Tet2 (tet methylcytosine dioxygenase 2) - Rat Genome Database

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Gene: Tet2 (tet methylcytosine dioxygenase 2) Mus musculus
Analyze
Symbol: Tet2
Name: tet methylcytosine dioxygenase 2
RGD ID: 1323180
MGI Page MGI
Description: Enables 5-methylcytosine dioxygenase activity. Involved in myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid progenitor cell differentiation; and positive regulation of gene expression, epigenetic. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; immune system; lower urogenital tract; and reproductive system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ayu17-44; Ayu17-449; E130014J05Rik; methylcytosine dioxygenase TET2; MGC37385; mKIAA1546; probable methylcytosine dioxygenase TET2; tet oncogene 2; tet oncogene family member 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(hydroxymethyl)cytosine  (EXP,ISO)
5-methylcytosine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chloroquine  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
curcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
Geniposide  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
methimazole  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
p-chloromercuribenzoic acid  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (EXP)
sulfadimethoxine  (ISO)
tetrachloro-1,4-benzoquinone  (EXP)
tetrachlorohydroquinone  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
nucleoplasm  (TAS)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal monocyte differentiation  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal tumor pathology  (IAGP)
anemia  (IAGP)
decreased B cell number  (IAGP)
decreased effector memory T-helper cell number  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased pro-B cell number  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
hypochromic macrocytic anemia  (IAGP)
increased B cell number  (IAGP)
increased bone marrow cell number  (IAGP)
increased chronic myelocytic leukemia incidence  (IAGP)
increased DN1 thymic pro-T cell number  (IAGP)
increased double-negative T cell number  (IAGP)
increased erythroblast number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic cell number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemoglobin content  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased mean corpuscular volume  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to autoimmune disorder  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
macrocytosis  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
thrombocytopenia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer. Atlasy N, etal., Avicenna J Med Biotechnol. 2019 Apr-Jun;11(2):156-161.
2. Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice. Cao D, etal., Life Sci. 2020 Dec 15;263:118580. doi: 10.1016/j.lfs.2020.118580. Epub 2020 Oct 12.
3. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
4. FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities. de Oliveira FM, etal., Med Oncol. 2013 Mar;30(1):483. doi: 10.1007/s12032-013-0483-1. Epub 2013 Feb 7.
5. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
6. LncRNA-ANRIL promotes gastric cancer progression by enhancing NF-kB signaling. Deng W, etal., Exp Biol Med (Maywood). 2019 Sep;244(12):953-959. doi: 10.1177/1535370219860207. Epub 2019 Jun 26.
7. TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells. Deng W, etal., IUBMB Life. 2016 May;68(5):355-64. doi: 10.1002/iub.1490. Epub 2016 Mar 29.
8. Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. Dziaman T, etal., Clin Epigenetics. 2018 May 30;10:72. doi: 10.1186/s13148-018-0505-0. eCollection 2018.
9. DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients. Elashi AA, etal., Oncoimmunology. 2018 Nov 10;8(2):e1542918. doi: 10.1080/2162402X.2018.1542918. eCollection 2019.
10. Loss of nuclear localization of TET2 in colorectal cancer. Huang Y, etal., Clin Epigenetics. 2016 Jan 26;8:9. doi: 10.1186/s13148-016-0176-7. eCollection 2016.
11. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Jiang Y, etal., PLoS One. 2014 Dec 30;9(12):e116179. doi: 10.1371/journal.pone.0116179. eCollection 2014.
12. FGFR3â–³7-9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma. Jin Z, etal., Cell Death Dis. 2020 Oct 23;11(10):903. doi: 10.1038/s41419-020-03089-2.
13. Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma. Jäwert F, etal., Anticancer Res. 2013 Oct;33(10):4325-8.
14. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Liu J, etal., Hepatology. 2019 Jan;69(1):196-208. doi: 10.1002/hep.30146. Epub 2018 Dec 17.
15. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Ma H, etal., J Immunol Res. 2018 Jun 14;2018:6985031. doi: 10.1155/2018/6985031. eCollection 2018.
16. TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Murata A, etal., Oncotarget. 2015 Sep 15;6(27):23372-82.
17. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Saint-Martin C, etal., Blood. 2009 Aug 20;114(8):1628-32. doi: 10.1182/blood-2009-01-197525. Epub 2009 Jun 29.
23. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Sawada G, etal., Gastroenterology. 2016 May;150(5):1171-1182. doi: 10.1053/j.gastro.2016.01.035. Epub 2016 Feb 10.
24. Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. Scopim-Ribeiro R, etal., Eur J Haematol. 2015 May;94(5):413-8. doi: 10.1111/ejh.12445. Epub 2014 Oct 1.
25. Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma. Shi X, etal., PLoS One. 2016 Apr 6;11(4):e0153100. doi: 10.1371/journal.pone.0153100. eCollection 2016.
26. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Smith AE, etal., Blood. 2010 Nov 11;116(19):3923-32. doi: 10.1182/blood-2010-03-274704. Epub 2010 Aug 6.
27. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
28. The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells. Yang G, etal., Exp Cell Res. 2018 Feb 15;363(2):218-226. doi: 10.1016/j.yexcr.2018.01.011. Epub 2018 Jan 10.
29. TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. Zhang X, etal., Cancer Cell Int. 2020 Aug 3;20:363. doi: 10.1186/s12935-020-01456-9. eCollection 2020.
30. Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. Zhao D, etal., Lung Cancer. 2020 Aug;146:174-181. doi: 10.1016/j.lungcan.2020.05.025. Epub 2020 May 24.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12646957   PMID:12904583  
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PMID:21817016   PMID:21863549   PMID:21873190   PMID:21873635   PMID:22355785   PMID:22445327   PMID:22467095   PMID:22469782   PMID:22569366   PMID:22569552   PMID:22902501   PMID:22981865  
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PMID:25281607   PMID:25395421   PMID:25501021   PMID:25557551   PMID:25601757   PMID:25608811   PMID:25862091   PMID:25873173   PMID:25886910   PMID:25915124   PMID:26095772   PMID:26231219  
PMID:26275994   PMID:26287468   PMID:26325469   PMID:26328763   PMID:26378518   PMID:26493943   PMID:26576615   PMID:26586431   PMID:26598602   PMID:26607761   PMID:26620559   PMID:26773568  
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PMID:27384303   PMID:27424808   PMID:27428748   PMID:27622333   PMID:27694924   PMID:27760115   PMID:27778125   PMID:27821816   PMID:27863519   PMID:27869616   PMID:27869820   PMID:27895551  
PMID:27930333   PMID:27941786   PMID:28077417   PMID:28100914   PMID:28104796   PMID:28167288   PMID:28192139   PMID:28193779   PMID:28272491   PMID:28378742   PMID:28440315   PMID:28504700  
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PMID:30193945   PMID:30220521   PMID:30228234   PMID:30274972   PMID:30343588   PMID:30526882   PMID:30538121   PMID:30540950   PMID:30554962   PMID:30651561   PMID:30726915   PMID:30778220  
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Genomics

Comparative Map Data
Tet2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.84NCBI
TET2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,145,875 - 105,279,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4105,145,875 - 105,279,816 (+)EnsemblGRCh38hg38GRCh38
GRCh374106,067,032 - 106,200,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,287,392 - 106,383,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera4103,367,233 - 103,500,234 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4101,802,173 - 101,936,091 (+)NCBIHuRef
CHM1_14106,044,130 - 106,178,054 (+)NCBICHM1_1
T2T-CHM13v2.04108,456,807 - 108,590,746 (+)NCBIT2T-CHM13v2.0
Tet2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,662,654 - 224,746,819 (-)NCBIGRCr8
mRatBN7.22221,988,645 - 222,072,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02238,719,389 - 238,802,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,252,323 - 257,335,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42231,016,023 - 231,039,777 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12231,002,809 - 231,063,981 (-)NCBI
Celera2214,215,516 - 214,299,103 (-)NCBICelera
Cytogenetic Map2q43NCBI
Tet2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554963,885,035 - 3,926,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554963,885,684 - 3,963,056 (-)NCBIChiLan1.0ChiLan1.0
TET2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23103,232,771 - 103,365,873 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14103,525,110 - 103,658,251 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0497,612,439 - 97,745,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14108,225,209 - 108,358,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4108,269,082 - 108,358,400 (+)Ensemblpanpan1.1panPan2
TET2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13226,021,745 - 26,145,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3226,059,693 - 26,143,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3215,878,947 - 16,004,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03226,234,028 - 26,359,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3226,233,933 - 26,357,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13226,252,220 - 26,377,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03225,996,769 - 26,121,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03213,740,508 - 13,865,760 (-)NCBIUU_Cfam_GSD_1.0
Tet2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530115,030,779 - 15,167,846 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936752440,136 - 577,615 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936752440,137 - 577,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TET2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8116,415,267 - 116,545,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18116,413,253 - 116,546,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28125,007,902 - 125,139,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TET2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1753,193,824 - 53,326,813 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl753,193,941 - 53,326,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603731,808,498 - 31,945,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tet2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248303,446,141 - 3,519,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248303,446,331 - 3,543,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tet2
3969 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:858
Count of miRNA genes:516
Interacting mature miRNAs:614
Transcripts:ENSMUST00000098603
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3131736617148451178Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3131754536146017669Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3124993649137205761Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse

Markers in Region
45.MMHAP66FLG6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,529,715 - 133,529,872UniSTSGRCm38
MGSCv373133,192,679 - 133,192,836UniSTSGRCm37
Celera3139,952,940 - 139,953,097UniSTS
Cytogenetic Map3G3UniSTS
Whitehead_YAC18 UniSTS
UniSTS:234827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,463,988 - 133,464,301UniSTSGRCm38
MGSCv373133,126,952 - 133,127,265UniSTSGRCm37
Celera3139,887,026 - 139,887,339UniSTS
Cytogenetic Map3G3UniSTS
Tet2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383133,476,526 - 133,476,628UniSTSGRCm38
Celera3139,899,576 - 139,899,678UniSTS
Cytogenetic Map3G3UniSTS
cM Map361.84UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001040400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001346736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE137977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF463367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ079067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU079949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000098603   ⟹   ENSMUSP00000096203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,440 - 133,250,151 (-)Ensembl
GRCm38.p6 Ensembl3133,463,679 - 133,544,390 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,244,523 - 133,250,047 (-)Ensembl
GRCm38.p6 Ensembl3133,538,762 - 133,544,286 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,219,218 - 133,250,063 (-)Ensembl
GRCm38.p6 Ensembl3133,513,457 - 133,544,302 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196398   ⟹   ENSMUSP00000143029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,600 - 133,250,129 (-)Ensembl
GRCm38.p6 Ensembl3133,463,839 - 133,544,368 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197118   ⟹   ENSMUSP00000143619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,194,296 - 133,250,900 (-)Ensembl
GRCm38.p6 Ensembl3133,488,535 - 133,545,139 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,171,608 - 133,177,578 (-)Ensembl
GRCm38.p6 Ensembl3133,465,847 - 133,471,817 (-)Ensembl
Ensembl Acc Id: ENSMUST00000198974   ⟹   ENSMUSP00000143468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,173,288 - 133,182,331 (-)Ensembl
GRCm38.p6 Ensembl3133,467,527 - 133,476,570 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,180,836 - 133,184,687 (-)Ensembl
GRCm38.p6 Ensembl3133,475,075 - 133,478,926 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199381
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,169,444 - 133,180,580 (-)Ensembl
GRCm38.p6 Ensembl3133,463,683 - 133,474,819 (-)Ensembl
Ensembl Acc Id: ENSMUST00000200203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3133,184,817 - 133,186,443 (-)Ensembl
GRCm38.p6 Ensembl3133,479,056 - 133,480,682 (-)Ensembl
RefSeq Acc Id: NM_001040400   ⟹   NP_001035490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,438 - 133,250,151 (-)NCBI
GRCm383133,463,677 - 133,544,390 (-)NCBI
MGSCv373133,126,641 - 133,207,354 (-)RGD
Celera3139,886,715 - 139,967,658 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001346736   ⟹   NP_001333665
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,438 - 133,250,151 (-)NCBI
GRCm383133,463,677 - 133,544,390 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501283   ⟹   XP_006501346
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,882 (-)NCBI
GRCm383133,463,677 - 133,545,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501286   ⟹   XP_006501349
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,356 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006501287   ⟹   XP_006501350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,356 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240068   ⟹   XP_011238370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,245 (-)NCBI
GRCm383133,463,677 - 133,544,699 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163012   ⟹   XP_036018905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393133,169,443 - 133,250,155 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001035490   ⟸   NM_001040400
- Peptide Label: isoform 1
- UniProtKB: Q8K2K3 (UniProtKB/Swiss-Prot),   Q6ZPN2 (UniProtKB/Swiss-Prot),   Q4JK59 (UniProtKB/Swiss-Prot),   Q3UAI0 (UniProtKB/Swiss-Prot),   Q3U633 (UniProtKB/Swiss-Prot),   Q3U5R5 (UniProtKB/Swiss-Prot),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501346   ⟸   XM_006501283
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501350   ⟸   XM_006501287
- Peptide Label: isoform X3
- UniProtKB: D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501349   ⟸   XM_006501286
- Peptide Label: isoform X2
- UniProtKB: D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238370   ⟸   XM_011240068
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001333665   ⟸   NM_001346736
- Peptide Label: isoform 2
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000143468   ⟸   ENSMUST00000198974
Ensembl Acc Id: ENSMUSP00000143619   ⟸   ENSMUST00000197118
Ensembl Acc Id: ENSMUSP00000096203   ⟸   ENSMUST00000098603
Ensembl Acc Id: ENSMUSP00000143029   ⟸   ENSMUST00000196398
RefSeq Acc Id: XP_036018905   ⟸   XM_036163012
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JF55 (UniProtKB/TrEMBL),   D0VLQ5 (UniProtKB/TrEMBL)
Protein Domains
Methylcytosine dioxygenase TET1-3 oxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4JK59-F1-model_v2 AlphaFold Q4JK59 1-1912 view protein structure

Promoters
RGD ID:6833680
Promoter ID:MM_KWN:36143
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008RKO.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,134,301 - 133,135,662 (-)MPROMDB
RGD ID:6833677
Promoter ID:MM_KWN:36144
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008RKP.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,137,256 - 133,137,756 (-)MPROMDB
RGD ID:6834533
Promoter ID:MM_KWN:36145
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000041994,   NM_001040400
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363133,207,061 - 133,208,282 (-)MPROMDB
RGD ID:6882410
Promoter ID:EPDNEW_M4656
Type:multiple initiation site
Name:Tet2_2
Description:Mus musculus tet methylcytosine dioxygenase 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4657  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383133,506,672 - 133,506,732EPDNEW
RGD ID:6882412
Promoter ID:EPDNEW_M4657
Type:multiple initiation site
Name:Tet2_1
Description:Mus musculus tet methylcytosine dioxygenase 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4656  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383133,544,292 - 133,544,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443298 AgrOrtholog
Ensembl Genes ENSMUSG00000040943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098603 ENTREZGENE
  ENSMUST00000098603.8 UniProtKB/Swiss-Prot
  ENSMUST00000196398 ENTREZGENE
  ENSMUST00000196398.5 UniProtKB/TrEMBL
  ENSMUST00000197118.5 UniProtKB/TrEMBL
  ENSMUST00000198974.2 UniProtKB/TrEMBL
InterPro 2OGFeDO_noxygenase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TET1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TET_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:214133 UniProtKB/Swiss-Prot
MGD MGI:2443298 ENTREZGENE
NCBI Gene Tet2 ENTREZGENE
PANTHER METHYLCYTOSINE DIOXYGENASE TET2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tet2 PhenoGen
SMART Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JF55 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JG87_MOUSE UniProtKB/TrEMBL
  A0A0G2JGM1_MOUSE UniProtKB/TrEMBL
  D0VLQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q3U1R1_MOUSE UniProtKB/TrEMBL
  Q3U5R5 ENTREZGENE
  Q3U633 ENTREZGENE
  Q3UAI0 ENTREZGENE
  Q4JK59 ENTREZGENE
  Q6ZPN2 ENTREZGENE
  Q8K2K3 ENTREZGENE
  TET2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U5R5 UniProtKB/Swiss-Prot
  Q3U633 UniProtKB/Swiss-Prot
  Q3UAI0 UniProtKB/Swiss-Prot
  Q6ZPN2 UniProtKB/Swiss-Prot
  Q8K2K3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Tet2  tet methylcytosine dioxygenase 2  E130014J05Rik  RIKEN cDNA E130014J05 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 E130014J05Rik  RIKEN cDNA E130014J05 gene  Tet2  tet methylcytosine dioxygenase 2  Symbol and/or name change 5135510 APPROVED
2012-02-14 Tet2  tet methylcytosine dioxygenase 2  Tet2  tet oncogene family member 2  Symbol and/or name change 5135510 APPROVED