902 (+)NCBI
UU_Cfam_GSD_1.02037,936,949 - 37,947,576 (+)NCBI
UU_Cfam_GSD_1.02037,950,172 - 37,954,949 (+)NCBI
TLR9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11334,353,444 - 34,370,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,634,343 - 37,652,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
PMC133006P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,226,259 - 106,226,577UniSTSGRCm38
MGSCv379106,128,590 - 106,128,908UniSTSGRCm37
Celera9105,852,550 - 105,852,868UniSTS
Cytogenetic Map9F1UniSTS
Tlr9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,223,733 - 106,223,897UniSTSGRCm38
Celera9105,850,024 - 105,850,188UniSTS
Cytogenetic Map9F1UniSTS
cM Map957.46UniSTS
PMC212800P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,225,043 - 106,225,138UniSTSGRCm38
MGSCv379106,127,374 - 106,127,469UniSTSGRCm37
Celera9105,851,334 - 105,851,429UniSTS
Cytogenetic Map9F1UniSTS
PMC55404P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389106,226,301 - 106,226,560UniSTSGRCm38
MGSCv379106,128,632 - 106,128,891UniSTSGRCm37
Celera9105,852,592 - 105,852,851UniSTS
Cytogenetic Map9F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:117
Interacting mature miRNAs:123
Transcripts:ENSMUST00000062241
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062241   ⟹   ENSMUSP00000082207
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9106,099,797 - 106,104,082 (+)Ensembl
GRCm38.p6 Ensembl9106,222,598 - 106,226,883 (+)Ensembl
RefSeq Acc Id: NM_031178   ⟹   NP_112455
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399106,099,797 - 106,104,075 (+)NCBI
GRCm389106,222,598 - 106,226,876 (+)ENTREZGENE
MGSCv379106,124,929 - 106,129,207 (+)RGD
Celera9105,848,890 - 105,853,167 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112455   ⟸   NM_031178
- Peptide Label: precursor
- UniProtKB: Q9EQU3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000082207   ⟸   ENSMUST00000062241
Protein Domains
TIR

Promoters
RGD ID:6845246
Promoter ID:MM_KWN:58654
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_031178
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369106,124,839 - 106,125,339 (+)MPROMDB
RGD ID:8670714
Promoter ID:EPDNEW_M13387
Type:initiation region
Name:Tlr9_1
Description:Mus musculus toll-like receptor 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389106,222,616 - 106,222,676EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1932389 AgrOrtholog
Ensembl Genes ENSMUSG00000045322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000082207 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062241 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_12 UniProtKB/Swiss-Prot
  TIR_dom UniProtKB/Swiss-Prot
  TLR9 UniProtKB/Swiss-Prot
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:81897 UniProtKB/Swiss-Prot
MGD MGI:1932389 ENTREZGENE
NCBI Gene 81897 ENTREZGENE
PANTHER PTHR47410:SF3 UniProtKB/Swiss-Prot
Pfam LRR_12 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
PhenoGen Tlr9 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
SMART LRR_TYP UniProtKB/Swiss-Prot
  TIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52200 UniProtKB/Swiss-Prot
UniProt Q9EQU3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F8VPN5 UniProtKB/Swiss-Prot
  Q4L0K3 UniProtKB/Swiss-Prot
  Q4L0K4 UniProtKB/Swiss-Prot
  Q99MF2 UniProtKB/Swiss-Prot
  Q99MQ8 UniProtKB/Swiss-Prot