RGD Reference Report - The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells. - Rat Genome Database

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The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells.

Authors: Yang, Guohua  Zeng, Xiang  Wang, Mengchuan  Wu, Aiguo 
Citation: Yang G, etal., Exp Cell Res. 2018 Feb 15;363(2):218-226. doi: 10.1016/j.yexcr.2018.01.011. Epub 2018 Jan 10.
RGD ID: 150429595
Pubmed: PMID:29331390   (View Abstract at PubMed)
DOI: DOI:10.1016/j.yexcr.2018.01.011   (Journal Full-text)

The poor outcome of hepatocellular carcinoma (HCC) is mainly due to the development of fast growth, invasion and metastasis. The role of TET2 has been implicated in some cancer types, but its role and mechanisms in HCC remains elusive. In this study, our findings indicated that TET2 expression frequently increased in HCC and that TET2 expressional upregulation correlated with HCC progression. TET2 knockdown inhibited HCC cells proliferation in vitro and growth in vivo, and inhibited the invasion potential of HCC cells. Mechanically, TET2 knockdown upregulated E-cadherin expression and then attenuated β-catenin transactivation in HCC cells. TET2 repressed E-cadherin expression via recruited HDAC1 to E-cadherin promoter to reduce the H3K9Ac and H4K16Ac levels. Moreover, β-catenin signaling transcriptionally regulated TET2 expression to form a positive feedback in HCC cells. These findings indicate that the dysregulation of TET2/E-cadherin/β-catenin regulatory loop is a critical oncogenic event in HCC progression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TET2Humanhepatocellular carcinoma amelioratesIMP human cells in mouse modelRGD 
TET2Humanhepatocellular carcinoma severityIEP mRNA and protein:increased expression:liver (human)RGD 
Tet2Rathepatocellular carcinoma amelioratesISOTET2 (Homo sapiens)human cells in mouse modelRGD 
Tet2Rathepatocellular carcinoma severityISOTET2 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 
Tet2Mousehepatocellular carcinoma amelioratesISOTET2 (Homo sapiens)human cells in mouse modelRGD 
Tet2Mousehepatocellular carcinoma severityISOTET2 (Homo sapiens)mRNA and protein:increased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tet2  (tet methylcytosine dioxygenase 2)

Genes (Mus musculus)
Tet2  (tet methylcytosine dioxygenase 2)

Genes (Homo sapiens)
TET2  (tet methylcytosine dioxygenase 2)


Additional Information