TET2 (tet methylcytosine dioxygenase 2) - Rat Genome Database

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Gene: TET2 (tet methylcytosine dioxygenase 2) Homo sapiens
Analyze
Symbol: TET2
Name: tet methylcytosine dioxygenase 2
RGD ID: 1606790
HGNC Page HGNC:25941
Description: Enables ferrous iron binding activity; methylcytosine dioxygenase activity; and zinc ion binding activity. Involved in several processes, including 5-methylcytosine catabolic process; hemopoiesis; and protein modification process. Predicted to be active in nucleus. Implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Biomarker of acute myeloid leukemia; breast cancer; colon adenoma; and gastrointestinal system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ20032; IMD75; KIAA1546; MDS; methylcytosine dioxygenase TET2; MGC125715; probable methylcytosine dioxygenase TET2; ten-eleven translocation 2; tet oncogene family member 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,145,875 - 105,279,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4105,145,875 - 105,279,816 (+)EnsemblGRCh38hg38GRCh38
GRCh374106,067,032 - 106,200,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,287,392 - 106,383,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera4103,367,233 - 103,500,234 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4101,802,173 - 101,936,091 (+)NCBIHuRef
CHM1_14106,044,130 - 106,178,054 (+)NCBICHM1_1
T2T-CHM13v2.04108,456,807 - 108,590,746 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
5-(hydroxymethyl)cytosine  (EXP,ISO)
5-methylcytosine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldrin  (EXP)
all-trans-retinoic acid  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
chloroquine  (EXP)
choline  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP)
curcumin  (EXP)
desferrioxamine B  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
geldanamycin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
methylmercury chloride  (EXP)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
p-chloromercuribenzoic acid  (EXP)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
potassium chromate  (EXP)
propanal  (EXP)
SB 431542  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachlorohydroquinone  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
uranium atom  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abdominal cramps  (IAGP)
Abdominal pain  (IAGP)
Abnormal bleeding  (IAGP)
Abnormal blistering of the skin  (IAGP)
Abnormal cardiac ventricular function  (IAGP)
Abnormal fingernail morphology  (IAGP)
Abnormal mast cell morphology  (IAGP)
Abnormal megakaryocyte morphology  (IAGP)
Abnormal number of granulocyte precursors  (IAGP)
Abnormal platelet morphology  (IAGP)
Abnormality of the respiratory system  (IAGP)
Acute leukemia  (IAGP)
Acute myeloid leukemia  (IAGP)
Amaurosis fugax  (IAGP)
Amyloidosis  (IAGP)
Anaphylactic shock  (IAGP)
Anemia  (IAGP)
Angina pectoris  (IAGP)
Anorexia  (IAGP)
Arterial thrombosis  (IAGP)
Arthralgia  (IAGP)
Ascites  (IAGP)
Autosomal recessive inheritance  (IAGP)
Bone marrow hypercellularity  (IAGP)
Bone marrow hypocellularity  (IAGP)
Bone pain  (IAGP)
Bronchiectasis  (IAGP)
Bruising susceptibility  (IAGP)
Budd-Chiari syndrome  (IAGP)
Cachexia  (IAGP)
Chest pain  (IAGP)
Chronic infection  (IAGP)
Chronic lymphatic leukemia  (IAGP)
Chronic myelomonocytic leukemia  (IAGP)
Congestive heart failure  (IAGP)
Decreased FasL-mediated apoptosis  (IAGP)
Decreased liver function  (IAGP)
Decreased proportion of class-switched memory B cells  (IAGP)
Diarrhea  (IAGP)
Dysplastic granulopoesis  (IAGP)
Dyspnea  (IAGP)
Easy fatigability  (IAGP)
Ecchymosis  (IAGP)
Elevated circulating alkaline phosphatase concentration  (IAGP)
Elevated total serum tryptase  (IAGP)
Eosinophilia  (IAGP)
Epistaxis  (IAGP)
Erythroid hypoplasia  (IAGP)
Extramedullary hematopoiesis  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Flank pain  (IAGP)
Flushing  (IAGP)
Follicular hyperplasia  (IAGP)
Gastrointestinal hemorrhage  (IAGP)
Gingival bleeding  (IAGP)
Granulocytic hyperplasia  (IAGP)
Granulocytopenia  (IAGP)
Headache  (IAGP)
Hemangioma  (IAGP)
Hematological neoplasm  (IAGP)
Hepatomegaly  (IAGP)
Hepatosplenomegaly  (IAGP)
Hypersplenism  (IAGP)
Hypertension  (IAGP)
Hypochromic anemia  (IAGP)
Hyposegmentation of neutrophil nuclei  (IAGP)
Hypotension  (IAGP)
Increased basophil count  (IAGP)
Increased circulating lactate dehydrogenase concentration  (IAGP)
Increased megakaryocyte count  (IAGP)
Increased proportion of CD25+ mast cells  (IAGP)
Increased susceptibility to fractures  (IAGP)
Infantile onset  (IAGP)
Intermittent claudication  (IAGP)
Leukemia  (IAGP)
Leukocytosis  (IAGP)
Low-grade fever  (IAGP)
Lymphadenopathy  (IAGP)
Lymphoma  (IAGP)
Macrocytic anemia  (IAGP)
Maculopapular exanthema  (IAGP)
Malabsorption  (IAGP)
Megaloblastic erythroid hyperplasia  (IAGP)
Moderate global developmental delay  (IAGP)
Multiple myeloma  (IAGP)
Myalgia  (IAGP)
Myelodysplasia  (IAGP)
Myelofibrosis  (IAGP)
Myeloproliferative disorder  (IAGP)
Myocardial infarction  (IAGP)
Nausea  (IAGP)
Nephroblastoma  (IAGP)
Neutropenia  (IAGP)
Neutrophilia  (IAGP)
Non-small cell lung carcinoma  (IAGP)
Normochromic anemia  (IAGP)
Normocytic anemia  (IAGP)
Osteolysis  (IAGP)
Osteoporosis  (IAGP)
Pallor  (IAGP)
Pancytopenia  (IAGP)
Paresthesia  (IAGP)
Pathologic fracture  (IAGP)
Peptic ulcer  (IAGP)
Persistent EBV viremia  (IAGP)
Petechiae  (IAGP)
Poikilocytosis  (IAGP)
Portal hypertension  (IAGP)
Portal vein thrombosis  (IAGP)
Prolonged bleeding time  (IAGP)
Pruritus  (IAGP)
Pulmonary embolism  (IAGP)
Recurrent respiratory infections  (IAGP)
Refractory anemia with ringed sideroblasts  (IAGP)
Respiratory insufficiency  (IAGP)
Single lineage myelodysplasia  (IAGP)
Somatic mutation  (IAGP)
Splenomegaly  (IAGP)
Stroke  (IAGP)
Syncope  (IAGP)
Tachycardia  (IAGP)
Third degree atrioventricular block  (IAGP)
Thrombocytopenia  (IAGP)
Thrombocytosis  (IAGP)
Tinnitus  (IAGP)
Transient ischemic attack  (IAGP)
Urticaria  (IAGP)
Venous thrombosis  (IAGP)
Vertigo  (IAGP)
Weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer. Atlasy N, etal., Avicenna J Med Biotechnol. 2019 Apr-Jun;11(2):156-161.
2. Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice. Cao D, etal., Life Sci. 2020 Dec 15;263:118580. doi: 10.1016/j.lfs.2020.118580. Epub 2020 Oct 12.
3. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
4. FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities. de Oliveira FM, etal., Med Oncol. 2013 Mar;30(1):483. doi: 10.1007/s12032-013-0483-1. Epub 2013 Feb 7.
5. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
6. LncRNA-ANRIL promotes gastric cancer progression by enhancing NF-kB signaling. Deng W, etal., Exp Biol Med (Maywood). 2019 Sep;244(12):953-959. doi: 10.1177/1535370219860207. Epub 2019 Jun 26.
7. TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells. Deng W, etal., IUBMB Life. 2016 May;68(5):355-64. doi: 10.1002/iub.1490. Epub 2016 Mar 29.
8. Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. Dziaman T, etal., Clin Epigenetics. 2018 May 30;10:72. doi: 10.1186/s13148-018-0505-0. eCollection 2018.
9. DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients. Elashi AA, etal., Oncoimmunology. 2018 Nov 10;8(2):e1542918. doi: 10.1080/2162402X.2018.1542918. eCollection 2019.
10. Loss of nuclear localization of TET2 in colorectal cancer. Huang Y, etal., Clin Epigenetics. 2016 Jan 26;8:9. doi: 10.1186/s13148-016-0176-7. eCollection 2016.
11. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Jiang Y, etal., PLoS One. 2014 Dec 30;9(12):e116179. doi: 10.1371/journal.pone.0116179. eCollection 2014.
12. FGFR3â–³7-9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma. Jin Z, etal., Cell Death Dis. 2020 Oct 23;11(10):903. doi: 10.1038/s41419-020-03089-2.
13. Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma. Jäwert F, etal., Anticancer Res. 2013 Oct;33(10):4325-8.
14. Expression of AMP-activated protein kinase/ten-eleven translocation 2 and their clinical relevance in colorectal cancer. Kang DH, etal., Oncol Lett. 2021 Feb;21(2):164. doi: 10.3892/ol.2021.12425. Epub 2021 Jan 4.
15. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Liu J, etal., Hepatology. 2019 Jan;69(1):196-208. doi: 10.1002/hep.30146. Epub 2018 Dec 17.
16. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Ma H, etal., J Immunol Res. 2018 Jun 14;2018:6985031. doi: 10.1155/2018/6985031. eCollection 2018.
17. TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Murata A, etal., Oncotarget. 2015 Sep 15;6(27):23372-82.
18. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
23. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Saint-Martin C, etal., Blood. 2009 Aug 20;114(8):1628-32. doi: 10.1182/blood-2009-01-197525. Epub 2009 Jun 29.
24. Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma. Sajadian SO, etal., Clin Epigenetics. 2015 Sep 11;7:98. doi: 10.1186/s13148-015-0133-x. eCollection 2015.
25. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Sawada G, etal., Gastroenterology. 2016 May;150(5):1171-1182. doi: 10.1053/j.gastro.2016.01.035. Epub 2016 Feb 10.
26. Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. Scopim-Ribeiro R, etal., Eur J Haematol. 2015 May;94(5):413-8. doi: 10.1111/ejh.12445. Epub 2014 Oct 1.
27. Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma. Shi X, etal., PLoS One. 2016 Apr 6;11(4):e0153100. doi: 10.1371/journal.pone.0153100. eCollection 2016.
28. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Smith AE, etal., Blood. 2010 Nov 11;116(19):3923-32. doi: 10.1182/blood-2010-03-274704. Epub 2010 Aug 6.
29. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
30. The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells. Yang G, etal., Exp Cell Res. 2018 Feb 15;363(2):218-226. doi: 10.1016/j.yexcr.2018.01.011. Epub 2018 Jan 10.
31. TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. Zhang X, etal., Cancer Cell Int. 2020 Aug 3;20:363. doi: 10.1186/s12935-020-01456-9. eCollection 2020.
32. Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. Zhao D, etal., Lung Cancer. 2020 Aug;146:174-181. doi: 10.1016/j.lungcan.2020.05.025. Epub 2020 May 24.
Additional References at PubMed
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PMID:20061559   PMID:20093295   PMID:20156304   PMID:20171768   PMID:20195608   PMID:20301658   PMID:20332099   PMID:20334914   PMID:20428194   PMID:20489055   PMID:20508616   PMID:20520643  
PMID:20564319   PMID:20573398   PMID:20595094   PMID:20629097   PMID:20644105   PMID:20671051   PMID:20678218   PMID:20880116   PMID:20881960   PMID:20955399   PMID:21042320   PMID:21057493  
PMID:21087791   PMID:21130701   PMID:21173100   PMID:21251613   PMID:21273266   PMID:21275969   PMID:21307773   PMID:21310937   PMID:21339759   PMID:21343549   PMID:21346257   PMID:21494260  
PMID:21508122   PMID:21625234   PMID:21690245   PMID:21723200   PMID:21723201   PMID:21729597   PMID:21734233   PMID:21760590   PMID:21794915   PMID:21828143   PMID:21873635   PMID:21904853  
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PMID:31829736   PMID:31836704   PMID:31836856   PMID:31867779   PMID:31901078   PMID:31925810   PMID:31941838   PMID:31990036   PMID:32024762   PMID:32066746   PMID:32174258   PMID:32192357  
PMID:32193150   PMID:32203209   PMID:32319378   PMID:32319620   PMID:32330418   PMID:32342329   PMID:32367481   PMID:32518206   PMID:32518946   PMID:32572734   PMID:32574963   PMID:32619551  
PMID:32658928   PMID:32668244   PMID:32807901   PMID:32807949   PMID:32814053   PMID:32957806   PMID:32963106   PMID:33008340   PMID:33022573   PMID:33085059   PMID:33113366   PMID:33172974  
PMID:33184433   PMID:33207953   PMID:33241418   PMID:33410283   PMID:33452460   PMID:33509440   PMID:33512451   PMID:33535102   PMID:33626359   PMID:33640491   PMID:33786584   PMID:33803981  
PMID:33832602   PMID:33913570   PMID:33915173   PMID:33961781   PMID:34019487   PMID:34039392   PMID:34099923   PMID:34111946   PMID:34147657   PMID:34210413   PMID:34215619   PMID:34226983  
PMID:34267355   PMID:34362476   PMID:34417463   PMID:34449560   PMID:34576030   PMID:34654019   PMID:34663818   PMID:34667079   PMID:34689714   PMID:34692086   PMID:34695415   PMID:34728620  
PMID:34768283   PMID:34826027   PMID:34879277   PMID:34883445   PMID:34884685   PMID:34905094   PMID:34929447   PMID:35011643   PMID:35066499   PMID:35085104   PMID:35128634   PMID:35136034  
PMID:35140242   PMID:35176127   PMID:35235761   PMID:35248720   PMID:35271311   PMID:35279121   PMID:35306971   PMID:35339897   PMID:35345350   PMID:35351824   PMID:35405783   PMID:35660018  
PMID:35697791   PMID:35714308   PMID:35819319   PMID:35931086   PMID:35941108   PMID:35965615   PMID:36066697   PMID:36076297   PMID:36093687   PMID:36469134   PMID:36580013   PMID:36639817  


Genomics

Comparative Map Data
TET2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,145,875 - 105,279,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4105,145,875 - 105,279,816 (+)EnsemblGRCh38hg38GRCh38
GRCh374106,067,032 - 106,200,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,287,392 - 106,383,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera4103,367,233 - 103,500,234 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4101,802,173 - 101,936,091 (+)NCBIHuRef
CHM1_14106,044,130 - 106,178,054 (+)NCBICHM1_1
T2T-CHM13v2.04108,456,807 - 108,590,746 (+)NCBIT2T-CHM13v2.0
Tet2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
Tet2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22221,988,645 - 222,072,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02238,719,389 - 238,802,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,252,323 - 257,335,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42231,016,023 - 231,039,777 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12231,002,809 - 231,063,981 (-)NCBI
Celera2214,215,516 - 214,299,103 (-)NCBICelera
Cytogenetic Map2q43NCBI
Tet2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554963,885,035 - 3,926,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554963,885,684 - 3,963,056 (-)NCBIChiLan1.0ChiLan1.0
TET2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14108,225,209 - 108,358,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4108,269,082 - 108,358,400 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0497,612,439 - 97,745,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TET2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13226,021,745 - 26,145,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3226,059,693 - 26,143,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3215,878,947 - 16,004,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03226,234,028 - 26,359,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3226,233,933 - 26,357,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13226,252,220 - 26,377,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03225,996,769 - 26,121,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03213,740,508 - 13,865,760 (-)NCBIUU_Cfam_GSD_1.0
Tet2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530115,030,779 - 15,167,846 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936752440,136 - 577,615 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936752440,137 - 577,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TET2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8116,415,267 - 116,545,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18116,413,253 - 116,546,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28125,007,902 - 125,139,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TET2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1753,193,824 - 53,326,813 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl753,193,941 - 53,326,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603731,808,498 - 31,945,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tet2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248303,446,141 - 3,519,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248303,446,331 - 3,543,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TET2
131 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001127208.2(TET2):c.-192-14281A>G single nucleotide variant Lung cancer [RCV000093916] Chr4:105176079 [GRCh38]
Chr4:106097236 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.2(TET2):c.-47+14754C>T single nucleotide variant Lung cancer [RCV000093917] Chr4:105205259 [GRCh38]
Chr4:106126416 [GRCh37]
Chr4:4q24		 uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3		 pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3		 pathogenic
NM_001127208.3(TET2):c.5284A>G (p.Ile1762Val) single nucleotide variant not provided [RCV001709493]|not specified [RCV000122102] Chr4:105275794 [GRCh38]
Chr4:106196951 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.5284A>T (p.Ile1762Leu) single nucleotide variant not specified [RCV000122103] Chr4:105275794 [GRCh38]
Chr4:106196951 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5333A>G (p.His1778Arg) single nucleotide variant not specified [RCV000122104] Chr4:105275843 [GRCh38]
Chr4:106197000 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5453A>T (p.Lys1818Ile) single nucleotide variant not specified [RCV000122105] Chr4:105275963 [GRCh38]
Chr4:106197120 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.6004A>G (p.Ile2002Val) single nucleotide variant not specified [RCV000122106] Chr4:105276514 [GRCh38]
Chr4:106197671 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5167C>T (p.Pro1723Ser) single nucleotide variant not provided [RCV000953714]|not specified [RCV000122107] Chr4:105275677 [GRCh38]
Chr4:106196834 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.5449C>A (p.His1817Asn) single nucleotide variant not specified [RCV000122108] Chr4:105275959 [GRCh38]
Chr4:106197116 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5885C>T (p.Pro1962Leu) single nucleotide variant not specified [RCV000122109] Chr4:105276395 [GRCh38]
Chr4:106197552 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.4817G>C (p.Gly1606Ala) single nucleotide variant not specified [RCV000122110] Chr4:105275327 [GRCh38]
Chr4:106196484 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5103G>A (p.Met1701Ile) single nucleotide variant not provided [RCV000963435]|not specified [RCV000122111] Chr4:105275613 [GRCh38]
Chr4:106196770 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.5152G>T (p.Val1718Leu) single nucleotide variant not provided [RCV000963300]|not specified [RCV000122112] Chr4:105275662 [GRCh38]
Chr4:106196819 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.5305G>C (p.Ala1769Pro) single nucleotide variant Immunodeficiency 75 [RCV001836734]|not specified [RCV000122113] Chr4:105275815 [GRCh38]
Chr4:106196972 [GRCh37]
Chr4:4q24		 uncertain significance|not provided
NM_001127208.3(TET2):c.5914G>C (p.Ala1972Pro) single nucleotide variant not specified [RCV000122114] Chr4:105276424 [GRCh38]
Chr4:106197581 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.5162T>G (p.Leu1721Trp) single nucleotide variant not specified [RCV000122115] Chr4:105275672 [GRCh38]
Chr4:106196829 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1745A>G (p.Asn582Ser) single nucleotide variant not specified [RCV000122117] Chr4:105235687 [GRCh38]
Chr4:106156844 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.2429A>G (p.Gln810Arg) single nucleotide variant not provided [RCV001753505]|not specified [RCV000122118] Chr4:105236371 [GRCh38]
Chr4:106157528 [GRCh37]
Chr4:4q24		 likely benign|uncertain significance|not provided
NM_001127208.3(TET2):c.2549A>G (p.His850Arg) single nucleotide variant not specified [RCV000122119] Chr4:105236491 [GRCh38]
Chr4:106157648 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.2771A>G (p.His924Arg) single nucleotide variant not provided [RCV000956243]|not specified [RCV000122120] Chr4:105236713 [GRCh38]
Chr4:106157870 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.3251A>C (p.Gln1084Pro) single nucleotide variant not provided [RCV000954910]|not specified [RCV000122121] Chr4:105237193 [GRCh38]
Chr4:106158350 [GRCh37]
Chr4:4q24		 benign|likely benign|not provided
NM_001127208.3(TET2):c.899A>G (p.Asp300Gly) single nucleotide variant not specified [RCV000122122] Chr4:105234841 [GRCh38]
Chr4:106155998 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.100C>T (p.Leu34Phe) single nucleotide variant not specified [RCV000122123] Chr4:105234042 [GRCh38]
Chr4:106155199 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1088C>T (p.Pro363Leu) single nucleotide variant not specified [RCV000122124] Chr4:105235030 [GRCh38]
Chr4:106156187 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1379C>T (p.Ser460Phe) single nucleotide variant not specified [RCV000122125] Chr4:105235321 [GRCh38]
Chr4:106156478 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1724C>T (p.Ala575Val) single nucleotide variant not specified [RCV000122126] Chr4:105235666 [GRCh38]
Chr4:106156823 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.2440C>T (p.Arg814Cys) single nucleotide variant not specified [RCV000122127] Chr4:105236382 [GRCh38]
Chr4:106157539 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3035C>T (p.Pro1012Leu) single nucleotide variant not specified [RCV000122128] Chr4:105236977 [GRCh38]
Chr4:106158134 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3116C>T (p.Ser1039Leu) single nucleotide variant not provided [RCV000912201]|not specified [RCV000122129] Chr4:105237058 [GRCh38]
Chr4:106158215 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.521C>A (p.Pro174His) single nucleotide variant not provided [RCV002262716]|not specified [RCV000122130] Chr4:105234463 [GRCh38]
Chr4:106155620 [GRCh37]
Chr4:4q24		 likely benign|uncertain significance|not provided
NM_001127208.3(TET2):c.86C>G (p.Pro29Arg) single nucleotide variant not specified [RCV000122131] Chr4:105234028 [GRCh38]
Chr4:106155185 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1064G>A (p.Gly355Asp) single nucleotide variant not specified [RCV000122132] Chr4:105235006 [GRCh38]
Chr4:106156163 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1285G>A (p.Gly429Arg) single nucleotide variant not specified [RCV000122133] Chr4:105235227 [GRCh38]
Chr4:106156384 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.1819G>A (p.Gly607Arg) single nucleotide variant not specified [RCV000122134] Chr4:105235761 [GRCh38]
Chr4:106156918 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.434G>A (p.Ser145Asn) single nucleotide variant not specified [RCV000122135] Chr4:105234376 [GRCh38]
Chr4:106155533 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.652G>A (p.Val218Met) single nucleotide variant not provided [RCV001682836]|not specified [RCV000122136] Chr4:105234594 [GRCh38]
Chr4:106155751 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.197T>C (p.Met66Thr) single nucleotide variant not specified [RCV000122137] Chr4:105234139 [GRCh38]
Chr4:106155296 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.2599T>C (p.Tyr867His) single nucleotide variant not provided [RCV000953713]|not specified [RCV000122138] Chr4:105236541 [GRCh38]
Chr4:106157698 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.2604T>G (p.Phe868Leu) single nucleotide variant not specified [RCV000122139] Chr4:105236546 [GRCh38]
Chr4:106157703 [GRCh37]
Chr4:4q24		 benign|not provided
NM_001127208.3(TET2):c.920T>G (p.Leu307Arg) single nucleotide variant not specified [RCV000122140] Chr4:105234862 [GRCh38]
Chr4:106156019 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3409+18A>G single nucleotide variant not specified [RCV000122141] Chr4:105237369 [GRCh38]
Chr4:106158526 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3409+42G>T single nucleotide variant not specified [RCV000122142] Chr4:105237393 [GRCh38]
Chr4:106158550 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3409+70G>A single nucleotide variant not specified [RCV000122143] Chr4:105237421 [GRCh38]
Chr4:106158578 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.3409+15T>A single nucleotide variant not specified [RCV000122144] Chr4:105237366 [GRCh38]
Chr4:106158523 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.959AAC[1] (p.Gln321del) microsatellite not specified [RCV000122116] Chr4:105234901..105234903 [GRCh38]
Chr4:106156058..106156060 [GRCh37]
Chr4:4q24		 not provided
NM_001127208.3(TET2):c.2084T>C (p.Met695Thr) single nucleotide variant not provided [RCV002288039] Chr4:105236026 [GRCh38]
Chr4:106157183 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.2131G>C (p.Glu711Gln) single nucleotide variant Familial cancer of breast [RCV000207332] Chr4:105236073 [GRCh38]
Chr4:106157230 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4456T>C (p.Ser1486Pro) single nucleotide variant Nephroblastoma [RCV000505569] Chr4:105272837 [GRCh38]
Chr4:106193994 [GRCh37]
Chr4:4q24		 other
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001127208.3(TET2):c.2964_2967dup (p.His990fs) duplication not provided [RCV000498812] Chr4:105236904..105236905 [GRCh38]
Chr4:106158061..106158062 [GRCh37]
Chr4:4q24		 uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001127208.3(TET2):c.4145A>G (p.His1382Arg) single nucleotide variant Immunodeficiency 75 [RCV001270922]|not provided [RCV000494659] Chr4:105269710 [GRCh38]
Chr4:106190867 [GRCh37]
Chr4:4q24		 pathogenic|uncertain significance
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q24-25(chr4:105039193-110409978)x3 copy number gain not provided [RCV000743885] Chr4:105039193..110409978 [GRCh37]
Chr4:4q24-25		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
NM_001127208.3(TET2):c.3641G>A (p.Arg1214Gln) single nucleotide variant not provided [RCV001531406] Chr4:105243616 [GRCh38]
Chr4:106164773 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.1438C>T (p.Pro480Ser) single nucleotide variant Multiple myeloma [RCV000984111] Chr4:105235380 [GRCh38]
Chr4:106156537 [GRCh37]
Chr4:4q24		 likely pathogenic
NM_001127208.3(TET2):c.4182+9G>A single nucleotide variant not provided [RCV000969780] Chr4:105269756 [GRCh38]
Chr4:106190913 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.3090G>A (p.Gln1030=) single nucleotide variant not provided [RCV000968041] Chr4:105237032 [GRCh38]
Chr4:106158189 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.606C>T (p.Asn202=) single nucleotide variant not provided [RCV000923518] Chr4:105234548 [GRCh38]
Chr4:106155705 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.-46-63ATAG[4] microsatellite not provided [RCV001620742] Chr4:105233834..105233841 [GRCh38]
Chr4:106154991..106154998 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.3594+200T>G single nucleotide variant not provided [RCV001657186] Chr4:105243127 [GRCh38]
Chr4:106164284 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.4538-113C>T single nucleotide variant not provided [RCV001598992] Chr4:105274935 [GRCh38]
Chr4:106196092 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.3589A>G (p.Lys1197Glu) single nucleotide variant not provided [RCV001531405] Chr4:105242922 [GRCh38]
Chr4:106164079 [GRCh37]
Chr4:4q24		 pathogenic
NM_001127208.3(TET2):c.3852C>T (p.Ser1284=) single nucleotide variant not provided [RCV000916876] Chr4:105259667 [GRCh38]
Chr4:106180824 [GRCh37]
Chr4:4q24		 likely benign
NC_000004.12:g.104314621_104314622insG insertion Multiple myeloma [RCV000984135] Chr4:104314621..104314622 [GRCh38]
Chr4:105235778..105235779 [GRCh37]
Chr4:4q24		 likely pathogenic
NM_001127208.3(TET2):c.36C>T (p.Asn12=) single nucleotide variant not provided [RCV000930679] Chr4:105233978 [GRCh38]
Chr4:106155135 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.4800C>G (p.Thr1600=) single nucleotide variant not provided [RCV000894923] Chr4:105275310 [GRCh38]
Chr4:106196467 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.1884G>A (p.Glu628=) single nucleotide variant not provided [RCV000946802] Chr4:105235826 [GRCh38]
Chr4:106156983 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.879T>C (p.Ser293=) single nucleotide variant not provided [RCV000913323] Chr4:105234821 [GRCh38]
Chr4:106155978 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.3595-4G>A single nucleotide variant not provided [RCV000889525] Chr4:105243566 [GRCh38]
Chr4:106164723 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.1268A>G (p.Lys423Arg) single nucleotide variant Myelodysplastic syndrome [RCV001293996] Chr4:105235210 [GRCh38]
Chr4:106156367 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4894C>T (p.Gln1632Ter) single nucleotide variant Immunodeficiency 75 [RCV001270923] Chr4:105275404 [GRCh38]
Chr4:106196561 [GRCh37]
Chr4:4q24		 pathogenic
NM_001127208.3(TET2):c.1864C>T (p.Gln622Ter) single nucleotide variant not provided [RCV001531404] Chr4:105235806 [GRCh38]
Chr4:106156963 [GRCh37]
Chr4:4q24		 likely pathogenic
NM_001127208.3(TET2):c.*329_*330dup duplication not provided [RCV001655228] Chr4:105276838..105276839 [GRCh38]
Chr4:106197995..106197996 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.2230C>T (p.Gln744Ter) single nucleotide variant not provided [RCV001755599] Chr4:105236172 [GRCh38]
Chr4:106157329 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.2216_2264dup (p.Glu755delinsAspSerLysProAlaThrAlaAlaLysIleThrAsnLysGluTer) duplication not provided [RCV001755517] Chr4:105236157..105236158 [GRCh38]
Chr4:106157314..106157315 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4879C>T (p.Gln1627Ter) single nucleotide variant not provided [RCV001755454] Chr4:105275389 [GRCh38]
Chr4:106196546 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.2029_2032del (p.Cys677fs) microsatellite Myelodysplastic syndrome [RCV002246770] Chr4:105235969..105235972 [GRCh38]
Chr4:106157126..106157129 [GRCh37]
Chr4:4q24		 pathogenic
NM_001127208.3(TET2):c.4600C>T (p.Gln1534Ter) single nucleotide variant Immunodeficiency 75 [RCV002272867] Chr4:105275110 [GRCh38]
Chr4:106196267 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.6002_*30del (p.Arg2000_Tyr2001insTer) deletion not provided [RCV001753274] Chr4:105276511..105276548 [GRCh38]
Chr4:106197668..106197705 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.416del (p.Pro139fs) deletion Immunodeficiency 75 [RCV002255232] Chr4:105234357 [GRCh38]
Chr4:106155514 [GRCh37]
Chr4:4q24		 pathogenic
NM_001127208.3(TET2):c.5834A>G (p.His1945Arg) single nucleotide variant not provided [RCV001774864] Chr4:105276344 [GRCh38]
Chr4:106197501 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4624C>T (p.Gln1542Ter) single nucleotide variant not provided [RCV001768215] Chr4:105275134 [GRCh38]
Chr4:106196291 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4354C>T (p.Arg1452Ter) single nucleotide variant not provided [RCV001768250] Chr4:105272735 [GRCh38]
Chr4:106193892 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4042C>T (p.Gln1348Ter) single nucleotide variant not provided [RCV001768216] Chr4:105261846 [GRCh38]
Chr4:106183003 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.1924C>T (p.Gln642Ter) single nucleotide variant not provided [RCV001768247] Chr4:105235866 [GRCh38]
Chr4:106157023 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.744C>A (p.His248Gln) single nucleotide variant not provided [RCV001799901] Chr4:105234686 [GRCh38]
Chr4:106155843 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3028G>A (p.Glu1010Lys) single nucleotide variant not specified [RCV001817477] Chr4:105236970 [GRCh38]
Chr4:106158127 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3109G>A (p.Ala1037Thr) single nucleotide variant not specified [RCV001820550] Chr4:105237051 [GRCh38]
Chr4:106158208 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.2385C>T (p.Ser795=) single nucleotide variant not specified [RCV001817362] Chr4:105236327 [GRCh38]
Chr4:106157484 [GRCh37]
Chr4:4q24		 benign
NM_001127208.3(TET2):c.5599A>G (p.Thr1867Ala) single nucleotide variant not specified [RCV001822507] Chr4:105276109 [GRCh38]
Chr4:106197266 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.5484G>A (p.Gln1828=) single nucleotide variant not specified [RCV001822621] Chr4:105275994 [GRCh38]
Chr4:106197151 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.5413A>T (p.Asn1805Tyr) single nucleotide variant not specified [RCV001822678] Chr4:105275923 [GRCh38]
Chr4:106197080 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.723G>T (p.Ala241=) single nucleotide variant not specified [RCV001822686] Chr4:105234665 [GRCh38]
Chr4:106155822 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.4715G>A (p.Arg1572Gln) single nucleotide variant not specified [RCV001822367] Chr4:105275225 [GRCh38]
Chr4:106196382 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3825G>T (p.Gly1275=) single nucleotide variant not specified [RCV001822564] Chr4:105259640 [GRCh38]
Chr4:106180797 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.2633T>G (p.Leu878Arg) single nucleotide variant not specified [RCV001822573] Chr4:105236575 [GRCh38]
Chr4:106157732 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3387T>C (p.Asp1129=) single nucleotide variant not specified [RCV001822611] Chr4:105237329 [GRCh38]
Chr4:106158486 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.2199C>T (p.Ser733=) single nucleotide variant not specified [RCV001822615] Chr4:105236141 [GRCh38]
Chr4:106157298 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.4965G>A (p.Pro1655=) single nucleotide variant not specified [RCV001822662] Chr4:105275475 [GRCh38]
Chr4:106196632 [GRCh37]
Chr4:4q24		 likely benign
NM_001127208.3(TET2):c.4975T>C (p.Tyr1659His) single nucleotide variant not specified [RCV001822787] Chr4:105275485 [GRCh38]
Chr4:106196642 [GRCh37]
Chr4:4q24		 uncertain significance
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3 copy number gain not provided [RCV001827745] Chr4:95490755..109977216 [GRCh37]
Chr4:4q22.3-25		 likely pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21		 pathogenic
NM_001127208.3(TET2):c.3500+6T>G single nucleotide variant not provided [RCV002224917] Chr4:105241435 [GRCh38]
Chr4:106162592 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3804-2A>C single nucleotide variant Myelodysplastic syndrome [RCV002247164] Chr4:105259617 [GRCh38]
Chr4:106180774 [GRCh37]
Chr4:4q24		 likely pathogenic
NM_001127208.3(TET2):c.1588C>T (p.Gln530Ter) single nucleotide variant not provided [RCV002263353] Chr4:105235530 [GRCh38]
Chr4:106156687 [GRCh37]
Chr4:4q24		 likely pathogenic
NM_001127208.3(TET2):c.4276G>A (p.Val1426Met) single nucleotide variant not provided [RCV002293644] Chr4:105272657 [GRCh38]
Chr4:106193814 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.95C>T (p.Thr32Ile) single nucleotide variant not provided [RCV002274689] Chr4:105234037 [GRCh38]
Chr4:106155194 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3223del (p.Asp1075fs) deletion not provided [RCV002293634] Chr4:105237165 [GRCh38]
Chr4:106158322 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3821A>T (p.Gln1274Leu) single nucleotide variant not provided [RCV002293635] Chr4:105259636 [GRCh38]
Chr4:106180793 [GRCh37]
Chr4:4q24		 uncertain significance
NM_001127208.3(TET2):c.3562A>T (p.Lys1188Ter) single nucleotide variant Third degree atrioventricular block [RCV002305645] Chr4:105242895 [GRCh38]
Chr4:106164052 [GRCh37]
Chr4:4q24		 pathogenic
GRCh37/hg19 4q24(chr4:106183434-106427730)x3 copy number gain not provided [RCV002475792] Chr4:106183434..106427730 [GRCh37]
Chr4:4q24		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13146
Count of miRNA genes:1376
Interacting mature miRNAs:1804
Transcripts:ENST00000265149, ENST00000305737, ENST00000380013, ENST00000394764, ENST00000413648, ENST00000504042, ENST00000505801, ENST00000513237, ENST00000514870, ENST00000540549, ENST00000545826
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH69608  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,200,521 - 106,200,673UniSTSGRCh37
Build 364106,419,970 - 106,420,122RGDNCBI36
Celera4103,499,797 - 103,499,949RGD
Cytogenetic Map4q24UniSTS
HuRef4101,935,652 - 101,935,804UniSTS
GeneMap99-GB4 RH Map4499.01UniSTS
NCBI RH Map41175.8UniSTS
SHGC-67291  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,193,758 - 106,193,991UniSTSGRCh37
Build 364106,413,207 - 106,413,440RGDNCBI36
Celera4103,493,034 - 103,493,267RGD
Cytogenetic Map4q24UniSTS
HuRef4101,928,889 - 101,929,122UniSTS
TNG Radiation Hybrid Map486734.0UniSTS
GeneMap99-GB4 RH Map4500.66UniSTS
SHGC-78137  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,114,668 - 106,114,938UniSTSGRCh37
Build 364106,334,117 - 106,334,387RGDNCBI36
Celera4103,413,953 - 103,414,223RGD
Cytogenetic Map4q24UniSTS
HuRef4101,849,787 - 101,850,057UniSTS
SHGC-23097  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,107,457 - 106,107,546UniSTSGRCh37
Build 364106,326,906 - 106,326,995RGDNCBI36
Celera4103,406,742 - 103,406,831RGD
Cytogenetic Map4q24UniSTS
HuRef4101,842,576 - 101,842,665UniSTS
TNG Radiation Hybrid Map491780.0UniSTS
G34465  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,112,441 - 106,112,639UniSTSGRCh37
Build 364106,331,890 - 106,332,088RGDNCBI36
Celera4103,411,726 - 103,411,924RGD
Cytogenetic Map4q24UniSTS
HuRef4101,847,560 - 101,847,758UniSTS
SHGC-67957  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,158,208 - 106,158,364UniSTSGRCh37
Build 364106,377,657 - 106,377,813RGDNCBI36
Celera4103,457,494 - 103,457,650RGD
Cytogenetic Map4q24UniSTS
HuRef4101,893,348 - 101,893,504UniSTS
TNG Radiation Hybrid Map491756.0UniSTS
GeneMap99-GB4 RH Map4508.0UniSTS
NCBI RH Map41175.8UniSTS
D4S3313  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,112,462 - 106,112,631UniSTSGRCh37
Build 364106,331,911 - 106,332,080RGDNCBI36
Celera4103,411,747 - 103,411,916RGD
Cytogenetic Map4q24UniSTS
HuRef4101,847,581 - 101,847,750UniSTS
AFM199yb2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374106,069,043 - 106,069,276UniSTSGRCh37
Build 364106,288,492 - 106,288,725RGDNCBI36
Celera4103,368,334 - 103,368,567RGD
Cytogenetic Map4q24UniSTS
HuRef4101,804,185 - 101,804,418UniSTS
Whitehead-RH Map4540.6UniSTS
Whitehead-YAC Contig Map4 UniSTS
NCBI RH Map41175.8UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 34 294 32 6 802 3 686 32 221 34 231 196 5 4 424 3
Low 2397 2640 1683 609 1129 454 3662 2111 3426 381 1216 1411 165 1200 2363 1
Below cutoff 1 52 8 7 8 8 5 51 65 3 3 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001127208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001741246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007057933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_244633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_427546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_938746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_938747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB075496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC026029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI084057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ006500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA391215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR000714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR005542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM992369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT746187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265149   ⟹   ENSP00000265149
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,786 - 105,279,803 (+)Ensembl
RefSeq Acc Id: ENST00000305737   ⟹   ENSP00000306705
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,145,875 - 105,242,771 (+)Ensembl
RefSeq Acc Id: ENST00000380013   ⟹   ENSP00000369351
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,876 - 105,279,803 (+)Ensembl
RefSeq Acc Id: ENST00000413648   ⟹   ENSP00000391448
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,886 - 105,242,762 (+)Ensembl
RefSeq Acc Id: ENST00000504042
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,878 - 105,202,546 (+)Ensembl
RefSeq Acc Id: ENST00000505801
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,933 - 105,190,703 (+)Ensembl
RefSeq Acc Id: ENST00000513237   ⟹   ENSP00000425443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,293 - 105,279,816 (+)Ensembl
RefSeq Acc Id: ENST00000514870   ⟹   ENSP00000426885
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,147,457 - 105,234,272 (+)Ensembl
RefSeq Acc Id: ENST00000540549   ⟹   ENSP00000442788
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl4105,146,293 - 105,279,816 (+)Ensembl
RefSeq Acc Id: NM_001127208   ⟹   NP_001120680
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,279,803 (+)NCBI
GRCh374106,067,032 - 106,200,960 (+)ENTREZGENE
HuRef4101,802,173 - 101,936,091 (+)ENTREZGENE
CHM1_14106,044,940 - 106,178,054 (+)NCBI
T2T-CHM13v2.04108,457,808 - 108,590,746 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017628   ⟹   NP_060098
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,145,875 - 105,242,771 (+)NCBI
GRCh374106,067,032 - 106,200,960 (+)ENTREZGENE
Build 364106,287,392 - 106,383,377 (+)NCBI Archive
HuRef4101,802,173 - 101,936,091 (+)ENTREZGENE
CHM1_14106,044,130 - 106,141,045 (+)NCBI
T2T-CHM13v2.04108,456,807 - 108,553,709 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005263082   ⟹   XP_005263139
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,279,803 (+)NCBI
GRCh374106,067,032 - 106,200,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006714242   ⟹   XP_006714305
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,279,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008319   ⟹   XP_016863808
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,240,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024454102   ⟹   XP_024309870
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,279,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024454103   ⟹   XP_024309871
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,145,875 - 105,279,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047415839   ⟹   XP_047271795
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,269,746 (+)NCBI
RefSeq Acc Id: XM_047415840   ⟹   XP_047271796
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,259,764 (+)NCBI
RefSeq Acc Id: XM_047415841   ⟹   XP_047271797
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,243,767 (+)NCBI
RefSeq Acc Id: XM_047415842   ⟹   XP_047271798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,241,396 (+)NCBI
RefSeq Acc Id: XM_047415843   ⟹   XP_047271799
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,240,928 (+)NCBI
RefSeq Acc Id: XR_007057933
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,876 - 105,242,916 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_060098   ⟸   NM_017628
- Peptide Label: isoform b
- UniProtKB: Q6N021 (UniProtKB/Swiss-Prot),   A0A024RDF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001120680   ⟸   NM_001127208
- Peptide Label: isoform a
- UniProtKB: Q9NXW0 (UniProtKB/Swiss-Prot),   Q6N021 (UniProtKB/Swiss-Prot),   A0A158SIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005263139   ⟸   XM_005263082
- Peptide Label: isoform X1
- UniProtKB: Q9NXW0 (UniProtKB/Swiss-Prot),   Q6N021 (UniProtKB/Swiss-Prot),   A0A158SIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006714305   ⟸   XM_006714242
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016863808   ⟸   XM_017008319
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_024309871   ⟸   XM_024454103
- Peptide Label: isoform X1
- UniProtKB: Q9NXW0 (UniProtKB/Swiss-Prot),   A0A158SIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024309870   ⟸   XM_024454102
- Peptide Label: isoform X1
- UniProtKB: Q9NXW0 (UniProtKB/Swiss-Prot),   A0A158SIU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000391448   ⟸   ENST00000413648
RefSeq Acc Id: ENSP00000369351   ⟸   ENST00000380013
RefSeq Acc Id: ENSP00000425443   ⟸   ENST00000513237
RefSeq Acc Id: ENSP00000426885   ⟸   ENST00000514870
RefSeq Acc Id: ENSP00000442788   ⟸   ENST00000540549
RefSeq Acc Id: ENSP00000265149   ⟸   ENST00000265149
RefSeq Acc Id: ENSP00000306705   ⟸   ENST00000305737
RefSeq Acc Id: XP_047271795   ⟸   XM_047415839
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047271796   ⟸   XM_047415840
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047271797   ⟸   XM_047415841
- Peptide Label: isoform X5
RefSeq Acc Id: XP_047271798   ⟸   XM_047415842
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047271799   ⟸   XM_047415843
- Peptide Label: isoform X6
Protein Domains
Tet_JBP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6N021-F1-model_v2 AlphaFold Q6N021 1-2002 view protein structure

Promoters
RGD ID:6868184
Promoter ID:EPDNEW_H7257
Type:initiation region
Name:TET2_3
Description:tet methylcytosine dioxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7258  EPDNEW_H7259  EPDNEW_H7260  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,145,563 - 105,145,623EPDNEW
RGD ID:6868186
Promoter ID:EPDNEW_H7258
Type:initiation region
Name:TET2_4
Description:tet methylcytosine dioxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7257  EPDNEW_H7259  EPDNEW_H7260  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,145,967 - 105,146,027EPDNEW
RGD ID:6868188
Promoter ID:EPDNEW_H7259
Type:initiation region
Name:TET2_1
Description:tet methylcytosine dioxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7257  EPDNEW_H7258  EPDNEW_H7260  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,146,886 - 105,146,946EPDNEW
RGD ID:6868190
Promoter ID:EPDNEW_H7260
Type:single initiation site
Name:TET2_2
Description:tet methylcytosine dioxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7257  EPDNEW_H7258  EPDNEW_H7259  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384105,203,832 - 105,203,892EPDNEW
RGD ID:6802659
Promoter ID:HG_KWN:48844
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:ENST00000305737
Position:
Human AssemblyChrPosition (strand)Source
Build 364106,286,171 - 106,286,671 (+)MPROMDB
RGD ID:6801999
Promoter ID:HG_KWN:48845
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001127208,   OTTHUMT00000253952,   UC010ILP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364106,286,761 - 106,287,577 (+)MPROMDB
RGD ID:6802657
Promoter ID:HG_KWN:48846
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:UC003HXJ.2,   UC010ILQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364106,375,011 - 106,377,657 (+)MPROMDB
RGD ID:6802658
Promoter ID:HG_KWN:48847
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:ENST00000265149
Position:
Human AssemblyChrPosition (strand)Source
Build 364106,383,411 - 106,384,412 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25941 AgrOrtholog
COSMIC TET2 COSMIC
Ensembl Genes ENSG00000168769 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000265149 ENTREZGENE
  ENSP00000265149.5 UniProtKB/Swiss-Prot
  ENSP00000306705 ENTREZGENE
  ENSP00000306705.2 UniProtKB/Swiss-Prot
  ENSP00000369351 ENTREZGENE
  ENSP00000369351.4 UniProtKB/Swiss-Prot
  ENSP00000391448.2 UniProtKB/TrEMBL
  ENSP00000425443.1 UniProtKB/TrEMBL
  ENSP00000426885.1 UniProtKB/TrEMBL
  ENSP00000442788.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000265149 ENTREZGENE
  ENST00000265149.9 UniProtKB/Swiss-Prot
  ENST00000305737 ENTREZGENE
  ENST00000305737.6 UniProtKB/Swiss-Prot
  ENST00000380013 ENTREZGENE
  ENST00000380013.9 UniProtKB/Swiss-Prot
  ENST00000413648.2 UniProtKB/TrEMBL
  ENST00000513237.5 UniProtKB/TrEMBL
  ENST00000514870.1 UniProtKB/TrEMBL
  ENST00000540549.5 UniProtKB/Swiss-Prot
GTEx ENSG00000168769 GTEx
HGNC ID HGNC:25941 ENTREZGENE
Human Proteome Map TET2 Human Proteome Map
InterPro 2OGFeDO_noxygenase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TET1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54790 ENTREZGENE
OMIM 612839 OMIM
  614286 OMIM
  619126 OMIM
PANTHER PTHR23358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162405634 PharmGKB
SMART Tet_JBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RDF7 ENTREZGENE, UniProtKB/TrEMBL
  A0A158SIU0 ENTREZGENE, UniProtKB/TrEMBL
  A7E237_HUMAN UniProtKB/TrEMBL
  D6RE87_HUMAN UniProtKB/TrEMBL
  E7EPB1_HUMAN UniProtKB/TrEMBL
  E7EQS8_HUMAN UniProtKB/TrEMBL
  L8E8T1_HUMAN UniProtKB/TrEMBL
  Q6N021 ENTREZGENE
  Q9NXW0 ENTREZGENE
  TET2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B5MDU0 UniProtKB/Swiss-Prot
  Q2TB88 UniProtKB/Swiss-Prot
  Q3LIB8 UniProtKB/Swiss-Prot
  Q96JX5 UniProtKB/Swiss-Prot
  Q9HCM6 UniProtKB/Swiss-Prot
  Q9NXW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-04 TET2  tet methylcytosine dioxygenase 2  TET2  tet oncogene family member 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 TET2  tet oncogene family member 2  TET2  tet oncogene family member 2  Symbol and/or name change 5135510 APPROVED