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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases activityISOCDKN1A (Homo sapiens)6480464CTDChloroquine results in increased activity of CDKN1APMID:18089834
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDChloroquine results in increased expression of CDKN1A proteinPMID:12243503
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]PMID:22927544 PMID:30025493
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